公开(公告)号：US20140221634A1

公开(公告)日：2014-08-07

申请号：US13759820

申请日：2013-02-05

申请人： M. Iqbal Choudhary ,  Juveria Siddiqui ,  Ahmed Abbaskhan ,  Suad Naheed ,  Achyut Adhikari ,  Jalauddine A. Jalal Awalia

发明人： M. Iqbal Choudhary ,  Juveria Siddiqui ,  Ahmed Abbaskhan ,  Suad Naheed ,  Achyut Adhikari ,  Jalauddine A. Jalal Awalia

IPC分类号： C07H19/01

CPC分类号： C07H15/26 ,  A61K31/7042 ,  C07H17/065 ,  C07H17/075

摘要： The present invention relates to 5-O-[6″-(3-hydroxy-3methyl glutarate)β-D-glucodise as a new antioxidant.

摘要翻译： 本发明涉及作为新抗氧化剂的5-O- [6“ - （3-羟基-3-甲基戊二酸酯）＆bgr-D-糖苷。

公开(公告)号：US07863248B2

公开(公告)日：2011-01-04

申请号：US10577135

申请日：2004-10-20

申请人： Hitoshi Matsumoto ,  Yuko Nakamura ,  Megumi Yamagishi ,  Kyoko Ito

发明人： Hitoshi Matsumoto ,  Yuko Nakamura ,  Megumi Yamagishi ,  Kyoko Ito

IPC分类号： A61K31/70

CPC分类号： C07H17/065 ,  A23L33/105 ,  A61K8/97 ,  A61K31/7048 ,  A61K2800/782 ,  A61Q19/02

摘要： A tyrosinase activity inhibitor and an ameliorant for facial blood flow that are excellent in terms of safety, and medicinal compositions, food compositions, and cosmetic preparations that contain the inhibitor and the ameliorant as active ingredients are provided. A tyrosinase activity inhibitor and an ameliorant for facial blood flow that contain anthocyan obtained by concentration or extraction of plant material, and medicinal compositions, food compositions, and cosmetic preparations that have an inhibitory action on tyrosinase activity and ameliorating action on facial blood flow are provided.

摘要翻译： 提供了一种酪氨酸酶活性抑制剂和安全性优异的面部血流量改善剂，以及含有抑制剂和改善剂作为活性成分的药物组合物，食品组合物和化妆品制剂。 提供了含有通过浓缩或提取植物材料获得的花青的面部血液流出物的酪氨酸酶活性抑制剂和改善剂，以及对酪氨酸酶活性具有抑制作用并改善对面部血流的作用的药物组合物，食品组合物和化妆品制剂。 。

公开(公告)号：US07211413B2

公开(公告)日：2007-05-01

申请号：US10380056

申请日：2001-09-11

申请人： Hitoshi Matsumoto ,  Satoshi Hanamura ,  Masao Hirayama

发明人： Hitoshi Matsumoto ,  Satoshi Hanamura ,  Masao Hirayama

IPC分类号： C12P19/60

CPC分类号： C07H17/00 ,  C07H17/065 ,  C09B61/00 ,  C12P19/14 ,  C12P19/44

摘要： Provided are a process for producing purified anthocyanidin glucoside in which a rhamnose end of anthocyanidin rutinoside is cleaved using rhamnosidase to convert the anthocyanidin rutinoside component into anthocyanidin glucoside, the anthocyanidin glucoside component being then purified and isolated; or a crystalline anthocyanidin glucoside salt obtained by further crystallizing the purified anthocyanidin glucoside and a process for producing the same.Also provided are a process for producing purified anthocyanidin rutinoside in which a glucose end of anthocyanidin glucoside is cleaved using β-glucosidase to degrade and remove the end, the anthocyanidin rutinoside component being then purified and isolated; or a crystalline anthocyanidin rutinoside salt obtained by further crystallizing the purified anthocyanidin rutinoside and a process for producing the same.

摘要翻译： 提供了使用鼠李糖苷酶将花色素芸香糖苷成分转化为花色素苷葡糖苷的花青素芸香糖苷的鼠李糖末端切割纯化花青素葡糖苷的方法，然后纯化和分离花色素苷苷组分; 或通过进一步结晶纯化的花青素葡糖苷获得的结晶花色素苷糖苷及其制备方法。 还提供了生产纯化的花青素芸香糖苷的方法，其中使用β-葡糖苷酶切割花青素葡糖苷的葡萄糖末端以降解和除去末端，然后纯化和分离花色素芸香糖苷组分; 或通过进一步结晶纯化的花青素芸香苷获得的结晶花色素芸香糖苷盐及其制备方法。

