Non-nucleoside reverse transcriptase inhibitors
    9.
    发明授权
    Non-nucleoside reverse transcriptase inhibitors 有权
    非核苷逆转录酶抑制剂

    公开(公告)号:US08486975B2

    公开(公告)日:2013-07-16

    申请号:US13073631

    申请日:2011-03-28

    IPC分类号: A61K31/4439 C07D401/06

    摘要: Heteroaromatic compounds of Formula I: are HIV reverse transcriptase inhibitors, wherein R1, R2, R3, R4 and R5 are defined herein. The compounds of Formula I and their pharmaceutically acceptable salts are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

    摘要翻译: 式I的杂芳族化合物是HIV逆转录酶抑制剂,其中R 1,R 2,R 3,R 4和R 5在本文中定义。 式I化合物及其药学上可接受的盐可用于抑制HIV逆转录酶,预防和治疗HIV感染以及预防,延缓发病或进展以及AIDS治疗。 化合物及其盐可以用作药物组合物中的成分,任选与其它抗病毒剂,免疫调节剂,抗生素或疫苗组合使用。