公开(公告)号：US07758863B2

公开(公告)日：2010-07-20

申请号：US12412888

申请日：2009-03-27

Applicant: Samuel Bogoch ,  Elenore S. Bogoch

Inventor： Samuel Bogoch ,  Elenore S. Bogoch

IPC: A61K39/145 ,  C07K4/00 ,  C07K14/00

CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/53 ,  C07K14/195 ,  C07K14/205 ,  C07K14/21 ,  C07K14/22 ,  C07K14/24 ,  C07K14/245 ,  C07K14/255 ,  C07K14/26 ,  C07K14/27 ,  C07K14/28 ,  C07K14/285 ,  C07K14/30 ,  C07K14/305 ,  C07K14/31 ,  C07K14/315 ,  C07K14/32 ,  C07K14/33 ,  C07K14/335 ,  C07K14/34 ,  C07K14/345 ,  C07K14/35 ,  C07K14/355 ,  C07K14/36 ,  C07K14/37 ,  C07K14/38 ,  C07K14/385 ,  C07K14/39 ,  C07K14/40 ,  C07K14/405 ,  C07K14/415 ,  C07K14/44 ,  C07K14/445 ,  C07K14/47 ,  C12N2710/24122 ,  C12N2760/16022 ,  C12N2760/16122 ,  Y02A50/412

Abstract: Peptides of influenza virus hemagglutinin protein and Plasmodium falciparum malaria antigen, antibodies specific for the peptides, influenza vaccines, malaria vaccines and methods of stimulating the immune response of a subject to produce antibodies to influenza virus or malaria are disclosed. Also disclosed are methods for formulating vaccines for influenza virus.

Abstract translation: 公开了流感病毒血凝素蛋白和恶性疟原虫疟疾抗原肽，肽特异性抗体，流感疫苗，疟疾疫苗和刺激受试者的免疫应答以产生抗流感病毒或疟疾的方法。 还公开了用于制定用于流感病毒的疫苗的方法。

公开(公告)号：US20090137778A1

公开(公告)日：2009-05-28

申请号：US12252028

申请日：2008-10-15

Applicant: Samuel BOGOCH ,  Elenore S. BOGOCH

Inventor： Samuel BOGOCH ,  Elenore S. BOGOCH

IPC: C07K14/00

CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/53 ,  C07K14/195 ,  C07K14/205 ,  C07K14/21 ,  C07K14/22 ,  C07K14/24 ,  C07K14/245 ,  C07K14/255 ,  C07K14/26 ,  C07K14/27 ,  C07K14/28 ,  C07K14/285 ,  C07K14/30 ,  C07K14/305 ,  C07K14/31 ,  C07K14/315 ,  C07K14/32 ,  C07K14/33 ,  C07K14/335 ,  C07K14/34 ,  C07K14/345 ,  C07K14/35 ,  C07K14/355 ,  C07K14/36 ,  C07K14/37 ,  C07K14/38 ,  C07K14/385 ,  C07K14/39 ,  C07K14/40 ,  C07K14/405 ,  C07K14/415 ,  C07K14/44 ,  C07K14/445 ,  C07K14/47 ,  C12N2710/24122 ,  C12N2760/16022 ,  C12N2760/16122 ,  Y02A50/412

Abstract: The present invention provides a new class of peptides related to rapid replication and their use in diagnosing, preventing and treating disease.

