公开(公告)号：US06409764B1

公开(公告)日：2002-06-25

申请号：US09205150

申请日：1998-12-03

Applicant: Charles F. White ,  Charles Flynn ,  Alonzo D. Cook ,  William R. Hardwick ,  Ulf M. E. Wikesjo ,  Robert C. Thomson

Inventor： Charles F. White ,  Charles Flynn ,  Alonzo D. Cook ,  William R. Hardwick ,  Ulf M. E. Wikesjo ,  Robert C. Thomson

IPC: A61F228

CPC classification number: A61L27/3865 ,  A61C8/0006 ,  A61F2/2803 ,  A61F2/2846 ,  A61F2/468 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/30062 ,  A61F2002/30153 ,  A61F2002/30235 ,  A61F2002/30238 ,  A61F2002/30785 ,  A61F2002/30787 ,  A61F2002/3082 ,  A61F2002/30909 ,  A61F2002/30914 ,  A61F2002/30948 ,  A61F2002/30971 ,  A61F2210/0004 ,  A61F2230/0019 ,  A61F2230/0069 ,  A61F2310/00365 ,  A61L27/3847 ,  A61L27/48 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2300/64 ,  A61L2430/02 ,  Y10S623/901

Abstract: There are numerous medical situations involving deficiencies of living bone or periodontal tissue and where increase of living bone or periodontal tissue mass is desired. Methods are described wherein a configured, shell-like device that is capable of being penetrated by living cells and tissues, is implanted into the body of a mammal in such a way as to establish a space, the space being at least partly, bounded by the device. The configuration of the device is such that the configuration of the established space is essentially the same as the configuration of living bone or periodontal tissue that is desired for treatment of the tissue deficiency. At least one protein from the Transforming Growth Factor-Beta Superfamily of proteins is placed within the established space for the purpose of stimulating the growth of living bone or periodontal tissue within the established space. A kit for the generation of living bone or periodontal tissue, comprised of the components mentioned above, is also disclosed.

Abstract translation: 存在许多涉及活骨或牙周组织缺陷的医疗情况，并且需要活体骨或牙周组织块的增加。 描述了一种方法，其中能够被活细胞和组织穿透的构造的壳状装置被植入到哺乳动物的身体中，以便建立空间，该空间至少部分地由 装置。 该装置的构造使得所建立的空间的构造基本上与用于治疗组织缺陷所需的活骨或牙周组织的构造相同。 来自蛋白质转化生长因子-β超家族的至少一种蛋白质被置于已建立的空间内，以刺激已建立空间内的活骨或牙周组织的生长。 还公开了由上述组分组成的用于生成骨或牙周组织的试剂盒。

公开(公告)号：US6031148A

公开(公告)日：2000-02-29

申请号：US42293

申请日：1993-04-02

Applicant: Byron Kent Hayes ,  William R. Hardwick ,  Charles F. White ,  Mark D. Butler

Inventor： Byron Kent Hayes ,  William R. Hardwick ,  Charles F. White ,  Mark D. Butler

IPC: A61L27/00 ,  A61B17/00 ,  A61B17/06 ,  A61B19/00 ,  A61C8/00 ,  A61F2/00 ,  A61F2/02 ,  A61F2/06 ,  A61F2/28 ,  A61F2/30 ,  A61K6/00 ,  A61L27/18 ,  A61L27/34 ,  A61L27/58 ,  A61L31/00 ,  A61L31/06 ,  A61L31/10 ,  A61L31/14 ,  A61B17/08 ,  A61F2/04

CPC classification number: A61L31/148 ,  A61C8/0006 ,  A61F2/0063 ,  A61F2/0077 ,  A61F2/06 ,  A61F2/2846 ,  A61K6/0032 ,  A61L27/18 ,  A61L27/34 ,  A61L27/58 ,  A61L31/06 ,  A61L31/10 ,  A61B17/06166 ,  A61B2017/00004 ,  A61B2090/0816 ,  A61F2/3094 ,  A61F2002/30032 ,  A61F2002/30062 ,  A61F2002/30235 ,  A61F2002/30677 ,  A61F2210/0004 ,  A61F2230/0069 ,  A61F2240/001 ,  A61F2250/003 ,  A61F2250/0067

Abstract: An implantable bioabsorbable article for the separation and regeneration of tissue at a tissue defect site in the form of a fibrous matrix laminarly affixed to both surfaces of a cell-barrier sheet material. When implanted it allows ingrowth of tissue into the fibrous matrix side of the material; simultaneously the tissue to be regenerated at the tissue defect site is separated from the ingrowing tissue by the cell-barrier sheet material. A method for making the implantable bioabsorbable article is also described.

