公开(公告)号：US20220257619A1

公开(公告)日：2022-08-18

申请号：US17627000

申请日：2020-07-17

Applicant: Gilead Sciences, Inc. ,  Durect Corporation

Inventor： Susan Autio ,  Keith Edward Branham ,  James A. Filice ,  John W. Gibson ,  John J. Leonard ,  James Matriano ,  Whitney Moro ,  Michael Sekar ,  Chelsea Alexandra Snyder ,  Robert G. Strickley ,  Raju Subramanian ,  Felix Theeuwes ,  Monica Tijerina ,  Jeremy C. Wright ,  Su Il Yum ,  Faye Xu

IPC: A61K31/675 ,  A61K47/26 ,  A61K47/34 ,  A61K47/22 ,  A61P31/18

Abstract: The present disclosure provides long-acting formulations of tenofovir alafenamide, methods of making the same and methods of using the same.

公开(公告)号：US20210330582A1

公开(公告)日：2021-10-28

申请号：US17227236

申请日：2021-04-09

Applicant: Durect Corporation

Inventor： Xiaoping Song ,  Clarisa Peer ,  Su Il Yum

IPC: A61K9/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/20 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38

Abstract: A composition includes a salt; a polymer; and an antioxidant. A dispenser includes a flexible container having a closed end and an opposed open end; an osmotically-effective solute composition encapsulating at least a portion of the container, the solute composition including antioxidant in an amount of at least 0.5 wt %, based on weight of the solute composition; a semipermeable membrane encapsulating the osmotically-effective solute composition; a cap having a sealing surface adapted for sealing engagement with the open end of the container; and a port extending from an interior of the container and through the cap. Also disclosed are methods of making and using the composition and osmotic pumps.

公开(公告)号：US20190231702A1

公开(公告)日：2019-08-01

申请号：US16226345

申请日：2018-12-19

Applicant: Durect Corporation

Inventor： Su Il Yum ,  Wendy Chao ,  Huey-Ching Su ,  Roger Fu ,  Michael Zamloot

IPC: A61K9/48 ,  A61K31/4458 ,  A61K31/4402 ,  A61K31/137 ,  A61K31/485

CPC classification number: A61K9/4866 ,  A61K9/48 ,  A61K9/4858 ,  A61K31/137 ,  A61K31/4402 ,  A61K31/4458 ,  A61K31/485

Abstract: Abuse-resistant oral dosage forms suitable for administration of pharmacologically active agents are provided.

公开(公告)号：US20180289696A1

公开(公告)日：2018-10-11

申请号：US15887797

申请日：2018-02-02

Applicant: Durect Corporation

Inventor： Su Il Yum ,  Grant Schoenhard ,  Arthur J. Tipton ,  John W. Gibson ,  John C. Middleton ,  Roger Fu ,  Michael S. Zamloot

IPC: A61K31/485 ,  A61K47/14 ,  A61K31/4458 ,  A61K47/26 ,  A61K9/48 ,  A61K9/00 ,  A61K47/38

Abstract: Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.

公开(公告)号：US20170209581A1

公开(公告)日：2017-07-27

申请号：US15398426

申请日：2017-01-04

Applicant: Durect Corporation

Inventor： Su Il Yum ,  Wendy Chao ,  Huey-Ching Su ,  Roger Fu ,  Michael S. Zamloot ,  Karl Bratin ,  Ravi M. Shanker

IPC: A61K47/02 ,  A61K9/48 ,  A61K47/14 ,  A61K47/38 ,  A61K31/485 ,  A61K47/26

CPC classification number: A61K47/02 ,  A61K9/4816 ,  A61K9/485 ,  A61K31/485 ,  A61K47/14 ,  A61K47/26 ,  A61K47/38

Abstract: The present disclosure provides compositions (e.g., extended release compositions) which exhibit a desirable pharmacokinetic profile of an active agent while providing reduced dissolution sample variability, e.g., in the form of reduced inter-capsule variability and/or a reduction in storage-time dependent change in mean release of the active agent from the composition. Related methods of making and administering the disclosed compositions are also provided.

公开(公告)号：US20170196978A1

公开(公告)日：2017-07-13

申请号：US15380828

申请日：2016-12-15

Applicant: Durect Corporation

Inventor： Su Il Yum ,  Wendy Chao ,  Huey-Ching Su ,  Roger Fu ,  Michael S. Zamloot ,  Karl Bratin ,  Ravi M. Shanker

IPC: A61K47/02 ,  A61K47/38 ,  A61K47/26 ,  A61K31/485 ,  A61K47/14

CPC classification number: A61K47/02 ,  A61K9/4816 ,  A61K9/485 ,  A61K31/485 ,  A61K47/14 ,  A61K47/26 ,  A61K47/38

Abstract: The present disclosure provides compositions (e.g., extended release compositions) which exhibit a desirable pharmacokinetic profile of an active agent while providing reduced dissolution sample variability, e.g., in the form of reduced inter-capsule variability and/or a reduction in storage-time dependent change in mean release of the active agent from the composition. Related methods of making and administering the disclosed compositions and formulations are also provided.

