公开(公告)号：US09279110B2

公开(公告)日：2016-03-08

申请号：US13884063

申请日：2011-11-09

申请人： Lan Tang ,  Ye Liu ,  Kim Borch ,  Jesper Brask

发明人： Lan Tang ,  Ye Liu ,  Kim Borch ,  Jesper Brask

IPC分类号： C07H21/04 ,  C12N15/00 ,  C12N1/14 ,  C12N1/20 ,  C12N5/04 ,  C12N5/07 ,  C12P21/02 ,  C12N9/20 ,  C11B3/00

CPC分类号： A23D9/04 ,  C11B3/003 ,  C12N9/16 ,  C12N9/20 ,  C12Y301/04003

摘要： The present invention relates to isolated polypeptides having phospholipase C activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

摘要翻译： 本发明涉及具有磷脂酶C活性的分离的多肽和编码多肽的分离的多核苷酸。 本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

公开(公告)号：US09212354B2

公开(公告)日：2015-12-15

申请号：US13876507

申请日：2011-11-02

申请人： Ye Liu ,  Lan Tang ,  Junxin Duan

发明人： Ye Liu ,  Lan Tang ,  Junxin Duan

IPC分类号： C12P21/00 ,  C12N9/42 ,  C07K14/37 ,  C12P19/14 ,  C12P19/02

CPC分类号： C12P19/14 ,  C07K14/37 ,  C12N9/2437 ,  C12P19/02 ,  C12P21/00 ,  C12P2203/00 ,  C12Y302/01091 ,  Y02P20/52

摘要： The present invention provides isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also provides nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

摘要翻译： 本发明提供了具有纤维二糖水解酶活性的分离的多肽和编码多肽的分离的多核苷酸。 本发明还提供了包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

公开(公告)号：US09139823B2

公开(公告)日：2015-09-22

申请号：US13876529

申请日：2011-11-11

申请人： Ye Liu ,  Junxin Duan ,  Lan Tang

发明人： Ye Liu ,  Junxin Duan ,  Lan Tang

IPC分类号： C12N9/24 ,  C12N15/00 ,  C12P1/00 ,  C08B37/00 ,  C12N1/21 ,  C12N1/15 ,  C12P7/06 ,  C12N9/42 ,  C12P7/14 ,  C12P19/14

CPC分类号： C12N9/2437 ,  C07K2319/00 ,  C07K2319/50 ,  C12P7/14 ,  C12P19/14 ,  C12Y302/01004 ,  Y02E50/17

摘要： The present invention provides isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also provides nucleic acid constructs, vectors, and host cell comprising the polynucleotides as well as methods of producing and using the polypeptides.

摘要翻译： 本发明提供了具有内切葡聚糖酶活性的分离的多肽和编码多肽的分离的多核苷酸。 本发明还提供了包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

公开(公告)号：US20130139574A1

公开(公告)日：2013-06-06

申请号：US13487202

申请日：2012-06-02

申请人： Sau Lan Tang Staats

发明人： Sau Lan Tang Staats

IPC分类号： G01N30/30

CPC分类号： G01N30/30

摘要： Devices for heating and cooling chromatographic columns, transfer tubing, fittings and accessories and can also be placed next to the mass spectrometer's inlet region are disclosed. These devices have the advantage of allowing the user to dramatically reduce the post-column dead-volume while using the heating or cooling devices, a necessity for low-flowrate liquid chromatography. These devices also do not require the user to heat or cool the entire column with fittings to achieve optimized benefits for chromatography.

摘要翻译： 公开了用于加热和冷却色谱柱，输送管，配件和附件并且也可以放置在质谱仪入口区域旁边的装置。 这些装置具有允许使用者在使用加热或冷却装置时显着降低柱后死体积的优点，这是低流量液相色谱的必要条件。 这些设备也不需要用户通过配件来加热或冷却整个色谱柱，以实现色谱的优化优点。

公开(公告)号：US08420351B2

公开(公告)日：2013-04-16

申请号：US13548726

申请日：2012-07-13

申请人： Lan Tang ,  Ye Liu ,  Junxin Duan ,  Yu Zhang ,  Christian Isak Jorgensen ,  Randall Kramer

