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    Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers
    3.
    发明授权
    Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers 失效
    基于阴离子聚合物抑制细胞侵袭和纤维化的方法和组合物

    公开(公告)号：US5705178A

    公开(公告)日：1998-01-06

    申请号：US164266

    申请日：1993-12-08

    申请人： Dikla Roufa ,  Adrian Harel ,  Robert C. A. Frederickson ,  George T. Coker, III

    发明人： Dikla Roufa ,  Adrian Harel ,  Robert C. A. Frederickson ,  George T. Coker, III

    IPC分类号： A61K31/727 ,  A61K31/728 ,  A61K31/734 ,  A61K31/737 ,  A61K31/738 ,  A61K38/17 ,  A61K38/39 ,  A61L27/20 ,  A61L27/34 ,  A61L31/04 ,  A61K47/36

    CPC分类号： A61K31/734 ,  A61K31/727 ,  A61K31/728 ,  A61K31/737 ,  A61K31/738 ,  A61K38/1703 ,  A61K38/39 ,  A61L27/20 ,  A61L27/34 ,  A61L31/042

    摘要： The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. Anionic polymers for use in the invention include but are not limited to natural proteoglycans, and the glycosaminoglycan moieties of proteoglycans. Additionally, anionic carbohydrates and other anionic polymers may be used. The anionic polymers dextran sulfate and pentosan polysulfate are preferred. In a more preferred embodiment, dextran sulfate, in which the sulfur content is greater than about 10% by weight, may be used. In a more preferred embodiment, the average molecular weight is about 40,000 to 500,000 Daltons. The present invention further provides compositions and methods to inhibit glial cell invasion, detrimental bone growth and neurite outgrowth. In a preferred embodiment, the inhibitory compositions further comprise an adhesive protein.

    摘要翻译： 本发明涉及生物相容性阴离子聚合物可有效抑制纤维化，瘢痕形成和手术粘连的发现。 用于本发明的阴离子聚合物包括但不限于天然蛋白聚糖和蛋白聚糖的糖胺聚糖部分。 此外，可以使用阴离子碳水化合物和其它阴离子聚合物。 阴离子聚合物硫酸葡聚糖和聚山梨糖多糖是优选的。 在更优选的实施方案中，可以使用其中硫含量大于约10重量％的硫酸葡聚糖。 在更优选的实施方案中，平均分子量为约40,000至500,000道尔顿。 本发明还提供了抑制胶质细胞侵袭，有害的骨生长和神经突生长的组合物和方法。 在优选的实施方案中，抑制组合物还包含粘合蛋白。

    Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers
    6.
    发明授权
    Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers 失效
    基于阴离子聚合物抑制细胞侵袭和纤维化的方法和组合物

    公开(公告)号：US06756362B2

    公开(公告)日：2004-06-29

    申请号：US10138705

    申请日：2002-05-06

    申请人： Dikla Roufa ,  Adrian Harel ,  Robert C. A. Frederickson ,  George T. Coker, III

    发明人： Dikla Roufa ,  Adrian Harel ,  Robert C. A. Frederickson ,  George T. Coker, III

    IPC分类号： A61K31715

    CPC分类号： A61K31/734 ,  A61K31/727 ,  A61K31/728 ,  A61K31/737 ,  A61K31/738 ,  A61K38/1703 ,  A61K38/39 ,  A61L27/20 ,  A61L27/34 ,  A61L31/042 ,  Y10S530/857 ,  Y10S623/915 ,  Y10S623/924 ,  Y10S977/788 ,  Y10S977/793 ,  Y10S977/795 ,  Y10S977/908 ,  Y10S977/91 ,  A61K31/715 ,  A61K2300/00 ,  C08L5/00 ,  C08L5/02 ,  C08L5/04

    摘要： The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is predicated on the discovery that anionic polymers effectively inhibit invasion of cells associated with detrimental healing processes, and in particular, that the effectiveness of an anionic polymer at inhibiting cell invasion correlates with the anionic charge density of the polymer. Thus the present invention provides a large number of materials for use in methods of inhibiting fibrosis and fibroblast invasion. Anionic polymers for use in the invention include but are not limited to natural proteoglycans, and the glycosaminoglycan moieties of proteoglycans. Additionally, anionic carbohydrates and other anionic polymers may be used. The anionic polymers dextran sulfate and pentosan polysulfate are preferred. In a more preferred embodiment, dextran sulfate, in which the sulfur content is greater than about 10% by weight, may be used. In a more preferred embodiment, the average molecular weight is about 40,000 to 500,000 Daltons. The present invention provides compositions and methods to inhibit fibrosis and scarring associated with surgery. The invention further provides compositions and methods to inhibit glial cell invasion, detrimental bone growth and neurite outgrowth. In a preferred embodiment, the inhibitory compositions further comprise an adhesive protein.

