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1.发明申请PHENYLANALINE AMIDE DERIVATIVES USEFUL FOR TREATING INSULIN-RELATED DISEASES AND CONDITIONS 有权用于治疗胰岛素相关疾病和病症的苯胺衍生物公开(公告)号：US20120115811A1
公开(公告)日：2012-05-10
申请号：US13148296
申请日：2010-02-12
申请人： Xiaohui Du , Zice Fu , Jonathan B. Houze , Xian Yun Jiao , Yong-Jae Kim , Leping Li , Jinqian Liu , Mike Elias Lizarzaburu , Julio C. Medina , Wang Shen , Simon Turcotte , Ming Yu
发明人： Xiaohui Du , Zice Fu , Jonathan B. Houze , Xian Yun Jiao , Yong-Jae Kim , Leping Li , Jinqian Liu , Mike Elias Lizarzaburu , Julio C. Medina , Wang Shen , Simon Turcotte , Ming Yu
IPC分类号： A61K31/4439 , C07D417/12 , C07D401/14 , C07D401/04 , A61K31/444 , A61K31/506 , A61K31/427 , A61P3/10 , A61P3/04 , A61P3/00 , A61P29/00 , A61P11/06 , A61P17/06 , A61P19/02 , A61P1/00 , A61P35/00 , A61P25/00 , A61K31/702 , C07D417/14
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Provided herein are compounds of formula I: wherein A, B, X, R1, R2 and subscript n are as defined in the following disclosure. Compositions comprising the compounds are also provided, as well as methods for their use, for example, in treatment of type 2 diabetes and type 2 diabetes-related conditions.
摘要翻译： 本文提供了式I的化合物：其中A，B，X，R 1，R 2和下标n如以下公开内容所定义。 还提供了包含该化合物的组合物，以及其用于例如治疗2型糖尿病和2型糖尿病相关病症的方法。
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公开(公告)号：US20110190330A1
公开(公告)日：2011-08-04
申请号：US13119951
申请日：2009-10-13
申请人： Sean P. Brown , Paul Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , XianYun Jiao , Sujen Lai , An-Rong Li , Jiwen Liu , Zhihua Ma , Julio C. Medina , Vatee Pattaropong , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang , Ming Yu , Liusheng Zhu
发明人： Sean P. Brown , Paul Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , XianYun Jiao , Sujen Lai , An-Rong Li , Jiwen Liu , Zhihua Ma , Julio C. Medina , Vatee Pattaropong , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang , Ming Yu , Liusheng Zhu
IPC分类号： A61K31/4418 , C07C69/757 , C07C62/34 , C07D213/64 , C07D249/08 , C07D311/96 , C07D217/24 , C07D231/12 , A61K31/216 , A61K31/192 , A61K31/4196 , A61K31/352 , A61K31/415 , A61K31/426 , A61P3/10
CPC分类号： C07C62/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D213/643 , C07D217/24 , C07D253/065 , C07D277/22 , C07D311/04 , C07D401/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I′A or I′B: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式IA，IB，I'A或I'B：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。
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公开(公告)号：US20100075974A1
公开(公告)日：2010-03-25
申请号：US12613418
申请日：2009-11-05
申请人： Hilary Beck , Paul Dransfield , Zice Fu , Jonathan B. Houze , Xian Yun Jiao , Todd J. Kohn , SuJen Lai , Jinqian Liu , Jiwen Liu , Zhihua Ma , Julio C. Medina , Michael J. Schmitt , Rajiv Sharma , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang
发明人： Hilary Beck , Paul Dransfield , Zice Fu , Jonathan B. Houze , Xian Yun Jiao , Todd J. Kohn , SuJen Lai , Jinqian Liu , Jiwen Liu , Zhihua Ma , Julio C. Medina , Michael J. Schmitt , Rajiv Sharma , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang
IPC分类号： A61K31/498 , C07D261/06 , A61K31/42 , C07D277/22 , A61K31/426 , C07D271/06 , A61K31/4245 , C07D413/02 , A61K31/443 , C07D241/36 , A61P3/10 , A61P9/00
CPC分类号： C07D261/08 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。
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公开(公告)号：US08003648B2
公开(公告)日：2011-08-23
申请号：US12613418
申请日：2009-11-05
申请人： Hilary Beck , Paul Dransfield , Zice Fu , Jonathan B. Houze , XianYun Jiao , Todd J. Kohn , SuJen Lai , Jinqian Liu , Jiwen Liu , Zhihua Ma , Julio C. Medina , Michael J. Schmitt , Rajiv Sharma , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang
发明人： Hilary Beck , Paul Dransfield , Zice Fu , Jonathan B. Houze , XianYun Jiao , Todd J. Kohn , SuJen Lai , Jinqian Liu , Jiwen Liu , Zhihua Ma , Julio C. Medina , Michael J. Schmitt , Rajiv Sharma , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang
IPC分类号： A61K31/498 , A61K31/42 , A61K31/426 , A61K31/4245 , A61K31/443 , C07D261/06 , C07D277/22 , C07D271/06 , C07D413/02 , C07D241/36 , A61P3/10 , A61P9/00
CPC分类号： C07D261/08 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。
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公开(公告)号：US20090111859A1
公开(公告)日：2009-04-30
申请号：US12082645
申请日：2008-04-10
申请人： Sean P. Brown , Paul Dransfield , Zice Fu , Jonathan Houze , Xian Yun Jiao , Todd J. Kohn , Vatee Pattaropong , Marc Vimolratana , Michael J. Schmitt
发明人： Sean P. Brown , Paul Dransfield , Zice Fu , Jonathan Houze , Xian Yun Jiao , Todd J. Kohn , Vatee Pattaropong , Marc Vimolratana , Michael J. Schmitt
IPC分类号： C07C59/68 , C07D261/08 , A61K31/192 , A61K31/42 , C12N5/06 , A61K31/426 , A61K31/155 , A61P35/00 , A61P3/00 , A61P3/10 , A61P9/00
CPC分类号： C07C59/68 , C07C59/72 , C07D261/08
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
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公开(公告)号：US20080085891A1
公开(公告)日：2008-04-10
申请号：US11986863
申请日：2007-11-26
申请人： Zice Fu , Alan Huang , Jiwen Liu , Julio Medina , Michael Schmitt , H. Tang , Yingcai Wang , Qingge Xu
发明人： Zice Fu , Alan Huang , Jiwen Liu , Julio Medina , Michael Schmitt , H. Tang , Yingcai Wang , Qingge Xu
IPC分类号： A61K31/27 , A61K31/196 , A61K31/381 , A61K31/415 , A61K31/44 , A61K31/47 , A61K31/5375 , A61K31/55 , A61P11/06 , A61P29/00 , A61P35/00 , A61P37/08
CPC分类号： C07C205/37 , C07C205/56 , C07C233/75 , C07C271/28 , C07C275/42 , C07C311/08 , C07C311/21 , C07C311/29 , C07C317/44 , C07C2601/04 , C07C2601/08 , C07D209/22 , C07D209/26 , C07D213/71 , C07D215/36 , C07D233/84 , C07D243/12 , C07D243/24 , C07D257/04 , C07D295/192 , C07D307/91 , C07D333/34 , C07D333/62
摘要： Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives.
