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公开(公告)号：US10435752B2
公开(公告)日：2019-10-08
申请号：US14411970
申请日：2012-08-20
Applicant: Yeon Su Lee , Sung Ho Goh , In Hoo Kim , Seung Hyun Hong
Inventor： Yeon Su Lee , Sung Ho Goh , In Hoo Kim , Seung Hyun Hong
IPC: C12Q1/6886 , C12Q1/527 , G01N33/574 , C12N15/113
Abstract: The present invention relates to: a composition for detecting a gastric cancer marker comprising a preparation for measuring the expression level or methylation level of mRNA of ADCY3 or a protein thereof; a kit for diagnosing gastric cancer, containing the composition; a method for diagnosing gastric cancer by treating a biological sample with the preparation to ascertain whether a material for complementarily binding to the preparation exists and comparing the amount thereof with a control group; a composition for treating and preventing gastric cancer, containing a preparation capable of inhibiting ADCY3 polynucleotide or ADCY3 polypeptide; and a method for treating gastric cancer by administering the composition to an individual. According to the present invention, it is possible to diagnose gastric cancer with high diagnostic sensitivity and specificity using ADCY3 as a marker for diagnosing gastric cancer, and thus can greatly contribute to reducing mortality due to gastric cancer.
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公开(公告)号：US20150240313A1
公开(公告)日：2015-08-27
申请号：US14411970
申请日：2012-08-20
Applicant: Yeon Su Lee , Sung Ho Goh , In Hoo Kim , Seung Hyun Hong
Inventor： Yeon Su Lee , Sung Ho Goh , In Hoo Kim , Seung Hyun Hong
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12N15/1137 , C12N2310/14 , C12Q1/527 , C12Q2600/154 , C12Q2600/158 , C12Y406/01001 , G01N33/57446
Abstract: The present invention relates to: a composition for detecting a gastric cancer marker comprising a preparation for measuring the expression level or methylation level of mRNA of ADCY3 or a protein thereof; a kit for diagnosing gastric cancer, containing the composition; a method for diagnosing gastric cancer by treating a biological sample with the preparation to ascertain whether a material for complementarily binding to the preparation exists and comparing the amount thereof with a control group; a composition for treating and preventing gastric cancer, containing a preparation capable of inhibiting ADCY3 polynucleotide or ADCY3 polypeptide; and a method for treating gastric cancer by administering the composition to an individual. According to the present invention, it is possible to diagnose gastric cancer with high diagnostic sensitivity and specificity using ADCY3 as a marker for diagnosing gastric cancer, and thus can greatly contribute to reducing mortality due to gastric cancer.
Abstract translation: 本发明涉及：用于检测胃癌标志物的组合物，其包含用于测量ADCY3或其蛋白质的mRNA的表达水平或甲基化水平的制剂; 用于诊断胃癌的试剂盒，含有该组合物; 通过用该制剂处理生物样品来确定是否存在与该制剂的互补结合的材料并将其与对照组比较来诊断胃癌的方法; 用于治疗和预防胃癌的组合物，其含有能抑制ADCY3多核苷酸或ADCY3多肽的制剂; 以及通过将组合物给予个体来治疗胃癌的方法。 根据本发明，可以使用ADCY3作为诊断胃癌的标志物来诊断具有高诊断灵敏度和特异性的胃癌，因此可以大大有助于降低胃癌的死亡率。
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公开(公告)号：US20150004063A1
公开(公告)日：2015-01-01
申请号：US14288961
申请日：2014-05-28
Applicant: Yeon Su Lee , Dae Gon Han
Inventor： Yeon Su LEE
IPC: A61L9/16
CPC classification number: A61L9/16
Abstract: In an air purifying apparatus for removing contaminants, such as soot and the like, by burning contaminated air while passing the contaminated air through a filter heated by microwaves, the apparatus includes: a housing, which is hollow, and comprises an inlet on one side and an outlet on the other side; a ceramic filter of a longitudinal material, which is arranged in the housing in a longitudinal direction of the housing, and includes a plurality of partition walls formed so that a flow path where contaminated air flows may be divided in plurality; and a microwave generator configured to generate microwaves to be supplied to one end surface of the ceramic filter in a longitudinal direction thereof to heat the one end surface of the ceramic filter in the longitudinal direction.
