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公开(公告)号：US09586931B2
公开(公告)日：2017-03-07
申请号：US14431895
申请日：2013-09-24
Applicant: Michelle R. Machacek , Eric T. Romeo , Solomon D. Kattar , Matthew Christopher , Michael D. Altman , Alan B. Northrup , John Michael Ellis , Brendan O'Boyle , Anthony Donofrio , Jonathan Grimm , Michael H. Reutershan , Kaleen Konrad Childers , Ryan D. Otte , Brandon Cash , Yves Ducharme , Andrew M. Haidle , Kerrie Spencer , Dilrukshi Vitharana , Lingyun Wu , Li Zhang , Peng Zhang , Christian Beaulieu , Daniel Guay
Inventor： Michelle R. Machacek , Eric T. Romeo , Solomon D. Kattar , Matthew Christopher , Michael D. Altman , Alan B. Northrup , John Michael Ellis , Brendan O'Boyle , Anthony Donofrio , Jonathan Grimm , Michael H. Reutershan , Kaleen Konrad Childers , Ryan D. Otte , Brandon Cash , Yves Ducharme , Andrew M. Haidle , Kerrie Spencer , Dilrukshi Vitharana , Lingyun Wu , Li Zhang , Peng Zhang , Christian Beaulieu , Daniel Guay
IPC: A61K9/10 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D498/04 , C07D413/14 , C07D239/42 , A61K9/00 , A61K9/20 , A61K9/48 , C07D403/12 , C07D405/12 , C07D409/12 , C07D471/04
CPC classification number: C07D401/14 , A61K9/0019 , A61K9/0073 , A61K9/0075 , A61K9/10 , A61K9/2027 , A61K9/4858 , C07D239/42 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D498/04
Abstract: Provided are triazole derivatives of Formula I which are potent inhibitors of spleen tyrosine kinase and pharmaceutical composition. The triazole derivatives are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.
Abstract translation: 提供式I的三唑衍生物，其是脾脏酪氨酸激酶和药物组合物的有效抑制剂。 三唑衍生物可用于治疗和预防由所述酶介导的疾病，例如哮喘，COPD，类风湿性关节炎和癌症。
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公开(公告)号：US20150239866A1
公开(公告)日：2015-08-27
申请号：US14431895
申请日：2013-09-24
Applicant: Michelle R. MACHACEK , Eric T. ROMEO , Solomon D. KATTAR , Matthew CHRISTOPHER , Michael D. ALTMAN , Alan B. NORTHRUP , John Michael ELLIS , Brendan O BOYLE , Anthony DONOFRIO , Jonathan GRIMM , Michael H. REUTERSHAN , Kaleen Konrad CHILDERS , Ryan D. OTTE , Brandon CASH , Yves DUCHARME , Andrew M. HAIDLE , Kerrie SPENCER , Dilrukshi VITHARANA , Lingyun WU , Li ZHANG , Peng ZHANG , Christian BEAULIEU , Daniel GUAY
Inventor： Michelle R. Machacek , Eric T. Romeo , Solomon D. Kattar , Matthew Christopher , Michael D. Altman , Alan B. Northrup , John Michael Ellis , Brendan O'Boyle , Anthony Donofrio , Jonathan Grimm , Michael H. Reutershan , Kaleen Konrad Childers , Ryan D. Otte , Brandon Cash , Yves Ducharme , Andrew M. Haidle , Kerrie Spencer , Dilrukshi Vitharana , Lingyun Wu , Li Zhang , Peng Zhang , Christian Beaulieu , Daniel Guay
IPC: C07D401/14 , C07D471/04 , C07D405/14 , C07D413/14 , C07D498/04 , C07D409/14 , C07D417/14
CPC classification number: C07D401/14 , A61K9/0019 , A61K9/0073 , A61K9/0075 , A61K9/10 , A61K9/2027 , A61K9/4858 , C07D239/42 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D498/04
Abstract: Provided are triazole derivatives of Formula I which are potent inhibitors of spleen tyrosine kinase and pharmaceutical composition. The triazole derivatives are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.
