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    Cell encapsulating device containing a cell displacing core for maintaining cell viability
    2.
    发明授权
    Cell encapsulating device containing a cell displacing core for maintaining cell viability 有权
    包含用于维持细胞活力的细胞置换核心的细胞包封装置

    公开(公告)号：US06426214B1

    公开(公告)日：2002-07-30

    申请号：US09435510

    申请日：1999-11-08

    Applicant: Mark D. Butler ,  Stanley L. Mish

    Inventor： Mark D. Butler ,  Stanley L. Mish

    IPC: C12M300

    CPC classification number: A61K9/0092 ,  A61K9/0024 ,  A61K9/0085

    Abstract: Cell encapsulating devices capable of maintaining large numbers of viable cells are provided containing an inert, substantially cell-free core that displaces cells, a permeable membrane and a zone for maintaining cells. The permeable membrane surrounds the core such that the zone of cells is bounded by the core and the permeable membrane. A preferred device contains a polytetrafluoroethylene permeable membrane and a flexible polymer core having a plurality of ridges and valleys running lengthwise along the core. The cell zone may contain support means for cell attachment and the core may have an outer boundary containing a material that promotes cell adhesion. Preferably, the cell zone has a thickness such that at least about 10% of the cells, more preferably at least about 50% or 80%, in a cell layer located closest to the outer boundary of the core remain viable. The thickness is preferably less than 500 microns such as 25 to 250 microns or 50 to 100 microns. The devices are suitable for implantation into an individual in need of treatment and are capable of supplying therapeutic substances to such individuals.

    Abstract translation: 提供能够维持大量活细胞的细胞包封装置，其包含置换细胞，可渗透膜和用于维持细胞的区域的惰性，基本上无细胞的核。 渗透膜围绕核心，使得细胞区域被核心和可渗透膜界定。 优选的装置包含聚四氟乙烯可渗透膜和柔性聚合物芯，其具有沿着芯纵向延伸的多个脊和谷。 细胞区域可以包含用于细胞附着的支持装置，并且核心可以具有包含促进细胞粘附的材料的外边界。 优选地，细胞区具有这样的厚度，使得位于最靠近核的外边界的细胞层中至少约10％的细胞，更优选至少约50％或80％保持活性。 厚度优选小于500微米，例如25至250微米或50至100微米。 该装置适于植入需要治疗的个体中，并且能够向这些个体供应治疗物质。

    Cell encapsulating device containing a cell displacing core for maintaining cell viability
    3.
    发明授权
    Cell encapsulating device containing a cell displacing core for maintaining cell viability 失效
    包含用于维持细胞活力的细胞置换核心的细胞包封装置

    公开(公告)号：US5980889A

    公开(公告)日：1999-11-09

    申请号：US906367

    申请日：1997-08-05

    Applicant: Mark D. Butler ,  Stanley L. Mish

    Inventor： Mark D. Butler ,  Stanley L. Mish

    IPC: A61K9/00 ,  C12P21/04 ,  A01N63/00 ,  C12N5/00 ,  C12N11/04

    CPC classification number: A61K9/0092 ,  A61K9/0024 ,  A61K9/0085

    Abstract: Cell encapsulating devices capable of maintaining large numbers of viable cells are provided containing an inert, substantially cell-free core that displaces cells, a permeable membrane and a zone for maintaining cells. The permeable membrane surrounds the core such that the zone of cells is bounded by the core and the permeable membrane. The cell zone may contain a support means for cell attachment and the core may have an outer boundary containing a material that promotes cell adhesion. Preferably, the cell zone has a thickness such that at least about 10% of the cells, more preferably at least about 50% or 80%, in a cell layer located closest to the outer boundary of the core remain viable. The thickness is preferably less than 500 microns such as 25 to 250 microns or 50 to 100 microns. The devices are suitable for implantation into an individual in need of treatment and are capable of supplying therapeutic substances to such individuals.

    Abstract translation: 提供能够维持大量活细胞的细胞包封装置，其包含置换细胞，可渗透膜和用于维持细胞的区域的惰性，基本上无细胞的核。 渗透膜围绕核心，使得细胞区域被核心和可渗透膜界定。 细胞区域可以包含用于细胞附着的支持装置，并且核心可以具有包含促进细胞粘附的材料的外边界。 优选地，细胞区具有这样的厚度，使得位于最靠近核的外边界的细胞层中至少约10％的细胞，更优选至少约50％或80％保持活性。 厚度优选小于500微米，例如25至250微米或50至100微米。 该装置适于植入需要治疗的个体中，并且能够向这些个体供应治疗物质。

    Cell encapsulation device
    4.
    发明授权
    Cell encapsulation device 失效
    细胞封装装置

