公开(公告)号：US10435752B2

公开(公告)日：2019-10-08

申请号：US14411970

申请日：2012-08-20

Applicant: Yeon Su Lee ,  Sung Ho Goh ,  In Hoo Kim ,  Seung Hyun Hong

Inventor： Yeon Su Lee ,  Sung Ho Goh ,  In Hoo Kim ,  Seung Hyun Hong

IPC: C12Q1/6886 ,  C12Q1/527 ,  G01N33/574 ,  C12N15/113

Abstract: The present invention relates to: a composition for detecting a gastric cancer marker comprising a preparation for measuring the expression level or methylation level of mRNA of ADCY3 or a protein thereof; a kit for diagnosing gastric cancer, containing the composition; a method for diagnosing gastric cancer by treating a biological sample with the preparation to ascertain whether a material for complementarily binding to the preparation exists and comparing the amount thereof with a control group; a composition for treating and preventing gastric cancer, containing a preparation capable of inhibiting ADCY3 polynucleotide or ADCY3 polypeptide; and a method for treating gastric cancer by administering the composition to an individual. According to the present invention, it is possible to diagnose gastric cancer with high diagnostic sensitivity and specificity using ADCY3 as a marker for diagnosing gastric cancer, and thus can greatly contribute to reducing mortality due to gastric cancer.

公开(公告)号：US20150240313A1

公开(公告)日：2015-08-27

申请号：US14411970

申请日：2012-08-20

Applicant: Yeon Su Lee ,  Sung Ho Goh ,  In Hoo Kim ,  Seung Hyun Hong

Inventor： Yeon Su Lee ,  Sung Ho Goh ,  In Hoo Kim ,  Seung Hyun Hong

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12N15/1137 ,  C12N2310/14 ,  C12Q1/527 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Y406/01001 ,  G01N33/57446

Abstract: The present invention relates to: a composition for detecting a gastric cancer marker comprising a preparation for measuring the expression level or methylation level of mRNA of ADCY3 or a protein thereof; a kit for diagnosing gastric cancer, containing the composition; a method for diagnosing gastric cancer by treating a biological sample with the preparation to ascertain whether a material for complementarily binding to the preparation exists and comparing the amount thereof with a control group; a composition for treating and preventing gastric cancer, containing a preparation capable of inhibiting ADCY3 polynucleotide or ADCY3 polypeptide; and a method for treating gastric cancer by administering the composition to an individual. According to the present invention, it is possible to diagnose gastric cancer with high diagnostic sensitivity and specificity using ADCY3 as a marker for diagnosing gastric cancer, and thus can greatly contribute to reducing mortality due to gastric cancer.

Abstract translation: 本发明涉及：用于检测胃癌标志物的组合物，其包含用于测量ADCY3或其蛋白质的mRNA的表达水平或甲基化水平的制剂; 用于诊断胃癌的试剂盒，含有该组合物; 通过用该制剂处理生物样品来确定是否存在与该制剂的互补结合的材料并将其与对照组比较来诊断胃癌的方法; 用于治疗和预防胃癌的组合物，其含有能抑制ADCY3多核苷酸或ADCY3多肽的制剂; 以及通过将组合物给予个体来治疗胃癌的方法。 根据本发明，可以使用ADCY3作为诊断胃癌的标志物来诊断具有高诊断灵敏度和特异性的胃癌，因此可以大大有助于降低胃癌的死亡率。

公开(公告)号：US08673573B2

公开(公告)日：2014-03-18

申请号：US12997560

申请日：2010-10-07

Applicant: Yeon-Su Lee ,  Sung-Ho Goh ,  Sung-Hye Hong ,  In-Hoo Kim ,  Jin-Sook Jeong

Inventor： Yeon-Su Lee ,  Sung-Ho Goh ,  Sung-Hye Hong ,  In-Hoo Kim ,  Jin-Sook Jeong

IPC: A61K31/713 ,  C12Q1/68

CPC classification number: G01N33/57415 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/16 ,  C12N2310/531 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/156 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57426 ,  G01N33/5743

Abstract: Disclosed are a cancer marker-detecting composition comprising an agent for measuring an mRNA or protein expression level of eIF3m, a cancer diagnosis kit comprising the same, a method for detecting an eIF3m polynucleotide or protein by treating a biological specimen with the agent to detect a substance binding specifically to the agent and quantitatively comparing the substance between a subject and a normal control, and a method for the treatment and prevention of cancer comprising an agent for down-regulating the expression of an eIF3m polynucleotide or protein.

Abstract translation: 公开了包含用于测量eIF3m的mRNA或蛋白质表达水平的试剂的癌症标志物检测组合物，包含其的癌症诊断试剂盒，通过用该试剂处理生物样品来检测eIF3m多核苷酸或蛋白质的方法，以检测eIF3m多核苷酸 特异性结合药剂的物质和定量比较受试者和正常对照之间的物质，以及用于治疗和预防癌症的方法，其包含用于下调eIF3m多核苷酸或蛋白质表达的试剂。

公开(公告)号：US20120201837A1

公开(公告)日：2012-08-09

申请号：US12997560

申请日：2010-10-07

Applicant: Yeon-Su Lee ,  Sung-Ho Goh ,  Sung-Hye Hong ,  In-Hoo Kim ,  Jin-Sook Jeong

Inventor： Yeon-Su Lee ,  Sung-Ho Goh ,  Sung-Hye Hong ,  In-Hoo Kim ,  Jin-Sook Jeong

IPC: A61K39/395 ,  G01N33/574 ,  C07K16/18 ,  C40B40/10 ,  A61K31/713 ,  A61P35/00 ,  C40B40/06 ,  C12Q1/68 ,  C40B30/04

CPC classification number: G01N33/57415 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/16 ,  C12N2310/531 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/156 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57426 ,  G01N33/5743

Abstract: Disclosed are a cancer marker-detecting composition comprising an agent for measuring an mRNA or protein expression level of eIF3m, a cancer diagnosis kit comprising the same, a method for detecting an eIF3m polynucleotide or protein by treating a biological specimen with the agent to detect a substance binding specifically to the agent and quantitatively comparing the substance between a subject and a normal control, and a method for the treatment and prevention of cancer comprising an agent for down-regulating the expression of an eIF3m polynucleotide or protein.

Abstract translation: 公开了包含用于测量eIF3m的mRNA或蛋白质表达水平的试剂的癌症标志物检测组合物，包含其的癌症诊断试剂盒，通过用该试剂处理生物样品来检测eIF3m多核苷酸或蛋白质的方法，以检测eIF3m多核苷酸 特异性结合药剂的物质和定量比较受试者和正常对照之间的物质，以及用于治疗和预防癌症的方法，其包含用于下调eIF3m多核苷酸或蛋白质表达的试剂。