Abstract translation: 本发明提供了与快速复制相关的新一类肽及其在诊断，预防和治疗疾病中的用途。

公开(公告)号：US20060024669A1

公开(公告)日：2006-02-02

申请号：US11116203

申请日：2005-04-28

Applicant: Samuel Bogoch ,  Elenore Bogoch

Inventor： Samuel Bogoch ,  Elenore Bogoch

IPC: C12Q1/70 ,  G01N33/48 ,  C07H21/04 ,  G06F19/00 ,  G01N33/50 ,  C12N15/86

CPC classification number: G06F19/16 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/53 ,  C07K14/005 ,  C07K14/195 ,  C07K14/205 ,  C07K14/21 ,  C07K14/22 ,  C07K14/24 ,  C07K14/245 ,  C07K14/255 ,  C07K14/26 ,  C07K14/27 ,  C07K14/28 ,  C07K14/285 ,  C07K14/30 ,  C07K14/305 ,  C07K14/31 ,  C07K14/315 ,  C07K14/32 ,  C07K14/33 ,  C07K14/335 ,  C07K14/34 ,  C07K14/345 ,  C07K14/35 ,  C07K14/355 ,  C07K14/36 ,  C07K14/37 ,  C07K14/38 ,  C07K14/385 ,  C07K14/39 ,  C07K14/40 ,  C07K14/405 ,  C07K14/415 ,  C07K14/44 ,  C07K14/445 ,  C07K14/47 ,  C12N2710/24122 ,  C12N2760/16022 ,  C12N2760/16122 ,  C40B30/02 ,  G06F19/22

Abstract: A method and system are disclosed for identifying and/or locating complex patterns in an amino acid sequence stored in a computer file or database. According to an aspect of the present invention, techniques are provided to facilitate queries of protein databases. For protein descriptions received in response to the queries, embodiments of the present invention may scan the received protein descriptions to identify and locate Replikin patterns. A Replikin pattern is defined to be a sequence of 7 to about 50 amino acids that include the following three (3) characteristics, each of which may be recognized by an embodiment of the present invention: (1) the sequence has at least one lysine residue located six to ten amino acid residues from a second lysine residue; (2) the sequence has at least one histidine residue; and (3) at least 6% of the amino acids in the sequence are lysine residues.

公开(公告)号：US06489290B2

公开(公告)日：2002-12-03

申请号：US09381261

申请日：1999-12-07

Applicant: Joseph Loscalzo ,  Aida Inbal

Inventor： Joseph Loscalzo ,  Aida Inbal

IPC: A61K3800

CPC classification number: C07K14/355 ,  A61K38/00

Abstract: This invention combines the unique antiplatelet effects of S-nitrosothiols and the antiadhesive properties of fragments of von Willebrand (vWF) in the A1 domain to provide unique molecules that exploit both of these properties. Preferred molecules comprise a fragment of A1 (Ala 444-Asn 730) in which arginine at position 545 is replaced by cysteine (the most frequent von Willebrand disease type 2b mutation) that has been discovered to impair platelet adhesion, and to inhibit an antithrombotic activity in vivo. This cysteine residue may be S-nitrosated to produce a novel molecule that has the potential for impairing platelet adhesion as well as activation/aggregation, and such molecules form the basis of a novel therapeutic method for impairing platelet responses following vascular injury or in other thrombotic disorders according to this invention.

Abstract translation: 本发明结合了S-亚硝基硫醇的独特的抗血小板作用和缬沙坦（vWF）片段在A1结构域中的抗粘附性，以提供独特的分子，利用这两种特性。 优选的分子包含A1（Ala 444-Asn 730）的片段，其中545位的精氨酸被已被发现损伤血小板粘附的半胱氨酸（最常见的血管性血友病血型B型突变）代替，并且抑制抗血栓形成活性 体内。 该半胱氨酸残基可以被S-亚硝基化以产生具有损害血小板粘附和活化/聚集的潜力的新分子，并且这些分子形成用于损伤血管损伤或其它血栓形成后血小板反应的新型治疗方法的基础 根据本发明的病症。

公开(公告)号：US4094971A

公开(公告)日：1978-06-13

申请号：US717509

申请日：1976-08-25

Applicant: Louis A. Chedid ,  Francoise Marguerite Audibert

Inventor： Louis A. Chedid ,  Francoise Marguerite Audibert

IPC: C12N7/00 ,  A61K35/74 ,  A61K38/00 ,  A61K39/39 ,  C07K14/355 ,  A61K39/02

CPC classification number: A61K39/39 ,  C07K14/355 ,  A61K2039/5555 ,  A61K38/00

Abstract: Immunological adjuvants obtainable from already-known water-soluble adjuvants containing peptidoglycane fragments, which include saccharide units formed from N-acetylglucosamine and from an N-acyl-muramic acid wherein the acyl group is a glycolyl or acetyl group and to the muramyl group there are attached peptide chains, by modification of said already-known water-soluble adjuvants so that they bear acylating groups derived from physiologically-acceptable carboxylic polyacids, especially carboxylic diacids, and wherein preferably the acylating groups themselves include free carboxylic acid groups, for instance being derived from phthalic acid or succinic acid.

