公开(公告)号：US20130310374A1

公开(公告)日：2013-11-21

申请号：US13991841

申请日：2011-12-05

Applicant: Sanjay Kumar ,  Rajiv Sharma ,  Vijaykumar Bhagwan Deore ,  Nilambari Nilkanth Yewalkar ,  Veena R. Agarwal ,  Nilesh Dagia ,  Nishigandha Naik

Inventor： Sanjay Kumar ,  Rajiv Sharma ,  Vijaykumar Bhagwan Deore ,  Nilambari Nilkanth Yewalkar ,  Veena R. Agarwal ,  Nilesh Dagia ,  Nishigandha Naik

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: The present invention relates to substituted imidazo[4,5-c]quinoline derivatives of formula (I), wherein R1, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions comprising compounds of the present invention and their use in the treatment of diseases or disorders mediated by one or more kinases, particularly proliferative diseases or disorders such as cancer. These compounds can also be used in the treatment of inflammation and angiogenesis related disorders.

Abstract translation: 本发明涉及式（I）的取代咪唑并[4,5-c]喹啉衍生物，其中R 1，R 2和R 3如说明书中所定义，其制备方法，包含本发明化合物的药物组合物及其 用于治疗由一种或多种激酶介导的疾病或病症，特别是增殖性疾病或疾病如癌症。 这些化合物也可用于治疗炎症和血管发生相关疾病。

公开(公告)号：US08389533B2

公开(公告)日：2013-03-05

申请号：US12936725

申请日：2009-04-06

Applicant: Richard V. Connors ,  Kang Dai ,  John Eksterowicz ,  Pingchen Fan ,  Benjamin Fisher ,  Jiasheng Fu ,  Kexue Li ,  Zhihong Li ,  Lawrence R. McGee ,  Rajiv Sharma ,  Xiaodong Wang

Inventor： Richard V. Connors ,  Kang Dai ,  John Eksterowicz ,  Pingchen Fan ,  Benjamin Fisher ,  Jiasheng Fu ,  Kexue Li ,  Zhihong Li ,  Lawrence R. McGee ,  Rajiv Sharma ,  Xiaodong Wang

IPC: A01N43/54 ,  A61K31/505 ,  C07D237/00 ,  C07D239/00 ,  C07D241/00

CPC classification number: C07D471/04 ,  C07D239/70 ,  C07D401/12 ,  C07D471/10 ,  C07D487/10 ,  C07D491/10 ,  C07D491/107 ,  C07D491/20

Abstract: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are gem-disubstituted or spirocyclic pyridine, pyrimidine and triazine derivatives.

Abstract translation: 提供了可用于治疗CDK4介导的疾病如癌症的化合物，药物组合物和方法。 主题化合物是偕二取代或螺环吡啶，嘧啶和三嗪衍生物。

公开(公告)号：US20120214854A1

公开(公告)日：2012-08-23

申请号：US13505917

申请日：2010-11-01

Applicant: Ravindra Dnyandev Jadhav ,  Rajiv Sharma ,  Kishorkumar Shivajirao Kadam ,  Shivaji Sadashiv Kandre

Inventor： Ravindra Dnyandev Jadhav ,  Rajiv Sharma ,  Kishorkumar Shivajirao Kadam ,  Shivaji Sadashiv Kandre

IPC: A61K31/426 ,  C07D277/02 ,  C07D263/02 ,  A61P3/04 ,  A61P3/10 ,  A61P3/06 ,  A61P3/00 ,  A61P19/02 ,  A61P19/10 ,  A61P9/00 ,  A61P9/10 ,  A61P15/00 ,  A61P21/00 ,  A61P17/10 ,  A61P37/02 ,  A61P17/06 ,  A61P1/00 ,  A61K31/421

CPC classification number: C07D263/34 ,  C07D277/56 ,  C07D277/82 ,  C07D417/12

Abstract: Heteroaryl compounds, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or disorders mediated by Diacylglycerol acyltransferase (DGAT) enzyme, particularly DGAT-1 is described.

