公开(公告)号：US20060264424A1

公开(公告)日：2006-11-23

申请号：US10916868

申请日：2004-08-11

Applicant: Martin Harrison ,  Xian Jiao ,  Stuart Jones ,  Frank Kayser ,  David Kopecky

Inventor： Martin Harrison ,  Xian Jiao ,  Stuart Jones ,  Frank Kayser ,  David Kopecky

IPC: A61K31/54 ,  A61K31/537 ,  A61K31/495 ,  A61K31/445 ,  A61K31/40

CPC classification number: C07C311/21 ,  C07C311/38 ,  C07C317/32 ,  C07C323/49 ,  C07C2601/02 ,  C07D231/12 ,  C07D239/26 ,  C07D307/14 ,  C07F7/081

Abstract: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment or prevention of lipid disorders, metabolic disorders and cell-proliferative diseases. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in cholesterol metabolism. The subject compounds are particularly useful in the treatment of obesity, diabetes, hypercholesterolemia, atherosclerosis and hypolipoproteinemia.

Abstract translation: 提供了可用于治疗或预防脂质疾病，代谢紊乱和细胞增殖性疾病的化合物，药物组合物和方法。 特别地，本发明提供调节参与胆固醇代谢的蛋白质的表达和/或功能的化合物。 本发明化合物特别可用于治疗肥胖症，糖尿病，高胆固醇血症，动脉粥样硬化和低脂蛋白血症。

公开(公告)号：US20070072851A1

公开(公告)日：2007-03-29

申请号：US11506381

申请日：2006-08-18

Applicant: John Buchanan ,  William Buckner ,  Mario Cardozo ,  Erin DiMauro ,  Jiasheng Fu ,  Xiaolin Hao ,  Xian Jiao ,  Frank Kayser ,  David Kopecky ,  Craig Masse ,  Susan Tomlinson ,  Ryan White ,  Xiaotian Zhu

Inventor： John Buchanan ,  William Buckner ,  Mario Cardozo ,  Erin DiMauro ,  Jiasheng Fu ,  Xiaolin Hao ,  Xian Jiao ,  Frank Kayser ,  David Kopecky ,  Craig Masse ,  Susan Tomlinson ,  Ryan White ,  Xiaotian Zhu

IPC: A61K31/541 ,  A61K31/5377 ,  A61K31/519 ,  A61K31/503 ,  A61K31/498 ,  A61K31/497 ,  A61K31/496 ,  C07D487/02 ,  C07D471/02

CPC classification number: C07D403/06 ,  C07D231/56 ,  C07D401/14 ,  C07D405/06 ,  C07D487/04

Abstract: The present invention relates to compounds of Formula I or a stereomer, a tautomer, a solvate, a pharmaceutically acceptable salt, or a prodrug thereof, pharmaceutical formulations containing the compounds, methods of treatments using the compounds, for example, protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders and methods of preparing medicaments comprising the compounds.

Abstract translation: 本发明涉及式I化合物或立体异构体，互变异构体，溶剂合物，药学上可接受的盐或前药，含有化合物的药物制剂，使用该化合物的治疗方法，例如蛋白质酪氨酸激酶相关 诸如免疫学和肿瘤学障碍的疾病以及制备包含该化合物的药物的方法。

公开(公告)号：US20060270718A1

公开(公告)日：2006-11-30

申请号：US11501594

申请日：2006-08-08

Applicant: Xian Jiao ,  Frank Kayser ,  David Kopecky ,  Sharon McKendry ,  Derek Piper ,  Andrew Shiau

Inventor： Xian Jiao ,  Frank Kayser ,  David Kopecky ,  Sharon McKendry ,  Derek Piper ,  Andrew Shiau

IPC: A61K31/44 ,  A61K31/426 ,  A61K31/421 ,  A61K31/4196 ,  A61K31/4192 ,  A61K31/4172

CPC classification number: C07D207/333 ,  C07D207/335

Abstract: Heterocyclic arylsulfonamidobenzylic compounds are provided which are useful in treating lipid disorders, metabolic disorders and cell-proliferative diseases.

公开(公告)号：US20060040965A1

公开(公告)日：2006-02-23

申请号：US11169313

申请日：2005-06-29

Applicant: Christopher Farthing ,  Paul Faulder ,  Alexander Frenkel ,  Martin Harrison ,  Xianyun Jiao ,  Frank Kayser ,  David Kopecky ,  Jinqian Liu ,  Sarah Lively ,  Rajiv Sharma ,  Stephen Shuttleworth

Inventor： Christopher Farthing ,  Paul Faulder ,  Alexander Frenkel ,  Martin Harrison ,  Xianyun Jiao ,  Frank Kayser ,  David Kopecky ,  Jinqian Liu ,  Sarah Lively ,  Rajiv Sharma ,  Stephen Shuttleworth

IPC: A61K31/519 ,  C07D487/02

CPC classification number: C07D487/04

Abstract: Compounds that modulate the action of ACK1 and LCK, and related compositions methods for treating ACK1- and LCK-mediated diseases are described. In one aspect, the compounds have the general structure: where the values of the substituents are provided herein.

Abstract translation: 描述了调节ACK1和LCK的作用的化合物以及用于治疗ACK1和LCK介导的疾病的相关组合物方法。 在一个方面，化合物具有一般结构：其中本文提供取代基的值。

公开(公告)号：US20070155777A1

公开(公告)日：2007-07-05

申请号：US11709895

申请日：2007-02-21

Applicant: Simon Burkitt ,  Mario Cardozo ,  Timothy Cushing ,  Michael DeGraffeneid ,  Christopher Farthing ,  Xiaolin Hao ,  Juan Jaen ,  Xian Jiao ,  David Kopecky ,  Marc Labelle ,  Sarah Lively ,  Dustin McMinn ,  Sven Rasmussen ,  Youngsook Shin ,  Andrew Smith ,  Marie-Louise Smith

Inventor： Simon Burkitt ,  Mario Cardozo ,  Timothy Cushing ,  Michael DeGraffeneid ,  Christopher Farthing ,  Xiaolin Hao ,  Juan Jaen ,  Xian Jiao ,  David Kopecky ,  Marc Labelle ,  Sarah Lively ,  Dustin McMinn ,  Sven Rasmussen ,  Youngsook Shin ,  Andrew Smith ,  Marie-Louise Smith

IPC: A61K31/4743 ,  C07D498/02

CPC classification number: C07D231/56 ,  C07D239/74 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04 ,  C07D495/14 ,  C07D513/04

Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic, infectious and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism, infection and cell proliferation. The subject compounds contain a fused heterobicyclic ring.

Abstract translation: 本文提供了可用于治疗炎症，免疫调节，代谢，感染和细胞增殖性疾病或病症的化合物，组合物和方法。 特别地，本发明提供调节参与炎症，代谢，感染和细胞增殖的蛋白质的表达和/或功能的化合物。 主题化合物含有稠合的杂双环。