公开(公告)号：US20180289696A1

公开(公告)日：2018-10-11

申请号：US15887797

申请日：2018-02-02

Applicant: Durect Corporation

Inventor： Su Il Yum ,  Grant Schoenhard ,  Arthur J. Tipton ,  John W. Gibson ,  John C. Middleton ,  Roger Fu ,  Michael S. Zamloot

IPC: A61K31/485 ,  A61K47/14 ,  A61K31/4458 ,  A61K47/26 ,  A61K9/48 ,  A61K9/00 ,  A61K47/38

Abstract: Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.

公开(公告)号：US20170209581A1

公开(公告)日：2017-07-27

申请号：US15398426

申请日：2017-01-04

Applicant: Durect Corporation

Inventor： Su Il Yum ,  Wendy Chao ,  Huey-Ching Su ,  Roger Fu ,  Michael S. Zamloot ,  Karl Bratin ,  Ravi M. Shanker

IPC: A61K47/02 ,  A61K9/48 ,  A61K47/14 ,  A61K47/38 ,  A61K31/485 ,  A61K47/26

CPC classification number: A61K47/02 ,  A61K9/4816 ,  A61K9/485 ,  A61K31/485 ,  A61K47/14 ,  A61K47/26 ,  A61K47/38

Abstract: The present disclosure provides compositions (e.g., extended release compositions) which exhibit a desirable pharmacokinetic profile of an active agent while providing reduced dissolution sample variability, e.g., in the form of reduced inter-capsule variability and/or a reduction in storage-time dependent change in mean release of the active agent from the composition. Related methods of making and administering the disclosed compositions are also provided.

公开(公告)号：US20170196978A1

公开(公告)日：2017-07-13

申请号：US15380828

申请日：2016-12-15

Applicant: Durect Corporation

Inventor： Su Il Yum ,  Wendy Chao ,  Huey-Ching Su ,  Roger Fu ,  Michael S. Zamloot ,  Karl Bratin ,  Ravi M. Shanker

IPC: A61K47/02 ,  A61K47/38 ,  A61K47/26 ,  A61K31/485 ,  A61K47/14

CPC classification number: A61K47/02 ,  A61K9/4816 ,  A61K9/485 ,  A61K31/485 ,  A61K47/14 ,  A61K47/26 ,  A61K47/38

Abstract: The present disclosure provides compositions (e.g., extended release compositions) which exhibit a desirable pharmacokinetic profile of an active agent while providing reduced dissolution sample variability, e.g., in the form of reduced inter-capsule variability and/or a reduction in storage-time dependent change in mean release of the active agent from the composition. Related methods of making and administering the disclosed compositions and formulations are also provided.

公开(公告)号：US10300142B2

公开(公告)日：2019-05-28

申请号：US15826226

申请日：2017-11-29

Applicant: Durect Corporation

Inventor： Su Il Yum ,  Wendy Chao ,  Huey-Ching Su ,  Roger Fu ,  Michael S. Zamloot ,  Karl Bratin ,  Ravi M. Shanker

IPC: A61K9/48 ,  A61K47/02 ,  A61K47/14 ,  A61K47/26 ,  A61K47/38 ,  A61K31/485

Abstract: The present disclosure provides compositions (e.g., extended release compositions) which exhibit a desirable pharmacokinetic profile of an active agent while providing reduced dissolution sample variability, e.g., in the form of reduced inter-capsule variability and/or a reduction in storage-time dependent change in mean release of the active agent from the composition. Related methods of making and administering the disclosed compositions are also provided.

公开(公告)号：US09555113B2

公开(公告)日：2017-01-31

申请号：US14214057

申请日：2014-03-14

Applicant: Durect Corporation

Inventor： Su Il Yum ,  Wendy Chao ,  Huey-Ching Su ,  Roger Fu ,  Michael S. Zamloot ,  Karl Bratin ,  Ravi M. Shanker

IPC: A61K31/485 ,  A61K31/4458 ,  A61K31/137 ,  A61K47/02 ,  A61K9/48 ,  A61K47/14 ,  A61K47/26 ,  A61K47/38

CPC classification number: A61K47/02 ,  A61K9/4816 ,  A61K9/485 ,  A61K31/485 ,  A61K47/14 ,  A61K47/26 ,  A61K47/38

Abstract: The present disclosure provides compositions (e.g., extended release compositions) which exhibit a desirable pharmacokinetic profile of an active agent while providing reduced dissolution sample variability, e.g., in the form of reduced inter-capsule variability and/or a reduction in storage-time dependent change in mean release of the active agent from the composition. Related methods of making and administering the disclosed compositions and formulations are also provided.

Abstract translation: 本公开提供了组合物（例如延长释放组合物），其表现出活性剂所需的药代动力学特征，同时提供降低的溶解样品变异性，例如以减少的胶囊间变异性和/或减少存储时间依赖性 活性剂从组合物中平均释放的变化。 还提供了制备和施用所公开的组合物和制剂的相关方法。

公开(公告)号：US20160038479A1

公开(公告)日：2016-02-11

申请号：US14776608

申请日：2014-03-14

Applicant: DURECT CORPORATION

Inventor： Michael S. Zamloot ,  Roger Fu ,  Su Il Yum ,  Wendy Chao ,  Huey-Ching Su

IPC: A61K31/485 ,  A61K9/48

CPC classification number: A61K31/485 ,  A61K9/48 ,  A61K9/4816 ,  A61K9/485 ,  A61K9/4858 ,  A61K9/4866

Abstract: The present disclosure provides extended release compositions including, formulations that comprise such compositions, which exhibit desirable dissolution of an active agent while maintaining its physical stability in a dosage form including, for example, providing reduced sample variability, e.g., in the form of reduced inter-capsule variability and/or a reduction in storage-time dependent change in mean release of the active agent from the composition. Related methods of making and administering the disclosed compositions and formulations are also provided.