公开(公告)号：US06518250B2

公开(公告)日：2003-02-11

申请号：US09993194

申请日：2001-11-14

申请人： Toshikazu Yoshikawa ,  Hironobu Murase ,  Norimasa Yoshida

发明人： Toshikazu Yoshikawa ,  Hironobu Murase ,  Norimasa Yoshida

IPC分类号： A61K3170

CPC分类号： C07H17/065 ,  A61K31/704 ,  A61K31/7048 ,  C07H15/26 ,  Y10S514/824 ,  Y10S514/878 ,  Y10S514/925 ,  Y10S514/926

摘要： An agent for preventing and curing the hindrance of ischemic reperfusiton is disclosed which has as an active component thereof a chromanol glycoside represented by the following general formula: [wherein R1, R2, R3, and R4 independently denote a hydrogen atom or a lower alkyl group, R5 denotes a hydrogen atom, a lower alkyl group, or a lower acyl group, X denotes a monosaccharide residue or an oligosaccharide residue which may have a lower alkyl group or a lower acyl group substituted for the hydrogen atom of the hydroxyl group of the saccharide residue, n denotes an integer of 0-6, and m denotes an integer of 1-6]. The agent, even in a small dosage, acts safely and effectively on the affected part and allows the hindrances of ischemic reperfusion induced in heart, stomach, small intestine, liver, spleen, kidney, brain, and skin, and the hindrance induced during the transplantation of an internal organ to be prevented and cured.

摘要翻译： 公开了预防和治疗缺血再灌注障碍的药剂，其作为其活性成分是由以下通式表示的色原肌糖苷：其中R1，R2，R3和R4独立地表示氢原子或低级烷基 R5表示氢原子，低级烷基或低级酰基，X表示可以具有低级烷基或低级酰基取代羟基的氢原子的单糖残基或寡糖残基 糖残基，n表示0-6的整数，m表示1-6的整数]。 即使在小剂量下，该药物对患部的安全有效地起作用，并且允许在心脏，胃，小肠，肝脏，脾脏，肾脏，脑和皮肤中诱导的缺血再灌注障碍，以及在 移植内脏器官以防止和治愈。

公开(公告)号：US20240025937A1

公开(公告)日：2024-01-25

申请号：US18026321

申请日：2021-01-07

申请人： ZHEJIANG UNIVERSITY

发明人： Wei CHEN ,  Yang XU ,  Jiahong XIE ,  Haoxin CUI

IPC分类号： C07H17/065 ,  C07H1/08 ,  B01D15/16 ,  B01D15/24 ,  B01D15/18 ,  B01D11/04

CPC分类号： C07H17/065 ,  C07H1/08 ,  B01D15/166 ,  B01D15/24 ,  B01D15/1871 ,  B01D11/0492

摘要： The present disclosure provides a preparation method of peonidin-3-O-(6-p-coumaryl)glucoside and malvidin-3-O-(6-p-coumaryl)glucoside by separation. In the present disclosure, the preparation method includes alcohol extraction and concentration, macroporous resin purification, extraction, purification by preparative liquid chromatography, and separation by high-speed countercurrent chromatography (HSCCC). In this way, two high-purity monomers, peonidin-acylated anthocyanin and malvidin-acylated anthocyanin, are obtained by separation and purification from grapes. With the preparation method, at least 60 mg of the peonidin-3-O-(6-p-coumaryl)glucoside and at least 200 mg of the malvidin-3-O-(6-p-coumaryl)glucoside can be obtained from 10 kg of grape skins, both of which have a purity of not less than 98%. The preparation method has simple operations, a high processing capacity, and desirable repeatability, and provides a new idea for the development and utilization of grape resources.

公开(公告)号：US08722868B2

公开(公告)日：2014-05-13

申请号：US13389233

申请日：2010-01-21

申请人： Yoshihiro Ozeki ,  Nobuhiro Sasaki ,  Kazuo Nagasawa ,  Masayuki Tera ,  Yuki Matsuba ,  Haruka Nakamura ,  Yutaka Abe

发明人： Yoshihiro Ozeki ,  Nobuhiro Sasaki ,  Kazuo Nagasawa ,  Masayuki Tera ,  Yuki Matsuba ,  Haruka Nakamura ,  Yutaka Abe

IPC分类号： C07H21/04 ,  C12N9/10 ,  C12N15/00 ,  C12N5/10

CPC分类号： C12N9/1048 ,  C07H13/08 ,  C07H15/18 ,  C07H17/065 ,  C12P19/44 ,  C12P19/60

摘要： An object of the present invention is to provide a sugar donating reagent comprising a sugar donor compound other than a sugar nucleotide and an enzyme capable of catalyzing a glycosyl transfer reaction using a sugar donor compound other than a sugar nucleotide. The present invention provides the following: a sugar donating reagent containing a compound of formula (A): wherein R1 is independently selected from hydrogen, or C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl in which each of the groups is unsubstituted or substituted with one or more groups selected from OH, F, Cl, Br, I, CN, NO2, and SO2, n is 0, 1, 2, 3, 4 or 5, m is 0 or 1, and X represents a monosaccharide bound via a β bond on its anomeric carbon; a glycosyltransferase capable of catalyzing a glycosyl transfer reaction using the sugar donor; and a glycosyltransferase gene comprising DNA encoding the glycosyltransferase.

