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公开(公告)号：US09918982B2
公开(公告)日：2018-03-20
申请号：US15342956
申请日：2016-11-03
Applicant: DURECT CORPORATION
Inventor： Su Il Yum , Grant Schoenhard , Arthur J. Tipton , John W. Gibson , John C. Middleton , Roger Fu , Michael S. Zamloot
IPC: A61K31/485 , A61K47/38 , A61K9/00 , A61K9/48 , A61K47/26 , A61K47/14 , A61K31/4458
CPC classification number: A61K31/485 , A61K9/0053 , A61K9/48 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61K31/4458 , A61K47/14 , A61K47/26 , A61K47/38 , Y10S514/96
Abstract: Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
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公开(公告)号：US20170319538A1
公开(公告)日：2017-11-09
申请号：US15660133
申请日：2017-07-26
Applicant: SANOFI
Inventor： Bernard ABRAMOVICI , Jean-Claude GAUTIER , Jean-Claude GROMENIL , Jean-Marie MARRIER
IPC: A61K31/343 , A61K47/10 , A61K9/20 , A61K9/00
CPC classification number: A61K31/343 , A61K9/0053 , A61K9/2013 , A61K9/2018 , A61K9/2031 , A61K47/10 , Y02A50/465 , Y10S514/96 , Y10S514/975
Abstract: The present invention relates to a solid pharmaceutical composition for oral administration characterized in that it comprises a benzofuran derivative with antiarrhythmic activity, or one of the pharmaceutically acceptable salts thereof, as an active principle, and a pharmaceutically acceptable nonionic hydrophilic surfactant optionally in combination with one or more pharmaceutical excipients.
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公开(公告)号：US20170165255A1
公开(公告)日：2017-06-15
申请号：US15342956
申请日：2016-11-03
Applicant: DURECT CORPORATION
Inventor： Su Il Yum , Grant Schoenhard , Arthur J. Tipton , John W. Gibson , John C. Middleton , Roger Fu , Michael S. Zamloot
IPC: A61K31/485 , A61K9/00 , A61K9/48
CPC classification number: A61K31/485 , A61K9/0053 , A61K9/48 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61K31/4458 , A61K47/14 , A61K47/26 , A61K47/38 , Y10S514/96
Abstract: Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
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公开(公告)号：US20160193345A1
公开(公告)日：2016-07-07
申请号：US14957148
申请日：2015-12-02
Applicant: Durect Corporation
Inventor： Su Il Yum , Grant Schoenhard , Arthur J. Tipton , John W. Gibson , John C. Middleton , Roger Fu , Michael S. Zamloot
IPC: A61K47/38 , A61K9/48 , A61K47/14 , A61K31/485 , A61K47/26
CPC classification number: A61K31/485 , A61K9/0053 , A61K9/48 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61K31/4458 , A61K47/14 , A61K47/26 , A61K47/38 , Y10S514/96
Abstract: Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
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公开(公告)号：US09333176B2
公开(公告)日：2016-05-10
申请号：US14628363
申请日：2015-02-23
Applicant: DELAVAU L.L.C.
Inventor： Kevin W. Lang , James W. Dibble , Raya Levin , Gregory B. Murphy
CPC classification number: A61K9/2095 , A23L33/16 , A61K9/1652 , A61K9/1664 , A61K9/20 , A61K9/2059 , A61K9/2068 , A61K33/10 , C01F11/18 , Y10S514/96 , Y10T428/2982
Abstract: Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
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Patent Agency Ranking
公开(公告)号：US09233160B2
公开(公告)日：2016-01-12
申请号：US14574024
申请日：2014-12-17
Applicant: Durect Corporation
Inventor： Su Il Yum , Grant Schoenhard , Arthur J. Tipton , John W. Gibson , John C. Middleton , Roger Fu , Michael S. Zamloot
IPC: A61K47/26 , A61K9/48 , A61K31/485 , A61K31/4458 , A61K47/14 , A61K47/38
CPC classification number: A61K31/485 , A61K9/0053 , A61K9/48 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61K31/4458 , A61K47/14 , A61K47/26 , A61K47/38 , Y10S514/96
Abstract: Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
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公开(公告)号：US20150196644A1
公开(公告)日：2015-07-16
申请号：US14574024
申请日：2014-12-17
Applicant: Durect Corporation
Inventor： Su Il Yum , Grant Schoenhard , Arthur J. Tipton , John W. Gibson , John C. Middleton , Roger Fu , Michael S. Zamloot
IPC: A61K47/26 , A61K47/38 , A61K47/14 , A61K31/485
CPC classification number: A61K31/485 , A61K9/0053 , A61K9/48 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61K31/4458 , A61K47/14 , A61K47/26 , A61K47/38 , Y10S514/96
Abstract: Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
Abstract translation: 适用于药物化合物和组合物施用的剂型和药物递送装置，包括化合物的口服药物施用。
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8.发明申请公开(公告)号：US20150141516A1
公开(公告)日：2015-05-21
申请号：US14508488
申请日：2014-10-07
Applicant: Remedy Pharmaceuticals, Inc.
