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    Methods for determining intracranial pressure non-invasively
    2.
    发明授权
    Methods for determining intracranial pressure non-invasively 有权
    非侵入性确定颅内压的方法

    公开(公告)号：US07547283B2

    公开(公告)日：2009-06-16

    申请号：US10861197

    申请日：2004-06-03

    申请人： Pierre D. Mourad ,  Brandt Mohr ,  Michel Kliot ,  Robert C. A. Frederickson

    发明人： Pierre D. Mourad ,  Brandt Mohr ,  Michel Kliot ,  Robert C. A. Frederickson

    IPC分类号： A61B8/14

    CPC分类号： A61B5/031 ,  A61B5/0051 ,  A61B5/4064 ,  A61B5/415 ,  A61B5/418 ,  A61B5/4824 ,  A61B5/7267 ,  A61B8/00 ,  A61B8/04 ,  A61B8/065 ,  A61B8/08 ,  A61B8/0808 ,  A61B8/4236 ,  A61B8/4444 ,  A61B8/4472 ,  A61B8/4483 ,  A61B8/485 ,  A61B8/488

    摘要： Systems and methods for determining ICP based on parameters that can be measured using non-invasive or minimally invasive techniques are provided, wherein a non-linear relationship is used to determine ICP based on one or more variable inputs. The first variable input relates to one or more properties of a cranial blood vessel and/or blood flow, such as acoustic backscatter from an acoustic transducer having a focus trained on a cranial blood vessel, flow velocity in a cranial blood vessel, and the like. Additional variables, such as arterial blood pressure (ABP), may be used in combination with a first variable input relating to one or more properties of a cranial blood vessel, such as flow velocity of the middle cerebral artery (MCA) to derive ICP using a non-linear relationship. Methods and systems for locating target areas based on their acoustic properties and for acoustic scanning of an area, identification of a target area of interest based on acoustic properties, and automated focusing of an acoustic source and/or detector on a desired target area are also provided. Acoustic transducer assemblies are described.

    摘要翻译： 提供了基于可以使用非侵入性或微创技术测量的参数来确定ICP的系统和方法，其中使用非线性关系来基于一个或多个可变输入来确定ICP。 第一可变输入涉及颅血管和/或血流的一种或多种性质，例如来自具有在颅血管上训练的焦点的声学换能器的声学后向散射，颅血管中的流速等 。 另外的变量，例如动脉血压（ABP）可以与与颅血管的一种或多种性质（例如大脑中动脉（MCA）的流速）相关的第一可变输入组合使用，以便使用 非线性关系。 基于它们的声学特性和对于区域的声学扫描来定位目标区域的方法和系统也基于声学特性识别目标区域，以及声源和/或检测器在期望的目标区域上的自动聚焦也是 提供。 描述了声学换能器组件。

    Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers
    3.
    发明授权
    Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers 失效
    基于阴离子聚合物抑制细胞侵袭和纤维化的方法和组合物

    公开(公告)号：US06756362B2

    公开(公告)日：2004-06-29

    申请号：US10138705

    申请日：2002-05-06

    申请人： Dikla Roufa ,  Adrian Harel ,  Robert C. A. Frederickson ,  George T. Coker, III

    发明人： Dikla Roufa ,  Adrian Harel ,  Robert C. A. Frederickson ,  George T. Coker, III

    IPC分类号： A61K31715

    CPC分类号： A61K31/734 ,  A61K31/727 ,  A61K31/728 ,  A61K31/737 ,  A61K31/738 ,  A61K38/1703 ,  A61K38/39 ,  A61L27/20 ,  A61L27/34 ,  A61L31/042 ,  Y10S530/857 ,  Y10S623/915 ,  Y10S623/924 ,  Y10S977/788 ,  Y10S977/793 ,  Y10S977/795 ,  Y10S977/908 ,  Y10S977/91 ,  A61K31/715 ,  A61K2300/00 ,  C08L5/00 ,  C08L5/02 ,  C08L5/04

    摘要： The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is predicated on the discovery that anionic polymers effectively inhibit invasion of cells associated with detrimental healing processes, and in particular, that the effectiveness of an anionic polymer at inhibiting cell invasion correlates with the anionic charge density of the polymer. Thus the present invention provides a large number of materials for use in methods of inhibiting fibrosis and fibroblast invasion. Anionic polymers for use in the invention include but are not limited to natural proteoglycans, and the glycosaminoglycan moieties of proteoglycans. Additionally, anionic carbohydrates and other anionic polymers may be used. The anionic polymers dextran sulfate and pentosan polysulfate are preferred. In a more preferred embodiment, dextran sulfate, in which the sulfur content is greater than about 10% by weight, may be used. In a more preferred embodiment, the average molecular weight is about 40,000 to 500,000 Daltons. The present invention provides compositions and methods to inhibit fibrosis and scarring associated with surgery. The invention further provides compositions and methods to inhibit glial cell invasion, detrimental bone growth and neurite outgrowth. In a preferred embodiment, the inhibitory compositions further comprise an adhesive protein.

