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1.发明申请ISOPRENE SYNTHASE VARIANTS FOR IMPROVED MICROBIAL PRODUCTION OF ISOPRENE 审中-公开用于改善微生物生产异烟肼的异丙肾上腺素变异体公开(公告)号：US20150191712A1
公开(公告)日：2015-07-09
申请号：US14543628
申请日：2014-11-17
发明人： Richard R. BOTT , Marguerite A. Cervin , James T. Kellis, JR. , Joseph C. Mcauliffe , Andrei Miasnikov , Caroline M. Peres , Christopher L. Rife , Derek H. Wells , Walter Weyler , Gregory M. Whited
IPC分类号： C12N9/88
CPC分类号： C12N9/88 , C12P5/007 , C12Y402/03027
摘要： The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved catalytic activity and/or solubility. In particular, the present invention provides variant plant isoprene synthases for increased isoprene production in microbial host cells. Biosynthetically produced isoprene of the present invention finds use in the manufacture of rubber and elastomers.
摘要翻译： 本发明提供包含至少一种具有改善的催化活性和/或溶解度的异戊二烯合酶的方法和组合物。 特别地，本发明提供用于在微生物宿主细胞中增加异戊二烯生产的变体植物异戊二烯合酶。 本发明的生物合成生产的异戊二烯可用于制造橡胶和弹性体。
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2.发明申请THREE-DIMENSIONAL STRUCTURE OF ISOPRENE SYNTHASE AND ITS USE THEREOF FOR GENERATING VARIANTS 有权异丙肾上腺素的三维结构及其用于产生变异体公开(公告)号：US20130252303A1
公开(公告)日：2013-09-26
申请号：US13888265
申请日：2013-05-06
IPC分类号： C12P5/00
CPC分类号： C12P5/007 , C07K2299/00 , C12N9/88 , C12Y402/03027
摘要： The present invention provides a three-dimensional structures of P. tremuloides isoprene synthase and P. alba isoprene synthase. The invention also provides methods of using the three-dimensional structure to design isoprene synthases with improved activity for increased isoprene production in microbial host cells. Biosynthetically produced isoprene of the present invention finds use in the manufacture of rubber and elastomers.
摘要翻译： 本发明提供了三叶虫异戊二烯合酶和异戊二烯异戊二烯合酶的三维结构。 本发明还提供使用三维结构设计异戊二烯合酶的方法，所述异戊二烯合酶具有改进的微生物宿主细胞中异戊二烯生产增加的活性。 本发明的生物合成生产的异戊二烯可用于制造橡胶和弹性体。
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公开(公告)号：US20200332229A1
公开(公告)日：2020-10-22
申请号：US16305259
申请日：2017-05-31
申请人： DANISCO US INC.
发明人： David MARQUEZ , Michael STONER , James T. KELLIS, JR. , Adam GARSKE , Joshua Roy BASLER , Katherine AUGUSTYN , Priyanka CHANDRASEKARAN , Miles Christopher SCOTCHER , Lilia Maria BABE , Richard R. BOTT , David A. ESTELL , Gudrun VOGTENTANZ , Sina PRICELIUS , Jian YAO
摘要： Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more subtilisin variant that has improved stability and/or soil removal compared to one or more reference subtilisin.
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公开(公告)号：US20160122734A1
公开(公告)日：2016-05-05
申请号：US14650286
申请日：2013-12-10
申请人： DANISCO US INC.
发明人： Richard R. BOTT , Maria FOUKARAKI , Ronaldus Wilhelmus HOMMES , Thijs KAPER , Bradley R. KELEMEN , Slavko KRALJ , Igor NIKOLAEV , Mats SANDGREN , Johannes Franciscus Thomas VAN LIESHOUT , SANDER VAN STIGT THANS
CPC分类号： C12N9/2437 , C12N9/2434 , C12P19/02 , C12P19/14 , C12Y302/01004
摘要： Disclosed are a number of homologs and variants of Hypocrea jecorina Cel7A (formerly Trichoderma reesei cellobiohydrolase I or CBH1), nucleic acids encoding the same and methods for producing the same. The homologs and variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted and/or deleted.
