公开(公告)号：US06387977B1

公开(公告)日：2002-05-14

申请号：US09616256

申请日：2000-07-14

Applicant: Amarpreet S. Sawhney ,  David A. Melanson ,  Chandrashekar P. Pathak ,  Jeffrey A. Hubbell ,  Luis Z. Avila ,  Mark T. Kieras ,  Stephen D. Goodrich ,  Shikha P. Barman ,  Arthur J. Coury ,  Ronald S. Rudowsky ,  Douglas J. K. Weaver ,  Marc A. Levine ,  John C. Spiridigliozzi ,  Thomas S. Bromander ,  Dean M. Pichon ,  George Selecman ,  David J. Nedder ,  Bradley C. Poff ,  Donald L. Elbert

Inventor： Amarpreet S. Sawhney ,  David A. Melanson ,  Chandrashekar P. Pathak ,  Jeffrey A. Hubbell ,  Luis Z. Avila ,  Mark T. Kieras ,  Stephen D. Goodrich ,  Shikha P. Barman ,  Arthur J. Coury ,  Ronald S. Rudowsky ,  Douglas J. K. Weaver ,  Marc A. Levine ,  John C. Spiridigliozzi ,  Thomas S. Bromander ,  Dean M. Pichon ,  George Selecman ,  David J. Nedder ,  Bradley C. Poff ,  Donald L. Elbert

IPC: C09D400

CPC classification number: C09D4/00 ,  A61B17/00491 ,  A61B17/085 ,  A61B2017/00495 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/0042 ,  A61L24/046 ,  A61L24/06 ,  A61L2300/00 ,  C08F2/48 ,  C08F265/04 ,  C08F271/00 ,  C08F283/00 ,  C08F289/00 ,  C08F290/06 ,  C08F290/062 ,  C08F290/14 ,  C08F291/00 ,  C08L2666/02 ,  C09J151/00 ,  Y10S602/904 ,  C08L71/02 ,  C08L33/04 ,  C08F220/00

Abstract: An impoved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitiator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as “priming”. The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, “priming” can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. A first surface and a barrier, or another surface, are prestained with initiator, and a thin layer of gelable monomer containing initiator is placed between them. Strong adhesion is obtained between the two surfaces on gelation of the monomer. In a similar fashion, tissue surfaces can be adhered to each other in repair of wounds and formation of anastomoses. Methods for use of non-photochemical systems and combined chemical/photochemical systems are described.

Abstract translation: 公开了一种与其所施加的表面高粘附性的经阻挡或药物递送系统，以及用于制备屏障的方法。 在优选的实施方案中，用光引发剂对组织进行染色，然后将向其中加入定量的相同或不同的光引发剂的聚合物溶液或凝胶施加到组织上。 在暴露于光下时，所得体系在表面聚合，赋予优异的粘附性，并且在所施加的体积的其余部分中也形成凝胶。 因此，可以在表面上施加任意厚度的凝胶屏障，同时在界面处保持高粘附性。 该方法在本文中称为“起动”。 可聚合的阻挡材料对于密封组织表面和防止流体泄漏的接头非常有用。 在另一个实施例中，可以使用“起动”来将预先形成的障碍物可靠地粘附到组织或其它表面，或者将组织表面彼此附着。 第一表面和屏障或另一个表面用引发剂预处理，并且在它们之间放置一层含有起泡剂的可凝胶单体。 在单体凝胶化时，在两个表面之间获得强粘合性。 以类似的方式，组织表面可以在伤口的修复和吻合的形成中彼此粘合。 描述了使用非光化学体系和组合化学/光化学体系的方法。

公开(公告)号：US5844016A

公开(公告)日：1998-12-01

申请号：US478104

申请日：1995-06-07

Applicant: Amarpreet S. Sawhney ,  David A. Melanson ,  Chandrashekar P. Pathak ,  Jeffrey A. Hubbell ,  Luis Z. Avila ,  Mark T. Kieras ,  Stephen D. Goodrich ,  Shikha P. Barman ,  Arthur J. Coury ,  Ronald S. Rudowsky ,  Douglas J. K. Weaver