    摘要翻译： 本发明涉及生物相容性阴离子聚合物可有效抑制纤维化，瘢痕形成和手术粘连的发现。 本发明基于以下发现：阴离子聚合物有效地抑制与有害愈合过程相关的细胞的侵袭，特别是阴离子聚合物抑制细胞侵袭的有效性与聚合物的阴离子电荷密度相关。 因此，本发明提供了大量用于抑制纤维化和成纤维细胞侵袭的方法的材料。 用于本发明的阴离子聚合物包括但不限于天然蛋白聚糖和蛋白聚糖的糖胺聚糖部分。 此外，可以使用阴离子碳水化合物和其它阴离子聚合物。 阴离子聚合物硫酸葡聚糖和聚山梨糖多糖是优选的。 在更优选的实施方案中，可以使用其中硫含量大于约10重量％的硫酸葡聚糖。 在更优选的实施方案中，平均分子量为约40,000至500,000道尔顿。 本发明提供抑制与手术相关的纤维化和瘢痕形成的组合物和方法。 本发明还提供抑制胶质细胞侵袭，有害的骨生长和神经突生长的组合物和方法。 在优选的实施方案中，抑制组合物还包含粘合蛋白。

    Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers
    4.
    发明授权
    Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers 失效
    基于阴离子聚合物抑制细胞侵袭和纤维化的方法和组合物

    公开(公告)号：US06417173B1

    公开(公告)日：2002-07-09

    申请号：US09476158

    申请日：1999-12-30

    申请人： Dikla Roufa ,  Adrian Harel ,  Robert C. A. Frederickson ,  George T. Coker, III

    发明人： Dikla Roufa ,  Adrian Harel ,  Robert C. A. Frederickson ,  George T. Coker, III

    IPC分类号： A61K31715

    CPC分类号： A61K31/734 ,  A61K31/727 ,  A61K31/728 ,  A61K31/737 ,  A61K31/738 ,  A61K38/1703 ,  A61K38/39 ,  A61L27/20 ,  A61L27/34 ,  A61L31/042 ,  Y10S530/857 ,  Y10S623/915 ,  Y10S623/924 ,  Y10S977/788 ,  Y10S977/793 ,  Y10S977/795 ,  Y10S977/908 ,  Y10S977/91 ,  A61K31/715 ,  A61K2300/00 ,  C08L5/00 ,  C08L5/02 ,  C08L5/04

    摘要： The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is predicated on the discovery that anionic polymers effectively inhibit invasion of cells associated with detrimental healing processes, and in particular, that the effectiveness of an anionic polymer at inhibiting cell invasion correlates with the anionic charge density of the polymer. Thus the present invention provides a large number of materials for use in methods of inhibiting fibrosis and fibroblast invasion. Anionic polymers for use in the invention include but are not limited to natural proteoglycans, and the glycosaminoglycan moieties of proteoglycans. Additionally, anionic carbohydrates and other anionic polymers may be used. The anionic polymers dextran sulfate and pentosan polysulfate are preferred. In a more preferred embodiment, dextran sulfate, in which the sulfur content is greater than about 10% by weight, may be used. In a more preferred embodiment, the average molecular weight is about 40,000 to 500,000 Daltons. The present invention provides compositions and methods to inhibit fibrosis and scarring associated with surgery. The invention further provides compositions and methods to inhibit glial cell invasion, detrimental bone growth and neurite outgrowth. In a preferred embodiment, the inhibitory compositions further comprise an adhesive protein.