    摘要翻译： 本发明涉及生物相容性阴离子聚合物可有效抑制纤维化，瘢痕形成和手术粘连的发现。 本发明基于以下发现：阴离子聚合物有效地抑制与有害愈合过程相关的细胞的侵袭，特别是阴离子聚合物抑制细胞侵袭的有效性与聚合物的阴离子电荷密度相关。 因此，本发明提供了大量用于抑制纤维化和成纤维细胞侵袭的方法的材料。 用于本发明的阴离子聚合物包括但不限于天然蛋白聚糖和蛋白聚糖的糖胺聚糖部分。 此外，可以使用阴离子碳水化合物和其它阴离子聚合物。 阴离子聚合物硫酸葡聚糖和聚山梨糖多糖是优选的。 在更优选的实施方案中，可以使用其中硫含量大于约10重量％的硫酸葡聚糖。 在更优选的实施方案中，平均分子量为约40,000至500,000道尔顿。 本发明提供抑制与手术相关的纤维化和瘢痕形成的组合物和方法。 本发明还提供抑制胶质细胞侵袭，有害的骨生长和神经突生长的组合物和方法。 在优选的实施方案中，抑制组合物还包含粘合蛋白。

    Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers
    7.
    发明授权
    Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers 失效
    基于阴离子聚合物抑制细胞侵袭和纤维化的方法和组合物

    公开(公告)号：US06417173B1

    公开(公告)日：2002-07-09

    申请号：US09476158

    申请日：1999-12-30

    申请人： Dikla Roufa ,  Adrian Harel ,  Robert C. A. Frederickson ,  George T. Coker, III

    发明人： Dikla Roufa ,  Adrian Harel ,  Robert C. A. Frederickson ,  George T. Coker, III

    IPC分类号： A61K31715

    CPC分类号： A61K31/734 ,  A61K31/727 ,  A61K31/728 ,  A61K31/737 ,  A61K31/738 ,  A61K38/1703 ,  A61K38/39 ,  A61L27/20 ,  A61L27/34 ,  A61L31/042 ,  Y10S530/857 ,  Y10S623/915 ,  Y10S623/924 ,  Y10S977/788 ,  Y10S977/793 ,  Y10S977/795 ,  Y10S977/908 ,  Y10S977/91 ,  A61K31/715 ,  A61K2300/00 ,  C08L5/00 ,  C08L5/02 ,  C08L5/04

    摘要： The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is predicated on the discovery that anionic polymers effectively inhibit invasion of cells associated with detrimental healing processes, and in particular, that the effectiveness of an anionic polymer at inhibiting cell invasion correlates with the anionic charge density of the polymer. Thus the present invention provides a large number of materials for use in methods of inhibiting fibrosis and fibroblast invasion. Anionic polymers for use in the invention include but are not limited to natural proteoglycans, and the glycosaminoglycan moieties of proteoglycans. Additionally, anionic carbohydrates and other anionic polymers may be used. The anionic polymers dextran sulfate and pentosan polysulfate are preferred. In a more preferred embodiment, dextran sulfate, in which the sulfur content is greater than about 10% by weight, may be used. In a more preferred embodiment, the average molecular weight is about 40,000 to 500,000 Daltons. The present invention provides compositions and methods to inhibit fibrosis and scarring associated with surgery. The invention further provides compositions and methods to inhibit glial cell invasion, detrimental bone growth and neurite outgrowth. In a preferred embodiment, the inhibitory compositions further comprise an adhesive protein.

    摘要翻译： 本发明涉及生物相容性阴离子聚合物可有效抑制纤维化，瘢痕形成和手术粘连的发现。 本发明基于以下发现：阴离子聚合物有效地抑制与有害愈合过程相关的细胞的侵袭，特别是阴离子聚合物抑制细胞侵袭的有效性与聚合物的阴离子电荷密度相关。 因此，本发明提供了用于抑制纤维化和成纤维细胞侵入的方法中的大量材料。 用于本发明的阴离子聚合物包括但不限于天然蛋白聚糖和蛋白聚糖的糖胺聚糖部分。 此外，可以使用阴离子碳水化合物和其它阴离子聚合物。 阴离子聚合物硫酸葡聚糖和聚山梨糖多糖是优选的。 在更优选的实施方案中，可以使用其中硫含量大于约10重量％的硫酸葡聚糖。 在更优选的实施方案中，平均分子量为约40,000至500,000道尔顿。 本发明提供抑制与手术相关的纤维化和瘢痕形成的组合物和方法。 本发明还提供抑制胶质细胞侵袭，有害的骨生长和神经突生长的组合物和方法。 在优选的实施方案中，抑制组合物还包含粘合蛋白。