发明人： Lan Tang ,  Ye Liu ,  Junxin Duan ,  Yu Zhang ,  Christian Isak Jorgensen ,  Randall Kramer

IPC分类号： C12N1/00 ,  C12N15/79 ,  C12P21/06

CPC分类号： C12N9/2437 ,  C07K14/385 ,  C12N9/2434 ,  C12N15/01 ,  C12N15/1137 ,  C12N15/8218 ,  C12N15/8246 ,  C12N2310/14 ,  C12N2310/141 ,  C12P7/14 ,  C12P19/02 ,  C12P19/14 ,  C12P2203/00

摘要： The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

公开(公告)号：US20090221511A1

公开(公告)日：2009-09-03

申请号：US12394261

申请日：2009-02-27

申请人： Hans-Michael DOSCH ,  Lan Tang ,  Yin Chan ,  Michael Salter

发明人： Hans-Michael DOSCH ,  Lan Tang ,  Yin Chan ,  Michael Salter

IPC分类号： A61K38/08 ,  A61K31/165 ,  A61P3/10

CPC分类号： A61K38/046 ,  Y10S514/866

摘要： A process is disclosed for controlling inflammatory tissue access through release of neuropeptides, such as substance P (sP), to insulin-responsive sensory neurons, whereby simultaneous control of insulin sensitivity/resistance is manifested. In models of Type 1 and Type 2 diabetes, sensory afferents, in particular TRPV1, have fundamental roles in insulin/glucose homeostasis, islet physiology and autoimmune tissue inflammation. By manipulation of the TRPV1 neuro-β-cell circuit or enhancement of pancreatic sP levels, normalization of insulin resistance, clearance of inflammation and prevention of both Type 1 and Type 2 diabetes is realized.

摘要翻译： 公开了一种通过将神经肽（例如物质P（sP））释放到胰岛素反应性感觉神经元来控制炎症组织进入的方法，由此表现出胰岛素敏感性/抗性的同时控制。 在1型和2型糖尿病模型中，感觉传入特别是TRPV1在胰岛素/葡萄糖体内平衡，胰岛生理和自身免疫组织炎症中具有重要作用。 通过操纵TRPV1神经 - β细胞电路或增强胰腺sP水平，实现胰岛素抵抗的正常化，炎症清除和预防1型和2型糖尿病。

公开(公告)号：US07402798B2

公开(公告)日：2008-07-22

申请号：US11329508

申请日：2006-01-10

申请人： Sau Lan Tang Staats

发明人： Sau Lan Tang Staats

IPC分类号： H01J49/10 ,  H01J49/00

CPC分类号： H01J49/165

摘要： A system for controlling an electrostatically induced liquid spray includes an electrostatic spray device for generating a liquid spray from a liquid sample; a spray current sensing means placed in relation to the spray device and configured to generate a current output signal that represents a current of the liquid spray; and a mechanism that receives the current output signal and compares it to a pre-selected current value, with a difference between the two representing a control signal that is sent to one of (1) a pump that regulates the flow rate of the liquid sample and (2) a power supply to regulate an electric field associated with the spray device that generates the liquid spray according to a set level of current.

公开(公告)号：US20070008084A1

公开(公告)日：2007-01-11

申请号：US11172791

申请日：2005-07-05

申请人： Sen-Jia Wu ,  Hao-Lan Tang ,  Yu-Tsung Hsu ,  Yu-Tang Huang

发明人： Sen-Jia Wu ,  Hao-Lan Tang ,  Yu-Tsung Hsu ,  Yu-Tang Huang

IPC分类号： G05B19/00 ,  B60Q1/00

CPC分类号： G08G1/017

摘要： An electronic license plate system capable of changing information displayed thereon and method for the same is a display device installed on in a motor vehicle showing information according to random instructions given by a traffic control system, serving as an illuminated license plate for easy visual identification. The displayed contents of the license plate varies with time and location to prevent counterfeiting or a shut-down event, and alertness and road security may be raised in areas with poor visibility due to the illuminated license plate. The electronic license plate working with the traffic control system may reach the functions of unmanned charge, dynamic geographic information, unmanned traffic control, road use information, and traffic statistics, and may provide a functional intelligent traffic system (ITS) for prevention of license plate counterfeiting and vehicle theft.

