公开(公告)号：US20210115125A1

公开(公告)日：2021-04-22

申请号：US17030842

申请日：2020-09-24

Applicant: AMGEN INC.

Inventor： Jian WU ,  Nicole SABO ,  Michael DE LA CRUZ ,  Gregory FLYNN

IPC: C07K16/24 ,  C07K16/00 ,  C12P21/00 ,  C12N5/00

Abstract: The present invention relates to methods of modulating (e.g., reducing) the mannose content, particularly high-mannose content of recombinant glycoproteins.

公开(公告)号：US20220356502A1

公开(公告)日：2022-11-10

申请号：US17746008

申请日：2022-05-17

Applicant: Amgen Inc.

Inventor： Chetan GOUDAR ,  Sean COLE ,  Nicole SABO ,  Henry LIN ,  Jonathan LULL ,  Tharmala THARMALINGAM

IPC: C12P21/00 ,  C12M1/00 ,  C12N5/00 ,  C12M1/36 ,  C07K16/00 ,  C12M1/26

Abstract: The invention provides methods and materials for culturing mammalian cells and harvesting recombinant protein.

公开(公告)号：US20220136025A1

公开(公告)日：2022-05-05

申请号：US17537766

申请日：2021-11-30

Applicant: Amgen Inc.

Inventor： Chetan GOUDAR ,  Sean COLE ,  Nicole SABO ,  Henry LIN ,  Jonathan LULL ,  Tharmala THARMALINGAM

IPC: C12P21/00 ,  C12M1/00 ,  C07K16/00 ,  C12M1/26 ,  C12N5/00 ,  C12M1/36

Abstract: The invention provides methods and materials for culturing mammalian cells and harvesting recombinant protein.