Abstract translation: 提供式I的三唑衍生物，其是脾脏酪氨酸激酶和药物组合物的有效抑制剂。 三唑衍生物可用于治疗和预防由所述酶介导的疾病，例如哮喘，COPD，类风湿性关节炎和癌症。
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公开(公告)号：US09145391B2
公开(公告)日：2015-09-29
申请号：US14116199
申请日：2012-05-04
Applicant: Denis Deschenes , Michael D. Altman , John Michael Ellis , Christian Fischer , Andrew M. Haidle , Solomon D. Kattar , Alan B. Northrup , Adam J. Schell , Graham F. Smith , Brandon M. Taoka , Corey Bienstock , Maria Emilia Di Francesco , Anthony Donofrio , Scott Peterson , Kerrie B. Spencer , James Patrick Jewell , Amjad Ali , David Jonathan Bennett , Qun Dang , John Wai
Inventor： Denis Deschenes , Michael D. Altman , John Michael Ellis , Christian Fischer , Andrew M. Haidle , Solomon D. Kattar , Alan B. Northrup , Adam J. Schell , Graham F. Smith , Brandon M. Taoka , Corey Bienstock , Maria Emilia Di Francesco , Anthony Donofrio , Scott Peterson , Kerrie B. Spencer , James Patrick Jewell , Amjad Ali , David Jonathan Bennett , Qun Dang , John Wai
IPC: C07D213/73 , C07D401/14 , C07D401/12 , C07D409/14 , C07D417/14 , C07D471/04
CPC classification number: C07D401/14 , C07D401/12 , C07D409/14 , C07D417/14 , C07D471/04
Abstract: The present invention provides novel pyrimidine amines of formula I which are potent inhibitors of spleen tyrosine kinase, or are prodrugs thereof, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis and cancer.
Abstract translation: 本发明提供了式I的新型嘧啶胺，其是脾脏酪氨酸激酶的有效抑制剂，或其前药，并且可用于治疗和预防由所述酶介导的疾病，例如哮喘，COPD和类风湿性关节炎和癌症。
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公开(公告)号：US09120785B2
公开(公告)日：2015-09-01
申请号：US14116205
申请日：2012-05-04
Applicant: Michael D. Altman , Maria Emilia Di Francesco , Andrew M. Haidle , Ryan D. Otte , John Michael Ellis , Kaleen Konrad Childers , Alan B. Northrup , Liping Wang
Inventor： Michael D. Altman , Maria Emilia Di Francesco , Andrew M. Haidle , Ryan D. Otte , John Michael Ellis , Kaleen Konrad Childers , Alan B. Northrup , Liping Wang
IPC: C07D417/14 , A61P37/00 , A61K31/444
CPC classification number: C07D417/14
Abstract: The present invention provides novel pyrimidine amines of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.
Abstract translation: 本发明提供了式I的新型嘧啶胺，其是脾脏酪氨酸激酶的有效抑制剂，并且可用于治疗和预防由所述酶介导的疾病，例如哮喘，COPD，类风湿性关节炎和癌症。
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5.发明申请PROCESS FOR SPRAYING NATAMYCIN ONTO BAKERY PRODUCTS AND USE OF HEAT FOR THE REMOVAL OF SOLVENT FROM BAKED PRODUCTS 审中-公开将苯甲酸喷雾成饼干产品的过程和使用热处理从产品中除去溶剂公开(公告)号：US20110052769A1
公开(公告)日：2011-03-03
申请号：US12530163
申请日：2008-03-10
Applicant: Peter Wisler , Tania Serovski , John Michael Ellis
Inventor： Peter Wisler , Tania Serovski , John Michael Ellis
CPC classification number: A21D15/08 , A23L3/34635
Abstract: The present invention provides a process for increasing the shelf life of bakery products, comprising baking a shaped dough in an oven; placing the shaped baked product on a bed, spraying a solution or suspension of natamycin in a solvent onto the surfaces of said shaped baked product, said spray being provided from sprayers located in at least two directions so as to deposit natamycin in an amount from 0.5 to 10 μg per cm2 of surface area, and removing sprayed natamycin solvent from said surfaces. According to an embodiment of the invention, the solvent is removed by means selected from heat, blowing, micro waves and any combination thereof. The present invention further relates to the use of the heat in a hot baked bakery product for the removal of natamycin solvent sprayed onto the surfaces of said bakery product.
Abstract translation: 本发明提供了一种提高焙烤产品的保存期限的方法，包括在烘箱中烘烤成形的面团; 将成形的烘烤产品放置在床上，将游霉素的溶液或悬浮液在溶剂中喷洒到所述成型的烘烤产品的表面上，所述喷雾由位于至少两个方向的喷雾器提供，以将游霉素的含量从0.5 至10μg/ cm 2表面积，并从所述表面除去喷洒的那他霉素溶剂。 根据本发明的一个实施方案，通过选择热，吹，微波及其任何组合的方式除去溶剂。 本发明还涉及在热烘焙焙烤产品中用于去除喷洒在所述焙烤产品表面上的那他霉素溶剂的用途。
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Patent Agency Ranking
公开(公告)号：US09290490B2
公开(公告)日：2016-03-22
申请号：US14116207
申请日：2012-05-04
Applicant: Michael D. Altman , Kaleen Konrad Childers , Maria Emilia Di Francesco , John Michael Ellis , Christian Fischer , Jonathan Grimm , Andrew M. Haidle , Solomon D. Kattar , Alan B. Northrup , Ryan D. Otte , Alessia Petrocchi , Adam J. Schell , Hua Zhou
Inventor： Michael D. Altman , Kaleen Konrad Childers , Maria Emilia Di Francesco , John Michael Ellis , Christian Fischer , Jonathan Grimm , Andrew M. Haidle , Solomon D. Kattar , Alan B. Northrup , Ryan D. Otte , Alessia Petrocchi , Adam J. Schell , Hua Zhou
IPC: C07D401/12 , A61K31/506 , C07D487/04 , C07D401/14 , C07D417/12 , C07D417/14
CPC classification number: C07D417/12 , C07D417/14
Abstract: The present invention provides novel pyrimidine amines of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis and cancer.
