公开(公告)号：US11459479B2

公开(公告)日：2022-10-04

申请号：US16426506

申请日：2019-05-30

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  Chung-Yuan Chiang ,  Newton T. Samuel ,  Richard Govan ,  Ciara Dauenhauer

IPC: C09D133/02 ,  B29D11/00 ,  B29K683/00 ,  G02C7/04

Abstract: The invention is generally related to a method for producing coated silicone hydrogel contact lenses each of which has a hydrogel coating thereon and a relative high resistance to uptakes of polycationic antimicrobials as characterized by having a polyquaternium-1-uptake of less than 0.40 micrograms/lens. The hydrogel coating is formed by covalently attached a hydrophilic polymeric material onto a base coating of a polyanionic polymer on a SiHy contact lens. In this method, lower polyquaternium-1-uptake is achieved by using a rinse solution with a higher pH and/or a higher ionic strength (higher salt concentration) for rinsing a treated silicone hydrogel contact lens with a base coating of polyanionic polymer.

公开(公告)号：US20220032564A1

公开(公告)日：2022-02-03

申请号：US17385987

申请日：2021-07-27

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Ciara Dauenhauer ,  Chung-Yuan Chiang ,  Paul William Oyler ,  Robert Carey Tucker

IPC: B29D11/00 ,  G02C7/04 ,  C09D133/10 ,  C09D133/08

Abstract: The invention is related to a coated contact lens, especially a coated silicone hydrogel contact lens, which comprises an anterior surface, an opposite posterior surface, and a layered structural configuration from the anterior surface to the posterior surface. The layered structural configuration comprises an outer anterior surface hydrogel layer, an inner layer, and an outer posterior surface hydrogel layer. The inner layer is a lens bulk material. The coated contact lens has a superior lens surface softness and a good lens surface hydrophilicity while optionally having a desirably-lower polyquaternium-1 uptake.

公开(公告)号：US11952449B2

公开(公告)日：2024-04-09

申请号：US17148197

申请日：2021-01-13

Applicant: Alcon Inc.

Inventor： Frank Chang ,  Feng Jing ,  Troy Vernon Holland ,  Chung-Yuan Chiang ,  John Dallas Pruitt

IPC: C08F226/06 ,  C08F220/56 ,  C08F220/58 ,  C08G73/06 ,  C08L33/26 ,  C08L79/02 ,  C09D5/02 ,  C09D133/14 ,  C09D133/26 ,  C09D179/02 ,  C09D179/08 ,  G02B1/04 ,  C08F220/28 ,  C08F220/38

CPC classification number: C08F220/56 ,  C08L33/26 ,  C08L79/02 ,  C09D5/02 ,  C09D133/14 ,  C09D133/26 ,  C09D179/02 ,  C09D179/08 ,  G02B1/043 ,  C08F220/283 ,  C08F220/286 ,  C08F220/382 ,  C08F220/58 ,  C08F226/06 ,  C08F2800/10 ,  C08F2810/20 ,  C08G73/06 ,  C08F220/56 ,  C08F220/54 ,  C08F220/285 ,  C08F220/56 ,  C08F220/54 ,  C08F220/286 ,  C08F220/56 ,  C08F220/54 ,  C08F220/382 ,  C08F220/56 ,  C08F220/54 ,  C08F220/387 ,  C08L33/26 ,  C08L79/02 ,  C08L33/26 ,  C08L79/04

Abstract: The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymers each comprising dangling (i.e., pendant) reactive chains each terminated with a carboxyl group groups and at least 50% by mole of (meth)acrylamide repeating units relative to all repeating units of the hydrophilic poly(meth)acrylamide-based copolymer. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly-branched hydrophilic polymeric material and in producing water gradient contact lenses.

公开(公告)号：US20220372391A1

公开(公告)日：2022-11-24

申请号：US17659972

申请日：2022-04-20

Applicant: Alcon Inc.

