公开(公告)号：US11061169B2

公开(公告)日：2021-07-13

申请号：US16683886

申请日：2019-11-14

Applicant: Alcon Inc.

Inventor： Frank Chang ,  Houliang Tang ,  Troy Vernon Holland ,  Adam K. Sniady

IPC: G02B1/04 ,  C08F216/06 ,  C08F216/38 ,  C08F218/08 ,  C08F230/02 ,  G02B1/10 ,  G02C7/04

Abstract: The invention is generally related to a soft contact lens which comprises a hydrogel lens body and a coating thereon and to a method for producing the same. The hydrogel lens body is composed of a crosslinked polymeric material comprising repeating units of at least one arylborono-containing vinylic monomer having a boronic acid group, and the coating comprises a layer of a phosphorylcholine-containing polymer which comprises (a) repeating units of vinyl alcohol, and (b) repeating units of 6-membered acetal ring substituted with a phosphorylcholine-containing group. The coating is covalently-attached to the hydrogel lens body through cyclic boronic ester linkages each formed between one of the boronic acid groups of the crosslinked polymeric material and one of the 1,2-diol and 1,3-diol moieties of the phosphorylcholine-containing polymer.

公开(公告)号：US11952449B2

公开(公告)日：2024-04-09

申请号：US17148197

申请日：2021-01-13

Applicant: Alcon Inc.

Inventor： Frank Chang ,  Feng Jing ,  Troy Vernon Holland ,  Chung-Yuan Chiang ,  John Dallas Pruitt

IPC: C08F226/06 ,  C08F220/56 ,  C08F220/58 ,  C08G73/06 ,  C08L33/26 ,  C08L79/02 ,  C09D5/02 ,  C09D133/14 ,  C09D133/26 ,  C09D179/02 ,  C09D179/08 ,  G02B1/04 ,  C08F220/28 ,  C08F220/38

CPC classification number: C08F220/56 ,  C08L33/26 ,  C08L79/02 ,  C09D5/02 ,  C09D133/14 ,  C09D133/26 ,  C09D179/02 ,  C09D179/08 ,  G02B1/043 ,  C08F220/283 ,  C08F220/286 ,  C08F220/382 ,  C08F220/58 ,  C08F226/06 ,  C08F2800/10 ,  C08F2810/20 ,  C08G73/06 ,  C08F220/56 ,  C08F220/54 ,  C08F220/285 ,  C08F220/56 ,  C08F220/54 ,  C08F220/286 ,  C08F220/56 ,  C08F220/54 ,  C08F220/382 ,  C08F220/56 ,  C08F220/54 ,  C08F220/387 ,  C08L33/26 ,  C08L79/02 ,  C08L33/26 ,  C08L79/04

Abstract: The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymers each comprising dangling (i.e., pendant) reactive chains each terminated with a carboxyl group groups and at least 50% by mole of (meth)acrylamide repeating units relative to all repeating units of the hydrophilic poly(meth)acrylamide-based copolymer. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly-branched hydrophilic polymeric material and in producing water gradient contact lenses.

公开(公告)号：US20220251302A1

公开(公告)日：2022-08-11

申请号：US17666601

申请日：2022-02-08

Applicant: Alcon Inc.

Inventor： Frank Chang ,  Troy Vernon Holland ,  Houliang Tang ,  Adam K. Sniady

IPC: C08G77/04 ,  G02C7/04

Abstract: The invention provides a class of hydrophilized polydiorganosiloxane vinylic crosslinkers. Each of the hydrophilized polydiorganosiloxane vinylic crosslinkers of the invention comprise (1) a polydiorganosiloxane segment comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one organic substituent having a phosphorylcholine moiety; (2) ethylenically-unsaturated groups. The invention also provides a silicone hydrogel contact lens, which comprises a crosslinked polymeric material comprising repeating units of at least one of such a class of hydrophilized polydiorganosiloxane vinylic crosslinkers. The invention further provides a method of producing a hydrophilized contact lens from a polymerizable composition comprising at least one of such a class of hydrophilized polydiorganosiloxane vinylic crosslinkers.

公开(公告)号：US20210130644A1

公开(公告)日：2021-05-06

申请号：US17148197

申请日：2021-01-13

Applicant: Alcon Inc.

Inventor： Frank Chang ,  Feng Jing ,  Troy Vernon Holland ,  Chung-Yuan Chiang ,  John Dallas Pruitt

IPC: C09D133/26 ,  C08L33/26 ,  C08L79/02 ,  C09D179/02 ,  C08F220/28 ,  C08F220/38 ,  C08F220/56 ,  C09D5/02 ,  C09D133/14 ,  C09D179/08 ,  G02B1/04

Abstract: The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymers each comprising dangling (i.e., pendant) reactive chains each terminated with a carboxyl group groups and at least 50% by mole of (meth)acrylamide repeating units relative to all repeating units of the hydrophilic poly(meth)acrylamide-based copolymer. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly-branched hydrophilic polymeric material and in producing water gradient contact lenses.

公开(公告)号：US10906258B2

公开(公告)日：2021-02-02

申请号：US16114528

申请日：2018-08-28

Applicant: Alcon Inc.

