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    ENHANCED TRANSPORT USING MEMBRANE DISRUPTIVE AGENTS
    1.
    发明申请
    ENHANCED TRANSPORT USING MEMBRANE DISRUPTIVE AGENTS 有权
    使用薄膜破坏剂加强运输

    公开(公告)号：US20080199957A1

    公开(公告)日：2008-08-21

    申请号：US12105983

    申请日：2008-04-18

    Applicant: Allan S. Hoffman ,  Patrick Stayton ,  Oliver W. Press ,  Niren Murthy ,  Chantal Lackey Reed ,  Lawrence A. Crum ,  Pierre D. Mourad ,  Tyrone M. Porter ,  David Tirrell

    Inventor： Allan S. Hoffman ,  Patrick Stayton ,  Oliver W. Press ,  Niren Murthy ,  Chantal Lackey Reed ,  Lawrence A. Crum ,  Pierre D. Mourad ,  Tyrone M. Porter ,  David Tirrell

    IPC: C12N5/06

    CPC classification number: A61K47/481 ,  A61K41/0028 ,  A61K41/0047 ,  A61K47/48376 ,  A61K47/6801

    Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontophoresis, and/or electrophoresis can also be used with the disrupting agents.

    Abstract translation: 描述了用于从细胞，细胞内的细胞室或通过细胞层或屏障转运或释放治疗和诊断试剂或代谢物或其它分析物的组合物和方法。 组合物包括膜屏障转运增强剂，并且通常与增强剂和/或暴露于刺激物一起施用以实现破坏或改变渗透性，运输或释放。 在优选的实施方案中，组合物包括响应于内体中的低pH而破坏内体膜的化合物，但是与细胞膜相对无活性的化合物，直接或间接地与治疗剂或诊断剂偶联。 还可以使用其它破坏剂，对除了pH之外的刺激和/或增强剂如光，电刺激，电磁刺激，超声，温度或其组合都有反应。 这些化合物可以通过离子，共价键或H键连接到待递送的试剂上，或者与配制剂形成配合物。 待递送的药剂可以是治疗和/或诊断剂。 增强交付如超声波，离子电渗疗法和/或电泳的治疗也可与破坏剂一起使用。

    DEVICE AND METHOD FOR PREDICTING THE LIKELIHOOD OF CARIES DEVELOPMENT
    4.
    发明申请
    DEVICE AND METHOD FOR PREDICTING THE LIKELIHOOD OF CARIES DEVELOPMENT 审中-公开
    用于预测发展契约的装置和方法

    公开(公告)号：US20100279248A1

    公开(公告)日：2010-11-04

    申请号：US12718879

    申请日：2010-03-05

    Applicant: Pierre D. Mourad ,  Joel Berg ,  Paul Ray Illian

    Inventor： Pierre D. Mourad ,  Joel Berg ,  Paul Ray Illian

    IPC: A61B6/14 ,  G06N5/02

    CPC classification number: A61B6/145 ,  A61B5/0534 ,  A61B5/7275 ,  A61C19/04 ,  G16H50/30

    Abstract: A hand-held intra-oral dental device and method are described for the detection of pre-caries lesions and the prediction of evolution and prognosis of same. The present invention has as its foundation a low-cost tool for predicting the likelihood of the development of Early Childhood Caries (ECC), in contrast to other techniques and associated devices, where their focus is to identify individual pre-caries lesions. This method focuses on the detection of caries precursors or of their patterns and the relationship of those precursors and patterns to the likelihood of subsequent dental disease. The implications for the establishment for early preventive treatment are profound, namely the earliest implementation of preventative therapy for our approach relative to that of the other approaches.