Abstract translation: 本发明提供了式I的新型嘧啶胺，其是脾脏酪氨酸激酶的有效抑制剂，并且可用于治疗和预防由所述酶介导的疾病，例如哮喘，COPD，类风湿性关节炎和癌症。
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公开(公告)号：US20140249130A1
公开(公告)日：2014-09-04
申请号：US14116199
申请日：2012-05-04
Applicant: Denis Deschenes , Michael D. Altman , John Michael Ellis , Christian Fischer , Andrew M. Haidle , Solomon D. Kattar , Alan B. Northrup , Adam J. Schell , Graham F. Smith , Brandon M. Taoka , Corey Bienstock , Maria Emilia Di Francesco , Anthony Donofrio , Scott Peterson , Kerrie B. Spencer , James Patrick Jewell , Amjad Ali , David Jonathan Bennett , Qun Dang , John Wai
Inventor： Denis Deschenes , Michael D. Altman , John Michael Ellis , Christian Fischer , Andrew M. Haidle , Solomon D. Kattar , Alan B. Northrup , Adam J. Schell , Graham F. Smith , Brandon M. Taoka , Corey Bienstock , Maria Emilia Di Francesco , Anthony Donofrio , Scott Peterson , Kerrie B. Spencer , James Patrick Jewell , Amjad Ali , David Jonathan Bennett , Qun Dang , John Wai
IPC: C07D401/14
CPC classification number: C07D401/14 , C07D401/12 , C07D409/14 , C07D417/14 , C07D471/04
Abstract: The present invention provides novel pyrimidine amines of formula I which are potent inhibitors of spleen tyrosine kinase, or are prodrugs thereof, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis and cancer.
Abstract translation: 本发明提供了式I的新型嘧啶胺，其是脾脏酪氨酸激酶的有效抑制剂，或其前药，并且可用于治疗和预防由所述酶介导的疾病，例如哮喘，COPD和类风湿性关节炎和癌症。
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公开(公告)号：US20140243290A1
公开(公告)日：2014-08-28
申请号：US14255480
申请日：2014-04-17
Applicant: Michael D. Altman , Brian M. Andresen , Kenneth L. Arrington , Sathesh Bhat , Jason Burch , Kaleen Konrad Childers , Bernard Cote , Maria Emilia Di Francesco , Anthony Donofrio , Kristina Dupont-Gaudet , John Michael Ellis , Christian Fischer , Jean-Francois Fournier , Jacques Yves Gauthier , Jonathan Grimm , Daniel Guay , David Joseph Guerin , Andrew M. Haidle , Solomon D. Kattar , Sandra Lee Knowles , Chaomin Li , Jongwon Lim , Michelle R. Machacek , Matthew L. Maddess , Alan B. Northrup , Brendan M. O'Boyle , Ryan D. Otte , Alessia Petrocchi , Michael H. Reutershan , Joel S. Robichaud , Eric T. Romeo , Adam J. Schell , Tony Siu , Kerrie B. Spencer , Brandon M. Taoka , B. Wesley Trotter , Hyun Chong Woo , Hua Zhou
Inventor： Michael D. Altman , Brian M. Andresen , Kenneth L. Arrington , Sathesh Bhat , Jason Burch , Kaleen Konrad Childers , Bernard Cote , Maria Emilia Di Francesco , Anthony Donofrio , Kristina Dupont-Gaudet , John Michael Ellis , Christian Fischer , Jean-Francois Fournier , Jacques Yves Gauthier , Jonathan Grimm , Daniel Guay , David Joseph Guerin , Andrew M. Haidle , Solomon D. Kattar , Sandra Lee Knowles , Chaomin Li , Jongwon Lim , Michelle R. Machacek , Matthew L. Maddess , Alan B. Northrup , Brendan M. O'Boyle , Ryan D. Otte , Alessia Petrocchi , Michael H. Reutershan , Joel S. Robichaud , Eric T. Romeo , Adam J. Schell , Tony Siu , Kerrie B. Spencer , Brandon M. Taoka , B. Wesley Trotter , Hyun Chong Woo , Hua Zhou
IPC: C07D417/12 , C07D495/04 , C07D451/06 , C07F9/6558 , C07D471/08 , C07D487/04 , C07D471/04 , C07D417/14 , C07D491/08
CPC classification number: C07D417/12 , C07D417/14 , C07D451/06 , C07D471/04 , C07D471/08 , C07D487/04 , C07D491/08 , C07D495/04 , C07F9/65583
Abstract: The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.
