Use of ADCY3 for diagnosis and treatment of gastric cancer

    公开(公告)号:US10435752B2

    公开(公告)日:2019-10-08

    申请号:US14411970

    申请日:2012-08-20

    Abstract: The present invention relates to: a composition for detecting a gastric cancer marker comprising a preparation for measuring the expression level or methylation level of mRNA of ADCY3 or a protein thereof; a kit for diagnosing gastric cancer, containing the composition; a method for diagnosing gastric cancer by treating a biological sample with the preparation to ascertain whether a material for complementarily binding to the preparation exists and comparing the amount thereof with a control group; a composition for treating and preventing gastric cancer, containing a preparation capable of inhibiting ADCY3 polynucleotide or ADCY3 polypeptide; and a method for treating gastric cancer by administering the composition to an individual. According to the present invention, it is possible to diagnose gastric cancer with high diagnostic sensitivity and specificity using ADCY3 as a marker for diagnosing gastric cancer, and thus can greatly contribute to reducing mortality due to gastric cancer.

    USE OF ADCY3 FOR DIAGNOSIS AND TREATMENT OF GASTRIC CANCER
    3.
    发明申请
    USE OF ADCY3 FOR DIAGNOSIS AND TREATMENT OF GASTRIC CANCER 审中-公开
    使用ADCY3进行诊断和治疗胃癌

    公开(公告)号:US20150240313A1

    公开(公告)日:2015-08-27

    申请号:US14411970

    申请日:2012-08-20

    Abstract: The present invention relates to: a composition for detecting a gastric cancer marker comprising a preparation for measuring the expression level or methylation level of mRNA of ADCY3 or a protein thereof; a kit for diagnosing gastric cancer, containing the composition; a method for diagnosing gastric cancer by treating a biological sample with the preparation to ascertain whether a material for complementarily binding to the preparation exists and comparing the amount thereof with a control group; a composition for treating and preventing gastric cancer, containing a preparation capable of inhibiting ADCY3 polynucleotide or ADCY3 polypeptide; and a method for treating gastric cancer by administering the composition to an individual. According to the present invention, it is possible to diagnose gastric cancer with high diagnostic sensitivity and specificity using ADCY3 as a marker for diagnosing gastric cancer, and thus can greatly contribute to reducing mortality due to gastric cancer.

    Abstract translation: 本发明涉及:用于检测胃癌标志物的组合物,其包含用于测量ADCY3或其蛋白质的mRNA的表达水平或甲基化水平的制剂; 用于诊断胃癌的试剂盒,含有该组合物; 通过用该制剂处理生物样品来确定是否存在与该制剂的互补结合的材料并将其与对照组比较来诊断胃癌的方法; 用于治疗和预防胃癌的组合物,其含有能抑制ADCY3多核苷酸或ADCY3多肽的制剂; 以及通过将组合物给予个体来治疗胃癌的方法。 根据本发明,可以使用ADCY3作为诊断胃癌的标志物来诊断具有高诊断灵敏度和特异性的胃癌,因此可以大大有助于降低胃癌的死亡率。

    HEAT TREATMENT METHOD OF ALUMINUM ALLOY PANEL
    5.
    发明申请
    HEAT TREATMENT METHOD OF ALUMINUM ALLOY PANEL 审中-公开
    铝合金板的热处理方法

    公开(公告)号:US20100012236A1

    公开(公告)日:2010-01-21

    申请号:US12356439

    申请日:2009-01-20

    CPC classification number: C22F1/047 C22C21/06

    Abstract: The present invention provides a heat treatment method of an aluminum alloy panel, which can prevent surface curvature of molded aluminum alloy panel. For this purpose, the present heat treatment methods comprise: cold rolling an aluminum alloy panel at a reduction ratio of 45 to 50% at a final pass in a cold rolling process; first heat-treating the cold-rolled aluminum alloy panel at 450 to 510° C. for 3 hours; rapidly cooling the heat-treated aluminum alloy panel at a rate 60° C./sec or higher after the first heat treatment; and second heat-treating the rapidly cooled aluminum alloy panel at 200 to 220° C.

    Abstract translation: 本发明提供铝合金板的热处理方法,其能够防止模制的铝合金板的表面曲率。 为此目的,本发明的热处理方法包括:在冷轧过程中最后通过时以45%至50%的压缩比冷轧铝合金板; 首先在450〜510℃下对冷轧铝合金板进行3小时热处理; 在第一次热处理后以60℃/秒以上的速度快速冷却热处理的铝合金面板; 并在200〜220℃下对快速冷却的铝合金板进行二次热处理。

    Method of manufacturing Al-Mg-Si alloy sheet capable of forming a flat hemming
    7.
    发明申请
    Method of manufacturing Al-Mg-Si alloy sheet capable of forming a flat hemming 审中-公开
    制造能够形成平坦折边的Al-Mg-Si合金板的方法

    公开(公告)号:US20050205177A1

    公开(公告)日:2005-09-22

    申请号:US10998487

    申请日:2004-11-29

    Inventor: Seung Hyun Hong

    CPC classification number: C22C21/08 C22F1/04 C22F1/05

    Abstract: A method of manufacturing a rolling sheet of AA6000 aluminum alloy comprising Si and Mg as major components is disclosed. More specifically, the present invention provides a method of manufacturing a rolling sheet of an aluminum alloy sheet capable of forming a flat hemming wherein its fractional volume for cube orientation is 35 or higher.