Inventor： Chung-Yuan Chiang ,  Yongxing Qiu

IPC: C10M107/42 ,  B29D11/00 ,  C08J7/04 ,  C08J3/24 ,  C10M107/28 ,  C10M107/48 ,  G02C7/04

Abstract: The present invention generally relates to a method for applying a coating of hydrophilic polymers onto polyvinylalcohol-based hydrogel contact lenses to improve lubricity. In particular, the present invention is directed to a method for forming a coating on a contact lens, preferably a polyvinylalcohol-based hydrogel contact lens, directly in the primary package and maintaining the coated contact lens within said primary package until insertion of the coated contact lens in the eye of the contact lens user. The resultant polyvinylalcohol-based hydrogel contact lens has a coating with improved lubricity and good durability and also can be used directly from the lens package by a patient without washing and/or rinsing.

公开(公告)号：US20210130644A1

公开(公告)日：2021-05-06

申请号：US17148197

申请日：2021-01-13

Applicant: Alcon Inc.

Inventor： Frank Chang ,  Feng Jing ,  Troy Vernon Holland ,  Chung-Yuan Chiang ,  John Dallas Pruitt

IPC: C09D133/26 ,  C08L33/26 ,  C08L79/02 ,  C09D179/02 ,  C08F220/28 ,  C08F220/38 ,  C08F220/56 ,  C09D5/02 ,  C09D133/14 ,  C09D179/08 ,  G02B1/04

Abstract: The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymers each comprising dangling (i.e., pendant) reactive chains each terminated with a carboxyl group groups and at least 50% by mole of (meth)acrylamide repeating units relative to all repeating units of the hydrophilic poly(meth)acrylamide-based copolymer. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly-branched hydrophilic polymeric material and in producing water gradient contact lenses.

公开(公告)号：US12270968B2

公开(公告)日：2025-04-08

申请号：US18436094

申请日：2024-02-08

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Newton T. Samuel ,  Chung-Yuan Chiang ,  Robert Carey Tucker ,  Yuan Chang ,  Ethan Leveillee

IPC: G02B1/04 ,  B05D5/00 ,  B29D11/00 ,  B29K105/00 ,  B65B55/22 ,  C08L33/02 ,  C08L79/04 ,  C08L83/04 ,  C09D133/02 ,  G02B1/18 ,  G02C7/04 ,  B05D1/18 ,  B05D1/38 ,  B05D3/00 ,  B05D3/02 ,  B05D5/10 ,  B29K83/00

Abstract: The invention is related to contact lenses that not only comprise the much desired water gradient structural configurations, but also have a minimized uptakes of polycationic antimicrobials and a long-lasting surface hydrophilicity and wettability even after going through a 30-days lens care regime. Because of the water gradient structural configuration and a relatively-thick, extremely-soft and water-rich hydrogel surface layer, a contact lens of the invention can provide superior wearing comfort. Further, a contact lens of the invention is compatible with multipurpose lens care solutions present in the market and can endure the harsh lens care handling conditions (e.g., digital rubbings, accidental inversion of contact lenses, etc.) encountered in a daily lens care regime. As such, they are suitable to be used as weekly- or monthly-disposable water gradient contact lenses.

公开(公告)号：US20220299796A1

公开(公告)日：2022-09-22

申请号：US17834191

申请日：2022-06-07

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Kelly Kayi Tallau ,  Angela Driver-Scott ,  Chung-Yuan Chiang

IPC: G02C7/04 ,  B29D11/00 ,  G02B1/14 ,  C09D133/02 ,  C09D177/06 ,  G02B1/04

Abstract: The invention is related to a method for producing soft contact lenses comprises a silicone hydrogel lens body and a composite coating thereon. The composite coating comprises: a plasma base coating which is chemically-attached directly onto the surface of the silicone hydrogel contact lens and functions as a fail-proof measure for ensuring the hydrophobic silicone hydrogel lens material to be shielded from any exposure to ocular environments even after at least 30 days of daily uses including daily waring and daily cleaning/disinfecting; and a relatively-durable lubricious hydrogel top coating for ensuring wearing comfort. A method of the invention comprises forming a plasma-reactive hydrophilic polymer hybrid base coating having reactive functional groups on a silicone hydrogel contact lens and heating the silicone hydrogel contact lens with the hybrid base coating in an aqueous solution of a water-soluble and thermally crosslinkable hydrophilic polymeric material to form a stable lubricious hydrogel coating thereon. This method has a minimized adverse impact on the mechanical properties of silicone hydrogel lens body.

