LOW POLYDISPERSITY POLY-HEMA COMPOSITIONS
    3.
    发明申请
    LOW POLYDISPERSITY POLY-HEMA COMPOSITIONS 有权
    低聚物聚合物组合物

    公开(公告)号:US20080015322A1

    公开(公告)日:2008-01-17

    申请号:US11774453

    申请日:2007-07-06

    Abstract: The present invention relates to compositions comprising poly-HEMA having a peak molecular weight between about 25,000 and about 100,000, preferably between 25,000 and 80,000 and a polydispersity of less than about 2 to less than about 3.8 respectively and covalently bonded thereon, at least one cross-linkable functional group. The present invention further relates to low polydispersity poly-HEMA suitable for making the crosslinkable prepolymers, processes for functionalizing and purifying said poly-HEMA to form said crosslinkable prepolymers, viscous solutions made from said crosslinkable prepolymers, hydrogels made from said viscous solutions and articles made from said crosslinkable polymers, hydrogels and viscous solutions.

    Abstract translation: 本发明涉及包含聚合HEMA的组合物,其具有分子量约25,000至约100,000,优选25,000至80,000,多分散度分别小于约2至小于约3.8并且共价键合在其上,至少一个交叉 可链接的功能组。 本发明还涉及适用于制备可交联预聚物的低分散性聚HEMA,用于官能化和纯化所述聚HEMA以形成所述可交联预聚物的方法,由所述可交联预聚物制成的粘性溶液,由所述粘性溶液制成的水凝胶和制品 来自所述可交联聚合物,水凝胶和粘稠溶液。

    Printed label structure for packaging arrangements
    7.
    发明授权
    Printed label structure for packaging arrangements 失效
    印刷标签结构用于包装布置

    公开(公告)号:US5620087A

    公开(公告)日:1997-04-15

    申请号:US257795

    申请日:1994-06-10

    Abstract: A cover-forming laminated structure interconnecting a plurality of containers, such as the base members of blister packages each of which is adapted to contain a hydrophilic contact lens in a sterile aqueous solution. More specifically, disclosed is an array of such containers which are interconnected by a single laminated multi-layered material constituting a covering label for the containers, wherein the material may be severed intermediate each of the containers along weakening lines formed by micro-perforations provided therein so as to provide a separate packaging arrangement. The material is imprinted over the surface extent thereof covering the plurality of containers with a specific pattern of indicia and legends configured with the intent of thwarting diverters upon separation of any of the packaging arrangements from the array, through visual evidence afforded by an inspection of the printing pattern.

    Abstract translation: 互连多个容器的覆盖形成叠层结构,例如泡罩包装的基底构件,每个容器适于在无菌水溶液中容纳亲水性隐形眼镜。 更具体地,公开了这样的容器的阵列,其通过构成用于容器的覆盖标签的单层叠多层材料互连,其中,可以在每个容器之间沿着由其中提供的微穿孔形成的弱化线切断材料 以便提供单独的包装装置。 该材料在其覆盖多个容器的表面范围上印有特定图案的标记和图例,该图案和图例被构造成旨在通过任何包装装置与阵列分离而阻止转向器,通过视觉证据 印刷图案。

    Controlled release erodible composition
    8.
    发明授权
    Controlled release erodible composition 失效
    可控释放组分

    公开(公告)号:US5618560A

    公开(公告)日:1997-04-08

    申请号:US470828

    申请日:1995-06-06

    Abstract: Articles for the controlled delivery of an active substance into an aqueous phase by erosion of surfaces of the articles at a substantially constant and pH-independent rate, the articles comprising a matrix of crystalline polyethylene glycol polymer and a non-ionic emulsifier having an HLB value in the range of from about 4 to about 16 dispersed in the matrix in an amount of between about 2% and 50% by weight of the crystalline polyethylene glycol polymer and the emulsifier, the emulsifier having at least one domain which enables the emulsifier to become emulsified in the melted crystalline polyethylene glycol polymer and being selected from the group consisting of a fatty acid ester and a fatty alcohol ether, the active substance being dispersed in the matrix or located in geometrically well-defined zones within the crystalline PEG phase or dispersed in the emulsifier and, optionally, a filler. The non-ionic emulsifier or the active substance substantially eliminates water diffusion in the interface between the polymer crystals to thereby act as a repair medium and maintain substantially the geometric shape of the articles and, thus, maintain substantially constant the surface area exposed to solution.

    Abstract translation: 用于通过以基本上恒定和不依赖于pH的独立速率侵蚀制品表面将活性物质控制递送到水相中的制品,所述制品包含结晶聚乙二醇聚合物基质和具有HLB值的非离子乳化剂 在约4至约16的范围内,分散在基质中的量为结晶聚乙二醇聚合物和乳化剂的约2重量%至50重量%,乳化剂具有至少一个使乳化剂成为 在熔融的结晶聚乙二醇聚合物中乳化并且选自脂肪酸酯和脂肪醇醚,活性物质分散在基质中或位于结晶PEG相内的几何定义良好的区域中或分散在 乳化剂和任选的填料。 非离子乳化剂或活性物质基本上消除了在聚合物晶体之间的界面中的水扩散,由此用作修复介质并且基本上保持制品的几何形状,并因此保持暴露于溶液的表面积基本上恒定。

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