Inventor： Amarpreet S. Sawhney ,  David A. Melanson ,  Chandrashekar P. Pathak ,  Jeffrey A. Hubbell ,  Luis Z. Avila ,  Mark T. Kieras ,  Stephen D. Goodrich ,  Shikha P. Barman ,  Arthur J. Coury ,  Ronald S. Rudowsky ,  Douglas J. K. Weaver

IPC: A61B17/00 ,  A61B17/08 ,  A61L24/00 ,  A61L24/04 ,  A61L24/06 ,  A61L29/00 ,  A61L31/00 ,  C08F2/48 ,  C08F2/50 ,  C08F4/00 ,  C08F4/40 ,  C08F265/04 ,  C08F271/00 ,  C08F283/00 ,  C08F289/00 ,  C08F290/06 ,  C08F290/14 ,  C08F291/00 ,  C09D4/00 ,  C09D7/00 ,  C09D171/00 ,  C09J151/00 ,  C08F4/42

CPC classification number: A61L24/0031 ,  A61L24/0015 ,  A61L24/0042 ,  A61L24/046 ,  A61L24/06 ,  C08F2/48 ,  C08F265/04 ,  C08F271/00 ,  C08F283/00 ,  C08F289/00 ,  C08F290/06 ,  C08F290/062 ,  C08F290/14 ,  C08F291/00 ,  C09D4/00 ,  C09J151/00 ,  A61B17/00491 ,  A61B17/085 ,  A61B2017/00495 ,  A61L2300/00 ,  Y10S602/90 ,  Y10S602/904

Abstract: An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. The barrier can be prepared by staining tissue with a photoinitiator, applying a solution containing a polymerizable barrier material solution and a photoinitiator to the tissue, and polymerizing the polymer solution on exposure to light. The resulting polymer adheres strongly to the tissue surface, and also forms a gel in the rest of the applied volume. The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. The method can be used to adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. Tissue surfaces can be adhered to each other to repair wounds. In addition to photochemical initiators, non-photochemical initiators and combinations of chemical initiators and photochemical initiators can be used.

Abstract translation: 公开了与施加的表面高度附着的改进的屏障或药物递送系统，以及用于制造屏障的方法。 屏障可以通过用光引发剂染色组织，将含有可聚合阻挡材料溶液和光引发剂的溶液施加到组织上，以及在暴露于光下聚合聚合物溶液来制备。 所得聚合物强烈地粘附到组织表面，并且在其余施用体积中形成凝胶。 可聚合的阻挡材料对于密封组织表面和防止流体泄漏的接头非常有用。 该方法可用于将预先形成的障碍物粘附到组织或其它表面，或将组织表面彼此粘附。 组织表面可以彼此粘附以修复伤口。 除了光化学引发剂之外，还可以使用非光化学引发剂以及化学引发剂和光化学引发剂的组合。

公开(公告)号：US5707647A

公开(公告)日：1998-01-13

申请号：US749029

申请日：1996-11-14

Applicant: Richard L. Dunn ,  Gerald L. Yewey ,  Jeffrey L. Southard ,  John E. Urheim

Inventor： Richard L. Dunn ,  Gerald L. Yewey ,  Jeffrey L. Southard ,  John E. Urheim

IPC: A61L17/00 ,  A61K9/00 ,  A61L15/44 ,  A61L15/62 ,  A61L15/64 ,  A61L17/06 ,  A61L24/00 ,  A61L26/00 ,  A61L27/00 ,  A61L27/54 ,  A61L27/58 ,  A61L29/00 ,  A61L29/14 ,  A61L29/16 ,  A61L31/14 ,  A61L31/16 ,  A61L15/22

CPC classification number: A61K9/0024 ,  A61L15/44 ,  A61L15/62 ,  A61L15/64 ,  A61L17/06 ,  A61L24/0042 ,  A61L26/0066 ,  A61L26/0076 ,  A61L26/009 ,  A61L27/54 ,  A61L27/58 ,  A61L29/148 ,  A61L29/16 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00 ,  A61L2300/43 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/62 ,  Y10S528/905 ,  Y10S602/904

Abstract: A medical device which is a surgically implantable device coated with an adjunctive polymer system. The adjunctive polymer system forms a solid matrix when introduced into a human or animal body. The adjunctive polymer system can contain a drug or a medicament which is released over time from the solid matrix. The adjunctive polymer system contacts body tissue into which the surgically implantable device is implanted.