公开(公告)号：US20130195916A1

公开(公告)日：2013-08-01

申请号：US13787450

申请日：2013-03-06

Applicant: Samuel Bogoch ,  Elenore S. Bogoch ,  Anne-Elenore Bogoch Borsanyi ,  Samuel Winston Bogoch

Inventor： Samuel Bogoch ,  Elenore S. Bogoch ,  Anne-Elenore Bogoch Borsanyi ,  Samuel Winston Bogoch

IPC: G06F19/16 ,  C40B30/02

CPC classification number: G16B15/00 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/53 ,  C07K14/005 ,  C07K14/195 ,  C07K14/205 ,  C07K14/21 ,  C07K14/22 ,  C07K14/24 ,  C07K14/245 ,  C07K14/255 ,  C07K14/26 ,  C07K14/27 ,  C07K14/28 ,  C07K14/285 ,  C07K14/30 ,  C07K14/305 ,  C07K14/31 ,  C07K14/315 ,  C07K14/32 ,  C07K14/33 ,  C07K14/335 ,  C07K14/34 ,  C07K14/345 ,  C07K14/35 ,  C07K14/355 ,  C07K14/36 ,  C07K14/37 ,  C07K14/38 ,  C07K14/385 ,  C07K14/39 ,  C07K14/40 ,  C07K14/405 ,  C07K14/415 ,  C07K14/44 ,  C07K14/445 ,  C07K14/47 ,  C12N2710/24122 ,  C12N2760/16022 ,  C12N2760/16122 ,  G16B30/00 ,  G16B35/00 ,  G16C20/60

Abstract: A method and system are disclosed for identifying and/or locating complex patterns in an amino acid sequence stored in a computer file or database. According to an aspect of the present invention, techniques are provided to facilitate queries of protein databases. For protein descriptions received in response to the queries, embodiments of the present invention may scan the received protein descriptions to identify and locate Replikin patterns. A Replikin pattern is defined to be a sequence of 7 to about 50 amino acids that include the following three (3) characteristics, each of which may be recognized by an embodiment of the present invention: (1) the sequence has at least one lysine residue located six to ten amino acid residues from a second lysine residue; (2) the sequence has at least one histidine residue; and (3) at least 6% of the amino acids in the sequence are lysine residues.

Abstract translation: 公开了用于识别和/或定位存储在计算机文件或数据库中的氨基酸序列中的复杂模式的方法和系统。 根据本发明的一个方面，提供了用于促进蛋白质数据库查询的技术。 对于响应于查询而接收到的蛋白质描述，本发明的实施例可以扫描接收到的蛋白质描述以识别和定位Replikin模式。 复制素模式被定义为7至约50个氨基酸的序列，其包括以下三（3）个特征，每个特征可以被本发明的实施方案识别：（1）序列具有至少一个赖氨酸 残基位于第二赖氨酸残基6至10个氨基酸残基; （2）该序列具有至少一个组氨酸残基; 和（3）序列中至少6％的氨基酸是赖氨酸残基。

公开(公告)号：US20100278860A1

公开(公告)日：2010-11-04

申请号：US12349955

申请日：2009-01-07

Applicant: Samuel BOGOCH ,  Elenore S. BOGOCH ,  Anne Elenore BORSANYI ,  Samuel Winston BOGOCH

Inventor： Samuel BOGOCH ,  Elenore S. BOGOCH ,  Anne Elenore BORSANYI ,  Samuel Winston BOGOCH