摘要翻译： 本发明的目的是提供一种含糖糖核苷酸以外的糖供体化合物和能够使用糖核苷酸以外的糖供体化合物催化糖基转移反应的酶的供糖试剂。 本发明提供以下：含有式（A）化合物的给糖试剂：其中R 1独立地选自氢或C 1-6烷基，C 2-6烯基和C 2-6炔基，其中每个基团 未取代或被一个或多个选自OH，F，Cl，Br，I，CN，NO2和SO2的基团取代，n为0,1,2,3,4或5，m为0或1，X 代表通过＆bgr结合的单糖; 其端基异碳碳键; 能够使用糖供体催化糖基转移反应的糖基转移酶; 和包含编码糖基转移酶的DNA的糖基转移酶基因。

公开(公告)号：US08648049B2

公开(公告)日：2014-02-11

申请号：US13265026

申请日：2010-04-16

申请人： Huaibi Zhang ,  Simon Christopher Deroles ,  Kevin Davies

发明人： Huaibi Zhang ,  Simon Christopher Deroles ,  Kevin Davies

IPC分类号： A61K31/7048

CPC分类号： C07H17/065 ,  A23L5/43 ,  A23L33/10 ,  C09B61/00 ,  Y10T428/249921

摘要： The invention provides a method for in vitro formation of anthocyanic vacuolar inclusion (AVI)-like structures, the method comprising the step of combining at least one anthocyanin, and b) at least one lipid. The invention also provides AVI-like structures produced by the method of the invention, compositions comprising such AVI-like structures, and uses of such AVI-like structures.

摘要翻译： 本发明提供了一种体外形成花色素液泡包涵体（AVI）样结构的方法，所述方法包括将至少一种花青素组合的步骤，和b）至少一种脂质。 本发明还提供了通过本发明的方法制备的AVI样结构，包含这样的AVI样结构的组合物，以及这种AVI样结构的用途。

公开(公告)号：US5889164A

公开(公告)日：1999-03-30

申请号：US534409

申请日：1995-09-27

申请人： Hironobu Murase ,  Tsutomu Kunieda ,  Tetsuya Tsujii

发明人： Hironobu Murase ,  Tsutomu Kunieda ,  Tetsuya Tsujii

IPC分类号： C12P19/58 ,  A23L3/3544 ,  A23L3/3562 ,  C07H15/26 ,  C07H17/065 ,  C09K15/08 ,  C07H17/06 ,  C12P19/60

CPC分类号： A23L3/3544 ,  A23L3/3562 ,  C07H15/26 ,  C07H17/065

摘要： This invention provides a novel chromanol glycoside which is a water soluble antioxidant excellent in heat and pH stability and production method thereof. It is a chromanol glycoside represented by the general formula (1): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 independently are a hydrogen atom or a lower alkyl group, R.sup.5 is a hydrogen atom, a lower alkyl group, or a lower acyl group, X is a monosaccharide residue or an oligosacoharide residue, providing the hydrogen atom of the hydroxyl group of saccharide residue may be substituted by a lower alkyl group or a lower acyl group, n is an integer in the range of 0 to 4, and m is an integer in the range of 1 to 6.

摘要翻译： 本发明提供一种新型的色原烷醇糖苷，其是热和pH稳定性优异的水溶性抗氧化剂及其制备方法。 它是由通式（1）表示的色原烷醇糖苷：其中R1，R2，R3和R4独立地是氢原子或低级烷基，R5是氢原子，低级烷基 或低级酰基，X是单糖残基或寡糖残基，提供糖残基的羟基的氢原子可以被低级烷基或低级酰基取代，n是在 0〜4，m为1〜6的整数。

