公开(公告)号：US06574165B2

公开(公告)日：2003-06-03

申请号：US09879855

申请日：2001-06-12

Applicant: Rajiv Sharma ,  Sunanda Sharma

Inventor： Rajiv Sharma ,  Sunanda Sharma

IPC: G04B4700

CPC classification number: G04G15/006 ,  A61J7/0084 ,  A61J7/0418 ,  A61J7/0427 ,  A61J7/0481 ,  A61J2205/30 ,  A61J2205/70 ,  G04F3/02

Abstract: An apparatus for reminding individuals when to take a medication, in a first embodiment 10 is a mechanical timer with different varieties of pegs 18 disposed to ring an alarm when a medication is to be taken and indicative of the medication by their style. A second embodiment 10A actually dispenses the medication that is required at that time. A third embodiment 56 is in the form of a wrist watch and displays 64 the medication and (any caveats) that is to be taken. A fourth embodiment 56A is pre-programmed so that the patient cannot tamper with the settings. The invention is apt for multi-medication multi-dose time situations.

公开(公告)号：US20140045832A1

公开(公告)日：2014-02-13

申请号：US14113166

申请日：2012-04-19

Applicant: Sarala Balachandran ,  Christopher J. Dinsmore ,  Abhijit Roychowdhury ,  Rajiv Sharma ,  Ram Asrey Vishwakarma

Inventor： Sarala Balachandran ,  Christopher J. Dinsmore ,  Abhijit Roychowdhury ,  Rajiv Sharma ,  Ram Asrey Vishwakarma

IPC: C07D413/14 ,  C07D413/12

CPC classification number: C07D413/14 ,  A61K31/5377 ,  A61K45/06 ,  C07D413/12

Abstract: The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating Insulin-Like-Growth Factor I Receptor and Insulin Receptor. The compounds of the instant invention possess a core structure that comprises a sulfonyl indole moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.

Abstract translation: 本发明涉及能够抑制，调节和/或调节胰岛素样生长因子I受体和胰岛素受体的化合物。 本发明的化合物具有包含磺酰基吲哚部分的核心结构。 本发明还涉及这些化合物的药学上可接受的盐，水合物和立体异构体。

公开(公告)号：US07649110B2

公开(公告)日：2010-01-19

申请号：US11067377

申请日：2005-02-25

Applicant: Michelle Akerman ,  Jonathan Houze ,  Daniel C. H. Lin ,  Jinqian Liu ,  Jiwen Liu ,  Jian Luo ,  Zhihua Ma ,  Julio C. Medina ,  Wei Qiu ,  Jeffrey D. Reagan ,  Rajiv Sharma ,  Michael J. Schmitt ,  Stephen J. Shuttleworth ,  Ying Sun ,  Yingcai Wang ,  Jian Zhang ,  Liusheng Zhu

Inventor： Michelle Akerman ,  Jonathan Houze ,  Daniel C. H. Lin ,  Jinqian Liu ,  Jiwen Liu ,  Jian Luo ,  Zhihua Ma ,  Julio C. Medina ,  Wei Qiu ,  Jeffrey D. Reagan ,  Rajiv Sharma ,  Michael J. Schmitt ,  Stephen J. Shuttleworth ,  Ying Sun ,  Yingcai Wang ,  Jian Zhang ,  Liusheng Zhu

IPC: C07C59/40 ,  C07C65/03

CPC classification number: C07D277/24 ,  C07D277/30

Abstract: The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formula Q—L1—P—L2—M—X—L3—A wherein the definitions of the variables Q, L1, P, L2, M, X, L3 and A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.

Abstract translation: 本发明提供了可用于调节受试者胰岛素水平的化合物，其具有通式Q-L1-P-L2-MX-L3-A，其中变量Q，L1，P，L2， M，X，L3和A。 本发明还提供了用于治疗II型糖尿病的化合物的组合物和方法。

公开(公告)号：US07582803B2

公开(公告)日：2009-09-01

申请号：US11517992

申请日：2006-09-08

Applicant: Michelle Akerman ,  Sean Brown ,  Jonathan B. Houze ,  Jinqian Liu ,  Jiwen Liu ,  Zhihua Ma ,  Julio C. Medina ,  Wei Qiu ,  Michael J. Schmitt ,  Yingcai Wang ,  Liusheng Zhu ,  Rajiv Sharma

Inventor： Michelle Akerman ,  Sean Brown ,  Jonathan B. Houze ,  Jinqian Liu ,  Jiwen Liu ,  Zhihua Ma ,  Julio C. Medina ,  Wei Qiu ,  Michael J. Schmitt ,  Yingcai Wang ,  Liusheng Zhu ,  Rajiv Sharma

