公开(公告)号：US20120302927A1

公开(公告)日：2012-11-29

申请号：US13479067

申请日：2012-05-23

申请人： Vera A. Khokhlova ,  Petr Yuldashev ,  Oleg A. Sapozhnikov ,  Michael R. Bailey ,  Lawrence A. Crum

发明人： Vera A. Khokhlova ,  Petr Yuldashev ,  Oleg A. Sapozhnikov ,  Michael R. Bailey ,  Lawrence A. Crum

IPC分类号： A61N7/00

CPC分类号： A61N7/02 ,  A61N2007/0065 ,  A61N2007/0095

摘要： The present technology is directed to methods for characterizing nonlinear ultrasound fields and associated systems and devices. In several embodiments, for example, a method of calculating output of a high intensity focused ultrasound (HIFU) device comprises treating a target site with a multi-element HIFU array. In some embodiments, the array comprises a generally spherical segment. The method can further include simulating a field of the array by setting a boundary condition for the array. The boundary condition can be set by simplifying at least one geometrical aspect of the generally spherical segment.

摘要翻译： 本技术涉及用于表征非线性超声场和相关系统和装置的方法。 在几个实施例中，例如，计算高强度聚焦超声（HIFU）装置的输出的方法包括用多元素HIFU阵列处理靶位点。 在一些实施例中，阵列包括大致球形的段。 该方法还可以包括通过设置数组的边界条件来模拟阵列的一个字段。 可以通过简化大致球形段的至少一个几何方面来设定边界条件。

公开(公告)号：US20100226555A1

公开(公告)日：2010-09-09

申请号：US12716991

申请日：2010-03-03

申请人： Robert E. Sandstrom ,  Lawrence A. Crum

发明人： Robert E. Sandstrom ,  Lawrence A. Crum

IPC分类号： G06K9/00 ,  G01N29/06 ,  G01N29/04

CPC分类号： G01N29/0672 ,  A61B8/08 ,  A61B2017/3409 ,  A61B2017/3413 ,  A61B2090/367 ,  A61B2090/3987 ,  G01N29/225 ,  G01N2291/02475 ,  G01N2291/106 ,  G01S15/8918 ,  G01S15/8938

摘要： A tissue specimen imaging device, comprising: a container having an upwardly facing surface, adapted to receive a tissue specimen and a liquid, an ultrasound imaging assembly, adapted to automatically form a three dimensional image of the tissue specimen interior. In one preferred embodiment the device includes a transducer head that is automatically moved relative to the specimen.

摘要翻译： 一种组织标本成像装置，包括：适于接收组织样本和液体的向上表面的容器，适于自动形成组织样本内部的三维图像的超声成像组件。 在一个优选实施例中，该装置包括相对于试样自动移动的换能器头。

公开(公告)号：US07686763B2

公开(公告)日：2010-03-30

申请号：US10770350

申请日：2004-02-02

申请人： Shahram Vaezy ,  Roy W. Martin ,  Stephen J. Carter ,  Lawrence A. Crum

发明人： Shahram Vaezy ,  Roy W. Martin ,  Stephen J. Carter ,  Lawrence A. Crum

IPC分类号： A61B8/00 ,  A61N7/00

CPC分类号： A61B8/12 ,  A61B8/06 ,  A61B8/0833 ,  A61B8/445 ,  A61B8/4483 ,  A61B8/481 ,  A61B8/483 ,  A61B2017/4216 ,  A61B2090/378 ,  A61N7/02

摘要： Ultrasound contrast agents are used to enhance imaging and facilitate HIFU therapy in four different ways. A contrast agent is used: (1) before therapy to locate specific vascular structures for treatment; (2) to determine the focal point of a HIFU therapy transducer while the HIFU therapy transducer is operated at a relatively low power level, so that non-target tissue is not damaged as the HIFU is transducer is properly focused at the target location; (3) to provide a positive feedback mechanism by causing cavitation that generates heat, reducing the level of HIFU energy administered for therapy compared to that required when a contrast agent is not used; and, (4) to shield non-target tissue from damage, by blocking the HIFU energy. Various combinations of these techniques can also be employed in a single therapeutic implementation.