    Abstract translation: 描述了一种手持口腔内牙科装置和方法，用于检测龋前病变及其进展和预后的预测。 与其他技术和相关设备相比，本发明作为其基础是用于预测幼儿龋齿（ECC）发展的可能性的低成本工具，其中他们的重点是识别龋前病变。 该方法着重于检测龋齿前体或其模式，以及这些前体和模式与随后牙齿疾病的可能性的关系。 对早期预防治疗的建立的影响是深刻的，即我们的方法相对于其他方法最早实施预防性治疗。

    Systems and methods for making noninvasive assessments of cardiac tissue and parameters
    5.
    发明授权
    Systems and methods for making noninvasive assessments of cardiac tissue and parameters 失效
    用于进行心脏组织和参数的无创评估的系统和方法

    公开(公告)号：US07022077B2

    公开(公告)日：2006-04-04

    申请号：US10612483

    申请日：2003-07-01

    Applicant: Pierre D. Mourad ,  Michel Kliot ,  Rex Patterson ,  Alec Rooke

    Inventor： Pierre D. Mourad ,  Michel Kliot ,  Rex Patterson ,  Alec Rooke

    IPC: A61B8/14

    CPC classification number: A61B8/065 ,  A61B5/0048 ,  A61B5/031 ,  A61B5/4519 ,  A61B5/4824 ,  A61B5/4869 ,  A61B6/503 ,  A61B6/504 ,  A61B8/00 ,  A61B8/04 ,  A61B8/08 ,  A61B8/0808 ,  A61B8/0883 ,  A61B8/0891 ,  A61B8/4236 ,  A61B8/4444 ,  A61B8/4472 ,  A61B8/485 ,  A61B8/488

    Abstract: Systems and methods for noninvasive assessment of cardiac tissue properties and cardiac parameters using ultrasound techniques are disclosed. Determinations of myocardial tissue stiffness, tension, strain, strain rate, and the like, may be used to assess myocardial contractility, myocardial ischemia and infarction, ventricular filling and atrial pressures, and diastolic functions. Non-invasive systems in which acoustic techniques, such as ultrasound, are employed to acquire data relating to intrinsic tissue displacements are disclosed. Non-invasive systems in which ultrasound techniques are used to acoustically stimulate or palpate target cardiac tissue, or induce a response at a cardiac tissue site that relates to cardiac tissue properties and/or cardiac parameters are also disclosed.

    Abstract translation: 公开了使用超声技术非心脏评估心脏组织特性和心脏参数的系统和方法。 心肌组织刚度，张力，应变，应变速率等的测定可用于评估心肌收缩力，心肌缺血和梗死，心室充盈和心房压力以及舒张功能。 公开了诸如超声波之类的声学技术来采集与内在组织位移有关的数据的非侵入式系统。 还公开了其中使用超声技术来声学刺激或触诊靶心脏组织或诱导与心脏组织特性和/或心脏参数相关的心脏组织部位的应答的非侵入性系统。

    Enhanced transport using membrane disruptive agents
    6.
    发明授权
    Enhanced transport using membrane disruptive agents 有权
    增强运输使用膜破坏剂

    公开(公告)号：US06835393B2

    公开(公告)日：2004-12-28

    申请号：US09226044

    申请日：1999-01-05

    Applicant: Allan S. Hoffman ,  Patrick Stayton ,  Oliver W. Press ,  David Tirrell ,  Niren Murthy ,  Chantal Lackey ,  Lawrence A. Crum ,  Pierre D. Mourad ,  Tyrone M. Porter

    Inventor： Allan S. Hoffman ,  Patrick Stayton ,  Oliver W. Press ,  David Tirrell ,  Niren Murthy ,  Chantal Lackey ,  Lawrence A. Crum ,  Pierre D. Mourad ,  Tyrone M. Porter

    IPC: A61K9127

    CPC classification number: A61K47/481 ,  A61K41/0028 ,  A61K41/0047 ,  A61K47/48376 ,  A61K47/6801

    Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontopheresis, and/or electrophereis can also be used with the disrupting agents.

