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    TRPV1 + SENSORY NEURONS CONTROL OF BETA-CELL STRESS AND ISLET INFLAMMATION IN DIABETES
    1.
    发明申请
    TRPV1 + SENSORY NEURONS CONTROL OF BETA-CELL STRESS AND ISLET INFLAMMATION IN DIABETES 审中-公开
    TRPV1 +感觉神经元控制糖尿病患者的细胞应力和血小板渗透

    公开(公告)号：US20090221511A1

    公开(公告)日：2009-09-03

    申请号：US12394261

    申请日：2009-02-27

    申请人： Hans-Michael DOSCH ,  Lan Tang ,  Yin Chan ,  Michael Salter

    发明人： Hans-Michael DOSCH ,  Lan Tang ,  Yin Chan ,  Michael Salter

    IPC分类号： A61K38/08 ,  A61K31/165 ,  A61P3/10

    CPC分类号： A61K38/046 ,  Y10S514/866

    摘要： A process is disclosed for controlling inflammatory tissue access through release of neuropeptides, such as substance P (sP), to insulin-responsive sensory neurons, whereby simultaneous control of insulin sensitivity/resistance is manifested. In models of Type 1 and Type 2 diabetes, sensory afferents, in particular TRPV1, have fundamental roles in insulin/glucose homeostasis, islet physiology and autoimmune tissue inflammation. By manipulation of the TRPV1 neuro-β-cell circuit or enhancement of pancreatic sP levels, normalization of insulin resistance, clearance of inflammation and prevention of both Type 1 and Type 2 diabetes is realized.

    摘要翻译： 公开了一种通过将神经肽（例如物质P（sP））释放到胰岛素反应性感觉神经元来控制炎症组织进入的方法，由此表现出胰岛素敏感性/抗性的同时控制。 在1型和2型糖尿病模型中，感觉传入特别是TRPV1在胰岛素/葡萄糖体内平衡，胰岛生理和自身免疫组织炎症中具有重要作用。 通过操纵TRPV1神经 - β细胞电路或增强胰腺sP水平，实现胰岛素抵抗的正常化，炎症清除和预防1型和2型糖尿病。

    TRPV1+ sensory neurons control of β-cells stress and islet inflammation in diabetes
    2.
    发明授权
    TRPV1+ sensory neurons control of β-cells stress and islet inflammation in diabetes 有权
    TRPV1 +感觉神经元控制糖尿病中的β细胞应激和胰岛炎

    公开(公告)号：US07544365B2

    公开(公告)日：2009-06-09

    申请号：US11638830

    申请日：2006-12-14

    申请人： Hans-Michael Dosch ,  Lan Tang ,  Yin Chan ,  Michael Salter

    发明人： Hans-Michael Dosch ,  Lan Tang ,  Yin Chan ,  Michael Salter

    IPC分类号： A61K45/00 ,  A61K39/00 ,  C07K5/00 ,  C07K14/00

    CPC分类号： A61K38/046 ,  Y10S514/866

    摘要： A process is disclosed for controlling inflammatory tissue access through release of neuropeptides, such as substance P (sP), to insulin-responsive sensory neurons, whereby simultaneous control of insulin sensitivity/resistance is manifested. In models of Type 1 and Type 2 diabetes, sensory afferents, in particular TRPV1, have fundamental roles in insulin/glucose homeostasis, islet physiology and autoimmune tissue inflammation. By manipulation of the TRPV1 neuro-β-cell circuit or enhancement of pancreatic sP levels, normalization of insulin resistance, clearance of inflammation and prevention of both Type 1 and Type 2 diabetes is realized.

    摘要翻译： 公开了一种通过将神经肽（例如物质P（sP））释放到胰岛素反应性感觉神经元来控制炎症组织进入的方法，由此表现出胰岛素敏感性/抗性的同时控制。 在1型和2型糖尿病模型中，感觉传入特别是TRPV1在胰岛素/葡萄糖体内平衡，胰岛生理和自身免疫组织炎症中具有重要作用。 通过操纵TRPV1神经 - β细胞电路或增强胰腺sP水平，实现胰岛素抵抗的正常化，炎症清除和预防1型和2型糖尿病。

    STIMULATION OF TRPV1+ SENSORY NEURONS TO CONTROL BETA-CELL STRESS AND ISLET INFLAMMATION IN DIABETES
    3.
    发明申请
    STIMULATION OF TRPV1+ SENSORY NEURONS TO CONTROL BETA-CELL STRESS AND ISLET INFLAMMATION IN DIABETES 审中-公开
    刺激TRPV1 +感觉神经元以控制糖尿病中的细胞应力和血小板渗透

    公开(公告)号：US20090312255A1

    公开(公告)日：2009-12-17

    申请号：US12478898

    申请日：2009-06-05

    申请人： Hans-Michael DOSCH ,  Lan Tang ,  Yin Chan ,  Michael Salter

    发明人： Hans-Michael DOSCH ,  Lan Tang ,  Yin Chan ,  Michael Salter

    IPC分类号： A61K31/165 ,  A61P3/10 ,  A61K38/17

    CPC分类号： A61K38/046 ,  A61K31/165

    摘要： The present invention provides a method of altering the function of TRPV1+ sensory afferent neurons in the pancreas as a way of treating, managing, alleviating, etc., the symptoms and/or underlying causes of diabetes or abnormal glucose metabolism by increasing the release of neuropeptides, such as substance P (sP) or other tachykinin peptide, in the pancreas. This may be achieved by injecting a TRPV1 agonist, such as a capsaicinoid compound or capsaicin analog, or a neuropeptide, such as sP or other tachykinin peptide, directly into the pancreas, or alternatively, by stimulating one or more intercostal and/or subcostal nerves of spinal nerves derived from one or more thoracic segments T8 through T12 by chemical, electrical, surgical, mechanical, etc., methods.

