公开(公告)号：US20210115125A1

公开(公告)日：2021-04-22

申请号：US17030842

申请日：2020-09-24

Applicant: AMGEN INC.

Inventor： Jian WU ,  Nicole SABO ,  Michael DE LA CRUZ ,  Gregory FLYNN

IPC: C07K16/24 ,  C07K16/00 ,  C12P21/00 ,  C12N5/00

Abstract: The present invention relates to methods of modulating (e.g., reducing) the mannose content, particularly high-mannose content of recombinant glycoproteins.

公开(公告)号：US20130330770A1

公开(公告)日：2013-12-12

申请号：US13741280

申请日：2013-01-14

Applicant: AMGEN INC.

Inventor： Jian WU ,  Nicole LE ,  Michael DE LA CRUZ ,  Gregory FLYNN

IPC: C07K16/24

CPC classification number: C07K16/244 ,  A61K2039/505 ,  C07K16/00 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C12N5/0037 ,  C12N2500/02 ,  C12N2500/12 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2500/38 ,  C12N2500/60 ,  C12N2500/74 ,  C12N2500/76 ,  C12P21/005

Abstract: The present invention relates to methods of modulating (e.g., reducing) the mannose content, particularly high-mannose content of recombinant glycoproteins.

Abstract translation: 本发明涉及调节（例如，还原）甘露糖含量，特别是重组糖蛋白的高甘露糖含量的方法。