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    Aldolases, nucleic acids encoding them and methods for making and using them
    1.
    发明申请
    Aldolases, nucleic acids encoding them and methods for making and using them 有权
    醛缩酶，编码它们的核酸和制备和使用它们的方法

    公开(公告)号：US20080020435A1

    公开(公告)日：2008-01-24

    申请号：US11714909

    申请日：2007-03-07

    Applicant: Ellen Burke ,  Steven Gort ,  Paula Hicks ,  Peter Luginbuhl ,  Sara McFarlan ,  Toby Richardson ,  Christopher Solheid ,  David Weiner ,  Lishan Zhao

    Inventor： Ellen Burke ,  Steven Gort ,  Paula Hicks ,  Peter Luginbuhl ,  Sara McFarlan ,  Toby Richardson ,  Christopher Solheid ,  David Weiner ,  Lishan Zhao

    IPC: C12P17/10

    CPC classification number: C12P17/10 ,  C12N9/88 ,  C12P13/001 ,  Y02P20/52

    Abstract: This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S,R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R,R and S,R configurations, and salts thereof.

    Abstract translation: 本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。 在一些实施方案中，本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，包括耐热和耐热活性，以及​​编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和 多肽。 根据本发明的多肽可以用于各种药物，农业和工业环境。 在一些实施方案中，本发明提供了可用于制备R-2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸（R-MP）和莫纳甜的某些立体异构体的多肽和生物合成途径，例如R ，R和S，R莫纳甜及其盐，以及莫纳甜衍生物的某些立体异构体，例如R，R和S，R构型及其盐。

    Aldolases, nucleic acids encoding them and methods for making and using them
    3.
    发明授权
    Aldolases, nucleic acids encoding them and methods for making and using them 有权
    醛缩酶，编码它们的核酸和制备和使用它们的方法

    公开(公告)号：US09005938B2

    公开(公告)日：2015-04-14

    申请号：US13235107

    申请日：2011-09-16

    Applicant: Ellen Burke ,  Steven John Gort ,  Paula M. Hicks ,  Peter Luginbuhl ,  Sara C. McFarlan ,  Toby Richardson ,  Christopher Solheid ,  David Weiner ,  Lishan Zhao

    Inventor： Ellen Burke ,  Steven John Gort ,  Paula M. Hicks ,  Peter Luginbuhl ,  Sara C. McFarlan ,  Toby Richardson ,  Christopher Solheid ,  David Weiner ,  Lishan Zhao

    IPC: C12P17/10 ,  C12P13/22 ,  C12N9/10 ,  C12P21/06 ,  C12P19/34 ,  C07H21/04 ,  C12N9/88 ,  C12P13/00

    CPC classification number: C12P17/10 ,  C12N9/88 ,  C12P13/001 ,  Y02P20/52

    Abstract: This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S,R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R,R and S,R configurations, and salts thereof.

    Abstract translation: 本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。 在一些实施方案中，本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，包括耐热和耐热活性，以及​​编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和 多肽。 根据本发明的多肽可以用于各种药物，农业和工业环境。 在一些实施方案中，本发明提供了可用于制备R-2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸（R-MP）和莫纳甜的某些立体异构体的多肽和生物合成途径，例如R ，R和S，R莫纳甜及其盐，以及莫纳甜衍生物的某些立体异构体，例如R，R和S，R构型及其盐。

    CELLULOLYTIC ENZYMES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM
    5.
    发明申请
    CELLULOLYTIC ENZYMES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 有权
    纤维素酶，编码它们的核酸及其制备和使用它们的方法

    公开(公告)号：US20090220480A1

    公开(公告)日：2009-09-03

    申请号：US12278958

    申请日：2006-12-08

    Applicant: Kevin A. Gray ,  Lishan Zhao ,  Michelle H. Cayouette

    Inventor： Kevin A. Gray ,  Lishan Zhao ,  Michelle H. Cayouette

    IPC: A61K38/47 ,  C07H21/00 ,  C12N15/63 ,  C12N1/21 ,  C12N5/00 ,  C12N1/15 ,  C12N1/19 ,  C12N5/06 ,  C12N5/04 ,  A01K67/027 ,  A01H5/00 ,  C12N9/42 ,  C12N9/26 ,  C07K14/00 ,  C12P21/00 ,  C07H1/00 ,  C07K2/00 ,  C12P19/00 ,  D21H17/22 ,  D21C3/00 ,  C12P7/10 ,  A61P43/00 ,  A23L1/305 ,  A23L2/00 ,  A23L1/28

    CPC classification number: C12N9/2437 ,  C12N9/2402 ,  C12N9/2405 ,  C12N9/248 ,  C12Y302/01004 ,  C12Y302/01006 ,  C12Y302/01008 ,  C12Y302/01021 ,  C12Y302/01023 ,  C12Y302/01039 ,  C12Y302/01055 ,  C12Y302/01091 ,  Y02E50/16 ,  Y02E50/17 ,  Y10T428/249921