Abstract translation: 本公开内容提供了延长释放组合物，包括包含这种组合物的制剂，其表现出活性剂的理想溶解，同时保持其剂型的物理稳定性，包括例如提供降低的样品变异性，例如以减少的间隔 - 胶囊变异性和/或活性剂从组合物的平均释放的储存时间依赖性变化的降低。 还提供了制备和施用所公开的组合物和制剂的相关方法。

公开(公告)号：US09572885B2

公开(公告)日：2017-02-21

申请号：US14776585

申请日：2014-03-14

Applicant: Durect Corporation

Inventor： Su Il Yum ,  Wendy Chao ,  Huey-Ching Su ,  Roger Fu ,  Michael S. Zamloot ,  Karl Bratin ,  Ravi M. Shanker

IPC: A61K9/48 ,  A61K47/02 ,  A61K31/485 ,  A61K47/14 ,  A61K47/26 ,  A61K47/38

CPC classification number: A61K47/02 ,  A61K9/4816 ,  A61K9/485 ,  A61K31/485 ,  A61K47/14 ,  A61K47/26 ,  A61K47/38

Abstract: The present disclosure provides compositions (e.g., extended release compositions) which exhibit a desirable pharmacokinetic profile of an active agent while providing reduced dissolution sample variability, e.g., in the form of reduced inter-capsule variability and/or a reduction in storage-time dependent change in mean release of the active agent from the composition. Related methods of making and administering the disclosed compositions are also provided.

Abstract translation: 本公开提供了组合物（例如延长释放组合物），其表现出活性剂所需的药代动力学特征，同时提供降低的溶解样品变异性，例如以减少的胶囊间变异性和/或减少存储时间依赖性 活性剂从组合物中平均释放的变化。 还提供了制备和施用所公开的组合物的相关方法。

公开(公告)号：US20160038592A1

公开(公告)日：2016-02-11

申请号：US14776585

申请日：2014-03-14

Applicant: DURECT CORPORATION

Inventor： Su Il Yum ,  Wendy Chao ,  Huey-Ching Su ,  Roger Fu ,  Michael S. Zamloot ,  Karl Bratin ,  Ravi M. Shanker

IPC: A61K47/02 ,  A61K9/48 ,  A61K47/14 ,  A61K47/38 ,  A61K31/485 ,  A61K47/26

CPC classification number: A61K47/02 ,  A61K9/4816 ,  A61K9/485 ,  A61K31/485 ,  A61K47/14 ,  A61K47/26 ,  A61K47/38

Abstract: The present disclosure provides compositions (e.g., extended release compositions) which exhibit a desirable pharmacokinetic profile of an active agent while providing reduced dissolution sample variability, e.g., in the form of reduced inter-capsule variability and/or a reduction in storage-time dependent change in mean release of the active agent from the composition. Related methods of making and administering the disclosed compositions are also provided.

Abstract translation: 本公开提供了组合物（例如延长释放组合物），其表现出活性剂所需的药代动力学特征，同时提供降低的溶解样品变异性，例如以减少的胶囊间变异性和/或减少存储时间依赖性 活性剂从组合物中平均释放的变化。 还提供了制备和施用所公开的组合物的相关方法。

公开(公告)号：US08974821B2

公开(公告)日：2015-03-10

申请号：US13786109

申请日：2013-03-05

Applicant: Durect Corporation

Inventor： Su Il Yum ,  Grant Schoenhard ,  Arthur J. Tipton ,  John W. Gibson ,  John C. Middleton ,  Roger Fu ,  Michael S. Zamloot

IPC: A61K9/64 ,  A61K31/44 ,  A61K47/00 ,  A61K9/48 ,  A61K31/485 ,  A61K47/26 ,  A61K31/4458

CPC classification number: A61K31/485 ,  A61K9/0053 ,  A61K9/48 ,  A61K9/4825 ,  A61K9/4858 ,  A61K9/4866 ,  A61K31/4458 ,  A61K47/14 ,  A61K47/26 ,  A61K47/38 ,  Y10S514/96

Abstract: Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.

公开(公告)号：US20180236078A1

公开(公告)日：2018-08-23

申请号：US15872855

申请日：2018-01-16

Applicant: Durect Corporation

Inventor： Su Il Yum ,  Wendy Chao ,  Huey-Ching Su ,  Roger Fu ,  Michael S. Zamloot ,  Karl Bratin ,  Ravi M. Shanker

IPC: A61K47/02 ,  A61K47/14 ,  A61K47/26 ,  A61K47/38 ,  A61K31/485

CPC classification number: A61K47/02 ,  A61K9/4816 ,  A61K9/485 ,  A61K31/485 ,  A61K47/14 ,  A61K47/26 ,  A61K47/38

Abstract: The present disclosure provides compositions (e.g., extended release compositions) which exhibit a desirable pharmacokinetic profile of an active agent while providing reduced dissolution sample variability, e.g., in the form of reduced inter-capsule variability and/or a reduction in storage-time dependent change in mean release of the active agent from the composition. Related methods of making and administering the disclosed compositions and formulations are also provided.