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    Functionalized diphenolics and absorbable polymers therefrom
    7.
    发明授权
    Functionalized diphenolics and absorbable polymers therefrom 有权
    官能化二元酚和可吸收的聚合物

    公开(公告)号：US08288505B2

    公开(公告)日：2012-10-16

    申请号：US13071623

    申请日：2011-03-25

    Applicant: Rao S Bezwada

    Inventor： Rao S Bezwada

    IPC: C08G69/10 ,  A61F2/00

    CPC classification number: A61L31/10 ,  A61L27/18 ,  A61L27/58 ,  A61L31/06 ,  A61L31/148 ,  C07K5/06078 ,  C08L67/04

    Abstract: The present invention relates to dephenolic compounds, an example of which is shown below, which are functionalized, and polymers formed from the same. Polymers formed from the functionalized diphenolics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.

    Abstract translation: 本发明涉及脱模化合物，其实例如下所示，其被官能化，和由其形成的聚合物。 由功能性二元酚形成的聚合物预期具有可控的降解特征，使得它们能够在期望的时间范围内释放活性组分。 聚合物也预期在各种医疗应用中是有用的。

    BIOABSORBABLE AND BIOCOMPATIBLE POLYURETHANES AND POLYAMIDES FOR MEDICAL DEVICES
    8.
    发明申请
    BIOABSORBABLE AND BIOCOMPATIBLE POLYURETHANES AND POLYAMIDES FOR MEDICAL DEVICES 有权
    可生物降解的生物成分聚氨酯和医用器件的聚酰胺

    公开(公告)号：US20120158127A1

    公开(公告)日：2012-06-21

    申请号：US13402391

    申请日：2012-02-22

    Applicant: Rao S. Bezwada

    Inventor： Rao S. Bezwada

    IPC: A61F2/06 ,  C07C233/75 ,  C07C219/34 ,  C07C265/12 ,  B32B15/08 ,  C07C205/37 ,  C08G69/40 ,  C08G18/71 ,  C08G69/12 ,  A61K47/34 ,  C07C271/28

    CPC classification number: A61K47/34 ,  A61F2/442 ,  A61L15/64 ,  A61L17/06 ,  A61L17/105 ,  A61L24/043 ,  A61L24/046 ,  A61L27/18 ,  A61L27/58 ,  A61L31/10 ,  A61L31/148 ,  C08G18/10 ,  C08G18/711 ,  C08G18/771 ,  C08G69/26 ,  C08G69/40 ,  C08G69/44 ,  C08G2230/00 ,  C09J175/06 ,  Y10T428/31681 ,  C08L67/04 ,  C08L77/00 ,  C08L75/04

    Abstract: Absorbable polyurethanes, polyamides and polyester urethanes prepared from at least one compound selected from: or the corresponding diamines or diisocyanates thereof, wherein each X independently represents —CH2COO—, —CH(CH3)COO—, —CH2CH2OCH2COO—, —CH2CH2CH2CH2CH2COO—, —(CH2)yCOO— where y is 2 to 4 or 6 to 24, or —(CH2CH2O)z′CH2COO— where z′ is 2 to 24; each Y represents —COCH2O—, —COCH(CH3)O—, —COCH2OCH2CH2O—, —COCH2CH2CH2CH2CH2O—, —CO(CH2)mO— where m is 2 to 4 or 6 to 24, or —COCH2O(CH2CH2O)n— where n is 2 to 24; R′ is hydrogen, benzyl or straight-chained or branched alkyl; p is 1 to 4; and Rn represents one or more members selected from H, alkoxy, benzyloxy, aldehyde, halogen, carboxylic acid and —NO2, which is attached directly to an aromatic ring or attached through an aliphatic chain. Absorbable polymers prepared from these compounds are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention and other implantable medical devices.