Abstract translation: 本发明提供了新颖的式（I）嘧啶胺，其是脾脏酪氨酸激酶的有效抑制剂，并且可用于治疗和预防由所述酶介导的疾病，例如哮喘，COPD和类风湿性关节炎。
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公开(公告)号：US20140148474A1
公开(公告)日：2014-05-29
申请号：US14116207
申请日：2012-05-04
Applicant: Michael D. Altman , Kaleen Konrad Childers , Maria Emilia Di Francesco , John Michael Ellis , Christian Fischer , Jonathan Grimm , Andrew M. Haidle , Solomon D. Kattar , Alan B. Northrup , Ryan D. Otte , Alessia Petrocchi , Adam J. Schell , Hua Zhou
Inventor： Michael D. Altman , Kaleen Konrad Childers , Maria Emilia Di Francesco , John Michael Ellis , Christian Fischer , Jonathan Grimm , Andrew M. Haidle , Solomon D. Kattar , Alan B. Northrup , Ryan D. Otte , Alessia Petrocchi , Adam J. Schell , Hua Zhou
IPC: C07D417/12 , C07D417/14
CPC classification number: C07D417/12 , C07D417/14
Abstract: The present invention provides novel pyrimidine amines of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis and cancer.
Abstract translation: 本发明提供了式I的新型嘧啶胺，其是脾脏酪氨酸激酶的有效抑制剂，并且可用于治疗和预防由所述酶介导的疾病，例如哮喘，COPD，类风湿性关节炎和癌症。
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公开(公告)号：US20120277192A1
公开(公告)日：2012-11-01
申请号：US13516455
申请日：2010-12-15
Applicant: Michael D. Altman , Brian M. Andresen , Kenneth L. Arrington , Sathesh Bhat , Jason Burch , Kaleen Konrad Childers , Bernard Cote , Maria Emilia Di Francesco , Anthony Donofrio , Kristina Dupont-Gaudet , John Michael Ellis , Christian Fischer , Jean-Francois Fournier , Jacques Yves Gauthier , Jonathan Grimm , Daniel Guay , David Joseph Guerin , Andrew M. Haidle , Solomon Kattar , Sandra Lee Knowles , Chaomin Li , Jongwon Lim , Michelle R. Machacek , Matthew L. Maddess , Alan B. Northrup , Brendan M. O'Boyle , Ryan D. Otte , Alessia Petrocchi , Michael H. Reutershan , Joel S. Robichaud , Eric Romeo , Adam J. Schell , Tony Siu , Kerrie B. Spencer , Brandon M. Taoka , B. Wesley Trotter , Hyun Chong Woo , Hua Zhou
Inventor： Michael D. Altman , Brian M. Andresen , Kenneth L. Arrington , Sathesh Bhat , Jason Burch , Kaleen Konrad Childers , Bernard Cote , Maria Emilia Di Francesco , Anthony Donofrio , Kristina Dupont-Gaudet , John Michael Ellis , Christian Fischer , Jean-Francois Fournier , Jacques Yves Gauthier , Jonathan Grimm , Daniel Guay , David Joseph Guerin , Andrew M. Haidle , Solomon Kattar , Sandra Lee Knowles , Chaomin Li , Jongwon Lim , Michelle R. Machacek , Matthew L. Maddess , Alan B. Northrup , Brendan M. O'Boyle , Ryan D. Otte , Alessia Petrocchi , Michael H. Reutershan , Joel S. Robichaud , Eric Romeo , Adam J. Schell , Tony Siu , Kerrie B. Spencer , Brandon M. Taoka , B. Wesley Trotter , Hyun Chong Woo , Hua Zhou
IPC: A61K31/506 , A61K31/55 , A61K31/554 , A61K31/551 , A61P35/00 , C07D417/14 , C07F9/6539 , C07D417/12 , A61P19/02 , A61P11/06 , A61K31/675 , A61K31/5377
CPC classification number: C07D417/12 , C07D417/14 , C07D451/06 , C07D471/04 , C07D471/08 , C07D487/04 , C07D491/08 , C07D495/04 , C07F9/65583
Abstract: The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.
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