发明申请
- 专利标题： THREE-DIMENSIONAL STRUCTURE OF ISOPRENE SYNTHASE AND ITS USE THEREOF FOR GENERATING VARIANTS
- 专利标题（中）： 异丙肾上腺素的三维结构及其用于产生变异体
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申请号： US13888265申请日： 2013-05-06
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公开(公告)号： US20130252303A1公开(公告)日： 2013-09-26
- 发明人: Zachary Q. BECK , Richard R. BOTT , Jeffrey V. MILLER , Christopher L. RIFE , Derek H. WELLS
- 申请人： DANISCO US INC. , THE GOODYEAR TIRE & RUBBER COMPANY
- 申请人地址： US OH Akron US CA Palo Alto
- 专利权人： THE GOODYEAR TIRE & RUBBER COMPANY,DANISCO US INC.
- 当前专利权人： THE GOODYEAR TIRE & RUBBER COMPANY,DANISCO US INC.
- 当前专利权人地址： US OH Akron US CA Palo Alto
- 主分类号： C12P5/00
- IPC分类号： C12P5/00
摘要：
The present invention provides a three-dimensional structures of P. tremuloides isoprene synthase and P. alba isoprene synthase. The invention also provides methods of using the three-dimensional structure to design isoprene synthases with improved activity for increased isoprene production in microbial host cells. Biosynthetically produced isoprene of the present invention finds use in the manufacture of rubber and elastomers.
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