Tabletting of erythritol
    2.
    发明授权
    Tabletting of erythritol 有权
    赤藓糖醇片剂

    公开(公告)号:US6083438A

    公开(公告)日:2000-07-04

    申请号:US129383

    申请日:1998-08-05

    CPC分类号: A61K9/2018

    摘要: A process for preparing a composition suitable for use as an excipient for tabletting comprising the following steps is disclosed;a) mixing of erythritol and sorbitol in a dry form,b) heating up to a temperature where the mixed products are melted,c) cooling the product,d) milling the cooled product to obtain a composition having a desired particle size.Additionally tablets obtained after direct compression of an erythritol/sorbitol mixture are disclosed.

    摘要翻译: 公开了一种制备适合用作压片赋形剂的组合物的方法,包括以下步骤: a)以干燥形式混合赤藓糖醇和山梨糖醇,b)加热到混合产物熔化的温度,c)冷却产物,d)研磨冷却的产物以获得具有所需粒度的组合物。 另外公开了直接压缩赤藓糖醇/山梨糖醇混合物后得到的片剂。

    MICRONIZATION OF POLYOLS
    6.
    发明申请
    MICRONIZATION OF POLYOLS 审中-公开
    多元醇的微结构

    公开(公告)号:US20100255307A1

    公开(公告)日:2010-10-07

    申请号:US12668384

    申请日:2008-07-25

    IPC分类号: B32B1/00 B02C19/06

    摘要: Micronized polyols having a particle size distribution (d50) of from 20 to 60 μm, and a flowability below or equal to 5 s/100 g, preferably below 5 s/100 g, are disclosed. The micronized polyols, although they have a smaller particle size distribution compared to the corresponding milled polyols, have improved flowability. Most preferably, the polyol is one or more of maltitol, isomalt, mannitol, sorbitol, xylitol and erythritol. Preferred polyols also demonstrate a compressibility index (%) of not less than 40. The process for micronizing a polyol comprises the steps of a) taking a polyol having the chemical formula CnH2n+2On and which is solid at 20 to 25° C., b) feeding the polyol into a jet mill and applying pressure using nitrogen and c) collecting the micronized polyol. The micronized polyols are useful in food, feed, cosmetic and pharmaceutical compositions, especially chewing gum compositions.

    摘要翻译: 公开了具有20至60μm的粒度分布(d50)和低于或等于5s / 100g,优选低于5s / 100g的流动性的微粉化多元醇。 微粉化的多元醇尽管与相应的研磨多元醇相比具有较小的粒度分布,但具有改善的流动性。 最优选地,多元醇是麦芽糖醇,异麦芽糖醇,甘露醇,山梨醇,木糖醇和赤藓糖醇中的一种或多种。 优选的多元醇还表现出不小于40的可压缩指数(%)。用于微粉化多元醇的方法包括以下步骤:a)取化学式为C n H 2n + 20n的多元醇,其在20至25℃下为固体, b)将多元醇进料到喷射磨机中并使用氮气施加压力,和c)收集微粉化的多元醇。 微粉化多元醇可用于食品,饲料,化妆品和药物组合物,特别是口香糖组合物。