摘要翻译： 超声造影剂用于增强成像，并以四种不同的方式促进HIFU治疗。 使用造影剂：（1）治疗前定位特异性血管结构进行治疗; （2）确定HIFU治疗传感器的焦点，同时HIFU治疗传感器在相对较低的功率水平下运行，使得非靶组织不被损坏，因为HIFU换能器被适当地聚焦在目标位置; （3）通过引起产生热量的空化来提供正反馈机制，与不使用造影剂时所需的HIFU能量相比，降低施用的HIFU能量水平; 和（4）通过阻止HIFU能量来屏蔽非靶组织免受损伤。 这些技术的各种组合也可以在单一治疗实施中使用。

公开(公告)号：US5882302A

公开(公告)日：1999-03-16

申请号：US669601

申请日：1996-06-24

申请人： Edward C. Driscoll, Jr. ,  Lawrence A. Crum ,  Wing K. Law ,  Stan DeMarta

发明人： Edward C. Driscoll, Jr. ,  Lawrence A. Crum ,  Wing K. Law ,  Stan DeMarta

IPC分类号： A61B5/00 ,  A61B8/00 ,  A61B8/06 ,  A61B8/08 ,  A61B17/00 ,  A61B17/12 ,  A61B19/00 ,  A61N7/02

CPC分类号： A61B8/06 ,  A61B5/416 ,  A61B8/08 ,  A61B8/12 ,  A61B8/445 ,  A61B8/4461 ,  A61B8/461 ,  A61B8/467 ,  A61B8/483 ,  A61B8/485 ,  A61N7/022 ,  A61B2017/00274 ,  A61B2017/12004 ,  A61B2018/00547 ,  A61B2090/378 ,  A61B8/4281 ,  A61B8/4405 ,  A61N2007/0065 ,  A61N2007/0078

摘要： Methods and apparatus for the remote coagulation of blood using high-intensity focused ultrasound (HIFU) are provided. A remote hemostasis method comprises identifying a site of internal bleeding and focusing therapeutic ultrasound energy on the site, the energy being focused through an intervening tissue. An apparatus for producing remote hemostasis comprises a focused therapeutic ultrasound radiating surface and a sensor for identifying a site of internal bleeding, with a registration means coupled to the radiating surface and the sensor top bring a focal target and the bleeding site into alignment. The sensor generally comprises a Doppler imaging display. Hemostasis enhancing agents may be introduced to the site for actuation by the ultrasound energy.

摘要翻译： 提供了使用高强度聚焦超声（HIFU）进行血液远程凝血的方法和装置。 远程止血方法包括识别内部出血部位并将治疗超声能量聚焦在部位上，能量通过中间组织聚焦。 用于产生远端止血的装置包括聚焦的治疗超声辐射表面和用于识别内部出血部位的传感器，其中联接到辐射表面的对准装置和传感器顶部使焦点瞄准器和出血部位对准。 传感器通常包括多普勒成像显示器。 可以将止血增强剂引入该部位以通过超声能量致动。

公开(公告)号：US09498651B2

公开(公告)日：2016-11-22

申请号：US13444466

申请日：2012-04-11

申请人： Oleg A. Sapozhnikov ,  Michael R. Bailey ,  Lawrence A. Crum ,  Tatiana D. Khokhlova ,  Vera A. Khokhlova ,  Julianna C. Simon ,  Yak-Nam Wang

发明人： Oleg A. Sapozhnikov ,  Michael R. Bailey ,  Lawrence A. Crum ,  Tatiana D. Khokhlova ,  Vera A. Khokhlova ,  Julianna C. Simon ,  Yak-Nam Wang

IPC分类号： A61B8/00 ,  A61N7/02 ,  A61N7/00

CPC分类号： A61N7/02 ,  A61B8/00 ,  A61N2007/0039

摘要： The present technology is directed to methods of soft tissue emulsification using a mechanism of ultrasonic atomization inside gas or vapor cavities, and associated systems and devices. In several embodiments, for example, a method of non-invasively treating tissue includes pulsing ultrasound energy from the ultrasound source toward the target site in tissue. The ultrasound source is configured to emit high intensity focused ultrasound (HIFU) waves. The target site comprises a pressure-release interface of a gas or vapor cavity located within the tissue. The method continues by generating shock waves in the tissue to induce a lesion in the tissue at the target site. The method additionally includes characterizing the lesion based on a degree of at least one of a mechanical or thermal ablation of the tissue.

摘要翻译： 本技术涉及使用在气体或蒸气腔内的超声雾化机理以及相关系统和装置的软组织乳化方法。 在几个实施例中，例如，非侵入性治疗组织的方法包括将来自超声源的超声能量脉冲到组织中的靶位点。 超声波源被配置为发射高强度聚焦超声（HIFU）波。 靶位置包括位于组织内的气体或气体腔的压力释放界面。 该方法继续通过在组织中产生冲击波以在靶位点处的组织中引起损伤。 该方法还包括基于组织的机械或热消融中的至少一个程度来表征病变。

