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1.发明授权Replikin-based compounds for prevention and treatment of influenza and methods of differentiating infectivity and lethality in influenza 有权用于预防和治疗流感的基于复制素的化合物和分化流感中的感染性和致死性的方法公开(公告)号：US09233148B2
公开(公告)日：2016-01-12
申请号：US12581112
申请日：2009-10-16
IPC分类号： A61K39/145 , C07K14/00 , C07H21/00 , A61K39/00 , C07K14/005 , C07K14/44 , C07K14/72
CPC分类号： C07K16/1018 , A61K39/00 , A61K39/0011 , A61K2039/542 , A61K2039/552 , C07K7/06 , C07K7/08 , C07K14/005 , C07K14/11 , C07K14/44 , C07K14/72 , C12N2760/16122 , C12N2760/16134 , C12N2760/16222 , C12N2770/24122 , C12N2770/32022
摘要： The present invention provides methods of differentiating the infectivity and lethality of isolates of influenza virus and provides compounds for diagnosing, preventing, and treating outbreaks of influenza virus including compounds for diagnosing, preventing, and treating across different strains of influenza virus.
摘要翻译： 本发明提供了区分流感病毒分离物的感染性和致死性的方法，并提供用于诊断，预防和治疗流感病毒爆发的化合物，包括用于诊断，预防和治疗不同流感病毒株的化合物。
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公开(公告)号：US20140105904A1
公开(公告)日：2014-04-17
申请号：US14026567
申请日：2013-09-13
申请人： Samuel Bogoch , Elenore S. Bogoch
发明人： Samuel Bogoch , Elenore S. Bogoch
IPC分类号： C07K16/08
CPC分类号： C07K16/081 , A61K39/00 , C07K14/005 , C12N2710/24122
摘要： Isolated peptides of the Bacillus anthracis Anthrax Toxin Lethal factor Protein pX01-107, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Bacillus anthracis Anthrax Toxin Lethal factor Protein pX01-107 are disclosed. Also disclosed are isolated peptides of the Small Pox Virus Surface Antigen S Precursor Protein, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Small Pox Virus Surface Antigen S Precursor Protein.
摘要翻译： 炭疽芽孢杆菌炭疽毒素致死致死因子蛋白质pX01-107的分离肽，肽特异性抗体和刺激受试者的免疫应答的方法以产生针对炭疽芽孢杆菌炭疽杆菌毒素致死因子蛋白质pX01-107的抗体。 还公开了小型痘病毒表面抗原S前体蛋白质的分离肽，对肽有特异性的抗体以及刺激受试者的免疫应答以产生针对小痘病毒表面抗原S前体蛋白的抗体的方法。
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3.发明申请PEPTIDES SHARED AMONG LETHAL CANCERS AND THERAPEUTIC COMPOSITIONS COMPRISING SAID PEPTIDES 审中-公开肝癌组合物和包含上皮细胞的治疗组合物公开(公告)号：US20130084303A1
公开(公告)日：2013-04-04
申请号：US13553137
申请日：2012-07-19
CPC分类号： A61K39/0011 , C07K7/06 , C07K7/08 , C07K14/4748 , C07K16/30
摘要： The present invention provides cancer peptides related to rapid replication and shared among different histological cancer types. The peptides are provided in compositions for interfering with replication in cancer, in preventive and therapeutic vaccines, and in diagnostic applications. The compositions for interfering with replication in cancer are useful for preventing and treating different histological types of cancer including ectodermic, endodermic, and mesodermic cancers as well as cancers arising in association with HIV.
摘要翻译： 本发明提供了与快速复制相关的癌症肽，并且在不同的组织学癌症类型之间共享。 在用于干扰癌症，预防和治疗疫苗以及诊断应用中的复制的组合物中提供了肽。 用于干扰癌症复制的组合物可用于预防和治疗不同组织学类型的癌症，包括外胚层，内胚层和中胚层癌以及与HIV相关的癌症。
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4.发明授权Replikin peptides in rapid replication of glioma cells and in influenza epidemics 失效复制素肽在胶质瘤细胞和流行性感冒流行中的快速复制公开(公告)号：US07758863B2
公开(公告)日：2010-07-20
申请号：US12412888
申请日：2009-03-27
申请人： Samuel Bogoch , Elenore S. Bogoch
发明人： Samuel Bogoch , Elenore S. Bogoch
IPC分类号： A61K39/145 , C07K4/00 , C07K14/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/195 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C07K14/27 , C07K14/28 , C07K14/285 , C07K14/30 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/345 , C07K14/35 , C07K14/355 , C07K14/36 , C07K14/37 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/40 , C07K14/405 , C07K14/415 , C07K14/44 , C07K14/445 , C07K14/47 , C12N2710/24122 , C12N2760/16022 , C12N2760/16122 , Y02A50/412
摘要： Peptides of influenza virus hemagglutinin protein and Plasmodium falciparum malaria antigen, antibodies specific for the peptides, influenza vaccines, malaria vaccines and methods of stimulating the immune response of a subject to produce antibodies to influenza virus or malaria are disclosed. Also disclosed are methods for formulating vaccines for influenza virus.