公开(公告)号：US20170189547A1

公开(公告)日：2017-07-06

申请号：US15356488

申请日：2016-11-18

Applicant: Durect Corporation

Inventor： William W. van Osdol ,  Su Il Yum ,  Felix Theeuwes ,  Michael Sekar ,  John W. Gibson ,  Keith E. Branham ,  Huey-Ching Su

IPC: A61K48/00 ,  A61K47/14 ,  A61K47/10 ,  A61K9/00 ,  A61K38/27 ,  A61K38/21 ,  A61K31/7052 ,  A61K38/26 ,  A61K47/26 ,  A61K47/34 ,  A61K47/48

CPC classification number: A61K38/212 ,  A61K9/0019 ,  A61K31/7052 ,  A61K38/26 ,  A61K38/27 ,  A61K47/14 ,  A61K47/26 ,  A61K47/34 ,  A61K47/52 ,  A61K47/541 ,  A61K47/64

Abstract: The present disclosure provides a biodegradable drug delivery composition including a vehicle and an insoluble component comprising beneficial agent dispersed in the vehicle. Typically, the composition is not an emulsion, but has a low viscosity and further provides for minimized initial burst and sustained release of the beneficial agent over time. Also provided, are kits including the biodegradable drug delivery composition or components thereof, as well as methods of making and using the biodegradable drug delivery composition.

公开(公告)号：US20130337060A1

公开(公告)日：2013-12-19

申请号：US13786218

申请日：2013-03-05

Applicant: Durect Corporation

Inventor： Su Il Yum ,  Wendy Chao ,  Huey-Ching Su ,  Roger Fu ,  Michael Zamloot

IPC: A61K31/485 ,  A61K31/137 ,  A61K9/48

CPC classification number: A61K9/4866 ,  A61K9/48 ,  A61K9/4858 ,  A61K31/137 ,  A61K31/4402 ,  A61K31/4458 ,  A61K31/485

Abstract: Abuse-resistant oral dosage forms suitable for administration of pharmacologically active agents are provided.

Abstract translation: 提供了适合施用药理活性剂的耐药性口服剂型。

公开(公告)号：US20190070206A1

公开(公告)日：2019-03-07

申请号：US16053736

申请日：2018-08-02

Applicant: Durect Corporation

Inventor： Michael Sekar ,  Su Il Yum ,  Felix Theeuwes ,  William Van Osdol

IPC: A61K31/7052 ,  A61K41/00 ,  A61K47/52 ,  A61K9/16 ,  A61L2/00 ,  A61K9/00 ,  A61K9/19 ,  C07K14/575 ,  A61K38/22 ,  A61K38/17 ,  C07K14/61 ,  A61K31/198 ,  A61K45/06 ,  A61K38/27 ,  A61K38/26 ,  A61K47/64

Abstract: The present disclosure is directed to a method of making a composition by combining a vehicle, e.g., a single phase vehicle, and an insoluble component comprising a beneficial agent, and sterilizing the composition using ionizing radiation prior to use, wherein the beneficial agent is stable following exposure to a sterilizing dose of ionizing radiation. Related compositions and methods are provided.

公开(公告)号：US20180339049A1

公开(公告)日：2018-11-29

申请号：US15826226

申请日：2017-11-29

Applicant: Durect Corporation

Inventor： Su Il Yum ,  Wendy Chao ,  Huey-Ching Su ,  Roger Fu ,  Michael S. Zamloot ,  Karl Bratin ,  Ravi M. Shanker

IPC: A61K47/02 ,  A61K47/38 ,  A61K47/26 ,  A61K47/14 ,  A61K31/485 ,  A61K9/48

CPC classification number: A61K47/02 ,  A61K9/4816 ,  A61K9/485 ,  A61K31/485 ,  A61K47/14 ,  A61K47/26 ,  A61K47/38

Abstract: The present disclosure provides compositions (e.g., extended release compositions) which exhibit a desirable pharmacokinetic profile of an active agent while providing reduced dissolution sample variability, e.g., in the form of reduced inter-capsule variability and/or a reduction in storage-time dependent change in mean release of the active agent from the composition. Related methods of making and administering the disclosed compositions are also provided.