公开(公告)号：US08846106B2

公开(公告)日：2014-09-30

申请号：US13182756

申请日：2011-07-14

申请人： Allan S. Hoffman ,  Patrick Stayton ,  Oliver W. Press ,  Niren Murthy ,  Chantal Lackey Reed ,  Lawrence A. Crum ,  Pierre D. Mourad ,  Tyrone M. Porter ,  David Tirrell

发明人： Allan S. Hoffman ,  Patrick Stayton ,  Oliver W. Press ,  Niren Murthy ,  Chantal Lackey Reed ,  Lawrence A. Crum ,  Pierre D. Mourad ,  Tyrone M. Porter ,  David Tirrell

IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K47/00 ,  A61K41/00 ,  A61K47/48

CPC分类号： A61K47/481 ,  A61K41/0028 ,  A61K41/0047 ,  A61K47/48376 ,  A61K47/6801

摘要： Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontopheresis, and/or electrophoresis can also be used with the disrupting agents.

摘要翻译： 描述了用于从细胞，细胞内的细胞室或通过细胞层或屏障转运或释放治疗和诊断试剂或代谢物或其它分析物的组合物和方法。 组合物包括膜屏障转运增强剂，并且通常与增强剂和/或暴露于刺激物一起施用以实现破坏或改变渗透性，运输或释放。 在优选的实施方案中，组合物包括响应于内体中的低pH而破坏内体膜的化合物，但是与细胞膜相对无活性的化合物，直接或间接地与治疗剂或诊断剂偶联。 还可以使用其它破坏剂，对除了pH之外的刺激和/或增强剂如光，电刺激，电磁刺激，超声，温度或其组合都有反应。 这些化合物可以通过离子，共价键或H键连接到待递送的试剂上，或者与配制剂形成配合物。 待递送的药剂可以是治疗和/或诊断剂。 增强递送的治疗如超声波，离子分离和/或电泳也可与破坏剂一起使用。

公开(公告)号：US20110288410A1

公开(公告)日：2011-11-24

申请号：US13032583

申请日：2011-02-22

申请人： Gavriel A. Speyer ,  Andrew A. Brayman ,  Lawrence A. Crum ,  Peter J. Kaczkowski

发明人： Gavriel A. Speyer ,  Andrew A. Brayman ,  Lawrence A. Crum ,  Peter J. Kaczkowski

IPC分类号： A61B8/00

CPC分类号： A61B8/08 ,  A61B8/5223 ,  A61N7/02 ,  G01K11/22

摘要： Methods and systems for monitoring the progress of high intensity focused ultrasound (HIFU) therapy use diagnostic ultrasound to identify temperature differentials using scatterer tracking between two backscattered radio frequency frames. The observed displacement of the scatterers may be combined with knowledge of the exposure protocol, material properties, heat transfer, and/or measurement noise to estimate heating, thermal dose, and temperature conditions resulting from the HIFU therapy.

摘要翻译： 用于监测高强度聚焦超声（HIFU）治疗进展的方法和系统使用诊断超声波来识别使用两个反向散射射频帧之间的散射体跟踪的温差。 观察到的散射体的位移可以与暴露方案，材料性质，热传递和/或测量噪声的知识结合，以估计由HIFU治疗产生的加热，热剂量和温度条件。

公开(公告)号：US08003129B2

公开(公告)日：2011-08-23

申请号：US12105983

申请日：2008-04-18

申请人： Allan S. Hoffman ,  Patrick Stayton ,  Oliver W. Press ,  Niren Murthy ,  Chantal Lackey Reed ,  Lawrence A. Crum ,  Pierre D. Mourad ,  Tyrone M. Porter ,  David Tirrell

发明人： Allan S. Hoffman ,  Patrick Stayton ,  Oliver W. Press ,  Niren Murthy ,  Chantal Lackey Reed ,  Lawrence A. Crum ,  Pierre D. Mourad ,  Tyrone M. Porter ,  David Tirrell

IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K47/00 ,  A61K9/127

CPC分类号： A61K47/481 ,  A61K41/0028 ,  A61K41/0047 ,  A61K47/48376 ,  A61K47/6801

摘要： Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontophoresis, and/or electrophoresis can also be used with the disrupting agents.