    Abstract translation: 公开了一种制造包括Si和Mg作为主要成分的AA6000铝合金的轧制板的方法。 更具体地说,本发明提供一种能够形成平坦折边的铝合金板的轧制板的制造方法,其中立方体取向的分数体积为35或更高。

    ULTRAHIGH-STRENGTH TWIP STEEL SHEET AND MANUFACTURING METHOD THEREOF
    8.
    发明申请
    ULTRAHIGH-STRENGTH TWIP STEEL SHEET AND MANUFACTURING METHOD THEREOF 审中-公开
    超高强度双板钢板及其制造方法

    公开(公告)号:US20100037993A1

    公开(公告)日:2010-02-18

    申请号:US12276725

    申请日:2008-11-24

    Abstract: The present invention provides a TWIP steel sheet that has an austenite matrix structure and includes 15-25 wt % of manganese. The TWIP steel sheet has a recrystallization texture in which brass orientation is suppressed and {3 5 2} is developed as its main orientation during heat treatment subsequent to cold rolling, and has an average plastic strain ratio of 1.2 or more, preferably 1.5 or more. Since this TWIP steel sheet has high workability and strength, complicated vehicle body components can be easily manufactured through a press molding process without cracking or rupturing.

    Abstract translation: 本发明提供一种具有奥氏体矩阵结构并包含15-25重量%锰的TWIP钢板。 TWIP钢板具有抑制黄铜取向的再结晶织构,并且在冷轧之后的热处理中开发{3 5 2} <2 2 1>作为其主要取向,并且其平均塑性应变比为1.2以上 ,优选为1.5以上。 由于该TWIP钢板具有高的可加工性和强度,因此可以通过压制成型工艺容易地制造复杂的车体部件而不会发生裂纹或破裂。

    ULTRA HIGH STRENGTH TWIP STEEL SHEET AND MANUFACTURING METHOD THEREOF
    9.
    发明申请
    ULTRA HIGH STRENGTH TWIP STEEL SHEET AND MANUFACTURING METHOD THEREOF 审中-公开
    超高强度双辊钢板及其制造方法

    公开(公告)号:US20100012233A1

    公开(公告)日:2010-01-21

    申请号:US12400077

    申请日:2009-03-09

    Inventor: Seung Hyun Hong

    CPC classification number: C22C38/02 C21D8/0421 C22C38/04 C22C38/06

    Abstract: Disclosed herein is an ultra high strength TWIP steel sheet having an austenite matrix texture, comprising 0.15˜0.30 wt % of carbon, 0.01˜0.03 wt % of silicon, 15˜25 wt % of manganese, 1.2˜3.0 wt % of aluminum, 0.020 wt % or less of phosphorus, 0.001˜0.002 wt % of sulfur, and residual iron and other inevitable impurities, wherein the TWIP steel sheet is cold-rolled at a reduction ratio of 35˜40% per pass under a condition of 180˜220 Mpa in front and rear tension, and thus has an average plastic strain ratio of 1.2 or more. The ultra high strength TWIP steel sheet has an improved average plastic strain ratio and excellent formability because it has a developed Goss orientation.

    Abstract translation: 本发明公开了一种具有奥氏体基体织构的超高强度TWIP钢板,其包含0.15〜0.30重量%的碳,0.01〜0.03重量%的硅,15〜25重量%的锰,1.2〜3.0重量%的铝,0.020 重量%以下的磷,0.001〜0.002重量%的硫和残余铁等不可避免的杂质,其中TWIP钢板以180〜220的条件以每次通过的35〜40%的压缩比进行冷轧 Mpa在前后张力,因此平均塑性应变比为1.2以上。 超高强度TWIP钢板具有改进的平均塑性应变比和优异的成形性,因为它具有显着的高斯取向。

    METHOD AND SYSTEM FOR RECOGNITION OF A TARGET IN A THREE DIMENSIONAL SCENE
    10.
    发明申请
    METHOD AND SYSTEM FOR RECOGNITION OF A TARGET IN A THREE DIMENSIONAL SCENE 审中-公开
    在三维场景中识别目标的方法和系统

    公开(公告)号:US20090160985A1

    公开(公告)日:2009-06-25

    申请号:US12331984

    申请日:2008-12-10

    CPC classification number: G06K9/00214 G06K2209/40 H04N13/232

    Abstract: A method for three-dimensional reconstruction of a three-dimensional scene and target object recognition may include acquiring a plurality of elemental images of a three-dimensional scene through a microlens array; generating a reconstructed display plane based on the plurality of elemental images using three-dimensional volumetric computational integral imaging; and recognizing the target object in the reconstructed display plane by using an image recognition or classification algorithm.

    Abstract translation: 用于三维场景和目标对象识别的三维重建的方法可以包括通过微透镜阵列获取三维场景的多个元素图像; 使用三维体积计算积分成像基于所述多个元素图像生成重建的显示平面; 并通过使用图像识别或分类算法识别重建的显示平面中的目标对象。

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