公开(公告)号：US4156066A

公开(公告)日：1979-05-22

申请号：US809260

申请日：1977-06-23

Applicant: Francis E. Gould

Inventor： Francis E. Gould

IPC: A61L27/00 ,  A61F6/14 ,  A61K8/72 ,  A61K8/73 ,  A61K8/85 ,  A61K9/00 ,  A61K9/70 ,  A61K47/34 ,  A61L15/16 ,  A61L17/00 ,  A61L29/00 ,  A61L31/00 ,  A61Q9/04 ,  C08G18/00 ,  C08G18/08 ,  C08G18/32 ,  C08G18/34 ,  C08G18/65 ,  C08G18/66 ,  C08J5/00 ,  C09D175/00 ,  G02C1/00 ,  G02C7/04

CPC classification number: C08G18/348 ,  C08G18/0823 ,  C08G18/3203 ,  C08G18/667 ,  Y10S528/904 ,  Y10S602/904 ,  Y10T428/31591 ,  Y10T428/31601

Abstract: Polyurethane polymers characterized by a molecular weight above 6,000 and having lactone groups and hydroxyl groups in the polymer backbone are prepared by reacting a mixture of polyglycols proportioned so as to provide the desired polymer properties, a polyfunctional lactone and a polyfunctional isocyanate. The product is soluble in alkaline solutions and may be used for light sensitive photographic layers on films, paper or glass; in drug delivery systems, as burn dressings, in body implants such as vascular prosthesis, and in the manufacture of catheters. The novel polymers also find use in the manufacture of artificial finger nails, finger cots, adhesives, and in protective and hydrostatic drag resistant coatings. The water absorptivity of the polyurethane lactone polymers is above 10%, preferably above 20%, and these polymers may range to completely gel-like high water absorptive polymers. The polymers of the present invention can provide a leachable substrate wherein the leaching agent may be water, gases, alcohols, esters and body fluids, e.g., animal or human.

Abstract translation: 聚合物主链中分子量高于6000并具有内酯基团和羟基的聚氨酯聚合物通过使成比例的聚二醇混合物反应以提供所需的聚合物性质，多官能内酯和多官能异氰酸酯来制备。 该产品可溶于碱性溶液，可用于薄膜，纸张或玻璃上的感光照相层; 在药物递送系统中，作为烧伤敷料，体内植入物例如血管假体，以及制造导管。 新型聚合物也可用于制造人造指甲，手指套，粘合剂，以及保护和静电阻力涂层。 聚氨酯内酯聚合物的吸水率高于10％，优选高于20％，这些聚合物可以是完全凝胶状的高吸水性聚合物。 本发明的聚合物可以提供可浸出的底物，其中浸出剂可以是水，气体，醇，酯和体液，例如动物或人。

公开(公告)号：US2624690A

公开(公告)日：1953-01-06

申请号：US72643947

申请日：1947-02-04

Applicant: PORTLAND PLASTICS LTD

Inventor： ARTHUR LEADER SIDNEY

IPC: A61L15/44 ,  A61L15/58 ,  A61L26/00

CPC classification number: A61L26/0066 ,  A61L15/44 ,  A61L15/58 ,  A61L26/0014 ,  A61L2300/216 ,  A61L2300/404 ,  Y10S602/904 ,  C08L33/12

公开(公告)号：US06685682B1

公开(公告)日：2004-02-03

申请号：US09427245

申请日：1999-10-26

Applicant: Steven B. Heinecke ,  Donald G. Peterson

Inventor： Steven B. Heinecke ,  Donald G. Peterson

IPC: A61F1302

CPC classification number: A61F13/023 ,  A61F13/0203 ,  A61F13/0276 ,  A61F2013/00412 ,  A61F2013/00663 ,  A61F2013/0074 ,  A61F2013/00744 ,  A61F2013/00748 ,  A61F2013/00761 ,  A61F2013/00834 ,  A61F2013/00868 ,  A61F2013/00876 ,  A61F2013/0091 ,  A61F2013/15878 ,  A61F2013/15918 ,  Y10S602/904

Abstract: A carrier delivered dressing which has a conformable backing with a pressure sensitive adhesive coated on a bottom face and a low adhesion coating on a top face. The backing is supported during shipping and handling by a liner attached to the adhesive and a removable heat sealed carrier attached to the top face of the backing. The method according to the present invention discloses the steps of forming and optionally removing windows in a carrier material and nonpermanently heat sealing the carrier to the backing to form the dressings of the present invention.