    Abstract translation: 描述了用于从细胞，细胞内的细胞室或通过细胞层或屏障转运或释放治疗和诊断试剂或代谢物或其它分析物的组合物和方法。 组合物包括膜屏障转运增强剂，并且通常与增强剂和/或暴露于刺激物一起施用以实现破坏或改变渗透性，运输或释放。 在优选的实施方案中，组合物包括响应于内体中的低pH而破坏内体膜的化合物，但是与细胞膜相对无活性的化合物，直接或间接地与治疗剂或诊断剂偶联。 还可以使用其它破坏剂，对除了pH之外的刺激和/或增强剂如光，电刺激，电磁刺激，超声，温度或其组合都有反应。 这些化合物可以通过离子，共价键或H键连接到待递送的试剂上，或者与配制剂形成配合物。 待递送的药剂可以是治疗和/或诊断剂。 增强递送的治疗如超声波，离子分离和/或电泳也可与破坏剂一起使用。

    ENHANCED TRANSPORT USING MEMBRANE DISRUPTIVE AGENTS
    7.
    发明申请
    ENHANCED TRANSPORT USING MEMBRANE DISRUPTIVE AGENTS 有权
    使用薄膜破坏剂加强运输

    公开(公告)号：US20110288238A1

    公开(公告)日：2011-11-24

    申请号：US13182756

    申请日：2011-07-14

    Applicant: Allan S. Hoffman ,  Patrick Stayton ,  Oliver W. Press ,  Niren Murthy ,  Chantal Lackey Reed ,  Lawrence A. Crum ,  Pierre D. Mourad ,  Tyrone M. Porter ,  David Tirrell

    Inventor： Allan S. Hoffman ,  Patrick Stayton ,  Oliver W. Press ,  Niren Murthy ,  Chantal Lackey Reed ,  Lawrence A. Crum ,  Pierre D. Mourad ,  Tyrone M. Porter ,  David Tirrell

    IPC: C08F220/06 ,  C08F265/02 ,  C08F299/00

    CPC classification number: A61K47/481 ,  A61K41/0028 ,  A61K41/0047 ,  A61K47/48376 ,  A61K47/6801

    Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontopheresis, and/or electrophoresis can also be used with the disrupting agents.

    Abstract translation: 描述了用于从细胞，细胞内的细胞室或通过细胞层或屏障转运或释放治疗和诊断试剂或代谢物或其它分析物的组合物和方法。 组合物包括膜屏障转运增强剂，并且通常与增强剂和/或暴露于刺激物一起施用以实现破坏或改变渗透性，运输或释放。 在优选的实施方案中，组合物包括响应于内体中的低pH而破坏内体膜的化合物，但是与细胞膜相对无活性的化合物，直接或间接地与治疗剂或诊断剂偶联。 还可以使用其它破坏剂，对除了pH之外的刺激和/或增强剂如光，电刺激，电磁刺激，超声波，温度或其组合都有反应。 这些化合物可以通过离子，共价键或H键连接到待递送的试剂上，或者与配制剂形成配合物。 待递送的药剂可以是治疗和/或诊断剂。 增强递送的治疗如超声波，离子分离和/或电泳也可与破坏剂一起使用。

    TOOTHBRUSH EMPLOYING ACOUSTIC WAVEGUIDE
    8.
    发明申请
    TOOTHBRUSH EMPLOYING ACOUSTIC WAVEGUIDE 审中-公开
    牙刷使用声波

    公开(公告)号：US20110159461A1

    公开(公告)日：2011-06-30

    申请号：US13047229

    申请日：2011-03-14

    Applicant: Pierre D. Mourad ,  James Christopher McInnes ,  George A. Barrett ,  David A. Ballard ,  Gerald K. Brewer ,  Frederick Jay Bennett

    Inventor： Pierre D. Mourad ,  James Christopher McInnes ,  George A. Barrett ,  David A. Ballard ,  Gerald K. Brewer ,  Frederick Jay Bennett

    IPC: A61C17/16

    CPC classification number: A46B15/0002 ,  A46B15/0028 ,  A46B2200/1066 ,  A61C17/20 ,  A61C17/3481