Abstract translation: 在用于除去烟灰等的污染物的空气净化装置中，通过在使被污染空气通过微波加热的过滤器的同时燃烧污染的空气，该装置包括：壳体，其为中空的，并且包括一侧的入口 另一侧出口; 纵向材料的陶瓷过滤器，其沿壳体的纵向方向布置在壳体中，并且包括形成为使得被污染的空气流动的流动路径可分为多个的多个分隔壁; 以及微波发生器，被配置为产生要供应到陶瓷过滤器的纵向方向的一个端面的微波，以沿着纵向方向加热陶瓷过滤器的一个端面。
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4.发明授权Polynucleotide associated with breast cancer comprising single nucleotide polymorphism, microarray and diagnostic kit comprising the same and method for diagnosing breast cancer using the same 有权与包含单核苷酸多态性的乳腺癌相关的多核苷酸，包含相同的微阵列和诊断试剂盒以及使用该多核苷酸诊断乳腺癌的方法公开(公告)号：US07833710B2
公开(公告)日：2010-11-16
申请号：US11329299
申请日：2006-01-10
Applicant: Yeon-Su Lee , Kyung-Hee Park , Jae-Heup Kim , Kyusang Lee , Yeon-a Park , Ji-Young Cho , Ok-ryul Song , Tae-jin Ahn , Ok-kyoung Son
Inventor： Yeon-Su Lee , Kyung-Hee Park , Jae-Heup Kim , Kyusang Lee , Yeon-a Park , Ji-Young Cho , Ok-ryul Song , Tae-jin Ahn , Ok-kyoung Son
CPC classification number: C12Q1/6886 , C12Q2600/156
Abstract: Provided is a polynucleotide for diagnosis or treatment of breast cancer, including at least 10 contiguous nucleotides of a nucleotide sequence selected from the group consisting of nucleotide sequences of SEQ ID No: 1 to SEQ ID No: 5 and comprising a nucleotide at 101st position of the nucleotide sequence, or a complementary polynucleotide thereof.
Abstract translation: 提供了用于诊断或治疗乳腺癌的多核苷酸，包括选自SEQ ID No：1至SEQ ID No：5的核苷酸序列的核苷酸序列的至少10个连续核苷酸，并且包含第101位的核苷酸 核苷酸序列或其互补多核苷酸。
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5.发明申请GENETIC POLYMORPHISMS ASSOCIATED WITH MYOCARDIAL INFARCTION AND USES THEREOF 审中-公开与心肌梗塞相关的遗传多态性及其用途公开(公告)号：US20100203503A1
公开(公告)日：2010-08-12
申请号：US11993549
申请日：2006-05-17
Applicant: Byung-Chul Kim , Kyung-Hee Park , Tae-Jin Ahn , Kyu-Sang Lee , Jae-Heup Kim , Ki-Eun Kim , Yeon-Su Lee
Inventor： Byung-Chul Kim , Kyung-Hee Park , Tae-Jin Ahn , Kyu-Sang Lee , Jae-Heup Kim , Ki-Eun Kim , Yeon-Su Lee
IPC: C12Q1/68 , G01N33/53 , C12N5/02 , G01N33/566 , C40B30/04 , C40B40/06 , C40B40/10 , C07K14/435 , C07K16/18 , C07H21/04
CPC classification number: C07K14/4702 , C12N15/113 , C12N2310/11 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
Abstract: A genetic polymorphism associated with myocardial infarction is provided. More particularly, provided are a polynucleotide including a single nucleotide polymorphism (SNP) or a haplotype associated with myocardial infarction, a polynucleotide hybridized with the polynucleotide, a polypeptide encoded by one of the polynucleotides, an antibody bound to the polypeptide, a microarray and a kit including one of the polynucleotides, a myocardial infarction diagnosis method, a SNP detecting method and a method of screening pharmaceutical compositions for myocardial infarction.