Abstract translation: 一种用于在组织缺损部位分离和再生组织缺损部位的可植入生物可吸收制品，该组织缺损部位以层状贴附在细胞阻挡片材料的两个表面上的纤维状基质的形式。 当植入时，它允许组织进入材料的纤维基质侧; 同时将组织缺损部位再生的组织通过细胞阻挡片材料从成丝组织分离。 还描述了制造可植入生物可吸收制品的方法。

公开(公告)号：US06328765B1

公开(公告)日：2001-12-11

申请号：US09205521

申请日：1998-12-03

Applicant: William R. Hardwick ,  Robert C. Thomson ,  Robert L. Cleek ,  Shrikant M. Mane ,  Alonzo D. Cook

Inventor： William R. Hardwick ,  Robert C. Thomson ,  Robert L. Cleek ,  Shrikant M. Mane ,  Alonzo D. Cook

IPC: A61F224

CPC classification number: A61F2/2846 ,  A61F2/2803 ,  A61F2/30907 ,  A61F2002/2817 ,  A61F2002/30235 ,  A61F2002/30784 ,  A61F2002/30971 ,  A61F2230/0069 ,  A61K38/00 ,  A61L27/16 ,  A61L27/18 ,  A61L27/56 ,  A61L27/58 ,  A61L27/54 ,  A61L27/22 ,  C08L83/04 ,  C08L81/06 ,  C08L77/00 ,  C08L75/04 ,  C08L69/00 ,  C08L67/02 ,  C08L33/14 ,  C08L33/12 ,  C08L27/18 ,  C08L33/04

Abstract: There are numerous medical situations involving deficiencies of living tissue and where increase of living tissue mass is desired. Methods are described wherein a configured, shell-like device that is capable of being penetrated by living cells and tissues, is implanted into the body of a mammal in such a way as to establish a space, the space being at least partly, bounded by the device. The configuration of the device is such that the configuration of the established space is essentially the same as the configuration of living tissue that is desired for treatment of the tissue deficiency. At least one tissue stimulating molecular substance is placed within the established space for the purpose of stimulating the growth of desired living tissue within the established space. A kit for the generation of desired living tissue, comprised of the components mentioned above, is also disclosed.

Abstract translation: 存在许多涉及活组织缺陷的医疗情况，并且需要增加生物体组织质量。 描述了一种方法，其中能够被活细胞和组织穿透的构造的壳状装置被植入到哺乳动物的身体中，以便建立空间，该空间至少部分地由 装置。 该装置的结构使得所建立的空间的构造基本上与用于治疗组织缺陷所需的活组织的构型相同。 将至少一种刺激组织的分子物质放置在所建立的空间内，以刺激所建立的空间内期望的活组织的生长。 还公开了用于产生由上述组分组成的所需活组织的试剂盒。

公开(公告)号：US5093179A

公开(公告)日：1992-03-03

申请号：US696756

申请日：1991-05-07

Applicant: Todd V. Scantlebury ,  Jeanne B. Ambruster ,  Suzanne Motsinger ,  Daniel F. Davidson ,  William R. Hardwick ,  Stephen E. Campbell

Inventor： Todd V. Scantlebury ,  Jeanne B. Ambruster ,  Suzanne Motsinger ,  Daniel F. Davidson ,  William R. Hardwick ,  Stephen E. Campbell

IPC: A61C5/04 ,  A61C8/00 ,  A61C19/06 ,  A61F2/00 ,  A61F2/02 ,  A61F2/28 ,  A61K6/00

CPC classification number: A61C8/0006 ,  A61C8/0012 ,  A61F2/2846 ,  A61F2002/2835 ,  A61F2002/30062 ,  A61F2210/0004 ,  A61F2310/00293 ,  Y10T428/239 ,  Y10T428/24058 ,  Y10T428/24124 ,  Y10T428/24496 ,  Y10T428/24777 ,  Y10T428/2495 ,  Y10T428/249987 ,  Y10T428/28 ,  Y10T428/3154 ,  Y10T428/31544 ,  Y10T428/31551 ,  Y10T428/31663 ,  Y10T428/31786 ,  Y10T428/31855 ,  Y10T428/31935 ,  Y10T428/31938