    Abstract: The invention provides polypeptides having any cellulolytic activity, e.g., a cellulase activity, a endoglucanase, a cellobiohydrolase, a beta-glucosidase, a xylanase, a mannanse, a β-xylosidase, an arabinofuranosidase, and/or an oligomerase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides having any cellulolytic activity, e.g., a cellulase activity, e.g., endoglucanase, cellobiohydrolase, beta-glucosidase, xylanase, mannanse, β-xylosidase, arabinofuranosidase, and/or oligomerase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. In one aspect, the invention provides polypeptides having an oligomerase activity, e.g., enzymes that convert recalcitrant soluble oligomers to fermentable sugars in the saccharification of biomass. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural, food and feed processing and industrial contexts. The invention also provides compositions or products of manufacture comprising mixtures of enzymes comprising at least one enzyme of this invention.

    Abstract translation: 本发明提供了具有任何纤维素分解活性的多肽，例如纤维素酶活性，内切葡聚糖酶，纤维二糖水解酶，β-葡糖苷酶，木聚糖酶，甘露聚糖酶，β-木糖苷酶，阿拉伯呋喃糖苷酶和/或寡聚酶活性， 多肽，以及制备和使用这些多核苷酸和多肽的方法。 一方面，本发明涉及具有任何纤维素分解活性的多肽，例如纤维素酶活性，例如内切葡聚糖酶，纤维二糖水解酶，β-葡糖苷酶，木聚糖酶，甘露聚糖，β-木糖苷酶，阿拉伯呋喃糖苷酶和/或寡聚酶活性，包括热稳定和 耐热活性和编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。 一方面，本发明提供了具有寡聚酶活性的多肽，例如在生物质糖化中将顽固性可溶性寡聚物转化为可发酵糖的酶。 本发明的多肽可用于各种药物，农业，食品和饲料加工以及工业环境中。 本发明还提供包含本发明的至少一种酶的酶的混合物的组合物或制品。

    Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them
    10.
    发明授权
    Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them 有权
    纤维素分解酶，编码它们的核酸和制备和使用它们的方法

    公开(公告)号：US08101393B2

    公开(公告)日：2012-01-24

    申请号：US12278958

    申请日：2006-12-08

    Applicant: Kevin A. Gray ,  Lishan Zhao ,  Michelle H. Cayouette

    Inventor： Kevin A. Gray ,  Lishan Zhao ,  Michelle H. Cayouette

    IPC: C12N9/42 ,  C12N15/00 ,  C12P7/10 ,  C12P21/06 ,  C07H21/04 ,  C07H5/06 ,  C07K1/00 ,  A61K38/47 ,  A23L2/00 ,  A23L1/202 ,  A23L1/30

    CPC classification number: C12N9/2437 ,  C12N9/2402 ,  C12N9/2405 ,  C12N9/248 ,  C12Y302/01004 ,  C12Y302/01006 ,  C12Y302/01008 ,  C12Y302/01021 ,  C12Y302/01023 ,  C12Y302/01039 ,  C12Y302/01055 ,  C12Y302/01091 ,  Y02E50/16 ,  Y02E50/17 ,  Y10T428/249921

    Abstract: The invention provides polypeptides having any cellulolytic activity, e.g., a cellulase activity, a endoglucanase, a cellobiohydrolase, a beta-glucosidase, a xylanase, a mannanse, a β-xylosidase, an arabinofuranosidase, and/or an oligomerase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides having any cellulolytic activity, e.g., a cellulase activity, e.g., endoglucanase, cellobiohydrolase, beta-glucosidase, xylanase, mannanse, β-xylosidase, arabinofuranosidase, and/or oligomerase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. In one aspect, the invention provides polypeptides having an oligomerase activity, e.g., enzymes that convert recalcitrant soluble oligomers to fermentable sugars in the saccharification of biomass. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural, food and feed processing and industrial contexts. The invention also provides compositions or products of manufacture comprising mixtures of enzymes comprising at least one enzyme of this invention.

    Abstract translation: 本发明提供了具有任何纤维素分解活性的多肽，例如纤维素酶活性，内切葡聚糖酶，纤维二糖水解酶，β-葡糖苷酶，木聚糖酶，甘露聚糖酶，β-半乳糖苷酶，阿拉伯呋喃糖苷酶和/或寡聚酶活性，编码 这些多肽，以及制备和使用这些多核苷酸和多肽的方法。 在一个方面，本发明涉及具有任何纤维素分解活性的多肽，例如纤维素酶活性，例如内切葡聚糖酶，纤维二糖水解酶，β-葡糖苷酶，木聚糖酶，甘露聚糖，β-木糖苷酶，阿拉伯呋喃糖苷酶和/或寡聚酶活性，包括热稳定性 和耐热活性，以及​​编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。 一方面，本发明提供了具有寡聚酶活性的多肽，例如在生物质糖化中将顽固性可溶性寡聚物转化为可发酵糖的酶。 本发明的多肽可用于各种药物，农业，食品和饲料加工以及工业环境中。 本发明还提供包含本发明的至少一种酶的酶的混合物的组合物或制品。

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