Abstract translation: 提供与心肌梗死相关的遗传多态性。 更具体地，提供了包括单核苷酸多态性（SNP）或与心肌梗死相关的单元型的多核苷酸，与多核苷酸杂交的多核苷酸，由多核苷酸之一编码的多肽，与多肽结合的抗体，微阵列和 包括多核苷酸之一，心肌梗塞诊断方法，SNP检测方法和筛选用于心肌梗塞的药物组合物的方法。
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Patent Agency Ranking
6.发明授权Multiple SNP for diagnosing cardiovascular disease, microarray and kit comprising the same, and method of diagnosing cardiovascular disease using the same 有权用于诊断心血管疾病的多重SNP，包含该SNP的微阵列和试剂盒以及使用该SNP诊断心血管疾病的方法公开(公告)号：US07732139B2
公开(公告)日：2010-06-08
申请号：US11435662
申请日：2006-05-17
Applicant: Seung-Hak Choi , Yun-sun Nam , Jae-Heup Kim , Kyung-Hee Park , Yeon-Su Lee , Hyo-jeong Jeon , Ok-ryul Song , Tae-jin Ahn , Kyu-sang Lee
Inventor： Seung-Hak Choi , Yun-sun Nam , Jae-Heup Kim , Kyung-Hee Park , Yeon-Su Lee , Hyo-jeong Jeon , Ok-ryul Song , Tae-jin Ahn , Kyu-sang Lee
CPC classification number: C12Q1/6886 , C12Q2600/156 , C12Q2600/172
Abstract: A multiple single nucleotide polymorphism (multi-SNP) marker for cardiovascular disease diagnosis and a method of diagnosing cardiovascular disease are provided. Also, sets of polynucleotides, a microarray, and a kit including the microarray are provided.
Abstract translation: 提供了用于心血管疾病诊断的多重单核苷酸多态性（多SNP）标记物和诊断心血管疾病的方法。 此外，提供了多组核苷酸，微阵列和包含微阵列的试剂盒。
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7.发明授权Polynucleotide associated with a type II diabetes mellitus comprising single nucleotide polymorphism, microarray and diagnostic kit comprising the same and method for analyzing polynucleotide using the same 有权与包含单核苷酸多态性的II型糖尿病相关的多核苷酸，包含该多核苷酸的微阵列和诊断试剂盒以及使用其分析多核苷酸的方法公开(公告)号：US07635559B2
公开(公告)日：2009-12-22
申请号：US10546685
申请日：2004-12-24
Applicant: Kyu-Sang Lee , Jae-Heup Kim , Kyung-Hee Park , Yeon-Su Lee , Ok-Kyoung Son , Ji-Young Cho , Yeon-A Park , Sung-Woo Hong , Jung-Joo Hwang , Hyo-Jeong Jeon
Inventor： Kyu-Sang Lee , Jae-Heup Kim , Kyung-Hee Park , Yeon-Su Lee , Ok-Kyoung Son , Ji-Young Cho , Yeon-A Park , Sung-Woo Hong , Jung-Joo Hwang , Hyo-Jeong Jeon
CPC classification number: C12Q1/6883 , C12Q1/6837 , C12Q2600/156
Abstract: Provided is a polynucleotide for diagnosis or treatment of type II diabetes mellitus, including at least 10 contiguous nucleotides of a nucleotide sequence selected from the group consisting of nucleotide sequences of SEQ ID NOS: 1-80 and including a nucleotide at position 101 of the nucleotide sequence, or a complementary polynucleotide thereof.
Abstract translation: 提供了用于诊断或治疗II型糖尿病的多核苷酸，包括选自SEQ ID NO：1-80的核苷酸序列的核苷酸序列的至少10个连续核苷酸，并且包含核苷酸的位置101的核苷酸 序列或其互补多核苷酸。
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8.发明申请PROTEIN ASSOCIATED WITH COLORECTAL CANCER, POLYNUCLEOTIDE INCLUDING SINGLE-NUCLEOTIDE POLYMORPHISM ASSOCIATED WITH COLORECTAL CANCER, MICROARRAY AND DIAGNOSTIC KIT INCLUDING THE SAME, AND METHOD OF DIAGNOSING COLORECTAL CANCER USING THE SAME 审中-公开与彩色癌相关的蛋白质，包括与包含其中的彩色癌，微阵列和诊断试剂盒相关的单核多聚体的多核苷酸以及使用其的诊断癌性癌症的方法公开(公告)号：US20090258345A1
公开(公告)日：2009-10-15
申请号：US11576650
申请日：2006-02-25
Applicant: Yeon-Su Lee , Sang-Hoon Kim , Choon-Ryoul Shin , Kyung-Hee Park
Inventor： Yeon-Su Lee , Sang-Hoon Kim , Choon-Ryoul Shin , Kyung-Hee Park
CPC classification number: C07K14/4748 , G01N33/57419
Abstract: Provided are an isolated nucleolar protein having an amino acid sequence of NCBI GenBank Accession No. XP_033371, a method of diagnosing colorectal cancer in an individual, including measuring an expression level of a protein having an amino acid sequence of NCBI GenBank Accession No. XP_033371 in the individual, and a polynucleotide for diagnosis or treatment of colorectal cancer including at least 10 contiguous nucleotides of a nucleotide sequence selected from the group consisting of nucleotide sequences of SEQ ID NOS: 1-5 and including a nucleotide at position 101 of the nucleotide sequence, or a complementary polynucleotide thereof.