    摘要翻译： 本发明提供了一种通过增加神经肽的释放来改变胰腺中TRPV1 +感觉传入神经元的功能的方法，作为治疗，控制，缓解等症状和/或糖尿病异常或糖代谢异常的原因的方法 ，例如胰岛中的物质P（sP）或其他速激肽肽。 这可以通过将TRPV1激动剂如辣椒素化合物或辣椒素类似物或神经肽如sP或其它速激肽肽直接注射到胰腺中，或者通过刺激一种或多种肋间和/或肋下神经来实现 通过化学，电气，手术，机械等方法从一个或多个胸段T8至T12衍生的脊神经。

    TRPV1+ sensory neurons control of beta-cell stress and islet inflammation in diabetes
    4.
    发明申请
    TRPV1+ sensory neurons control of beta-cell stress and islet inflammation in diabetes 有权
    TRPV1 +感觉神经元控制糖尿病中的β细胞应激和胰岛炎

    公开(公告)号：US20080145386A1

    公开(公告)日：2008-06-19

    申请号：US11638830

    申请日：2006-12-14

    申请人： Hans-Michael Dosch ,  Lan Tang ,  Yin Chan ,  Michael Salter

    发明人： Hans-Michael Dosch ,  Lan Tang ,  Yin Chan ,  Michael Salter

    IPC分类号： A61K38/17 ,  A61K31/00

    CPC分类号： A61K38/046 ,  Y10S514/866

    摘要： A process is disclosed for controlling inflammatory tissue access through release of neuropeptides, such as substance P (sP), to insulin-responsive sensory neurons, whereby simultaneous control of insulin sensitivity/resistance is manifested. In models of Type 1 and Type 2 diabetes, sensory afferents, in particular TRPV1, have fundamental roles in insulin/glucose homeostasis, islet physiology and autoimmune tissue inflammation. By manipulation of the TRPV1 neuro-β-cell circuit or enhancement of pancreatic sP levels, normalization of insulin resistance, clearance of inflammation and prevention of both Type 1 and Type 2 diabetes is realized.

    摘要翻译： 公开了一种通过将神经肽（例如物质P（sP））释放到胰岛素反应性感觉神经元来控制炎症组织进入的方法，由此表现出胰岛素敏感性/抗性的同时控制。 在1型和2型糖尿病模型中，感觉传入特别是TRPV1在胰岛素/葡萄糖体内平衡，胰岛生理和自身免疫组织炎症中具有重要作用。 通过操纵TRPV1神经 - β细胞电路或增强胰腺sP水平，实现胰岛素抵抗的正常化，炎症清除和预防1型和2型糖尿病。

    Lifting and Barrier Mechanism
    7.
    发明申请
    Lifting and Barrier Mechanism 审中-公开
    提升和屏障机制

    公开(公告)号：US20070194674A1

    公开(公告)日：2007-08-23

    申请号：US11677314

    申请日：2007-02-21

    申请人： Michael Salter

    发明人： Michael Salter

    IPC分类号： A47B57/06

    CPC分类号： A47B51/00 ,  A47F3/002

    摘要： A movable support surface supported arms may be moved when a driving mechanism including a motor that drives the arms. Guides guide the arms such that the movable support surface moves between extended and retracted positions. A movable barrier is pivotally attached to a flexible rack using a clip assembly. A motor drives the flexible rack such that the movable barrier moves between open and closed positions. When disposed in a display case, the movable support moves between storage and display positions such that the movable barrier moves between a closed position to protect items in storage and an open position to display items on the movable support. The movable support surface and movable barrier are controlled by a control mechanism that may include limit switches to facilitate automatic control. The control mechanism may be responsive to various outside signals, and a plurality of display cases may be simultaneously controlled.

    摘要翻译： 当包括驱动臂的马达的驱动机构时，可移动的支撑表面支撑的臂可以移动。 引导引导臂，使得可移动的支撑表面在延伸位置和缩回位置之间移动。 可动挡板使用夹子组件可枢转地附接到柔性框架。 电动机驱动柔性机架，使得可动挡板在打开和关闭位置之间移动。 当放置在显示器壳体中时，可移动支撑件在存储和显示位置之间移动，使得可移动屏障在关闭位置之间移动以保护存储中的物品和打开位置以在可移动支撑件上显示物品。 可移动支撑表面和可移动屏障由控制机构控制，该控制机构可以包括限位开关以便于自动控制。 控制机构可以响应于各种外部信号，并且可以同时控制多个显示器壳体。