公开(公告)号：US20220137263A1

公开(公告)日：2022-05-05

申请号：US17572794

申请日：2022-01-11

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Newton T. Samuel ,  Chung-Yuan Chiang ,  Robert Carey Tucker ,  Yuan Chang ,  Ethan Leveillee

IPC: G02B1/04 ,  C08L83/04 ,  C08L33/02 ,  C08L79/04 ,  C09D133/02 ,  B05D5/00 ,  B29D11/00 ,  G02C7/04 ,  G02B1/18 ,  B65B55/22

Abstract: The invention is related to contact lenses that not only comprise the much desired water gradient structural configurations, but also have a minimized uptakes of polycationic antimicrobials and a long-lasting surface hydrophilicity and wettability even after going through a 30-days lens care regime. Because of the water gradient structural configuration and a relatively-thick, extremely-soft and water-rich hydrogel surface layer, a contact lens of the invention can provide superior wearing comfort. Further, a contact lens of the invention is compatible with multipurpose lens care solutions present in the market and can endure the harsh lens care handling conditions (e.g., digital rubbings, accidental inversion of contact lenses, etc.) encountered in a daily lens care regime. As such, they are suitable to be used as weekly- or monthly-disposable water gradient contact lenses.

公开(公告)号：US20240176047A1

公开(公告)日：2024-05-30

申请号：US18436094

申请日：2024-02-08

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Newton T. Samuel ,  Chung-Yuan Chiang ,  Robert Carey Tucker ,  Yuan Chang ,  Ethan Leveillee

IPC: G02B1/04 ,  B05D1/18 ,  B05D1/38 ,  B05D3/00 ,  B05D3/02 ,  B05D5/00 ,  B05D5/10 ,  B29D11/00 ,  B29K83/00 ,  B29K105/00 ,  B65B55/22 ,  C08L33/02 ,  C08L79/04 ,  C08L83/04 ,  C09D133/02 ,  G02B1/18 ,  G02C7/04

CPC classification number: G02B1/043 ,  B05D5/00 ,  B29D11/00038 ,  B29D11/00125 ,  B29D11/00865 ,  B65B55/22 ,  C08L33/02 ,  C08L79/04 ,  C08L83/04 ,  C09D133/02 ,  G02B1/18 ,  G02C7/049 ,  B05D1/18 ,  B05D1/38 ,  B05D3/002 ,  B05D3/02 ,  B05D5/10 ,  B29K2083/00 ,  B29K2105/0061 ,  C08L2201/10 ,  C08L2201/54 ,  G02B2207/109

Abstract: The invention is related to contact lenses that not only comprise the much desired water gradient structural configurations, but also have a minimized uptakes of polycationic antimicrobials and a long-lasting surface hydrophilicity and wettability even after going through a 30-days lens care regime. Because of the water gradient structural configuration and a relatively-thick, extremely-soft and water-rich hydrogel surface layer, a contact lens of the invention can provide superior wearing comfort. Further, a contact lens of the invention is compatible with multipurpose lens care solutions present in the market and can endure the harsh lens care handling conditions (e.g., digital rubbings, accidental inversion of contact lenses, etc.) encountered in a daily lens care regime. As such, they are suitable to be used as weekly- or monthly-disposable water gradient contact lenses.

公开(公告)号：US20200172756A1

公开(公告)日：2020-06-04

申请号：US16426506

申请日：2019-05-30

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  Chung-Yuan Chiang ,  Newton T. Samuel ,  Richard Govan ,  Ciara Dauenhauer

IPC: C09D133/02 ,  B29D11/00

Abstract: The invention is generally related to a method for producing coated silicone hydrogel contact lenses each of which has a hydrogel coating thereon and a relative high resistance to uptakes of polycationic antimicrobials as characterized by having a polyquaternium-1-uptake of less than 0.40 micrograms/lens. The hydrogel coating is formed by covalently attached a hydrophilic polymeric material onto a base coating of a polyanionic polymer on a SiHy contact lens. In this method, lower polyquaternium-1-uptake is achieved by using a rinse solution with a higher pH and/or a higher ionic strength (higher salt concentration) for rinsing a treated silicone hydrogel contact lens with a base coating of polyanionic polymer.