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公开(公告)号：US20240384238A1
公开(公告)日：2024-11-21
申请号：US18779687
申请日：2024-07-22
Applicant: Amgen Inc.
Inventor： Christopher Kenyon CROWELL , Jian WU , Neil KITCHEN , Alison Jean GILLESPIE , Simina Crina PETROVAN , Michael Charles BRANDENSTEIN , Athena Denise Nagi
Abstract: This invention relates to recombinantly-expressed denosumab molecules and methods for modulating glycan profiles of denosumab molecules.
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公开(公告)号：US20220136026A1
公开(公告)日：2022-05-05
申请号：US17554836
申请日：2021-12-17
Applicant: AMGEN INC.
Inventor： Jian WU , Sean DAVERN , Simina Crina PETROVAN , Michael Charles BRANDENSTEIN , Katherine Rose LINDAHL , Shawn Erik LILLIE
Abstract: The present invention relates to methods of modulating the mannose content of recombinant proteins.
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公开(公告)号：US20200087698A1
公开(公告)日：2020-03-19
申请号：US16654933
申请日：2019-10-16
Applicant: AMGEN INC.
Inventor： Jian WU , Sean DAVERN , Simina Crina PETROVAN , Michael Charles BRANDENSTEIN , Katherine Rose LINDAHL , Shawn Erik LILLIE
Abstract: The present invention relates to methods of modulating the mannose content of recombinant proteins.
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公开(公告)号：US20180002733A1
公开(公告)日：2018-01-04
申请号：US15652138
申请日：2017-07-17
Applicant: AMGEN INC.
Inventor： Jian WU , Sean DAVERN , Simina Crina PETROVAN , Michael Charles BRANDENSTEIN , Katherine Rose LINDAHL , Shawn Erik LILLIE
CPC classification number: C12P21/005 , C07K16/00 , C07K2317/14 , C07K2317/41 , C12N1/38 , C12N5/0037 , C12N2500/32 , C12N2500/34 , C12N2510/02
Abstract: The present invention relates to methods of modulating the mannose content of recombinant proteins.
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5.发明申请METHOD FOR CULTURING MAMMALIAN CELLS TO IMPROVE RECOMBINANT PROTEIN PRODUCTION 有权培养MAMMALIAN细胞以改善重组蛋白生产的方法公开(公告)号：US20160040207A1
公开(公告)日：2016-02-11
申请号：US14821574
申请日：2015-08-07
Applicant: AMGEN INC.
Inventor： Matthew I. JERUMS , Amanda KANO , Henry LIN , Shun LUO , Jian WU , Rebecca E. McCOY , Arvia E. MORRIS
IPC: C12P21/00
CPC classification number: C12P21/00 , C12N5/0037 , C12N5/0043 , C12N2500/32 , C12N2510/02 , C12N2511/00
Abstract: The present invention relates to methods for mammalian cell culture. The methods make use of independent tyrosine and cystine feed streams.
Abstract translation: 本发明涉及哺乳动物细胞培养的方法。 该方法利用独立的酪氨酸和胱氨酸进料流。
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Patent Agency Ranking
公开(公告)号：US20160032343A1
公开(公告)日：2016-02-04
申请号：US14776404
申请日：2014-03-10
Applicant: AMGEN INC.
Inventor： Jian WU , Sean DAVERN , Simina Crina PETROVAN , Michael Charles BRANDENSTEIN , Katherine Rose LINDAHL , Shawn Erik LILLIE
CPC classification number: C12P21/005 , C07K16/00 , C07K2317/14 , C07K2317/41 , C12N1/38 , C12N5/0037 , C12N2500/32 , C12N2500/34 , C12N2510/02
Abstract: The present invention relates to methods of modulating the mannose content of recombinant proteins.
Abstract translation: 本发明涉及调节重组蛋白质的甘露糖含量的方法。
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公开(公告)号：US20230287335A1
公开(公告)日：2023-09-14
申请号：US18018389
申请日：2021-07-27
Applicant: AMGEN INC.
Inventor： Nicholas MARCHAND , Glen BOLTON , Sara Ann GALL , Jian WU
CPC classification number: C12N5/0018 , B01D61/027 , B01D65/08 , C12N2501/105 , C12N2501/33 , B01D2321/168
Abstract: Presented herein are methods for preparing and treating mammalian cell culture media through the addition of low levels of poloxamer and nanofiltration. Low levels of poloxamer improved flux and retained greater levels of a growth factor.
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公开(公告)号：US20220213522A1
公开(公告)日：2022-07-07
申请号：US17704662
申请日：2022-03-25
Applicant: AMGEN INC.
Inventor： Jian WU , Sean DAVERN , Simina Crina PETROVAN , Michael Charles BRANDENSTEIN , Katherine Rose LINDAHL , Shawn Erik LILLIE
Abstract: The present invention relates to methods of modulating the mannose content of recombinant proteins.
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公开(公告)号：US20210115125A1
公开(公告)日：2021-04-22
申请号：US17030842
申请日：2020-09-24
Applicant: AMGEN INC.
Inventor： Jian WU , Nicole SABO , Michael DE LA CRUZ , Gregory FLYNN
Abstract: The present invention relates to methods of modulating (e.g., reducing) the mannose content, particularly high-mannose content of recombinant glycoproteins.
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公开(公告)号：US20230193340A1
公开(公告)日：2023-06-22
申请号：US18172670
申请日：2023-02-22
Applicant: AMGEN INC.
Inventor： Jian WU , Sean DAVERN , Simina Crina PETROVAN , Michael Charles BRANDENSTEIN , Katherine Rose LINDAHL , Shawn Erik LILLIE
CPC classification number: C12P21/005 , C12N5/0037 , C07K16/00 , C12N1/38 , C12N2500/32 , C12N2500/34 , C12N2510/02 , C07K2317/14 , C07K2317/41
Abstract: The present invention relates to methods of modulating the mannose content of recombinant proteins.
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