IPC: A61K39/145 ,  A61P31/16 ,  G01N33/68

CPC classification number: G06F19/16 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/53 ,  C07K14/005 ,  C07K14/195 ,  C07K14/205 ,  C07K14/21 ,  C07K14/22 ,  C07K14/24 ,  C07K14/245 ,  C07K14/255 ,  C07K14/26 ,  C07K14/27 ,  C07K14/28 ,  C07K14/285 ,  C07K14/30 ,  C07K14/305 ,  C07K14/31 ,  C07K14/315 ,  C07K14/32 ,  C07K14/33 ,  C07K14/335 ,  C07K14/34 ,  C07K14/345 ,  C07K14/35 ,  C07K14/355 ,  C07K14/36 ,  C07K14/37 ,  C07K14/38 ,  C07K14/385 ,  C07K14/39 ,  C07K14/40 ,  C07K14/405 ,  C07K14/415 ,  C07K14/44 ,  C07K14/445 ,  C07K14/47 ,  C12N2710/24122 ,  C12N2760/16022 ,  C12N2760/16122 ,  C40B30/02 ,  G06F19/22

Abstract: A method and system are disclosed for identifying and/or locating complex patterns in an amino acid sequence stored in a computer file or database. According to an aspect of the present invention, techniques are provided to facilitate queries of protein databases. For protein descriptions received in response to the queries, embodiments of the present invention may scan the received protein descriptions to identify and locate Replikin patterns. A Replikin pattern is defined to be a sequence of 7 to about 50 amino acids that include the following three (3) characteristics, each of which may be recognized by an embodiment of the present invention: (1) the sequence has at least one lysine residue located six to ten amino acid residues from a second lysine residue; (2) the sequence has at least one histidine residue; and (3) at least 6% of the amino acids in the sequence are lysine residues.

Abstract translation: 公开了用于识别和/或定位存储在计算机文件或数据库中的氨基酸序列中的复杂模式的方法和系统。 根据本发明的一个方面，提供了用于促进蛋白质数据库查询的技术。 对于响应于查询而接收到的蛋白质描述，本发明的实施例可以扫描接收到的蛋白质描述以识别和定位Replikin模式。 复制素模式被定义为7至约50个氨基酸的序列，其包括以下三（3）个特征，每个特征可以被本发明的实施方案识别：（1）序列具有至少一个赖氨酸 残基位于第二赖氨酸残基6至10个氨基酸残基; （2）该序列具有至少一个组氨酸残基; 和（3）序列中至少6％的氨基酸是赖氨酸残基。

公开(公告)号：US07452963B2

公开(公告)日：2008-11-18

申请号：US10189437

申请日：2002-07-08

Applicant: Samuel Bogoch ,  Elenore S. Bogoch

Inventor： Samuel Bogoch ,  Elenore S. Bogoch

IPC: A61K38/03 ,  A61K38/16

CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/53 ,  C07K14/195 ,  C07K14/205 ,  C07K14/21 ,  C07K14/22 ,  C07K14/24 ,  C07K14/245 ,  C07K14/255 ,  C07K14/26 ,  C07K14/27 ,  C07K14/28 ,  C07K14/285 ,  C07K14/30 ,  C07K14/305 ,  C07K14/31 ,  C07K14/315 ,  C07K14/32 ,  C07K14/33 ,  C07K14/335 ,  C07K14/34 ,  C07K14/345 ,  C07K14/35 ,  C07K14/355 ,  C07K14/36 ,  C07K14/37 ,  C07K14/38 ,  C07K14/385 ,  C07K14/39 ,  C07K14/40 ,  C07K14/405 ,  C07K14/415 ,  C07K14/44 ,  C07K14/445 ,  C07K14/47 ,  C12N2710/24122 ,  C12N2760/16022 ,  C12N2760/16122 ,  Y02A50/412

Abstract: The present invention provides a new class of peptides related to rapid replication and their use in diagnosing, preventing and treating disease.