Abstract translation: 载体输送敷料，其具有涂覆在底面上的压敏粘合剂的适形背衬和在顶面上的低粘合涂层。 背衬在运输和处理期间由附接到粘合剂的衬垫和附接到背衬的顶面的可移除的热密封载体支撑。 根据本发明的方法公开了在载体材料中形成和任选地除去窗口的步骤，并且将载体永久地热密封到背衬上以形成本发明的敷料。

公开(公告)号：US06326025B1

公开(公告)日：2001-12-04

申请号：US09530172

申请日：2000-04-24

Applicant: Gerry Sigler ,  Z. David Deng ,  Dale R. Peterson ,  Todd P. Glancy ,  Samuel I. Stupp

Inventor： Gerry Sigler ,  Z. David Deng ,  Dale R. Peterson ,  Todd P. Glancy ,  Samuel I. Stupp

IPC: A61F1302

CPC classification number: A61L24/04 ,  C08L101/02 ,  Y10S602/904

Abstract: The present invention is directed to a biocompatible tissue reactive composition comprising a functionalized polymer having tissue reactive substituents that are capable of forming covalent bonds with tissue associated functional groups.

Abstract translation: 本发明涉及生物相容性组织反应性组合物，其包含具有能与组织相关官能团形成共价键的组织反应性取代基的官能化聚合物。

公开(公告)号：US5575995A

公开(公告)日：1996-11-19

申请号：US470132

申请日：1995-06-06

Applicant: Richard L. Giovanoni

Inventor： Richard L. Giovanoni

IPC: A61K33/10 ,  A61K33/26 ,  A61K35/02 ,  A61L26/00 ,  A61L25/00

CPC classification number: A61L26/0066 ,  A61K33/10 ,  A61K33/26 ,  A61K35/02 ,  A61L26/0014 ,  A61L2300/102 ,  A61L2300/418 ,  Y10S514/944 ,  Y10S602/904

Abstract: Lesions surgically or otherwise induced on living tissue are treated by applying to the tissue a gel containing a water solution of ferric subsulfate, glycerin to thicken the solution and polyvinyl pyrrolidone as a film forming material.

Abstract translation: 通过向组织施加含有硫酸亚铁的水溶液，甘油以增稠溶液和聚乙烯吡咯烷酮作为成膜材料的凝胶来处理在生物组织上手术或其它诱导的病变。

公开(公告)号：US3577516A

公开(公告)日：1971-05-04

申请号：US3577516D

申请日：1969-12-02

Applicant: NAT PATENT DEV CORP

Inventor： GOULD FRANCIS E ,  SHEPHERD THOMAS H

IPC: A61D9/00 ,  A61F13/00 ,  A61L15/46 ,  A61L26/00 ,  C08J7/04 ,  A61L15/00

CPC classification number: A61L15/46 ,  A61F13/00008 ,  A61F13/00063 ,  A61F2013/0011 ,  A61F2013/00263 ,  A61F2013/00876 ,  A61L26/0014 ,  A61L26/0066 ,  A61L26/0076 ,  A61L2300/222 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/41 ,  Y10S602/904

Abstract: A BANDAGE IS FORMED IN SITU ON A WOUND BY SPRAYING ON SEPARATELY OR SIMULTANEOUSLY A HYDROPHILIC WATER INSOLUBLE POLYMER AND A HIGH BOILING PLASTICIZER OR SOLVENT THEREFOR. PREFERABLY THE POLYMER IS A HYDROXY LOWER ALKYL ACRYLATE OR METHACRYLATE. MEDICALLY ACTIVE INGREDIENTS CAN BE INCLUDED IN THE COMPOSITION.

公开(公告)号：US2804073A

公开(公告)日：1957-08-27

申请号：US33336653

申请日：1953-01-26

Applicant: PROTECTIVE TEATMENTS INC

Inventor： GALLIENNE WILLIAM F ,  LE MAY WILLIAM E ,  LOUIS PERENY

IPC: A61K9/10 ,  A61L26/00

CPC classification number: A61L26/0014 ,  A61K9/10 ,  Y10S424/13 ,  Y10S602/904