    摘要翻译： 本发明涉及生物相容性阴离子聚合物可有效抑制纤维化，瘢痕形成和手术粘连的发现。 本发明基于以下发现：阴离子聚合物有效地抑制与有害愈合过程相关的细胞的侵袭，特别是阴离子聚合物抑制细胞侵袭的有效性与聚合物的阴离子电荷密度相关。 因此，本发明提供了用于抑制纤维化和成纤维细胞侵入的方法中的大量材料。 用于本发明的阴离子聚合物包括但不限于天然蛋白聚糖和蛋白聚糖的糖胺聚糖部分。 此外，可以使用阴离子碳水化合物和其它阴离子聚合物。 阴离子聚合物硫酸葡聚糖和聚山梨糖多糖是优选的。 在更优选的实施方案中，可以使用其中硫含量大于约10重量％的硫酸葡聚糖。 在更优选的实施方案中，平均分子量为约40,000至500,000道尔顿。 本发明提供抑制与手术相关的纤维化和瘢痕形成的组合物和方法。 本发明还提供抑制胶质细胞侵袭，有害的骨生长和神经突生长的组合物和方法。 在优选的实施方案中，抑制组合物还包含粘合蛋白。

    Method for treating pregnant females for pain and anxiety
    8.
    发明授权
    Method for treating pregnant females for pain and anxiety 失效
    治疗怀孕女性疼痛和焦虑的方法

    公开(公告)号：US4430327A

    公开(公告)日：1984-02-07

    申请号：US379539

    申请日：1982-05-18

    申请人： Robert C. A. Frederickson

    发明人： Robert C. A. Frederickson

    IPC分类号： A61K38/00 ,  A61K38/04 ,  A61P25/04 ,  A61P25/20 ,  A61K37/02

    CPC分类号： A61K38/04 ,  Y10S514/809

    摘要： A method is described for preventing or minimizing the effects of a drug on an embryo or a fetus by placental transport while alleviating pain and anxiety of the pregnant female by administering a pharmaceutically effective amount of a compound of the formulaH-L-Tyr-D-Ala-Gly-L-Phe-L-(N-CH.sub.3)Met-NH.sub.2or a pharmaceutically acceptable salt thereof.

    摘要翻译： 描述了一种用于通过施用药学有效量的式HL-Tyr-D-Ala的化合物来预防或最小化通过胎盘运输对药物对胚胎或胎儿的影响的方法，同时减轻怀孕女性的疼痛和焦虑 -Gly-L-Phe-L-（N-CH 3）Met-NH 2或其药学上可接受的盐。

    Analgesic compounds
    9.
    发明授权
    Analgesic compounds 失效
    止痛化合物

    公开(公告)号：US4331593A

    公开(公告)日：1982-05-25

    申请号：US202514

    申请日：1980-10-31

    申请人： Edward L. Smithwick, Jr. ,  Robert C. A. Frederickson ,  Robert T. Shuman

    发明人： Edward L. Smithwick, Jr. ,  Robert C. A. Frederickson ,  Robert T. Shuman

    IPC分类号： C07K5/087 ,  C07K5/107 ,  C07C103/52

    CPC分类号： C07K5/1016 ,  C07K5/0812 ,  Y10S514/809

    摘要： Compounds of the formula ##STR1## and pharmaceutically acceptable non-toxic acid addition salts thereof, in which L and D, when applicable, define the chirality;R.sub.1 and R.sub.2 independently are hydrogen or C.sub.1 -C.sub.3 primary alkyl;R.sub.3 is C.sub.1 -C.sub.4 primary or secondary alkyl or --CH.sub.2 CH.sub.2 --S--CH.sub.3 ;R.sub.4 is hydrogen or C.sub.1 -C.sub.3 primary alkyl;R.sub.5 is hydrogen or C.sub.1 -C.sub.3 primary alkyl;Y is hydrogen or acetyl; andZ is ##STR2## --CH.sub.2 OH, or --CN; subject to the limitation that no more than one of R.sub.4 and R.sub.5 is C.sub.1 -C.sub.3 primary alkyl; are useful analgesic agents.

    摘要翻译： 式（I）的化合物及其药学上可接受的无毒的酸加成盐，其中当适用时，L和D定义手性; R 1和R 2独立地为氢或C 1 -C 3伯烷基; R3是C1-C4伯或仲烷基或-CH2CH2-S-CH3; R4是氢或C1-C3伯烷基; R5是氢或C1-C3伯烷基; Y是氢或乙酰基; 并且Z是-CH 2 OH或-CN; 限制在于不多于一个R 4和R 5是C 1 -C 3伯烷基; 是有用的止痛剂。