Abstract translation: 描述了杂芳基化合物，其制备方法，含有它们的药物组合物及其在治疗由二酰基甘油酰基转移酶（DGAT）酶，特别是DGAT-1介导的疾病或病症中的用途。

公开(公告)号：US20100075974A1

公开(公告)日：2010-03-25

申请号：US12613418

申请日：2009-11-05

Applicant: Hilary Beck ,  Paul Dransfield ,  Zice Fu ,  Jonathan B. Houze ,  Xian Yun Jiao ,  Todd J. Kohn ,  SuJen Lai ,  Jinqian Liu ,  Jiwen Liu ,  Zhihua Ma ,  Julio C. Medina ,  Michael J. Schmitt ,  Rajiv Sharma ,  Wang Shen ,  Marc Vimolratana ,  Yingcai Wang ,  Zhongyu Wang

Inventor： Hilary Beck ,  Paul Dransfield ,  Zice Fu ,  Jonathan B. Houze ,  Xian Yun Jiao ,  Todd J. Kohn ,  SuJen Lai ,  Jinqian Liu ,  Jiwen Liu ,  Zhihua Ma ,  Julio C. Medina ,  Michael J. Schmitt ,  Rajiv Sharma ,  Wang Shen ,  Marc Vimolratana ,  Yingcai Wang ,  Zhongyu Wang

IPC: A61K31/498 ,  C07D261/06 ,  A61K31/42 ,  C07D277/22 ,  A61K31/426 ,  C07D271/06 ,  A61K31/4245 ,  C07D413/02 ,  A61K31/443 ,  C07D241/36 ,  A61P3/10 ,  A61P9/00

CPC classification number: C07D261/08 ,  C07D409/12 ,  C07D413/06 ,  C07D413/12 ,  C07D417/12

Abstract: The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Abstract translation: 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

公开(公告)号：US20070066647A1

公开(公告)日：2007-03-22

申请号：US11517992

申请日：2006-09-08

Applicant: Michelle Akerman ,  Sean Brown ,  Jonathan Houze ,  Jinqian Liu ,  Jiwen Liu ,  Zhihua Ma ,  Julio Medina ,  Wei Qiu ,  Michael Schmitt ,  Rajiv Sharma ,  Yingcai Wang ,  Liusheng Zhu

Inventor： Michelle Akerman ,  Sean Brown ,  Jonathan Houze ,  Jinqian Liu ,  Jiwen Liu ,  Zhihua Ma ,  Julio Medina ,  Wei Qiu ,  Michael Schmitt ,  Rajiv Sharma ,  Yingcai Wang ,  Liusheng Zhu

IPC: A61K31/47 ,  A61K31/426 ,  A61K31/353 ,  A61K31/343 ,  A61K31/192 ,  A61K31/155

CPC classification number: C07D333/24 ,  C07C59/72 ,  C07D231/12 ,  C07D233/26 ,  C07D233/64 ,  C07D239/26 ,  C07D249/04 ,  C07D249/08 ,  C07D257/04 ,  C07D261/04 ,  C07D261/08 ,  C07D263/32 ,  C07D317/54 ,  C07D333/16

Abstract: The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables Q, L1, L2, M, X, L3, and A are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Abstract translation: 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式I：其中变量Q，L 1，L 2，M，X，L 3， 和A。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

公开(公告)号：US20060270724A1

公开(公告)日：2006-11-30

申请号：US11436732

申请日：2006-05-17

Applicant: Jonathan Houze ,  Jiwen Liu ,  Zhihua Ma ,  Julio Medina ,  Michael Schmitt ,  Rajiv Sharma ,  Ying Sun ,  Yingcai Wang ,  Liusheng Zhu

Inventor： Jonathan Houze ,  Jiwen Liu ,  Zhihua Ma ,  Julio Medina ,  Michael Schmitt ,  Rajiv Sharma ,  Ying Sun ,  Yingcai Wang ,  Liusheng Zhu

IPC: C07D249/08 ,  C07D233/61 ,  A61K31/4196 ,  A61K31/4172

CPC classification number: C07D277/24 ,  C07B2200/07 ,  C07C235/34 ,  C07D233/64 ,  C07D249/08 ,  C07D257/04 ,  C07D263/32 ,  C07D417/12

Abstract: The present invention provides compounds useful, for example, for modulating insulin levels in a subject, having the general formula I: wherein Q is an optionally substituted phenyl; L is a bond or O; P is a benzene or an optionally substituted thiazole ring; and R1 has the values provided herein. The present invention also provides compositions, uses, and methods for use of the compounds, for instance, for treatment of type II diabetes.