Abstract translation: 提供了具有NCBI GenBank登录号XP_033371的氨基酸序列的分离的核仁蛋白，其是个体中诊断结肠直肠癌的方法，包括测定具有NCBI GenBank登录号XP_033371的氨基酸序列的蛋白质的表达水平在 个体和用于诊断或治疗结肠直肠癌的多核苷酸，包括选自SEQ ID NO：1-5的核苷酸序列的核苷酸序列的至少10个连续核苷酸，并且包含核苷酸序列的101位的核苷酸 ，或其互补多核苷酸。
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9.发明申请Polynucleotide comprising single-nucleotide polymorphism associated with colorectal cancer, microarray and diagnostic kit comprising the same, and method of diagnosing colorectal cancer using the same 审中-公开包括与结肠直肠癌相关的单核苷酸多态性的多核苷酸，包含该结构域的微阵列和诊断试剂盒，以及使用该多核苷酸诊断结肠直肠癌的方法公开(公告)号：US20060281123A1
公开(公告)日：2006-12-14
申请号：US11451665
申请日：2006-06-13
Applicant: Min-sun Kim , Sung-woo Hong , Jae-Heup Kim , Yeon-Su Lee , Ki-eun Klm , Tae-Jin Ahn
Inventor： Min-sun Kim , Sung-woo Hong , Jae-Heup Kim , Yeon-Su Lee , Ki-eun Klm , Tae-Jin Ahn
CPC classification number: C12Q1/6886 , C12Q2600/172
Abstract: Provided are a polynucleotide for diagnosis or treatment of colorectal cancer including at least 10 contiguous nucleotides of a nucleotide sequence selected from the group consisting of nucleotide sequences of SEQ ID NOS: 1 and 2 and including a nucleotide at position 101 of the nucleotide sequence, or the complement thereof; a microarray having a substrate on which the polynucleotide is immobilized; a diagnostic kit for the detection of colorectal cancer including the polynucleotide; and a method of detecting colorectal cancer using the polynucleotide.
Abstract translation: 提供了用于诊断或治疗结肠直肠癌的多核苷酸，其包括选自SEQ ID NO：1和2的核苷酸序列并且包含核苷酸序列的101位的核苷酸的核苷酸序列的至少10个连续核苷酸，或 其补语 具有其上固定有多核苷酸的底物的微阵列; 用于检测包括多核苷酸的结肠直肠癌的诊断试剂盒; 以及使用该多核苷酸检测结肠直肠癌的方法。
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10.发明申请METHOD FOR DIAGNOSING DISEASE USING ADENOVIRUS HARBORING TRANS-SPLICING RIBOZYME BY MOLECULAR IMAGING 有权用分子成像技术利用腺病毒载体转移分离的RIBOZYME诊断疾病的方法公开(公告)号：US20110165690A1
公开(公告)日：2011-07-07
申请号：US12522597
申请日：2007-10-26
Applicant: In-Hoo Kim , Seong-Wook Lee , Seung-Hee Hong , Jin-Sook Jeong , Yeon-Su Lee , Haeng-Im Jung
Inventor： In-Hoo Kim , Seong-Wook Lee , Seung-Hee Hong , Jin-Sook Jeong , Yeon-Su Lee , Haeng-Im Jung
CPC classification number: A61K49/0045
Abstract: Disclosed herein is a composition for molecular imaging comprising a trans-splicing ribozyme coupled with an imaging reporter gene. The trans-splicing ribozyme targets a specific gene associated with a disease. Also disclosed is a molecular imaging method using the composition.
Abstract translation: 本文公开了一种用于分子成像的组合物，其包含与成像报道基因偶联的反式拼接核酶。 转拼核酶靶向与疾病相关的特定基因。 还公开了使用该组合物的分子成像方法。
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