公开(公告)号：US20060040981A1

公开(公告)日：2006-02-23

申请号：US10536250

申请日：2003-11-19

Applicant: Daniel Dube ,  Michel Gallant ,  Patrick Lacombe ,  Yves Girard ,  Dwight Macdonald ,  Richard Friesen ,  Yves Ducharme ,  Bernard Cote ,  Marc Blouin ,  Evelyn Martins ,  Daniel Guay ,  Pierre Hamel ,  Mario Girard ,  Richard Frenette ,  Sebastien Laliberte ,  Annette Robichaud ,  Anthony Mastracchio ,  Helene Perrier

Inventor： Daniel Dube ,  Michel Gallant ,  Patrick Lacombe ,  Yves Girard ,  Dwight Macdonald ,  Richard Friesen ,  Yves Ducharme ,  Bernard Cote ,  Marc Blouin ,  Evelyn Martins ,  Daniel Guay ,  Pierre Hamel ,  Mario Girard ,  Richard Frenette ,  Sebastien Laliberte ,  Annette Robichaud ,  Anthony Mastracchio ,  Helene Perrier

IPC: A61K31/4709 ,  A61K31/47

CPC classification number: A61K31/4709 ,  A61K31/277 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/47

Abstract: The present invention is directed to a method of enhancing cognition in a healthy subject comprising administering a safe cognition enhancing amount of a phosphodiesterase-4 inhibitor. In particular, this invention is directed to a method of enhancing memory, learning, retention, recall, awareness and judgement in health subjects comprising administering a safe and effective amount of a phosphodiesterase-4 inhibitor.

Abstract translation: 本发明涉及增强健康受试者的认知的方法，其包括施用安全认知增加量的磷酸二酯酶-4抑制剂。 特别地，本发明涉及增加健康受试者的记忆，学习，保留，召回，意识和判断的方法，包括施用安全有效量的磷酸二酯酶-4抑制剂。

公开(公告)号：US20050140544A1

公开(公告)日：2005-06-30

申请号：US10858211

申请日：2004-06-02

Applicant: Pierre Hamel ,  Manon Gaudet ,  Daniel Chabot ,  Marc Laframboise

Inventor： Pierre Hamel ,  Manon Gaudet ,  Daniel Chabot ,  Marc Laframboise

IPC: A61H3/06 ,  G01C21/20 ,  G01S5/14 ,  G01S19/14 ,  G01S19/34 ,  G01C21/26

CPC classification number: G01S19/47 ,  A61H3/061 ,  A61H3/068 ,  A61H2003/063 ,  A61H2003/065 ,  G01C21/20 ,  G01C21/206 ,  G01S19/14

Abstract: This invention relates to a system for orienting and guiding visually impaired pedestrians. The system combines a Global Positioning System (GPS) receiver to a dead reckoning unit that compensates for GPS imprecision and loss of signal. The system is highly portable: it is based on a handheld portable computing platform that communicates wirelessly with a self-powered strap containing the GPS receiver and the dead reckoning unit. The system also uses wireless protocols to receive additional orientation information from a remote location server or operator accessible through the internet. Additionally, a positioning algorithm for mapping the user near a street intersection is provided.

Abstract translation: 本发明涉及一种用于定向和引导视觉障碍的行人的系统。 该系统将全球定位系统（GPS）接收机与推算GPS不精确和信号丢失的航位推算单元相结合。 该系统是高度便携式的：它是基于手持式便携式计算平台，其与包含GPS接收器和推算单元的自供电带无线通信。 该系统还使用无线协议从远程位置服务器或可通过互联网访问的操作员接收额外的方向信息。 另外，提供了一种用于在街道交叉口附近映射用户的定位算法。

公开(公告)号：US06841564B2

公开(公告)日：2005-01-11

申请号：US10102552

申请日：2002-03-20

Applicant: Richard Freisen ,  Yves Ducharme ,  Bernard Cote ,  Marc Blouin ,  Evelyn Martins ,  Daniel Guay ,  Pierre Hamel ,  Mario Girard ,  Richard Frenette ,  Sebastien Laliberte

Inventor： Richard Freisen ,  Yves Ducharme ,  Bernard Cote ,  Marc Blouin ,  Evelyn Martins ,  Daniel Guay ,  Pierre Hamel ,  Mario Girard ,  Richard Frenette ,  Sebastien Laliberte

IPC: C07D417/04 ,  A61K31/4439 ,  A61K31/444 ,  A61K45/00 ,  A61P1/00 ,  A61P1/04 ,  A61P3/10 ,  A61P3/12 ,  A61P7/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/02 ,  A61P11/06 ,  A61P11/08 ,  A61P11/14 ,  A61P13/02 ,  A61P13/12 ,  A61P17/00 ,  A61P17/02 ,  A61P17/04 ,  A61P17/06 ,  A61P19/02 ,  A61P19/08 ,  A61P19/10 ,  A61P21/00 ,  A61P25/04 ,  A61P25/24 ,  A61P25/28 ,  A61P27/14 ,  A61P29/00 ,  A61P29/02 ,  A61P31/04 ,  A61P35/00 ,  A61P37/00 ,  A61P37/02 ,  A61P37/08 ,  A61P39/02 ,  A61P43/00 ,  C07D417/06 ,  C07D417/14 ,  A61K31/44

CPC classification number: C07D417/06

Abstract: Novel ethanes substituted with i) a phenyl, ii) a thiazole, and iii) a pyridyl moiety are PDE4 inhibitors.

