公开(公告)号：US20230193340A1

公开(公告)日：2023-06-22

申请号：US18172670

申请日：2023-02-22

Applicant: AMGEN INC.

Inventor： Jian WU ,  Sean DAVERN ,  Simina Crina PETROVAN ,  Michael Charles BRANDENSTEIN ,  Katherine Rose LINDAHL ,  Shawn Erik LILLIE

IPC: C12P21/00 ,  C12N5/00 ,  C07K16/00 ,  C12N1/38

CPC classification number: C12P21/005 ,  C12N5/0037 ,  C07K16/00 ,  C12N1/38 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2510/02 ,  C07K2317/14 ,  C07K2317/41

Abstract: The present invention relates to methods of modulating the mannose content of recombinant proteins.

公开(公告)号：US20220213522A1

公开(公告)日：2022-07-07

申请号：US17704662

申请日：2022-03-25

Applicant: AMGEN INC.

Inventor： Jian WU ,  Sean DAVERN ,  Simina Crina PETROVAN ,  Michael Charles BRANDENSTEIN ,  Katherine Rose LINDAHL ,  Shawn Erik LILLIE

IPC: C12P21/00 ,  C12N5/00 ,  C07K16/00 ,  C12N1/38

Abstract: The present invention relates to methods of modulating the mannose content of recombinant proteins.

公开(公告)号：US20210062156A1

公开(公告)日：2021-03-04

申请号：US17051528

申请日：2019-04-30

Applicant: Amgen Inc.

Inventor： Christopher Kenyon CROWELL ,  Jian W U ,  Athena Denise NAGI ,  Neil KITCHEN ,  Alison Jean GILLESPIE ,  Simina Crina PETROVAN ,  Michael Charles BRANDENSTEIN

IPC: C12N5/071 ,  C07K16/28

Abstract: This invention relates to recombinantly-expressed denosumab molecules and methods for modulating glycan profiles of denosumab molecules.

公开(公告)号：US20160032343A1

公开(公告)日：2016-02-04

申请号：US14776404

申请日：2014-03-10

Applicant: AMGEN INC.

Inventor： Jian WU ,  Sean DAVERN ,  Simina Crina PETROVAN ,  Michael Charles BRANDENSTEIN ,  Katherine Rose LINDAHL ,  Shawn Erik LILLIE

IPC: C12P21/00 ,  C07K16/00

CPC classification number: C12P21/005 ,  C07K16/00 ,  C07K2317/14 ,  C07K2317/41 ,  C12N1/38 ,  C12N5/0037 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2510/02

Abstract: The present invention relates to methods of modulating the mannose content of recombinant proteins.

Abstract translation: 本发明涉及调节重组蛋白质的甘露糖含量的方法。

公开(公告)号：US20240384238A1

公开(公告)日：2024-11-21

申请号：US18779687

申请日：2024-07-22

Applicant: Amgen Inc.

Inventor： Christopher Kenyon CROWELL ,  Jian WU ,  Neil KITCHEN ,  Alison Jean GILLESPIE ,  Simina Crina PETROVAN ,  Michael Charles BRANDENSTEIN ,  Athena Denise Nagi

IPC: C12N5/071 ,  C07K16/28

Abstract: This invention relates to recombinantly-expressed denosumab molecules and methods for modulating glycan profiles of denosumab molecules.

公开(公告)号：US20220136026A1

公开(公告)日：2022-05-05

申请号：US17554836

申请日：2021-12-17

Applicant: AMGEN INC.

Inventor： Jian WU ,  Sean DAVERN ,  Simina Crina PETROVAN ,  Michael Charles BRANDENSTEIN ,  Katherine Rose LINDAHL ,  Shawn Erik LILLIE

IPC: C12P21/00 ,  C12N5/00 ,  C07K16/00 ,  C12N1/38

Abstract: The present invention relates to methods of modulating the mannose content of recombinant proteins.

公开(公告)号：US20200087698A1

公开(公告)日：2020-03-19

申请号：US16654933

申请日：2019-10-16

Applicant: AMGEN INC.

Inventor： Jian WU ,  Sean DAVERN ,  Simina Crina PETROVAN ,  Michael Charles BRANDENSTEIN ,  Katherine Rose LINDAHL ,  Shawn Erik LILLIE

IPC: C12P21/00 ,  C12N5/00 ,  C07K16/00 ,  C12N1/38

Abstract: The present invention relates to methods of modulating the mannose content of recombinant proteins.

公开(公告)号：US20180002733A1

公开(公告)日：2018-01-04

申请号：US15652138

申请日：2017-07-17

Applicant: AMGEN INC.

Inventor： Jian WU ,  Sean DAVERN ,  Simina Crina PETROVAN ,  Michael Charles BRANDENSTEIN ,  Katherine Rose LINDAHL ,  Shawn Erik LILLIE

IPC: C12P21/00 ,  C12N1/38 ,  C07K16/00 ,  C12N5/00

CPC classification number: C12P21/005 ,  C07K16/00 ,  C07K2317/14 ,  C07K2317/41 ,  C12N1/38 ,  C12N5/0037 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2510/02

Abstract: The present invention relates to methods of modulating the mannose content of recombinant proteins.