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5.发明申请COMPOSITION COMPRISING VARIOUS PROTEORHODOPSINS AND/OR BACTERIORHODOPSINS AND USE THEREOF 审中-公开包含各种保护素和/或细菌体的组合物及其用途公开(公告)号：US20130135979A1
公开(公告)日：2013-05-30
申请号：US13741292
申请日：2013-01-14
申请人： Danisco US Inc.
发明人： Richard R. BOTT , Rasmus B. JENSEN , Bradley R. KELEMEN , Donald E. WARD, II , Gregory M. WHITED
IPC分类号： G11B7/242
CPC分类号： G11C7/00 , C07K14/215 , C09D11/037 , C09D11/50 , G11B7/242 , Y10S430/146 , Y10T428/249921 , Y10T428/31623 , Y10T428/31685 , Y10T428/31725 , Y10T428/31783
摘要： The present invention provides a solid material comprising an immobilized mixture of two or more proteorhodopsins, two or more bacteriorhodopsins, or one or more bacteriorhodopsin and one or more proteorhodopsins. The proteorhodopsins are selected from the group consisting of all-trans-retinal-containing proteorhodopsins and retinal analog-containing proteorhodopsins; all of which have absorption spectra that do not overlap. The bacteriorhodopsins are selected from the group consisting of all-trans-retinal-containing bacteriorhodopsins and retinal analog-containing bacteriorhodopsins; all of which have absorption spectra that do not overlap. The present invention also provides an optical information carrier, such as an optical data storage material and a fraud-proof optical data carrier, comprising the above-described solid material and a substrate selected from the group consisting of glass, paper, metal, fabric material, and plastic material, wherein said solid material is deposited on said substrate. The present invention further provides security ink comprising one or more hydrophilic polymers and a mixture of various photochromic materials.
摘要翻译： 本发明提供了一种固体材料，其包含两种或多种蛋白质视紫红质，两种或更多种细菌视紫红质，或一种或多种细菌视紫红质和一种或多种蛋白质视紫质的固定化混合物。 蛋白质视紫红质选自全反式视黄醛的蛋白质视黄素和含视网膜类似物的蛋白质视紫红质; 所有这些都具有不重叠的吸收光谱。 细菌视紫红质选自全反式视网膜含细菌视紫红质和视网膜类似物的细菌视紫红质; 所有这些都具有不重叠的吸收光谱。 本发明还提供一种光学信息载体，例如光学数据存储材料和防欺诈光学数据载体，其包括上述固体材料和选自玻璃，纸，金属，织物材料的基材 和塑料材料，其中所述固体材料沉积在所述基底上。 本发明还提供了包含一种或多种亲水聚合物和各种光致变色材料的混合物的安全油墨。
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公开(公告)号：US20170145396A1
公开(公告)日：2017-05-25
申请号：US15250626
申请日：2016-08-29
申请人： DANISCO US INC.
发明人： Richard R. BOTT , Thijs KAPER , Bradley R. KELEMEN , Frits GOEDEGEBUUR , Ronaldus Wilhelmus Joannes HOMMES , Slavko KRALJ , Paulien KRUITHOF , Igor NIKOLAEV , Wilhelmus Antonious Hendricus VAN DER KLEY , Johannes Franciscus Thomas VAN LIESHOUT , Sander VAN STIGT THANS , Gudrun VOGTENTANZ , Mats SANDGREN
CPC分类号： C12N9/2445 , C12N15/52 , C12P19/02 , C12P19/14 , C12Y302/01021
摘要： The present disclosure is generally directed to enzymes and in particular beta-glucosidase variants. Also described are nucleic acids encoding beta-glucosidase variants, compositions comprising beta-glucosidase variants, methods of using beta-glucosidase variants, and methods of identifying additional useful beta-glucosidase variants.
