Invention Grant
- Patent Title: Aminopyrimidines as Syk inhibitors
- Patent Title (中): 氨基嘧啶作为Syk抑制剂
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Application No.: US14116207Application Date: 2012-05-04
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Publication No.: US09290490B2Publication Date: 2016-03-22
- Inventor: Michael D. Altman , Kaleen Konrad Childers , Maria Emilia Di Francesco , John Michael Ellis , Christian Fischer , Jonathan Grimm , Andrew M. Haidle , Solomon D. Kattar , Alan B. Northrup , Ryan D. Otte , Alessia Petrocchi , Adam J. Schell , Hua Zhou
- Applicant: Michael D. Altman , Kaleen Konrad Childers , Maria Emilia Di Francesco , John Michael Ellis , Christian Fischer , Jonathan Grimm , Andrew M. Haidle , Solomon D. Kattar , Alan B. Northrup , Ryan D. Otte , Alessia Petrocchi , Adam J. Schell , Hua Zhou
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Eric A. Meade; Catherine D. Fitch
- International Application: PCT/US2012/036423 WO 20120504
- International Announcement: WO2012/154519 WO 20121115
- Main IPC: C07D401/12
- IPC: C07D401/12 ; A61K31/506 ; C07D487/04 ; C07D401/14 ; C07D417/12 ; C07D417/14
Abstract:
The present invention provides novel pyrimidine amines of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis and cancer.
Public/Granted literature
- US20140148474A1 AMINOPYRIMIDINES AS SYK INHIBITORS Public/Granted day:2014-05-29
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