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    ANTHRAX AND SMALL POX REPLIKINS AND METHODS OF USE
    3.
    发明申请
    ANTHRAX AND SMALL POX REPLIKINS AND METHODS OF USE 审中-公开
    ANTHRAX和小POX REPLIKINS和使用方法

    公开(公告)号：US20140105904A1

    公开(公告)日：2014-04-17

    申请号：US14026567

    申请日：2013-09-13

    申请人： Samuel Bogoch ,  Elenore S. Bogoch

    发明人： Samuel Bogoch ,  Elenore S. Bogoch

    IPC分类号： C07K16/08

    CPC分类号： C07K16/081 ,  A61K39/00 ,  C07K14/005 ,  C12N2710/24122

    摘要： Isolated peptides of the Bacillus anthracis Anthrax Toxin Lethal factor Protein pX01-107, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Bacillus anthracis Anthrax Toxin Lethal factor Protein pX01-107 are disclosed. Also disclosed are isolated peptides of the Small Pox Virus Surface Antigen S Precursor Protein, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Small Pox Virus Surface Antigen S Precursor Protein.

    摘要翻译： 炭疽芽孢杆菌炭疽毒素致死致死因子蛋白质pX01-107的分离肽，肽特异性抗体和刺激受试者的免疫应答的方法以产生针对炭疽芽孢杆菌炭疽杆菌毒素致死因子蛋白质pX01-107的抗体。 还公开了小型痘病毒表面抗原S前体蛋白质的分离肽，对肽有特异性的抗体以及刺激受试者的免疫应答以产生针对小痘病毒表面抗原S前体蛋白的抗体的方法。

    Detection of malignant tumor cells
    8.
    发明授权
    Detection of malignant tumor cells 失效
    检测恶性肿瘤细胞

    公开(公告)号：US5866690A

    公开(公告)日：1999-02-02

    申请号：US487345

    申请日：1995-06-07

    申请人： Samuel Bogoch

    发明人： Samuel Bogoch

    IPC分类号： G01N33/574 ,  A61K38/00 ,  A61K39/395 ,  A61P35/00 ,  C07K1/22 ,  C07K14/005 ,  C07K14/195 ,  C07K16/00 ,  C07K16/30 ,  C12N5/08 ,  C12N5/10 ,  C12N15/09 ,  C12P21/00 ,  C12R1/91 ,  G01N33/577

    CPC分类号： C07K16/30 ,  A61K38/00

    摘要： Described herein is the production of two products which are distinct species of human anti-malignin antibody, and the production of a cell line which has the distinguishing characteristic of manufacturing both species of anti-malignin antibody at different times. These anti-malignin products are useful to detect the presence of cancerous or malignant tumor cells. Additionally, these anti-malignin products preferentially attach to cancerous or malignant tumor cells in cell collections in vitro or in vivo and thus can be detected by any visible or other signal emitter attached to said anti-malignin product. This preferential attachment to malignant tumor cells also makes these products useful for metabolic and therapeutic purposes with or without an attached cytotoxic agent.

    摘要翻译： 本文描述了两种不同种类的人类抗恶性肿瘤抗体的产品的生产，以及具有在不同时间制造两种抗恶性肿瘤抗体的区别特征的细胞系的生产。 这些抗恶性肿瘤产品可用于检测癌细胞或恶性肿瘤细胞的存在。 此外，这些抗恶性肿瘤产品在体外或体内优先附着于细胞集合中的癌细胞或恶性肿瘤细胞，因此可通过附着于所述抗恶性肿瘤产品的任何可见或其他信号发射体来检测。 恶性肿瘤细胞的这种优先依附也使得这些产品在有或没有附着的细胞毒性剂的情况下可用于代谢和治疗目的。

    Recognins and their chemoreciprocals
    9.
    发明授权
    Recognins and their chemoreciprocals 失效
    识别及其化学相互作用

    公开(公告)号：US4624931A

    公开(公告)日：1986-11-25

    申请号：US519598

    申请日：1983-10-03

    申请人： Samuel Bogoch

    发明人： Samuel Bogoch

    IPC分类号： C07K14/47 ,  C07K16/18 ,  G01N33/574 ,  G01N33/544 ,  A61K39/00 ,  G01N33/53

    CPC分类号： C07K14/4731 ,  C07K16/18 ,  G01N33/57488 ,  G01N2333/473 ,  Y10S435/961

    摘要： The process for producing polypeptide products which are useful in tests for malignant cells is disclosed. The polypeptide products produced by this process are also disclosed. The process employs the steps of extraction of acidic fractionation and formation of a precipitate in the quantitative precipitin test and the Ouchterlony gel diffusion test. The product is characterized by being soluble in acidic solution, insoluble in basic solution, having a particular spectrophotometric absorption and an amino acid residue composition of high proportions of glutamic and aspartic acids and high ratios of glutamic and aspartic acids to histidine.

    摘要翻译： 公开了可用于恶性细胞试验的产生多肽产物的方法。 还公开了通过该方法生产的多肽产物。 该方法采用在定量沉淀试验和Ouchterlony凝胶扩散试验中提取酸性分馏和形成沉淀物的步骤。 该产品的特征在于可溶于酸性溶液，不溶于碱性溶液，具有特定的分光光度吸收和高比例的谷氨酸和天冬氨酸和高比例的谷氨酸和天冬氨酸与组氨酸的氨基酸残基组合物。