摘要翻译： 公开了流感病毒血凝素蛋白和恶性疟原虫疟疾抗原肽，肽特异性抗体，流感疫苗，疟疾疫苗和刺激受试者的免疫应答以产生抗流感病毒或疟疾的方法。 还公开了用于制定用于流感病毒的疫苗的方法。
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公开(公告)号：US20090137778A1
公开(公告)日：2009-05-28
申请号：US12252028
申请日：2008-10-15
申请人： Samuel BOGOCH , Elenore S. BOGOCH
发明人： Samuel BOGOCH , Elenore S. BOGOCH
IPC分类号： C07K14/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/195 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C07K14/27 , C07K14/28 , C07K14/285 , C07K14/30 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/345 , C07K14/35 , C07K14/355 , C07K14/36 , C07K14/37 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/40 , C07K14/405 , C07K14/415 , C07K14/44 , C07K14/445 , C07K14/47 , C12N2710/24122 , C12N2760/16022 , C12N2760/16122 , Y02A50/412
摘要： The present invention provides a new class of peptides related to rapid replication and their use in diagnosing, preventing and treating disease.
摘要翻译： 本发明提供了与快速复制相关的新一类肽及其在诊断，预防和治疗疾病中的用途。
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公开(公告)号：US20180265550A1
公开(公告)日：2018-09-20
申请号：US15464289
申请日：2017-03-20
IPC分类号： C07K14/005 , C07K7/06 , C07K7/08 , C12N7/00 , C07K16/10 , C12N15/113 , A61K39/12 , G01N33/68
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/543 , A61K2039/70 , A61P31/14 , C07K7/06 , C07K7/08 , C12N2770/24122 , C12N2770/24134 , G01N33/56983 , G01N2333/185 , Y02A50/53
摘要： The present invention provides therapies, vaccines, and predictive methods for Flaviviruses, including Zika virus, Dengue virus, and Japanese encephalitis virus, and provides compounds for diagnosing, preventing, and treating outbreaks of Zika virus, Dengue virus, and Japanese encephalitis virus.
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7.发明授权Synthetic replikin peptides against pathogenic infection of invertebrates in aquaculture 有权针对水产养殖中无脊椎动物感染的合成复制素肽公开(公告)号：US09408902B2
公开(公告)日：2016-08-09
申请号：US12108458
申请日：2008-04-23
IPC分类号： A61K39/12 , A61K39/125 , C07K14/72 , C07K14/005 , A61K39/00
CPC分类号： A61K39/125 , A61K38/08 , A61K38/10 , A61K38/162 , A61K39/00 , A61K39/12 , A61K2039/542 , A61K2039/552 , C07K7/06 , C07K7/08 , C07K14/005 , C07K14/72 , C12N2710/18022 , C12N2760/16022 , C12N2770/22022 , C12N2770/24122 , C12N2770/32022 , C12N2770/32034
摘要： The present invention provides isolated or synthesized peptides of about 7 to about 50 amino acids identified in the genome of pathogens in invertebrates in aquaculture for prevention and treatment of outbreaks of these pathogens in aquaculture and methods of preventing and treating pathogenic outbreaks using the identified peptides.
摘要翻译： 本发明提供在水产养殖中无脊椎动物病原体基因组中鉴定的约7至约50个氨基酸的分离或合成的肽，用于预防和治疗水产养殖中这些病原体的爆发以及使用鉴定的肽预防和治疗致病性爆发的方法。
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公开(公告)号：US20130195916A1
公开(公告)日：2013-08-01
申请号：US13787450
申请日：2013-03-06
CPC分类号： G16B15/00 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/005 , C07K14/195 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C07K14/27 , C07K14/28 , C07K14/285 , C07K14/30 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/345 , C07K14/35 , C07K14/355 , C07K14/36 , C07K14/37 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/40 , C07K14/405 , C07K14/415 , C07K14/44 , C07K14/445 , C07K14/47 , C12N2710/24122 , C12N2760/16022 , C12N2760/16122 , G16B30/00 , G16B35/00 , G16C20/60
摘要： A method and system are disclosed for identifying and/or locating complex patterns in an amino acid sequence stored in a computer file or database. According to an aspect of the present invention, techniques are provided to facilitate queries of protein databases. For protein descriptions received in response to the queries, embodiments of the present invention may scan the received protein descriptions to identify and locate Replikin patterns. A Replikin pattern is defined to be a sequence of 7 to about 50 amino acids that include the following three (3) characteristics, each of which may be recognized by an embodiment of the present invention: (1) the sequence has at least one lysine residue located six to ten amino acid residues from a second lysine residue; (2) the sequence has at least one histidine residue; and (3) at least 6% of the amino acids in the sequence are lysine residues.