Abstract translation: 本发明提供了可用于例如用于调节受试者中具有通式I的胰岛素水平的化合物：其中Q是任选取代的苯基; L是一个键或O; P是苯或任选取代的噻唑环; 且R 1具有本文提供的值。 本发明还提供了用于治疗II型糖尿病的化合物的组合物，用途和方法。

公开(公告)号：US07019006B2

公开(公告)日：2006-03-28

申请号：US10624289

申请日：2003-07-21

Applicant: Pier F. Cirillo ,  Steffen Breitfelder ,  Usha R. Patel ,  John R. Proudfoot ,  Alan D. Swinamer ,  Hidenori Takahashi ,  Thomas A. Gilmore ,  Rajiv Sharma

Inventor： Pier F. Cirillo ,  Steffen Breitfelder ,  Usha R. Patel ,  John R. Proudfoot ,  Alan D. Swinamer ,  Hidenori Takahashi ,  Thomas A. Gilmore ,  Rajiv Sharma

IPC: C07D413/02 ,  A61K31/47

CPC classification number: C07D213/74 ,  C07D213/38 ,  C07D213/76 ,  C07D231/38 ,  C07D307/12 ,  C07D307/52 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D493/08 ,  C07D495/08

Abstract: Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds.

公开(公告)号：US06574165B2

公开(公告)日：2003-06-03

申请号：US09879855

申请日：2001-06-12

Applicant: Rajiv Sharma ,  Sunanda Sharma

Inventor： Rajiv Sharma ,  Sunanda Sharma

IPC: G04B4700

CPC classification number: G04G15/006 ,  A61J7/0084 ,  A61J7/0418 ,  A61J7/0427 ,  A61J7/0481 ,  A61J2205/30 ,  A61J2205/70 ,  G04F3/02

Abstract: An apparatus for reminding individuals when to take a medication, in a first embodiment 10 is a mechanical timer with different varieties of pegs 18 disposed to ring an alarm when a medication is to be taken and indicative of the medication by their style. A second embodiment 10A actually dispenses the medication that is required at that time. A third embodiment 56 is in the form of a wrist watch and displays 64 the medication and (any caveats) that is to be taken. A fourth embodiment 56A is pre-programmed so that the patient cannot tamper with the settings. The invention is apt for multi-medication multi-dose time situations.

公开(公告)号：US06492393B1

公开(公告)日：2002-12-10

申请号：US09714539

申请日：2000-11-16

Applicant: Steffen Breitfelder ,  Pier F. Cirillo ,  Ming-Hong Hao ,  Eugene R. Hickey ,  Rajiv Sharma ,  Sanxing Sun ,  Hidenori Takahashi

Inventor： Steffen Breitfelder ,  Pier F. Cirillo ,  Ming-Hong Hao ,  Eugene R. Hickey ,  Rajiv Sharma ,  Sanxing Sun ,  Hidenori Takahashi

IPC: A61K31445

CPC classification number: C07D207/404 ,  C07C275/34 ,  C07C323/44 ,  C07C2601/02 ,  C07D211/74 ,  C07D213/30 ,  C07D213/38 ,  C07D213/66 ,  C07D213/68 ,  C07D213/73 ,  C07D213/74 ,  C07D213/75 ,  C07D215/46 ,  C07D231/12 ,  C07D233/56 ,  C07D233/64 ,  C07D239/42 ,  C07D249/08 ,  C07D265/30 ,  C07D265/36 ,  C07D295/088 ,  C07D295/13 ,  C07D295/135 ,  C07D295/15 ,  C07D295/185 ,  C07D307/14 ,  C07D309/06 ,  C07D309/12 ,  C07D333/48 ,  C07D401/06 ,  C07D405/12 ,  C07D413/12 ,  C07D471/04

Abstract: Disclosed are novel aromatic compounds of the formula (I) wherein G, X, Ar, L and Q are defined herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are processes of making such compounds.

Abstract translation: 公开了式（I）的新型芳族化合物，其中G，X，Ar，L和Q在本文中定义。 该化合物可用于治疗涉及炎症的疾病或病理状况的药物组合物，例如慢性炎性疾病。 还公开了制备这些化合物的方法。

公开(公告)号：US06353007B1

公开(公告)日：2002-03-05

申请号：US09616014

申请日：2000-07-13

Applicant: Rajiv Sharma

Inventor： Rajiv Sharma

IPC: C07D40110

CPC classification number: C07D405/14 ,  C07D209/08 ,  C07D209/42 ,  C07D401/12 ,  C07D417/14

Abstract: 1-(4-Aminophenyl) indoles optionally substituted on the 2-,4-,5-,6- and 7-positions of the indole ring and on the amino group on the 4-position of the phenyl ring, which indoles inhibit IL-2 production in T-lymphocytes.

Abstract translation: 任选在吲哚环的2-，4-，5-，6-和7-位上取代的1-（4-氨基苯基）吲哚，苯基环的4-位上的氨基上，该吲哚抑制IL -2生产在T淋巴细胞。