Abstract translation: 用I）苯基取代的新型乙烷，ii）噻唑，和iii）吡啶基部分是PDE4抑制剂。

公开(公告)号：US06180650B2

公开(公告)日：2001-01-30

申请号：US09525600

申请日：2000-03-14

Applicant: Richard Frenette ,  Richard Friesen ,  Mario Girard ,  Yves Girard ,  Cedrickx Godbout ,  Daaniel Guay ,  Pierre Hamel ,  Helene Perrier

Inventor： Richard Frenette ,  Richard Friesen ,  Mario Girard ,  Yves Girard ,  Cedrickx Godbout ,  Daaniel Guay ,  Pierre Hamel ,  Helene Perrier

IPC: C07D40102

CPC classification number: C07D213/64 ,  C07D213/76 ,  C07D213/79 ,  C07D213/89 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14

Abstract: The invention encompasses the novel compound of Formula I useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3′,5′-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE 4). The invention also encompasses pharmaceutical compositions and methods for treatment.

Abstract translation: 本发明包括通过抑制磷酸二酯酶IV（PDE 4）提高环腺苷-3'，5'-单磷酸（cAMP）的水平，可用于治疗包括哮喘在内的疾病的新颖化合物。本发明 还包括用于治疗的药物组合物和方法。

公开(公告)号：US5093356A

公开(公告)日：1992-03-03

申请号：US465295

申请日：1990-01-16

Applicant: Yves Girard ,  Pierre Hamel ,  Daniel Delorme

Inventor： Yves Girard ,  Pierre Hamel ,  Daniel Delorme

IPC: C07C275/64 ,  C07C317/42 ,  C07C323/44 ,  C07C323/47 ,  C07C323/62 ,  C07D307/52 ,  C07D333/20

CPC classification number: C07C323/62 ,  C07C275/64 ,  C07C317/42 ,  C07C323/44 ,  C07C323/47 ,  C07D307/52 ,  C07D333/20

Abstract: Compounds having the formula I: ##STR1## are inhibitors of the 5-lipoxygenase enzyme. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.

Abstract translation: 具有式I的化合物：I是5-脂氧合酶的抑制剂。 这些化合物可用作抗哮喘，抗过敏，抗炎和细胞保护剂。 它们也可用于治疗腹泻，高血压，心绞痛，血小板聚集，脑痉挛，早产，自然流产，痛经和偏头痛。

公开(公告)号：US20130025250A1

公开(公告)日：2013-01-31

申请号：US13555599

申请日：2012-07-23

Applicant: Pierre HAMEL ,  Yannick CHAMPAGNE ,  Louis LAMONTAGNE

Inventor： Pierre HAMEL ,  Yannick CHAMPAGNE ,  Louis LAMONTAGNE

IPC: A01D34/66

CPC classification number: A01D34/667

Abstract: The present relates to a front mount rotary cutter. The present front mount rotary cutter comprises a shell, a drive coupler affixed to the shell, and a plurality of rotary blades hingedly mounted to the shell. The plurality of rotary blades is driven by the drive coupler. The present front mount rotary cutter also comprises a plurality of discharge chutes. The plurality of discharge chutes protects a vehicle and/or the drive coupler from dust and debris generated upon operation of the plurality of rotary blades.

Abstract translation: 本发明涉及一种前端旋转切割机。 本发明的前安装旋转切割机包括外壳，固定在外壳上的驱动联接器和铰接地安装在外壳上的多个旋转刀片。 多个旋转叶片由驱动联接器驱动。 本前置旋转切割机还包括多个排放滑槽。 多个排放滑槽保护车辆和/或驱动联接器免受多个旋转叶片操作时产生的灰尘和碎屑的影响。

公开(公告)号：US20090255050A1

公开(公告)日：2009-10-15

申请号：US12421062

申请日：2009-04-09

Applicant: Nicolas LEBRUN ,  David SAUVAGEAU ,  Paul ISABELLE ,  Patrice GENOIS ,  Pierre HAMEL

Inventor： Nicolas LEBRUN ,  David SAUVAGEAU ,  Paul ISABELLE ,  Patrice GENOIS ,  Pierre HAMEL

IPC: A47K3/02

CPC classification number: A47K3/161

Abstract: The present invention relates generally to structures for enclosing bathing fixtures, such as bathtubs, whirlpools and showers. More particularly, it relates to an apron assembly comprising a frame member and an access panel that are held together through magnetic means.