公开(公告)号：US5780445A

公开(公告)日：1998-07-14

申请号：US594619

申请日：1996-02-02

申请人： Gunther Schneider ,  Joachim Thiem ,  Martina Lahmann

发明人： Gunther Schneider ,  Joachim Thiem ,  Martina Lahmann

IPC分类号： C07H17/06 ,  A61K8/00 ,  A61K8/60 ,  A61K8/67 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K31/715 ,  A61P17/00 ,  A61P43/00 ,  A61Q17/00 ,  A61Q19/00 ,  A61Q19/08 ,  B01F17/56 ,  C07H15/04 ,  C07H17/065 ,  C08B37/00 ,  C09K15/06 ,  C11B5/00 ,  C11D1/66

CPC分类号： C11B5/0035 ,  A61K31/702 ,  A61K31/715 ,  A61K8/602 ,  A61K8/678 ,  A61Q17/00 ,  A61Q19/00 ,  A61Q19/08 ,  C07H17/065 ,  C08B37/00 ,  A61K2800/522

摘要： Tocopheryl glycosides of the general formula ##STR1## or of the general formula ##STR2## where n can adopt values of 0-6 and where R represents a radical from the group consisting of H, branched and unbranched alkyl of 1-18 carbon atoms, branched and unbranched acyl of 1-18 carbon atoms, and where R within one molecule can be identical in all positions of tie glycosyl groups, but can also adopt different meanings within one molecule, such that it is possible within one molecule to choose any desired combinations of the radicals represented.

摘要翻译： 通式 + TR 或通式 + TR 的生育酚糖苷，其中n可以取0-6的值，其中R表示由H，支链 和1-18个碳原子的无支链烷基，1-18个碳原子的支链和非支链酰基，其中一个分子中的R可以在连接糖基的所有位置上相同，但也可以在一个分子内采用不同的含义，使得 在一个分子内可能选择所表示的基团的所需组合。

公开(公告)号：US5280111A

公开(公告)日：1994-01-18

申请号：US856710

申请日：1992-03-24

申请人： Tadao Shoji ,  Naoya Ikushima ,  Kaname Katsuraya ,  Nahoko Takahashi ,  Fusayo Kobayashi ,  Toshiyuki Uryu ,  Takashi Yoshida ,  Naoki Yamamoto ,  Hideki Nakashima

发明人： Tadao Shoji ,  Naoya Ikushima ,  Kaname Katsuraya ,  Nahoko Takahashi ,  Fusayo Kobayashi ,  Toshiyuki Uryu ,  Takashi Yoshida ,  Naoki Yamamoto ,  Hideki Nakashima

IPC分类号： A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/12 ,  A61P31/18 ,  C07H17/065 ,  C07H15/20 ,  A61K31/72 ,  C07H11/00 ,  C07H13/02 ,  C07H17/04

CPC分类号： C07H17/065 ,  A61K31/70

摘要： The present invention relates to novel tocopheryl oligosaccharides, acylated tocopheryl oligosaccharides, sulfated tocopheryl oligosaccharides, and antiviral agents including the sulfated tocopheryl oligosaccharides as active ingredients. In the tocopheryl oligosaccharide, the hydrogen atom of the hydroxy group at the 1-position in the terminal sugar moiety of an oligosaccharide which consists of 3.about.20 of identical or different repeating monosaccharide units selected from the group consisting of glucose, galactose, mannose, talose, idose, altrose, allose, glucose, xylose, arabinose, rhamnose, fucose, and fructose, which are glycoside-linked, is substituted by a tocopherol group. In the acylated tocopheryl oligosaccharides, each of any hydroxy group of the sugar moiety, other than the hydroxy group at the 1-position in the terminal sugar moiety of the oligosaccharide described above, is protected by an acyl group. The antiviral agents including the sulfated tocopheryl oligosaccharides or the biologically acceptable salt of the same as active ingredients have low toxicities and exhibit improved antiviral action, especially against the Human Immunodeficiency Virus.

摘要翻译： 本发明涉及新的生育酚低聚糖，酰化生育酚低聚糖，硫酸生育酚寡糖，以及包含硫酸生育酚寡糖作为活性成分的抗病毒剂。 在生育酚低聚糖中，低聚糖的末端糖部分的1位的羟基的氢原子由3〜20个相同或不同的重复单糖单元组成，所述重复单糖单元选自葡萄糖，半乳糖，甘露糖， 与糖生成酚基取代的与糖苷连接的谷氨酸，阿糖，阿卓糖，阿洛糖，葡萄糖，木糖，阿拉伯糖，鼠李糖，岩藻糖和果糖。 在酰化的生育酚低聚糖中，除了上述寡糖的末端糖部分的1位以外的除了羟基以外的糖部分的任何羟基都被酰基保护。 包括硫酸生育酚寡糖或与生物活性成分相同的生物学上可接受的盐的抗病毒剂具有低毒性，并且表现出改善的抗病毒作用，特别是针对人类免疫缺陷病毒。