Inventor： Sven Jacobson
CPC classification number: A61K9/1682 , A61K9/0019 , A61K9/1611 , A61K9/1623 , A61K9/19 , A61K31/175 , A61K31/451 , A61K31/64 , Y10S514/96
Abstract: The present invention provides compositions, methods for lyophilizing compounds and making pharmaceutical compositions, and kits providing solutions and lyophilized formulations of compounds. The compositions, methods, and kits are particularly useful in pharmaceutical applications involving therapeutic agents that have low solubility at low pH and medium pH values. Certain embodiments provide methods for lyophilizing compounds in liquid solutions, which include the steps of: a) preparing aqueous solutions of a compound of interest in the absence of buffer; b) adjusting the pH to high values of pH in order to increase the solubility of the compound of interest; and c) freeze-drying the solution to provide a lyophilized solid composition. Aqueous solutions including buffer are also disclosed. Lyophilized formulations, including micronized and non-micronized powders, are provided.
Abstract translation: 本发明提供组合物，冻干化合物和制备药物组合物的方法，以及提供化合物溶液和冻干制剂的试剂盒。 组合物，方法和试剂盒在涉及在低pH值和中等pH值下具有低溶解度的治疗剂的药物应用中特别有用。 某些实施方案提供了在液体溶液中冻干化合物的方法，其包括以下步骤：a）在不存在缓冲液的情况下制备目的化合物的水溶液; b）将pH调节至高的pH值，以增加目标化合物的溶解度; 和c）冷冻干燥该溶液以提供冻干固体组合物。 还公开了包括缓冲液的水溶液。 提供冻干制剂，包括微粉化和非微粉化粉末。
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公开(公告)号：US08975296B2
公开(公告)日：2015-03-10
申请号：US13847794
申请日：2013-03-20
Applicant: Merck, Sharp & Dohme, Corp.
Inventor： Haihong Fan , Majid Mahjour , Justin Moser , Bhagwant Rege
IPC: A61K31/275 , A61K31/50 , A61K31/501 , A61K31/44 , A61K47/38 , A61K9/10 , A61K9/20 , A61K31/424 , A61K47/32
CPC classification number: A61K47/38 , A61K9/10 , A61K9/2018 , A61K9/2054 , A61K31/275 , A61K31/424 , A61K31/44 , A61K47/32 , Y10S514/96 , Y10S514/961
Abstract: The instant invention relates to pharmaceutical compositions containing cathespin K inhibitors. Also disclosed are processes for making said pharmaceutical compositions.
Abstract translation: 本发明涉及含有cathespin K抑制剂的药物组合物。 还公开了制备所述药物组合物的方法。
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公开(公告)号：US08951556B2
公开(公告)日：2015-02-10
申请号：US13786110
申请日：2013-03-05
Applicant: Durect Corporation
Inventor： Su Il Yum , Grant Schoenhard , Arthur J. Tipton , John W. Gibson , John C. Middleton , Roger Fu , Michael S. Zamloot
IPC: A61K9/64 , A61K31/44 , A61K47/00 , A61K31/4458 , A61K9/48 , A61K31/485 , A61K47/26
CPC classification number: A61K31/485 , A61K9/0053 , A61K9/48 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61K31/4458 , A61K47/14 , A61K47/26 , A61K47/38 , Y10S514/96
Abstract: Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
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