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    Aromatic heterocyclic derivatives and their therapeutic and cosmetic use
    7.
    发明授权
    Aromatic heterocyclic derivatives and their therapeutic and cosmetic use 失效
    芳香杂环衍生物及其治疗和美容用途

    公开(公告)号：US5428052A

    公开(公告)日：1995-06-27

    申请号：US160225

    申请日：1993-12-02

    申请人： Braham Shroot ,  Jacques Eustache ,  Jean-Michel Bernardon

    发明人： Braham Shroot ,  Jacques Eustache ,  Jean-Michel Bernardon

    IPC分类号： C07C59/64 ,  C07D209/10 ,  C07D235/18 ,  C07D263/56 ,  C07D263/57 ,  C07D277/66 ,  C07D307/79 ,  C07D333/54 ,  C07D405/04 ,  A61K31/40 ,  C07D209/12

    CPC分类号： C07D263/57 ,  C07C59/64 ,  C07D209/10 ,  C07D235/18 ,  C07D277/66 ,  C07D307/79 ,  C07D333/54 ,  C07D405/04

    摘要： Aromatic heterocyclic derivatives have the formula ##STR1## wherein R.sub.1 represents (i)--CH.sub.3, (ii)--CH.sub.2 OH or (iii) ##STR2## wherein R.sub.3 represents hydrogen, --OR.sub.4 wherein R.sub.4 represents hydrogen, alkyl having 1-20 carbon atoms or mono- or polyhydroxyalkyl or R.sub.3 represents ##STR3## wherein r' and r" represent hydrogen, lower alkyl or together form a heterocycle, R.sub.2 represents hydrogen or --CH.sub.3 and Ar represents ##STR4## wherein R.sub.6 is hydrogen or alkyl having 1-10 carbon atoms and R.sub.7 represents alkyl having 4-12 carbon atoms or cycoalkyl, Y is CH or a nitrogen atom and X represents oxygen, sulfur or --N--R.sub.8 when R.sub.8 represents hydrogen, lower alkyl or lower alkoxycarbonyl, with the proviso that (i) when Y is CH and X is oxygen or sulfur Ar is other than C and (ii) when Y is nitrogen and X is oxygen, Ar is other than (C) or (D) in which R.sub.6 is alkyl having 1-4 carbon atoms and R.sub.7 is branched alkyl having 4-12 atoms.

    摘要翻译： 芳族杂环衍生物具有下式（其中R 1表示（i）-CH 3，（ii）-CH 2 OH或（iii）其中R 3表示氢，-OR 4，其中R 4表示氢，具有1-20个碳原子的烷基或 单或多羟基烷基或R 3表示其中r'和r“表示氢，低级烷基或一起形成杂环，R 2表示氢或-CH 3，Ar表示（A） （C）（D）其中R6是氢或具有1-10个碳原子的烷基，R7代表具有4-12个碳原子的烷基或环烷基，Y是CH或氮原子，X代表氧，硫或 （ⅰ）当Y为CH且X为氧或硫时Ar为C以外，（ⅱ）当Y为氮且X为氧时，R为氢，低级烷基或低级烷氧基羰基， Ar不是（C）或（D），其中R6是具有1-4个碳原子的烷基，R7是具有4-12个原子的支链烷基。

    Aromatic benzamido compounds; their preparation and their use in human or veterinary medicine or in cosmetic preparations
    9.
    发明授权
    Aromatic benzamido compounds; their preparation and their use in human or veterinary medicine or in cosmetic preparations 失效
    芳香族苯甲酰胺化合物; 它们的制备及其在人或兽医学或化妆品制剂中的应用

    公开(公告)号：US5212203A

    公开(公告)日：1993-05-18

    申请号：US483625

    申请日：1990-02-23

    申请人： Braham Shroot ,  Jacques Eustache ,  Jean-Michel Bernardon

    发明人： Braham Shroot ,  Jacques Eustache ,  Jean-Michel Bernardon

    IPC分类号： C07D295/192

    CPC分类号： C07D295/192 ,  Y10S514/826 ,  Y10S514/859 ,  Y10S514/863 ,  Y10S514/912

    摘要： An aromatic benzamido compound having the formula ##STR1## wherein R.sub.1 represents --CH.sub.2 OH, --CHOHCH.sub.3 or --COR.sub.5,R.sub.5 represents hydrogen, lower alkyl, --OR.sub.6 or ##STR2## R.sub.6 represents hydrogen, lower alkyl or mono- or polyhydroxyalkyl, r' and r" represent hydrogen, lower alkyl, mono or polyhydroxyalkyl, aryl or benzyl optionally substituted, the residue of an amino acid or aminated sugar or taken together form a heterocycle,R.sub.2 represents an .alpha.,.alpha.'-disubstituted alkyl having 4-12 carbon atoms or mono or polycyclic cycloalkyl having 5-12 carbon atoms, the linking carbon of which is quaternary,R.sub.3 represents hydrogen or alkyl having 1-10 carbon atoms, andR.sub.4 represents hydrogen, lower alkyl or hydroxy, andthe salts of this aromatic benzamido compound when R.sub.6 represents hydrogen.

    摘要翻译： 具有式（I）的芳族苯甲酰氨基化合物，其中R 1表示-CH 2 OH，-CHOHCH 3或-COR 5，R 5表示氢，低级烷基，-OR 6或R 6表示氢，低级烷基或单 - 或多羟基烷基， r'和r“表示氢，低级烷基，单羟基烷基或多羟基烷基，芳基或任选取代的苄基，氨基酸或胺化糖的残基或一起形成杂环，R2表示具有4个的α，α'-二取代的烷基 -12个碳原子或具有5-12个碳原子的单环或多环环烷基，其连接碳为季，R 3表示氢或具有1-10个碳原子的烷基，R 4表示氢，低级烷基或羟基， 当R6表示氢时，该芳族苯甲酰氨基化合物。