Abstract translation: 本发明一般涉及用于封闭洗浴装置的结构，诸如浴缸，旋涡和淋浴。 更具体地，本发明涉及一种围裙组件，其包括框架构件和通过磁性装置保持在一起的检修面板。

公开(公告)号：US07432912B2

公开(公告)日：2008-10-07

申请号：US11080661

申请日：2005-03-16

Applicant: Derek Côté ,  Gilles Pepin ,  Lucia Gomez ,  Richard Nadeau ,  Luc Blanchette ,  Maryse Legault ,  Jacques Desmarais ,  Pierre Émond ,  Alain Bélanger ,  Danny Thibaudeau ,  Dany Desbiens ,  Dominic Labbé ,  Ivan Lagacé ,  Pierre Hamel

Inventor： Derek Côté ,  Gilles Pepin ,  Lucia Gomez ,  Richard Nadeau ,  Luc Blanchette ,  Maryse Legault ,  Jacques Desmarais ,  Pierre Émond ,  Alain Bélanger ,  Danny Thibaudeau ,  Dany Desbiens ,  Dominic Labbé ,  Ivan Lagacé ,  Pierre Hamel

IPC: G09G5/00

CPC classification number: G06F3/0219 ,  G06F1/1626 ,  G06F1/1662 ,  G06F3/0224 ,  G06F3/0238 ,  G09B21/003

Abstract: The adaptation of a regular pocket size computer for use by a visually impaired person is provided. A framework is firstly provided for building adapted applications, having adapted input and output services, a system resources library including tools for interacting with these adapted services and an adaptation library. A tactile keyboard is further provided to allow data entry through the screen interface of the computer. The tactile keyboard includes a membrane having raised keys on one side and corresponding screen activating tips on the other. Means for mounting the keyboard above the computer with the screen activating tips positioned in contact less alignment with the corresponding selected areas of the screen interface are also provided.

Abstract translation: 提供了适合视障者使用的普通口袋大小的计算机。 首先提供框架，用于构建适应的应用程序，具有适应的输入和输出服务，系统资源库，包括与这些适应的服务交互的工具和适应库。 进一步提供触觉键盘以允许数据通过计算机的屏幕界面输入。 触觉键盘包括在一侧具有升高的键和在另一侧具有相应的屏幕激活尖端的膜。 还提供了用于将键盘安装在计算机上方的装置，其中屏幕启动尖端定位成与屏幕界面的对应的选定区域较少对准。

公开(公告)号：US06399636B2

公开(公告)日：2002-06-04

申请号：US09810119

申请日：2001-03-16

Applicant: Richard Freisen ,  Yves Ducharme ,  Bernard Cote ,  Marc Blouin ,  Evelyn Martins ,  Daniel Guay ,  Pierre Hamel ,  Mario Girard ,  Richard Frenette ,  Sebastien Laliberte

Inventor： Richard Freisen ,  Yves Ducharme ,  Bernard Cote ,  Marc Blouin ,  Evelyn Martins ,  Daniel Guay ,  Pierre Hamel ,  Mario Girard ,  Richard Frenette ,  Sebastien Laliberte

IPC: A61K314439

CPC classification number: C07D417/06

Abstract: Novel ethanes substituted with i) a phenyl, ii) a thiazole, and iii) a pyridyl moiety are PDE4 inhibitors.

公开(公告)号：US5710170A

公开(公告)日：1998-01-20

申请号：US763566

申请日：1996-12-10

Applicant: Daniel Guay ,  Yves Girard ,  Yves Ducharme ,  Marc Blouin ,  Pierre Hamel ,  Mario Girard

Inventor： Daniel Guay ,  Yves Girard ,  Yves Ducharme ,  Marc Blouin ,  Pierre Hamel ,  Mario Girard

IPC: C07D213/30 ,  C07D213/34 ,  C07D213/89 ,  A61K31/415 ,  A61K31/44 ,  C07D233/64

CPC classification number: C07D213/30 ,  C07D213/34 ,  C07D213/89

Abstract: The invention encompasses the novel compound of Formula I useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE IV). ##STR1## The invention also encompasses certain pharmaceutical compositions and methods for treatment of diseases by inhibition of PDE IV, resulting in an elevation of cAMP, comprising the use of compounds of Formula I.

Abstract translation: 本发明包括通过抑制磷酸二酯酶IV（PDE IV）提高环腺苷-3'，5'-单磷酸（cAMP）的水平，可用于治疗包括哮喘在内的疾病的新型式I化合物。 本发明还包括通过抑制PDE IV治疗疾病的某些药物组合物和方法，导致cAMP升高，包括使用式I化合物。