    公开(公告)号：US5902745A

    公开(公告)日：1999-05-11

    申请号：US859946

    申请日：1997-05-21

    Applicant: Mark D. Butler ,  Paul D. Drumheller ,  Stanley L. Mish

    Inventor： Mark D. Butler ,  Paul D. Drumheller ,  Stanley L. Mish

    IPC: A61F2/02 ,  A61K9/00 ,  C12G1/073 ,  C12M1/40 ,  C12M3/06

    CPC classification number: A61K9/0024 ,  A61F2/022 ,  C12G1/064 ,  C12M23/08 ,  C12M23/22 ,  C12M23/34 ,  C12M23/38 ,  C12M25/16 ,  C12M33/14

    Abstract: The present invention is directed to a cell encapsulation device that permits rapid and straightforward cell transfer into the device. The preferred device includes components that allow a user to quickly transfer cells into the device with minimal risk to the cells. Among the most important improvements of the present invention are: automatic filtration of excess solution during cell transfer; an instantly wettable cover, allowing ready view into the cell chamber; and a swellable core, allowing cells to be transferred with minimal shear force while assuring optimal cell placement in the device during use. The device of the present invention may be used either in vivo, such as to deliver therapeutic substances, or in vitro, such as to serve as a bioreactor.

    Abstract translation: 本发明涉及允许快速且直接的细胞转移到装置中的细胞封装装置。 优选的设备包括允许用户以最小的细胞风险将细胞快速传送到设备中的组件。 本发明最重要的改进之一是：在细胞转移过程中过量溶液的自动过滤; 立即可湿的盖子，允许准备观察细胞室; 和可膨胀的芯，允许以最小剪切力转移细胞，同时确保在使用期间在装置中最佳的细胞放置。 本发明的装置可以在体内使用，例如递送治疗物质，或体外使用，例如用作生物反应器。

    Method for loading and reloading a therapeutical device in a vascularized implantable containment apparatus
    5.
    发明授权
    Method for loading and reloading a therapeutical device in a vascularized implantable containment apparatus 失效
    用于在血管化植入式容纳装置中装载和重新装载治疗装置的方法

    公开(公告)号：US5787900A

    公开(公告)日：1998-08-04

    申请号：US731353

    申请日：1996-10-11

    Applicant: Mark D. Butler ,  Stanley L. Mish

    Inventor： Mark D. Butler ,  Stanley L. Mish

    IPC: A61M37/00 ,  A61F2/02 ,  A61K9/00 ,  A61B19/00

    CPC classification number: A61F2/022

    Abstract: This invention relates generally to a method of loading and reloading a therapeutical device in a vascularized implantable containment apparatus made of selectively permeable material. Suitable therapeutical devices for use in the present invention include devices such as drug delivery devices, cell encapsulation devices, or gene therapy devices. A therapeutical device can be easily placed and replaced in a vascularized apparatus of the present invention without damaging tissues associated with the selectively permeable material of the apparatus.

    Abstract translation: 本发明一般涉及在选择性渗透性材料制成的血管化可植入容纳装置中加载和重新加载治疗装置的方法。 用于本发明的合适的治疗装置包括诸如药物递送装置，细胞包封装置或基因治疗装置的装置。 治疗装置可以容易地在本发明的血管化装置中放置和替换，而不损害与装置的选择性渗透性材料相关联的组织。

    Implantable containment apparatus for a therapeutical device and method for loading and reloading the device therein
    9.
    发明授权
    Implantable containment apparatus for a therapeutical device and method for loading and reloading the device therein 失效
    用于治疗装置的植入式容纳装置和用于在其中装载和重新装载装置的方法

    公开(公告)号：US5626561A

    公开(公告)日：1997-05-06

    申请号：US479932

    申请日：1995-06-07

    Applicant: Mark D. Butler ,  Stanley L. Mish

    Inventor： Mark D. Butler ,  Stanley L. Mish

    IPC: A61M37/00 ,  A61F2/02 ,  A61K9/00 ,  A61M31/00

    CPC classification number: A61F2/022

    Abstract: This invention relates generally to an implantable containment apparatus made of selectively permeable material. In particular, the implantable containment apparatus is used to contain a therapeutical device, such as a drug delivery device, a cell encapsulation device, or a gene therapy device. A therapeutical device can be easily placed and replaced in an apparatus of the present invention without damaging tissues associated with the selectively permeable material of the apparatus.

    Abstract translation: 本发明一般涉及由选择性渗透材料制成的可植入容纳装置。 特别地，可植入的容纳装置用于包含治疗装置，例如药物递送装置，细胞包封装置或基因治疗装置。 可以在本发明的装置中容易地放置和替换治疗装置，而不损害与装置的选择性渗透性材料相关联的组织。

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