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    Modular implant system containing active substances and method for the production thereof
    1.
    发明授权
    Modular implant system containing active substances and method for the production thereof 有权
    含有活性物质的模块化植入体系及其生产方法

    公开(公告)号：US08003121B1

    公开(公告)日：2011-08-23

    申请号：US10343363

    申请日：2000-08-01

    Applicant: Elvira Dingeldein ,  Helmut Wahlig ,  Jörg Bauer ,  Edgar Wüst ,  Christoph Sattig

    Inventor： Elvira Dingeldein ,  Helmut Wahlig ,  Jörg Bauer ,  Edgar Wüst ,  Christoph Sattig

    IPC: A61L24/00 ,  A61L24/06

    CPC classification number: A61L24/0015 ,  A61L24/06 ,  A61L2300/406 ,  A61L2300/416 ,  A61L2300/44 ,  C08L33/06

    Abstract: System of implant components containing active agents, wherein each component is intended to function as an additive for an implant material produced with a powdery or finely granulated starting material and/or active agents and additives.Each component is powdery or finely granulated and includes at least one powdery or finely granulated active agent or additive having a higher dosage than the desired concentration for the application. The components themselves are made of a powdery or finely granulated starting material for the implant material, as well as of the active agent or additive. The active agents can be chemotherapeutical agents, such as antibiotics, whereas the additives can be x-ray contrast materials and/or or additives that alter the physical properties of the starting material, such as its elasticity or viscosity.

    Abstract translation: 包含活性剂的植入物组分的系统，其中每个组分旨在作为用粉末状或精细粒化的原料和/或活性剂和添加剂生产的植入材料的添加剂。 每种组分是粉状或细粒化的，并且包括至少一种粉末状或细粒状的活性剂或添加剂，其用量高于所需应用浓度。 组分本身由用于植入材料以及活性剂或添加剂的粉末状或精细制粒的起始材料制成。 活性剂可以是化学治疗剂，例如抗生素，而添加剂可以是改变起始物质的物理性质的X射线对比材料和/或添加剂，例如其弹性或粘度。

    Penicillins and their preparation
    2.
    发明授权
    Penicillins and their preparation 失效
    青霉素及其制备

    公开(公告)号：US4119631A

    公开(公告)日：1978-10-10

    申请号：US764786

    申请日：1977-02-02

    Applicant: Rudolf Gottschlich ,  Werner Rogalski ,  Rolf Bergmann ,  Rosmarie Steinigeweg ,  Helmut Wahlig

    Inventor： Rudolf Gottschlich ,  Werner Rogalski ,  Rolf Bergmann ,  Rosmarie Steinigeweg ,  Helmut Wahlig

    IPC: C07D499/00 ,  C07D499/64 ,  C07D233/06

    CPC classification number: C07D499/00

    Abstract: Carbamic acid lactones of the formula ##STR1## wherein Y is H or alkyl of 1-4 carbon atoms and R.sub.2 and R.sub.3 each are H or collectively with the carbon atoms to which they are attached form a first benzene or pyridine ring which is unsubstituted, substituted by up to two of alkyl, alkoxy of 1-4 carbon atoms, dialkylamino or halogen, wherein alkyl and alkoxy in each instance are of 1-4 carbon atoms, or is fused at two adjacent carbons to a second benzene or pyridine ring, are useful as intermediates for the production of penicillins by reaction with a penicillin of the formula ##STR2##

    Abstract translation: 其中Y是H或1-4个碳原子的烷基，R 2和R 3各自是H或与它们所连接的碳原子一起形成的第一个苯或吡啶环，其是未取代的， 被至多两个烷基，1-4个碳原子的烷氧基，二烷基氨基或卤素取代，其中每个实例中的烷基和烷氧基为1-4个碳原子，或者在两个相邻的碳上与第二个苯或吡啶环稠合， 可用作通过与式（IMAGE）的青霉素反应生产青霉素的中间体

    Implant material
    7.
    发明授权
    Implant material 失效
    植入材料

    公开(公告)号：US5338772A

    公开(公告)日：1994-08-16

    申请号：US901481

    申请日：1992-06-22

    Applicant: Hans-Jorg Bauer ,  Gerd Bauer ,  Elvira Dingeldein ,  Helmut Wahlig

    Inventor： Hans-Jorg Bauer ,  Gerd Bauer ,  Elvira Dingeldein ,  Helmut Wahlig

    IPC: A61F2/00 ,  A61L27/46 ,  A61L27/56 ,  B32B3/26

    CPC classification number: A61L27/46 ,  A61L27/56 ,  A61F2/0077 ,  Y10T428/249953 ,  Y10T428/258

    Abstract: The invention relates to an implant material which is based on a composite material of calcium phosphate ceramic particles and bioabsorbable polymer, in which the proportion of calcium phosphate ceramic particles is at least 50% by weight and the particles are joined to one another by polymer bridges to give a three-dimensional open-pore structure in which the particle surfaces are covered with polymer to the extent of not more than 50%. This implant material is distinguished by particularly favorable growing-in and healing-in properties.