    Abstract: A power toothbrush (10) is disclosed having a handle (15), battery (12), ultrasonic drive circuit (14), motor (16), control unit (18), and toothbrush head (20). The toothbrush head includes bristles (26) and a waveguide (24) that is operatively connected to an ultrasonic transducer (22). The waveguide facilitates the transmission of acoustic energy into the dental fluid to achieve improved cleaning and stain removal and improved cleaning in interproximal and subgingival regions. In one embodiment an ultrasound transducer module (30) includes a plurality of piezoelectric elements (32, 34) that may be mechanically connected in series, and electrically connected in parallel. One or more contacts (36) connect the elements, and a waveguide structure (50). An impedance matching layer (38) may be provided between the waveguide and the ultrasonic transducer module. The waveguide may be formed from a relatively soft material, for example, a polymer having a hardness between 10 and 65 Shore A.

    Abstract translation: 公开了具有手柄（15），电池（12），超声波驱动电路（14），马达（16），控制单元（18）和牙刷头（20）的动力牙刷（10）。 牙刷头包括刷毛（26）和可操作地连接到超声换能器（22）的波导（24）。 波导有助于将声能传输到牙科液体中，以实现改善的清洁和污渍去除以及改善邻近和龈下区域的清洁。 在一个实施例中，超声换能器模块（30）包括多个压电元件（32,34），其可以串联机械连接并并联电连接。 一个或多个触点（36）连接元件和波导结构（50）。 可以在波导和超声换能器模块之间设置阻抗匹配层（38）。 波导可以由相对柔软的材料形成，例如硬度在10和65肖氏A之间的聚合物。

    Systems and methods for determining blood pressure
    9.
    发明授权
    Systems and methods for determining blood pressure 有权
    用于确定血压的系统和方法

    公开(公告)号：US07815574B2

    公开(公告)日：2010-10-19

    申请号：US11395437

    申请日：2006-03-31

    Applicant: Pierre D. Mourad ,  Michel Kliot ,  Rex Patterson ,  Alec Rooke

    Inventor： Pierre D. Mourad ,  Michel Kliot ,  Rex Patterson ,  Alec Rooke

    IPC: A61B8/00

    CPC classification number: A61B8/065 ,  A61B5/0048 ,  A61B5/031 ,  A61B5/4519 ,  A61B5/4824 ,  A61B5/4869 ,  A61B6/503 ,  A61B6/504 ,  A61B8/00 ,  A61B8/04 ,  A61B8/08 ,  A61B8/0808 ,  A61B8/0883 ,  A61B8/0891 ,  A61B8/4236 ,  A61B8/4444 ,  A61B8/4472 ,  A61B8/485 ,  A61B8/488

    Abstract: Systems and methods for noninvasive assessment of cardiac tissue properties and cardiac parameters using ultrasound techniques are disclosed. Determinations of myocardial tissue stiffness, tension, strain, strain rate, and the like, may be used to assess myocardial contractility, myocardial ischemia and infarction, ventricular filling and atrial pressures, and diastolic functions. Non-invasive systems in which acoustic techniques, such as ultrasound, are employed to acquire data relating to intrinsic tissue displacements are disclosed. Non-invasive systems in which ultrasound techniques are used to acoustically stimulate or palpate target cardiac tissue, or induce a response at a cardiac tissue site that relates to cardiac tissue properties and/or cardiac parameters are also disclosed.

    Abstract translation: 公开了使用超声技术非心脏评估心脏组织特性和心脏参数的系统和方法。 心肌组织刚度，张力，应变，应变速率等的测定可用于评估心肌收缩力，心肌缺血和梗死，心室充盈和心房压力以及舒张功能。 公开了诸如超声波之类的声学技术来采集与内在组织位移有关的数据的非侵入式系统。 还公开了其中使用超声技术来声学刺激或触诊靶心脏组织或诱导与心脏组织特性和/或心脏参数相关的心脏组织部位的应答的非侵入性系统。

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