Abstract: A method for treatment of periodontal disease is disclosed. The gingival tissue is separated from the tooth surface in an area where periodontal disease is present. A biocompatible, porous material such as expanded polytetrafluoroethylene capable of supporting ingrowth of gingival connective tissue and preventing apical migration of gingival epithelium is placed in a laminar relationship to a portion of the perimenter of the tooth surface. The gingival tissue is repositioned around the tooth and in contact with the porous material, with the porous material positioned between the gingival tissue and the tooth. Articles for the treatment of periodontal disease are also disclosed. One article comprises a first portion which is capable of supporting ingrowth of gingival connective tissue and preventing apical migration of gingival epithelium and a second portion which is impermeable to oral tissues and bacteria. Articles and methods for the treatment of bone defects are also disclosed. The articles have a first portion with a surface capable of supporting connective tissue ingrowth configured to contact the bone surrounding the defect and a second portion with a surface substantially impermeable to tissue ingrowth and bacteria invasion extending from the first portion to cover the defect.

Abstract translation: 公开了治疗牙周病的方法。 在存在牙周病的区域，牙齿组织与牙齿表面分离。 能够支持牙龈结缔组织向内生长并防止牙龈上皮的顶端迁移的生物相容性多孔材料如膨胀聚四氟乙烯与牙齿表面的一部分的层状关系放置。 牙齿组织重新定位在牙齿周围并与多孔材料接触，多孔材料位于牙龈组织和牙齿之间。 还公开了治疗牙周病的物品。 一种制品包括能够支持牙龈结缔组织向内生长并防止牙龈上皮的顶端移动的第一部分和不能渗透口腔组织和细菌的第二部分。 还公开了用于治疗骨缺损的制品和方法。 制品具有第一部分，其表面能够支撑构造成接触围绕缺陷的骨骼的结缔组织向内生长，第二部分具有基本上不可渗透组织向内生长的表面和从第一部分延伸以覆盖缺陷的细菌侵入。

公开(公告)号：US5032445A

公开(公告)日：1991-07-16

申请号：US333289

申请日：1989-04-05

Applicant: Todd V. Scantlebury ,  Jeanne B. Ambruster ,  Suzanne Motsinger ,  Daniel F. Davidson ,  William R. Hardwick ,  Stephen E. Campbell

Inventor： Todd V. Scantlebury ,  Jeanne B. Ambruster ,  Suzanne Motsinger ,  Daniel F. Davidson ,  William R. Hardwick ,  Stephen E. Campbell

IPC: A61C5/02 ,  A61C8/00 ,  A61K6/00

CPC classification number: A61C5/02 ,  A61C8/0006 ,  A61C8/0012 ,  A61K6/0011 ,  A61K6/0023 ,  Y10T428/239 ,  Y10T428/24058 ,  Y10T428/24124 ,  Y10T428/24496 ,  Y10T428/24777 ,  Y10T428/2495 ,  Y10T428/249987 ,  Y10T428/28 ,  Y10T428/31544

Abstract: A method for treatment of periodontal disease is disclosed. The gingival tissue is separated from the tooth surface in an area where periodontal disease is present. A biocompatible, porous material such as expanded polytetrafluoroethylene capable of supporting ingrowth of gingival connective tissue and preventing apical migration of gingival epithelium is placed in a laminar relationship to a portion of the perimeter of the tooth surface. The gingival tissue is repositioned around the tooth and in contact with the porous material, with the porous material positioned between the gingival tissue and the tooth. Articles for the treatment of periodontal disease are also disclosed. One article comprises a first portion which is capable of supporting ingrowth of gingival connective tissue and preventing apical migration of gingival epithelium and a second portion which is impermeable to oral tissues and bacteria.

Abstract translation: 公开了治疗牙周病的方法。 在存在牙周病的区域，牙齿组织与牙齿表面分离。 能够支持牙龈结缔组织向内生长并防止牙龈上皮的顶端迁移的生物相容性多孔材料如膨胀聚四氟乙烯与牙齿表面周边的一部分层叠。 牙齿组织重新定位在牙齿周围并与多孔材料接触，多孔材料位于牙龈组织和牙齿之间。 还公开了治疗牙周病的物品。 一种制品包括能够支持牙龈结缔组织向内生长并防止牙龈上皮的顶端移动的第一部分和不能渗透口腔组织和细菌的第二部分。