Invention Grant
- Patent Title: Triazolyl derivatives as Syk inhibitors
- Patent Title (中): 三唑基衍生物作为Syk抑制剂
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Application No.: US14431895Application Date: 2013-09-24
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Publication No.: US09586931B2Publication Date: 2017-03-07
- Inventor: Michelle R. Machacek , Eric T. Romeo , Solomon D. Kattar , Matthew Christopher , Michael D. Altman , Alan B. Northrup , John Michael Ellis , Brendan O'Boyle , Anthony Donofrio , Jonathan Grimm , Michael H. Reutershan , Kaleen Konrad Childers , Ryan D. Otte , Brandon Cash , Yves Ducharme , Andrew M. Haidle , Kerrie Spencer , Dilrukshi Vitharana , Lingyun Wu , Li Zhang , Peng Zhang , Christian Beaulieu , Daniel Guay
- Applicant: Michelle R. Machacek , Eric T. Romeo , Solomon D. Kattar , Matthew Christopher , Michael D. Altman , Alan B. Northrup , John Michael Ellis , Brendan O'Boyle , Anthony Donofrio , Jonathan Grimm , Michael H. Reutershan , Kaleen Konrad Childers , Ryan D. Otte , Brandon Cash , Yves Ducharme , Andrew M. Haidle , Kerrie Spencer , Dilrukshi Vitharana , Lingyun Wu , Li Zhang , Peng Zhang , Christian Beaulieu , Daniel Guay
- Applicant Address: US NJ Rahway CA Kirkland, Quebec
- Assignee: Merck Sharp & Dohme Corp.,Merck Canada Inc.
- Current Assignee: Merck Sharp & Dohme Corp.,Merck Canada Inc.
- Current Assignee Address: US NJ Rahway CA Kirkland, Quebec
- Agent Eric A. Meade; Anna L. Cocuzzo
- International Application: PCT/CN2013/001132 WO 20130924
- International Announcement: WO2014/048065 WO 20140403
- Main IPC: A61K9/10
- IPC: A61K9/10 ; C07D401/14 ; C07D405/14 ; C07D409/14 ; C07D417/14 ; C07D498/04 ; C07D413/14 ; C07D239/42 ; A61K9/00 ; A61K9/20 ; A61K9/48 ; C07D403/12 ; C07D405/12 ; C07D409/12 ; C07D471/04
Abstract:
Provided are triazole derivatives of Formula I which are potent inhibitors of spleen tyrosine kinase and pharmaceutical composition. The triazole derivatives are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.
Public/Granted literature
- US20150239866A1 TRIAZOLYL DERIVATIVES AS SYK INHIBITORS Public/Granted day:2015-08-27
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