Abstract translation: 本发明提供了与快速复制相关的新一类肽及其在诊断，预防和治疗疾病中的用途。

公开(公告)号：US07176275B2

公开(公告)日：2007-02-13

申请号：US09984056

申请日：2001-10-26

Applicant: Samuel Bogoch ,  Elenore S. Bogoch

Inventor： Samuel Bogoch ,  Elenore S. Bogoch

IPC: C07K4/00 ,  C07K11/00 ,  C07K14/195

CPC classification number: C07K16/44 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/005 ,  C07K14/195 ,  C07K14/205 ,  C07K14/21 ,  C07K14/22 ,  C07K14/24 ,  C07K14/245 ,  C07K14/255 ,  C07K14/26 ,  C07K14/27 ,  C07K14/28 ,  C07K14/285 ,  C07K14/30 ,  C07K14/305 ,  C07K14/31 ,  C07K14/315 ,  C07K14/32 ,  C07K14/33 ,  C07K14/335 ,  C07K14/34 ,  C07K14/345 ,  C07K14/35 ,  C07K14/355 ,  C07K14/36 ,  C07K14/37 ,  C07K14/38 ,  C07K14/385 ,  C07K14/39 ,  C07K14/40 ,  C07K14/405 ,  C07K14/415 ,  C07K14/44 ,  C07K14/445 ,  C07K14/47 ,  C12N2710/24122 ,  C12N2760/16122

Abstract: Isolated peptides of the Bacillus anthracis Anthrax Toxin Lethal factor Protein pX01–107, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Bacillus anthracis Anthrax Toxin Lethal factor Protein pX01–107 are disclosed. Also disclosed are isolated peptides of the Small Pox Virus Surface Antigen S Precursor Protein, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Small Pox Virus Surface Antigen S Precursor Protein.

Abstract translation: 炭疽芽孢杆菌炭疽毒素致死致死因子蛋白质pX01-107的分离肽，肽特异性抗体和刺激受试者的免疫应答的方法以产生针对炭疽芽孢杆菌炭疽杆菌毒素致死因子蛋白质pX01-107的抗体。 还公开了小型痘病毒表面抗原S前体蛋白质的分离肽，对肽有特异性的抗体以及刺激受试者的免疫应答以产生针对小痘病毒表面抗原S前体蛋白的抗体的方法。

公开(公告)号：US20030194414A1

公开(公告)日：2003-10-16

申请号：US10189437

申请日：2002-07-08

Inventor： Samuel Bogoch ,  Elenore S. Bogoch

IPC: C12Q001/68 ,  C07H021/04 ,  A61K039/395 ,  A61K039/12 ,  C07K002/00 ,  C07K004/00 ,  C07K005/00 ,  C07K007/00 ,  C07K014/00 ,  C07K016/00 ,  C07K017/00 ,  A61K038/00

CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/53 ,  C07K14/195 ,  C07K14/205 ,  C07K14/21 ,  C07K14/22 ,  C07K14/24 ,  C07K14/245 ,  C07K14/255 ,  C07K14/26 ,  C07K14/27 ,  C07K14/28 ,  C07K14/285 ,  C07K14/30 ,  C07K14/305 ,  C07K14/31 ,  C07K14/315 ,  C07K14/32 ,  C07K14/33 ,  C07K14/335 ,  C07K14/34 ,  C07K14/345 ,  C07K14/35 ,  C07K14/355 ,  C07K14/36 ,  C07K14/37 ,  C07K14/38 ,  C07K14/385 ,  C07K14/39 ,  C07K14/40 ,  C07K14/405 ,  C07K14/415 ,  C07K14/44 ,  C07K14/445 ,  C07K14/47 ,  C12N2710/24122 ,  C12N2760/16022 ,  C12N2760/16122 ,  Y02A50/412

Abstract: The present invention provides a new class of peptides related to rapid replication and their use in diagnosing, preventing and treating disease.

Abstract translation: 本发明提供了与快速复制相关的新一类肽及其在诊断，预防和治疗疾病中的用途。