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公开(公告)号：US20170096653A1
公开(公告)日：2017-04-06
申请号：US15128100
申请日：2015-03-20
申请人： DANISCO US INC.
发明人： Marc KOLKMAN , Anja HEMMINGSEN KELLETT-SMITH , Rie MEJLDAL , Richard R. BOTT , Lilia Maria BABE
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38681 , C11D11/0017 , C12Y304/21
摘要： The present disclosure relates to serine proteases cloned from Bacillus spp., and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.
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公开(公告)号：US20150315560A1
公开(公告)日：2015-11-05
申请号：US14650290
申请日：2013-12-10
申请人： DANISCO US INC.
发明人： Richard R. BOTT , Maria FOUKARAKI , Ronaldus Wilhelmus HOMMES , Thijs KAPER , Bradley R. KELEMEN , Slavko KRALJ , Igor NIKOLAEV , Mats SANDGREN , Johannes Franciscus Thomas VAN LIESHOUT , SANDER VAN STIGT THANS
CPC分类号： C12N9/2437 , A23K20/189 , C11D3/38645 , C12N9/2434 , C12P19/02 , C12P19/14 , C12P2203/00 , C12Y302/01004 , C12Y302/01091
摘要： Disclosed are a number of homologs and variants of Hypocrea jecorina Cel7A (formerly Trichoderma reesei cellobiohydrolase I or CBH1), nucleic acids encoding the same and methods for producing the same. The homologs and variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted and/or deleted.
摘要翻译： 公开了许多Hypocrea jecorina Cel7A（以前的里氏木霉纤维二糖水解酶I或CBH1）的同系物和变体，编码它们的核酸及其制备方法。 同系物和变体纤维素酶具有7A族糖基水解酶的氨基酸序列，其中一个或多个氨基酸残基被取代和/或缺失。
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公开(公告)号：US20160272959A1
公开(公告)日：2016-09-22
申请号：US14650289
申请日：2013-12-10
申请人： DANISCO US INC.
发明人： Richard R. BOTT , Maria FOUKARAKI , Ronaldus Wilhelmus HOMMES , Thijs KAPER , Bradley R. KELEMEN , Slavko KRALJ , Igor NIKOLAEV , Mats SANDGREN , Johannes Franciscus Thomas VAN LIESHOUT , SANDER VAN STIGT THANS
CPC分类号： C12N9/2437 , C11D3/38645 , C11D3/38681 , C12P19/02 , C12P19/14 , C12Y302/01091 , C12Y302/01099
摘要： Disclosed are a number of homologs and variants of Hypocrea jecorina Cel7A (formerly Trichoderma reesei cellobiohydrolase I or CBH1), nucleic acids encoding the same and methods for producing the same. The homologs and variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted and/or deleted.
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公开(公告)号：US20160201104A1
公开(公告)日：2016-07-14
申请号：US14650285
申请日：2013-12-10
申请人： DANISCO US INC.
发明人： Richard R. BOTT , Maria FOUKARAKI , Ronaldus Wilhelmus HOMMES , Thijs KAPER , Bradley R. KELEMEN , Slavko KRALJ , Igor NIKOLAEV , Mats SANDGREN , Johannes Franciscus Thomas VAN LIESHOUT , SANDER VAN STIGT THANS
CPC分类号： C12P19/14 , C12N9/2434 , C12N9/2437 , C12P19/02 , C12Y302/01091
摘要： Disclosed are a number of homologs and variants of Hypocrea jecorina Ce17A (formerly Trichoderma reesei cellobiohydrolase I or CBH1), nucleic acids encoding the same and methods for producing the same. The homologs and variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted and/or deleted.
摘要翻译： 公开了许多Hypocrea jecorina Ce17A（以前的里氏木霉纤维二糖水解酶I或CBH1）的同系物和变体，编码它们的核酸及其制备方法。 同系物和变体纤维素酶具有7A族糖基水解酶的氨基酸序列，其中一个或多个氨基酸残基被取代和/或缺失。
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