摘要翻译： 描述了用于从细胞，细胞内的细胞室或通过细胞层或屏障转运或释放治疗和诊断试剂或代谢物或其它分析物的组合物和方法。 组合物包括膜屏障转运增强剂，并且通常与增强剂和/或暴露于刺激物一起施用以实现破坏或改变渗透性，运输或释放。 在优选的实施方案中，组合物包括响应于内体中的低pH而破坏内体膜的化合物，但是与细胞膜相对无活性的化合物，直接或间接地与治疗剂或诊断剂偶联。 还可以使用其它破坏剂，对除了pH之外的刺激和/或增强剂如光，电刺激，电磁刺激，超声，温度或其组合都有反应。 这些化合物可以通过离子，共价键或H键连接到待递送的试剂上，或者与配制剂形成配合物。 待递送的药剂可以是治疗和/或诊断剂。 增强交付如超声波，离子电渗疗法和/或电泳的治疗也可与破坏剂一起使用。

公开(公告)号：US07722539B2

公开(公告)日：2010-05-25

申请号：US11207554

申请日：2005-08-18

申请人： Stephen J. Carter ,  Shahram Vaezy ,  Roy W. Martin ,  George W. Keilman ,  Lawrence A. Crum

发明人： Stephen J. Carter ,  Shahram Vaezy ,  Roy W. Martin ,  George W. Keilman ,  Lawrence A. Crum

IPC分类号： A61B8/00

CPC分类号： A61N7/02 ,  A61B8/08 ,  A61B8/4209 ,  A61B8/4254 ,  A61B8/4281 ,  A61B34/20 ,  A61B2034/2051 ,  A61B2090/378 ,  A61H23/0245

摘要： A noninvasive technique that can be used to deny blood flow to a particular region of tissue, without the inherent risks associated with invasive procedures such as surgery and minimally-invasive procedures such as embolization. Blood flow in selected portions of the vasculature can be occluded by selectively treating specific portions of the vasculature with high intensity focused ultrasound (HIFU). The occlusion denies undesired tissue the nutrients and oxygen provided by blood flow, causing necrosis in the undesired tissue. An imaging technology (such as magnetic resonance imaging, magnetic resonance angiography, ultrasound imaging, Doppler based ultrasound imaging, or computed tomographic angiography) is used to identify the undesired tissue, and the vascular structures associated with the undesired tissue. A portion of the vasculature providing blood flow to the undesired tissue is selected, and HIFU is administered to the selected portion of the vasculature to occlude blood flow through that portion of the vasculature.

摘要翻译： 一种非侵入性技术，可用于阻止血液流向组织的特定区域，而不会与诸如手术和诸如栓塞的微创手术等侵入性手术相关的固有风险。 通过用高强度聚焦超声（HIFU）选择性处理脉管系统的特定部分，可以阻断脉管系统选定部分的血流。 闭塞阻止不需要的组织由血液流动提供的营养物质和氧气，从而引起不想要的组织中的坏死。 使用成像技术（例如磁共振成像，磁共振血管造影术，超声成像，基于多普勒超声成像或计算机断层造影血管造影术）来鉴别不需要的组织以及与不想要的组织相关的血管结构。 选择向不想要的组织提供血液流动的脉管系统的一部分，并且将HIFU施用于脉管系统的选定部分以阻塞通过脉管系统的那部分的血流。

公开(公告)号：US07374778B2

公开(公告)日：2008-05-20

申请号：US10857626

申请日：2004-05-28

申请人： Allan S. Hoffman ,  Patrick Stayton ,  Oliver W. Press ,  Niren Murthy ,  Chantal Lackey Reed ,  Lawrence A. Crum ,  Pierre D. Mourad ,  Tyrone M. Porter ,  David Tirrell

发明人： Allan S. Hoffman ,  Patrick Stayton ,  Oliver W. Press ,  Niren Murthy ,  Chantal Lackey Reed ,  Lawrence A. Crum ,  Pierre D. Mourad ,  Tyrone M. Porter ,  David Tirrell

IPC分类号： A61K9/127 ,  A61K9/14 ,  A61K9/16 ,  A61K47/00

CPC分类号： A61K47/481 ,  A61K41/0028 ,  A61K41/0047 ,  A61K47/48376 ,  A61K47/6801

摘要： Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontopheresis, and/or electrophereis can also be used with the disrupting agents.

摘要翻译： 描述了用于从细胞，细胞内的细胞室或通过细胞层或屏障转运或释放治疗和诊断试剂或代谢物或其它分析物的组合物和方法。 组合物包括膜屏障转运增强剂，并且通常与增强剂和/或暴露于刺激物一起施用以实现破坏或改变渗透性，运输或释放。 在优选的实施方案中，组合物包括响应于内体中的低pH而破坏内体膜的化合物，但是与细胞膜相对无活性的化合物，直接或间接地与治疗剂或诊断剂偶联。 还可以使用其它破坏剂，对除了pH之外的刺激和/或增强剂如光，电刺激，电磁刺激，超声，温度或其组合都有反应。 这些化合物可以通过离子，共价键或H键连接到待递送的试剂上，或者与配制剂形成配合物。 待递送的药剂可以是治疗和/或诊断剂。 还可以与破坏剂一起使用增强交付如超声，离子层析和/或电穿孔的处理。