Inventor： Troy Vernon Holland ,  Frank Chang ,  Ryan DeSousa

IPC: B29D11/00 ,  C08F16/06 ,  G02B1/04 ,  B29K105/24 ,  B29K105/00 ,  B29K29/00

Abstract: Described herein is a cast-molding process for producing contact lenses in a relatively short curing time. The short curing time has been achieved by adding a chain transfer agent into a lens-forming composition.

公开(公告)号：US20240392055A1

公开(公告)日：2024-11-28

申请号：US18665682

申请日：2024-05-16

Applicant: Alcon Inc.

Inventor： Troy Vernon Holland ,  Adam K. Sniady ,  Frank Chang

IPC: C08F230/08 ,  B29D11/00 ,  B29K83/00 ,  B29K105/00 ,  G02B1/04 ,  G02C7/10

Abstract: Described herein is a UV/HEVL-filtering SiHy contact lens that not only has a relatively high UV/HEVL filtering capability but also has an aesthetic appealing color. The bulk silicone hydrogel of the UV/HEVL-filtering SiHy contact lens comprises repeating units of (1) at least one hydrophilic vinylic monomer, (2) at least one siloxane-containing vinylic monomer and/or at least one polysiloxane vinylic crosslinker, (3) at least one UV-absorbing vinylic monomer having an absorption peak at a wavelength of from 280 nm and 380 nm, (4) a first HEVL-absorbing benzotriazole-containing vinylic monomer having an absorption peak at a wavelength of from 410 nm and 420 nm, (5) a second HEVL-absorbing benzotriazole-containing vinylic monomer having an absorption peak at a wavelength of from 415 nm and 425 nm, and (6) from about 90 ppm to about 300 ppm of repeating units of at least one polymerizable blue dye.

公开(公告)号：US20230374306A1

公开(公告)日：2023-11-23

申请号：US18321435

申请日：2023-05-22

Applicant: Alcon Inc.

Inventor： Frank Chang ,  Troy Vernon Holland ,  Adam K. Sniady ,  Houliang Tang

IPC: C08L83/04 ,  C08J3/075

CPC classification number: C08L83/04 ,  C08J3/075 ,  C08J2383/04 ,  C08J2471/02

Abstract: Described herein is UV/HEVL-absorbing contact lens of the invention comprises a bulk hydrogel material that comprises repeating units of at least one UV-absorbing vinylic monomer, repeating units of at least one UV/HEVL-absorbing vinylic monomer, and derivatives of a reactive Cu(II)-porphyrin present in selected amounts and at a selected ratio. A UV/HEVL-filtering contact lens of the invention not only can provide Class I UV protection against UVA and UVB rays (i.e., filtering more than 90% of UVA and 99% of UVB rays) but also can mimics the natural crystalline lens of a human eye in providing HEVL protection.

公开(公告)号：US20230364832A1

公开(公告)日：2023-11-16

申请号：US18308210

申请日：2023-04-27

Applicant: Alcon Inc.

Inventor： Frank Chang ,  Troy Vernon Holland ,  Houliang Tang ,  Adam K. Sniady

IPC: B29C39/02 ,  B29C39/00 ,  B29C39/26 ,  B29C39/36 ,  B29D11/00 ,  G02B1/04

CPC classification number: B29C39/026 ,  B29C39/006 ,  B29C39/26 ,  B29C39/36 ,  B29D11/00038 ,  G02B1/043 ,  B29K2101/10

Abstract: Described herein is a cost-effective and time-efficient method for producing UV- and HEVL-absorbing silicone hydrogel contact lenses capable of blocking ultra-violet (“UV”) radiation and high-energy-violet light (HEVL) with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV and HEVL radiation. This invention also provides UV- and HEVL-absorbing absorbing contact lenses made according to a method of the invention.

公开(公告)号：US10829574B2

公开(公告)日：2020-11-10

申请号：US16807844

申请日：2020-03-03

Applicant: Alcon Inc.

Inventor： Frank Chang ,  Troy Vernon Holland ,  Feng Jing ,  Ryan DeSousa

IPC: C08F28/02 ,  G02B1/04 ,  C08F8/34 ,  C08F8/48 ,  C08F8/30 ,  C08B37/00 ,  C08F24/00 ,  C08F26/06 ,  C08F20/56 ,  G02C7/04

Abstract: The invention is related to a class of hydrophilic copolymers comprising loosely dangling thiol-containing pendant groups. The hydrophilic copolymers are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating and can find particular use in for producing water-soluble highly-branched hydrophilic polymeric material useful for producing water gradient contact lenses.

公开(公告)号：US20240383865A1

公开(公告)日：2024-11-21

申请号：US18665691

申请日：2024-05-16

Applicant: Alcon Inc.

Inventor： Troy Vernon Holland ,  Adam K. Sniady ,  Frank Chang

IPC: C07D249/20 ,  B29D11/00 ,  B29K55/00 ,  B29K105/00 ,  C08F220/54 ,  C08F230/08 ,  C08K5/00 ,  G02B1/04 ,  G02C7/10

Abstract: Described herein is high-energy-violet-light (HEVL) absorbing benzotriazole vinylic monomers that have an adequate solubility in an organic solvent (e.g., 1-propanol), a better compatibility with polymerizable components present in a hydrogel lens formulation, and an absorption peak at a wavelength of from 410 nm to 425 nm. They are suitable for making hydrogel contact lenses that can significantly block HEVL from 380 nm to 450 nm but cannot block significantly blue lights (from 450 nm to 495 nm).