    Abstract translation: 由选自以下的至少一种化合物或其相应的二胺或二异氰酸酯制备的可吸收的聚氨酯，聚酰胺和聚酯聚氨酯，其中每个X独立地表示-CH 2 COO-， - CH（CH 3）COO-， - CH 2 CH 2 OCH 2 COO-， - CH 2 CH 2 CH 2 CH 2 COO-， - （CH2）yCOO-，其中y为2至4或6至24，或 - （CH2CH2O）z'CH2COO-，其中z'为2至24; 每个Y表示-COCH 2 O-，-COCH（CH 3）O - ， - COCH 2 CH 2 CH 2 CH 2 - ， - COCH 2 CH 2 CH 2 CH 2 CH 2 O - ， - CO（CH 2）m O-，其中m为2至4或6至24，或-COCH 2 O（CH 2 CH 2 O） n为2〜24; R'是氢，苄基或直链或支链烷基; p为1〜4; 并且R n表示选自H，烷氧基，苄氧基，醛，卤素，羧酸和-NO 2中的一种或多种，​​其直接连接到芳环上或通过脂族链连接。 由这些化合物制备的可吸收聚合物可用于药物递送，组织工程，组织粘合剂，防止粘附和其他可植入医疗器械。

    Controlled Release of Nitric Oxide And Drugs From Functionalized Macromers And Oligomers
    9.
    发明申请
    Controlled Release of Nitric Oxide And Drugs From Functionalized Macromers And Oligomers 有权
    从功能化大分子单体和低聚物控制释放一氧化氮和药物

    公开(公告)号：US20120035259A1

    公开(公告)日：2012-02-09

    申请号：US13276552

    申请日：2011-10-19

    Applicant: Rao S. Bezwada

    Inventor： Rao S. Bezwada

    IPC: A61K31/21 ,  A61P7/00 ,  A61P17/02 ,  A61P9/08 ,  C07C203/04 ,  A61P9/00

    CPC classification number: C08G63/06 ,  A61L17/005 ,  A61L17/145 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/114 ,  A61L2300/402 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/45 ,  A61L2300/604 ,  C07C203/04 ,  C07C235/12 ,  C08G63/6852

    Abstract: The present invention provides NO and, optionally, drug releasing macromers and oligomers wherein the drug molecule and NO releasing moiety are linked an absorbable macromer or oligomeric chain susceptible to hydrolytic degradation and wherein the macromer or oligomer comprises of repeat units derived from safe and biocompatible molecules such as glycolic acid, lactic acid, caprolactone and p-dioxanone. Furthermore, the present invention relates to controlled release of nitric oxide (NO) and/or drug molecule from a NO and drug releasing macromer or oligomer. Moreover, the present invention also relates to medical devices, medical device coatings and therapeutic formulations comprising of nitric oxide and drug releasing macromers and oligomers of the present invention.

    Abstract translation: 本发明提供NO和任选的药物释放大分子单体和低聚物，其中药物分子和NO释放部分连接易于水解降解的可吸收的大分子单体或低聚链，其中大分子单体或低聚物包含衍生自安全和生物相容性分子的重复单元 如乙醇酸，乳酸，己内酯和对二恶烷酮。 此外，本发明涉及NO和药物释放大分子单体或低聚物的一氧化氮（NO）和/或药物分子的控制释放。 此外，本发明还涉及包含一氧化氮和药物释放大分子单体和本发明的低聚物的医疗装置，医疗装置涂层和治疗制剂。

    CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS FROM MULTI-ARMED OLIGOMERS
    10.
    发明申请
    CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS FROM MULTI-ARMED OLIGOMERS 有权
    生物活性化合物从多臂寡聚体的控制释放

    公开(公告)号：US20120010284A1

    公开(公告)日：2012-01-12

    申请号：US13236622

    申请日：2011-09-19

    Applicant: Rao S. Bezwada

    Inventor： Rao S. Bezwada

    IPC: A61K31/21 ,  A61P31/00 ,  A61P39/02 ,  A61P29/00 ,  C07C317/46 ,  C07C69/76

    CPC classification number: A61K47/593 ,  A61K47/55 ,  A61K47/552 ,  A61K47/60

    Abstract: The present invention relates to the discovery of biodegradable multi-armed oligomers wherein the end groups of these oligomers have been functionalized with biologically active molecules. The resultant multi-armed oligomers end-functionalized with biologically active molecules have a controllable degradation profile. The hydrolytic degradation of oligomers of the present invention releases the biologically active compound as such with no change in native chemical structure.

    Abstract translation: 本发明涉及可生物降解的多臂寡聚物的发现，其中这些低聚物的端基已被生物活性分子官能化。 用生物活性分子终止功能化的所得多臂寡聚体具有可控的降解特征。 本发明的低聚物的水解降解本身释放生物活性化合物，天然化学结构没有变化。

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