摘要翻译： 提供了可用于治疗炎症和免疫相关疾病和病症的化合物，药物组合物和方法。 特别地，本发明提供调节参与特应性疾病，炎性病症和癌症的蛋白质的功能和/或表达的化合物。 主题化合物是羧酸衍生物。
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7.发明申请Compounds, compositions and methods for prevention and treatment of inflammatory and immunoregulatory disorders and diseases 失效用于预防和治疗炎性和免疫调节性疾病和疾病的化合物，组合物和方法公开(公告)号：US20060069099A1
公开(公告)日：2006-03-30
申请号：US11168005
申请日：2005-06-27
申请人： Zice Fu , Michael Johnson , An-Rong Li , Andrew Marcus , Julio Medina , Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason Duquette , Darin Gustin , Jeffrey Mihalic
发明人： Zice Fu , Michael Johnson , An-Rong Li , Andrew Marcus , Julio Medina , Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason Duquette , Darin Gustin , Jeffrey Mihalic
IPC分类号： A61K31/525 , A61K31/519 , C07D475/02 , C07D487/02
CPC分类号： C07D471/04 , C07D239/91 , C07D401/12
摘要： Compounds are provided having the formula: wherein variables Ra, R1, R2, R3, R4, A1, A4, L, Q, X and subscript n as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
摘要翻译： 提供具有下式的化合物：
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公开(公告)号：US08748462B2
公开(公告)日：2014-06-10
申请号：US13119951
申请日：2009-10-13
申请人： Sean P. Brown , Paul Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , XianYun Jiao , Sujen Lai , An-Rong Li , Jiwen Liu , Zhihua Ma , Julio C. Medina , Vatee Pattaropong , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang , Ming Yu , Liusheng Zhu
发明人： Sean P. Brown , Paul Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , XianYun Jiao , Sujen Lai , An-Rong Li , Jiwen Liu , Zhihua Ma , Julio C. Medina , Vatee Pattaropong , Wang Shen , Marc Vimolratana , Yingcai Wang , Zhongyu Wang , Ming Yu , Liusheng Zhu
IPC分类号： A61K31/19 , C07C69/76 , C07D211/72 , C07D211/84 , C07D213/62 , A61K31/44
CPC分类号： C07C62/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D213/643 , C07D217/24 , C07D253/065 , C07D277/22 , C07D311/04 , C07D401/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I′A or I′B: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译： 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式IA，IB，I'A或I'B：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。
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公开(公告)号：US08022061B2
公开(公告)日：2011-09-20
申请号：US11973900
申请日：2007-10-09
申请人： Yasuyuki Ogawa , Ryo Okuyama , Satoshi Shibuya , Narihiro Toda , Zhaodan Cao , Zice Fu , Xiaolin Hao , Yong-Jae Kim , Leping Li , Sarah E. Lively , Mike Lizarzaburu , Hui Tian , Ming Yu
发明人： Yasuyuki Ogawa , Ryo Okuyama , Satoshi Shibuya , Narihiro Toda , Zhaodan Cao , Zice Fu , Xiaolin Hao , Yong-Jae Kim , Leping Li , Sarah E. Lively , Mike Lizarzaburu , Hui Tian , Ming Yu
IPC分类号： C07D403/04 , C07D417/14 , A61K31/506
CPC分类号： C07D409/14 , C07D401/14 , C07D403/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Compounds having formula I: where A1, A2, L, V, W, R1, R2, R3, R4 and R5 are as described herein, compositions thereof, and their use for the treatment or prevention of type 2 diabetes and type 2 diabetes-related conditions are provided herein.
摘要翻译： 具有式I的化合物：其中A1，A2，L，V，W，R1，R2，R3，R4和R5如本文所述，其组合物及其用于治疗或预防2型糖尿病和2型糖尿病 - 在此提供相关条件。
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公开(公告)号：US07541383B2
公开(公告)日：2009-06-02
申请号：US11986863
申请日：2007-11-26
申请人： Zice Fu , Xi Alan Huang , Jiwen Liu , Julio C. Medina , Michael J. Schmitt , H. Lucy Tang , Yingcai Wang , Qingge Xu
发明人： Zice Fu , Xi Alan Huang , Jiwen Liu , Julio C. Medina , Michael J. Schmitt , H. Lucy Tang , Yingcai Wang , Qingge Xu
CPC分类号： C07C205/37 , C07C205/56 , C07C233/75 , C07C271/28 , C07C275/42 , C07C311/08 , C07C311/21 , C07C311/29 , C07C317/44 , C07C2601/04 , C07C2601/08 , C07D209/22 , C07D209/26 , C07D213/71 , C07D215/36 , C07D233/84 , C07D243/12 , C07D243/24 , C07D257/04 , C07D295/192 , C07D307/91 , C07D333/34 , C07D333/62
摘要： Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives.
摘要翻译： 提供了可用于治疗炎症和免疫相关疾病和病症的化合物，药物组合物和方法。 特别地，本发明提供调节参与特应性疾病，炎性病症和癌症的蛋白质的功能和/或表达的化合物。 主题化合物是羧酸衍生物。
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