摘要翻译： 能够改变显示在其上的信息的电子牌照系统及其方法是安装在机动车辆中的显示装置，显示根据由交通控制系统给出的随机指令的信息，用作易于视觉识别的照明车牌。 车牌的显示内容随时间和地点而变化，以防止假冒或关闭事件，并且由于照明车牌而导致能见度差的地区可能会提高警觉性和道路安全性。 与交通控制系统一起使用的电子牌照可以达到无人值班，动态地理信息，无人值守交通管制，道路使用信息，交通统计等功能，并可提供功能智能交通系统（ITS），防止车牌 假冒和车辆盗窃。

公开(公告)号：US07150815B2

公开(公告)日：2006-12-19

申请号：US10380608

申请日：2001-10-03

申请人： James William Ashmead ,  Sau Lan Tang

发明人： James William Ashmead ,  Sau Lan Tang

IPC分类号： G01N27/453

CPC分类号： G01N30/6095 ,  B01L3/5027 ,  B01L3/502707 ,  B01L3/50273 ,  B01L7/00 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/185 ,  B01L2300/1894 ,  B01L2400/0418 ,  G01N21/05 ,  G01N21/33 ,  G01N27/44708 ,  G01N27/44721 ,  G01N27/44791 ,  G01N2021/0346 ,  G01N2030/3007 ,  G01N30/74

摘要： A polymer-based microfluidic device and its manufacturing methods. This microfluidic device is suitable for chromatographic and electrophoretic separations in which the detection of the components in the fluid is by means of ultraviolet (UV) spectroscopy. The device further comprises at least one cooling channel adjacent the separation channel, said cooling channel conducting a cooling fluid through the device for removing heat from the the separation channel. At least one section of the separation channel has an increased cross-sectional dimension with respect to other sections of said channel to provide an increased optical path length when the device is used in an ultraviolet detection arrangement.

摘要翻译： 一种基于聚合物的微流体装置及其制造方法。 该微流体装置适用于通过紫外（UV）光谱法检测流体中的组分的色谱和电泳分离。 所述装置还包括与所述分离通道相邻的至少一个冷却通道，所述冷却通道通过所述装置传导冷却流体，以从所述分离通道移除热量。 分离通道的至少一个部分相对于所述通道的其它部分具有增加的横截面尺寸，以在该装置用于紫外线检测装置时提供增加的光程长度。

公开(公告)号：US07060227B2

公开(公告)日：2006-06-13

申请号：US10213202

申请日：2002-08-05

申请人： Sau Lan Tang Staats

发明人： Sau Lan Tang Staats

IPC分类号： B81B1/00

CPC分类号： B81C1/00071 ,  B01L3/0241 ,  B01L3/0268 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/0822 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2400/0421 ,  B01L2400/0487 ,  B33Y80/00 ,  B81B2201/058 ,  C07K1/24 ,  G01N27/44773 ,  G01N30/6026 ,  G01N30/6095 ,  G01N30/90 ,  G01N30/92 ,  H01J49/04 ,  G01N30/463

摘要： A microfluidic device is provided and comprises a device that is assembled from segments of microfluidic features using built-in alignment features, such as the raised walls of the channels or protrusion/recess pairs to comprise channels, nozzles, optical detectors, distillation columns, etc., to form a device for a specific application, such as an electrospray-mass spectrometer interface. Some of the segments can be of standard dimensions with standard alignment features so that the user may assemble microfluidic devices for specific applications using standard prefabricated segments as part thereof.

摘要翻译： 提供了微流体装置，并且包括使用内置对准特征（例如通道的凸起壁或突起/凹槽对）包括通道，喷嘴，光学检测器，蒸馏塔等的由微流体特征的部分组装的装置 形成用于特定应用的装置，例如电喷雾 - 质谱仪界面。 一些片段可以是具有标准对准特征的标准尺寸，使得用户可以使用标准预制片段来组装用于特定应用的微流体装置作为其一部分。