    Abstract translation: 本发明涉及一种植入材料，其基于磷酸钙陶瓷颗粒和生物可吸收聚合物的复合材料，其中磷酸钙陶瓷颗粒的比例为至少50重量％，并且颗粒通过聚合物桥彼此连接 得到三维开孔结构，其中颗粒表面被聚合物覆盖到不大于50％的程度。 这种植入材料的特征在于特别有利的生长和愈合特性。

    Basic thioethers
    9.
    发明授权
    Basic thioethers 失效
    碱性硫醚

    公开(公告)号：US4285961A

    公开(公告)日：1981-08-25

    申请号：US82456

    申请日：1979-10-09

    Applicant: Helmut Prucher ,  Jurgen Uhl ,  Hans-Adolf Kurmeier ,  Volkmar Rudolph ,  Helmut Wahlig

    Inventor： Helmut Prucher ,  Jurgen Uhl ,  Hans-Adolf Kurmeier ,  Volkmar Rudolph ,  Helmut Wahlig

    IPC: A61K31/135 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/41 ,  A61K31/435 ,  A61P7/00 ,  A61P17/00 ,  A61P25/00 ,  A61P29/00 ,  A61P31/00 ,  A61P31/10 ,  C07C67/00 ,  C07C313/00 ,  C07C323/37 ,  C07D233/60 ,  C07D249/08 ,  C07D295/084 ,  C07D295/096 ,  C07D333/76 ,  C07D521/00 ,  A61K31/415 ,  C07D233/20

    CPC classification number: C07D295/096 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D295/092 ,  C07D333/76

    Abstract: Basic thioethers of the formulaR--A--(CH.sub.2).sub.n --Zwherein R is p-R.sup.5 -S-phenyl or 2-dibenzothienyl; A is --CHR.sup.3 --CHR.sup.4 --, --CR.sup.3 (OH)--CHR.sup.4 --, --CHR.sup.3 --CR.sup.4 (OH)-- or --CR.sup.3 .dbd.CR.sup.4 --; Z is --NR.sup.1 R.sup.2, 1-imidazolyl or 1,2,4-triazol-1-yl; n is 1, 2 or 3; R.sup.1 and R.sup.2 are the same or different and each is H, alkyl of 1-4 carbon atoms or together form alkylene of 4-7 ring carbon atoms, or form 3-oxapentamethylene; R.sup.3 and R.sup.4 are the same or different and each is H, alkyl of 1-4 carbon atoms or phenyl; R.sup.5 is an unsubstituted phenyl or benzyl group or a phenyl or benzyl group substituted with 1 or 2 of halogen, nitro, amino and/or alkoxy of 1-4 carbon atoms, alkyl of 1-6 carbon atoms, or cycloalkyl of 3-7 ring carbon atoms, with the proviso that R.sup.5 is alkyl of 1-6 carbon atoms, or cycloalkyl of 3-7 ring carbon atoms when A is --CHR.sup.3 --CH.sub.2 -- and Z is 1-imidazolyl possess valuable pharmacological properties.

    Abstract translation: 式R-A-（CH2）n-Z的碱式硫醚，其中R是对 - R-R-S-苯基或2-二苯并噻吩基; A是-CHR 3 -CHR 4 - ， - CR 3（OH）-CHR 4 - ， - CH 3 - CR 4（OH） - 或-CR 3 = CR 4 - ; Z是-NR 1 R 2，1-咪唑基或1,2,4-三唑-1-基; n为1,2或3; R1和R2相同或不同，分别为H，1-4个碳原子的烷基或一起形成4-7个环碳原子的亚烷基，或形成3-氧杂五亚甲基; R3和R4相同或不同，分别为H，1-4个碳原子的烷基或苯基; R5是未取代的苯基或苄基或被1或2个1-4个碳原子的卤素，硝基，氨基和/或烷氧基取代的苯基或苄基，1-6个碳原子的烷基或3-7的环烷基 环状碳原子，条件是当A为-CHR 3 -CH 2 - 且Z为1-咪唑基时，R 5为1-6个碳原子的烷基或3-7环碳原子的环烷基具有有价值的药理学性质。

    Antibacterial wound dressing
    10.
    发明授权
    Antibacterial wound dressing 失效
    抗菌伤口敷料

    公开(公告)号：US4191743A

    公开(公告)日：1980-03-04

    申请号：US847868

    申请日：1977-11-02

    Applicant: Klaus Klemm ,  Helmut Wahlig

    Inventor： Klaus Klemm ,  Helmut Wahlig

    IPC: A61L15/44 ,  A61L15/46 ,  A61F13/00 ,  A61F7/02 ,  A61L15/03

    CPC classification number: A61L15/46 ,  A61L2300/406

    Abstract: Antibiotics can be effectively administered to wounds over long time periods by a wound dressing which comprises at least two layers of synthetic resin arranged one above the other and an intermediate layer composed of a synthetic resin granulate (particle size: 0.5-3mm) having an antibiotic incorporated therein.

    Abstract translation: 通过伤口敷料可以有效地对伤口施用抗生素，所述伤口敷料包括至少两层合成树脂层叠在一起的中间层和由具有抗生素的合成树脂颗粒（粒径：0.5-3mm）组成的中间层 并入其中。

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