IPC: C07C43/18 ,  C07C43/21 ,  A61K31/075 ,  A61K31/085

CPC classification number: C07D333/24 ,  C07C59/72 ,  C07D231/12 ,  C07D233/26 ,  C07D233/64 ,  C07D239/26 ,  C07D249/04 ,  C07D249/08 ,  C07D257/04 ,  C07D261/04 ,  C07D261/08 ,  C07D263/32 ,  C07D317/54 ,  C07D333/16

Abstract: The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables Q, L1, L2, M, X, L3, and A are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Abstract translation: 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供变量Q，L1，L2，M，X，L3和A的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

公开(公告)号：US07465804B2

公开(公告)日：2008-12-16

申请号：US11436732

申请日：2006-05-17

Applicant: Jonathan Houze ,  Jiwen Liu ,  Zhihua Ma ,  Julio C. Medina ,  Michael J. Schmitt ,  Rajiv Sharma ,  Ying Sun ,  Yingcai Wang ,  Liusheng Zhu

Inventor： Jonathan Houze ,  Jiwen Liu ,  Zhihua Ma ,  Julio C. Medina ,  Michael J. Schmitt ,  Rajiv Sharma ,  Ying Sun ,  Yingcai Wang ,  Liusheng Zhu

IPC: C07D263/32 ,  C07D257/04 ,  C07D249/04 ,  C07D249/08 ,  C07D277/22 ,  C07D277/24 ,  C07C59/13

CPC classification number: C07D277/24 ,  C07B2200/07 ,  C07C235/34 ,  C07D233/64 ,  C07D249/08 ,  C07D257/04 ,  C07D263/32 ,  C07D417/12

Abstract: The present invention provides compounds useful, for example, for modulating insulin levels in a subject, having the general formula I: wherein Q is an optionally substituted phenyl; L is a bond or O; P is a benzene or an optionally substituted thiazole ring; and R1 has the values provided herein. The present invention also provides compositions, uses, and methods for use of the compounds, for instance, for treatment of type II diabetes.

Abstract translation: 本发明提供了可用于例如用于调节受试者中具有通式I的胰岛素水平的化合物：其中Q是任选取代的苯基; L是一个键或O; P是苯或任选取代的噻唑环; 并且R1具有本文提供的值。 本发明还提供了用于治疗II型糖尿病的化合物的组合物，用途和方法。

公开(公告)号：US20080090840A1

公开(公告)日：2008-04-17

申请号：US11900006

申请日：2007-09-06

Applicant: Hilary Beck ,  Paul Dransfield ,  Zice Fu ,  Jonathan Houze ,  Xian Yun Jiao ,  Todd Kohn ,  SuJen Lai ,  Jinqian Liu ,  Jiwen Liu ,  Zhihua Ma ,  Michael Schmitt ,  Rajiv Sharma ,  Wang Shen ,  Marc Vimolratana ,  Yingcai Wang ,  Zhongyu Wang

Inventor： Hilary Beck ,  Paul Dransfield ,  Zice Fu ,  Jonathan Houze ,  Xian Yun Jiao ,  Todd Kohn ,  SuJen Lai ,  Jinqian Liu ,  Jiwen Liu ,  Zhihua Ma ,  Michael Schmitt ,  Rajiv Sharma ,  Wang Shen ,  Marc Vimolratana ,  Yingcai Wang ,  Zhongyu Wang

IPC: A61K31/41 ,  A61K31/42 ,  A61K31/44 ,  A61K31/4965 ,  A61P43/00 ,  C07D241/36 ,  C07D261/06 ,  C07D271/06 ,  C07D277/30 ,  C07D413/00

CPC classification number: C07D261/08 ,  C07D409/12 ,  C07D413/06 ,  C07D413/12 ,  C07D417/12

Abstract: The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Abstract translation: 本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

公开(公告)号：US20060040965A1

公开(公告)日：2006-02-23

申请号：US11169313

申请日：2005-06-29

Applicant: Christopher Farthing ,  Paul Faulder ,  Alexander Frenkel ,  Martin Harrison ,  Xianyun Jiao ,  Frank Kayser ,  David Kopecky ,  Jinqian Liu ,  Sarah Lively ,  Rajiv Sharma ,  Stephen Shuttleworth

Inventor： Christopher Farthing ,  Paul Faulder ,  Alexander Frenkel ,  Martin Harrison ,  Xianyun Jiao ,  Frank Kayser ,  David Kopecky ,  Jinqian Liu ,  Sarah Lively ,  Rajiv Sharma ,  Stephen Shuttleworth

IPC: A61K31/519 ,  C07D487/02

CPC classification number: C07D487/04

Abstract: Compounds that modulate the action of ACK1 and LCK, and related compositions methods for treating ACK1- and LCK-mediated diseases are described. In one aspect, the compounds have the general structure: where the values of the substituents are provided herein.