摘要翻译： 公开了用于识别和/或定位存储在计算机文件或数据库中的氨基酸序列中的复杂模式的方法和系统。 根据本发明的一个方面，提供了用于促进蛋白质数据库查询的技术。 对于响应于查询而接收到的蛋白质描述，本发明的实施例可以扫描接收到的蛋白质描述以识别和定位Replikin模式。 复制素模式被定义为7至约50个氨基酸的序列，其包括以下三（3）个特征，每个特征可以被本发明的实施方案识别：（1）序列具有至少一个赖氨酸 残基位于第二赖氨酸残基6至10个氨基酸残基; （2）该序列具有至少一个组氨酸残基; 和（3）序列中至少6％的氨基酸是赖氨酸残基。
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公开(公告)号：US20110171236A1
公开(公告)日：2011-07-14
申请号：US12688372
申请日：2010-01-15
申请人： Samuel BOGOCH , Elenore S. BOGOCH
发明人： Samuel BOGOCH , Elenore S. BOGOCH
CPC分类号： C07K16/081 , A61K39/00 , C07K14/005 , C12N2710/24122
摘要： Isolated peptides of the Bacillus anthracis Anthrax Toxin Lethal factor Protein pX01-107, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Bacillus anthracis Anthrax Toxin Lethal factor Protein pX01-107 are disclosed. Also disclosed are isolated peptides of the Small Pox Virus Surface Antigen S Precursor Protein, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Small Pox Virus Surface Antigen S Precursor Protein.
摘要翻译： 炭疽芽孢杆菌炭疽毒素致死致死因子蛋白质pX01-107的分离肽，肽特异性抗体和刺激受试者的免疫应答的方法以产生针对炭疽芽孢杆菌炭疽杆菌毒素致死因子蛋白质pX01-107的抗体。 还公开了小型痘病毒表面抗原S前体蛋白质的分离肽，对肽有特异性的抗体以及刺激受试者的免疫应答以产生针对小痘病毒表面抗原S前体蛋白的抗体的方法。
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公开(公告)号：US20100278860A1
公开(公告)日：2010-11-04
申请号：US12349955
申请日：2009-01-07
IPC分类号： A61K39/145 , A61P31/16 , G01N33/68
CPC分类号： G06F19/16 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/005 , C07K14/195 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C07K14/27 , C07K14/28 , C07K14/285 , C07K14/30 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/345 , C07K14/35 , C07K14/355 , C07K14/36 , C07K14/37 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/40 , C07K14/405 , C07K14/415 , C07K14/44 , C07K14/445 , C07K14/47 , C12N2710/24122 , C12N2760/16022 , C12N2760/16122 , C40B30/02 , G06F19/22
摘要： A method and system are disclosed for identifying and/or locating complex patterns in an amino acid sequence stored in a computer file or database. According to an aspect of the present invention, techniques are provided to facilitate queries of protein databases. For protein descriptions received in response to the queries, embodiments of the present invention may scan the received protein descriptions to identify and locate Replikin patterns. A Replikin pattern is defined to be a sequence of 7 to about 50 amino acids that include the following three (3) characteristics, each of which may be recognized by an embodiment of the present invention: (1) the sequence has at least one lysine residue located six to ten amino acid residues from a second lysine residue; (2) the sequence has at least one histidine residue; and (3) at least 6% of the amino acids in the sequence are lysine residues.
摘要翻译： 公开了用于识别和/或定位存储在计算机文件或数据库中的氨基酸序列中的复杂模式的方法和系统。 根据本发明的一个方面，提供了用于促进蛋白质数据库查询的技术。 对于响应于查询而接收到的蛋白质描述，本发明的实施例可以扫描接收到的蛋白质描述以识别和定位Replikin模式。 复制素模式被定义为7至约50个氨基酸的序列，其包括以下三（3）个特征，每个特征可以被本发明的实施方案识别：（1）序列具有至少一个赖氨酸 残基位于第二赖氨酸残基6至10个氨基酸残基; （2）该序列具有至少一个组氨酸残基; 和（3）序列中至少6％的氨基酸是赖氨酸残基。
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