Abstract translation: 描述了调节ACK1和LCK的作用的化合物以及用于治疗ACK1和LCK介导的疾病的相关组合物方法。 在一个方面，化合物具有一般结构：其中本文提供取代基的值。

公开(公告)号：US08841312B2

公开(公告)日：2014-09-23

申请号：US12808621

申请日：2008-12-18

Applicant: Richard V. Connors ,  Dai Kang ,  John Eksterowicz ,  Pingchen Fan ,  Benjamin Fisher ,  Jiasheng Fu ,  Kexue Li ,  Zhihong Li ,  Lawrence R. McGee ,  Rajiv Sharma ,  Xiaodong Wang ,  Dustin L. McMinn ,  Jeffrey T. Mihalic ,  Jeffrey Deignan

Inventor： Richard V. Connors ,  Dai Kang ,  John Eksterowicz ,  Pingchen Fan ,  Benjamin Fisher ,  Jiasheng Fu ,  Kexue Li ,  Zhihong Li ,  Lawrence R. McGee ,  Rajiv Sharma ,  Xiaodong Wang ,  Dustin L. McMinn ,  Jeffrey T. Mihalic ,  Jeffrey Deignan

IPC: A61K31/519 ,  A61K31/5377 ,  A61K31/5386 ,  C07D403/14 ,  C07D413/14

CPC classification number: C07D471/14 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5386 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/14 ,  C07D491/107 ,  C07D491/147 ,  C07D498/04 ,  C07D498/10 ,  C07D513/14

Abstract: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are fused pyridine, pyrimide and triazine derivatives.

Abstract translation: 提供了可用于治疗CDK4介导的疾病如癌症的化合物，药物组合物和方法。 本发明化合物是吡啶，吡嗪酰亚胺和三嗪衍生物。

公开(公告)号：US08741932B2

公开(公告)日：2014-06-03

申请号：US13508135

申请日：2010-11-04

Applicant: Sanjay Kumar ,  Sivaramakrishnan Hariharan ,  Mandar Bhonde ,  Nilesh Dagia ,  Rajiv Sharma ,  Pallavi Hanmantrao Mane ,  Pramod Bhaskar Kumar

Inventor： Sanjay Kumar ,  Sivaramakrishnan Hariharan ,  Mandar Bhonde ,  Nilesh Dagia ,  Rajiv Sharma ,  Pallavi Hanmantrao Mane ,  Pramod Bhaskar Kumar

IPC: A01N43/40 ,  A61K31/44 ,  A01N43/54 ,  A61K31/535 ,  C07D491/02 ,  C07D265/36 ,  C07D498/02 ,  C07D413/00

CPC classification number: C07D471/04

Abstract: The present invention relates to compounds of formula (I), wherein Ra, Rb, Rc, Rd, Re and Rf are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases mediated by phosphatidylinositol-3-kinase (PI3K), mammalian target of rapamycin (mTOR), Signal transducer and activator of transcription 3 (STAT 3), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) or a combination thereof particularly in the treatment of cancer and inflammation.

Abstract translation: 本发明涉及式（I）化合物，其中Ra，Rb，Rc，Rd，Re和Rf如本说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗由 磷脂酰肌醇-3-激酶（PI3K），雷帕霉素的哺乳动物靶（mTOR），信号转导和转录激活因子3（STAT3），肿瘤坏死因子-α（TNF-α），白细胞介素-6（IL-6）或 特别是在治疗癌症和炎症中的组合。

公开(公告)号：US20110196002A1

公开(公告)日：2011-08-11

申请号：US13034192

申请日：2011-02-24

Applicant: Ashok Kumar GANGOPADHYAY ,  Kishorkumar Shivajirao Kadam ,  Ravindra Dnyandev Jadhav ,  Hitesh Mistry ,  Rajiv Sharma

Inventor： Ashok Kumar GANGOPADHYAY ,  Kishorkumar Shivajirao Kadam ,  Ravindra Dnyandev Jadhav ,  Hitesh Mistry ,  Rajiv Sharma

IPC: A61K31/4245 ,  C07D413/02 ,  A61K31/428 ,  C07D275/02 ,  A61K31/42 ,  C07D271/06 ,  A61P3/00 ,  A61P9/00 ,  A61P19/00 ,  A61P17/00 ,  A61P1/00

CPC classification number: C07D417/12 ,  A61K31/42 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4439 ,  C07D261/08 ,  C07D261/14 ,  C07D261/18 ,  C07D271/06 ,  C07D277/56 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention relates to isoxazole, thiazole and oxidiazole derivatives, processes for their preparation, pharmaceutical compositions containing them and their use as medicaments, in particular to the use of these compounds in the prevention and treatment of diseases or disorders mediated by diacylglycerol acyltransferase (DGAT), particularly DGAT1.

Abstract translation: 本发明涉及异恶唑，噻唑和氧化噻唑衍生物，其制备方法，含有它们的药物组合物及其作为药物的用途，特别涉及这些化合物在预防和治疗由二酰基甘油酰基转移酶介导的疾病或病症（DGAT ），特别是DGAT1。