公开(公告)号：US20240272146A1

公开(公告)日：2024-08-15

申请号：US17701399

申请日：2022-03-22

Applicant: AAT Bioquest, Inc.

Inventor： Zhenjun DIWU ,  Qinglin MENG ,  Ruogu PENG ,  Qin ZHAO

IPC: G01N33/52 ,  C07H17/04 ,  G01N33/68

CPC classification number: G01N33/52 ,  C07H17/04 ,  G01N33/6803

Abstract: The disclosure provides chromogenic and fluorogenic compounds comprising amino acid or peptide appendages that are capable of detecting an activity in a bioassay. Also provided herein are methods for detecting a biological activity in a sample with the subject chromogenic and fluorogenic compounds. In one embodiment, provided herein is a method for detecting endotoxin in a sample. Further provided herein are kits including the subject chromogenic and fluorogenic compounds for detecting a biological activity in a sample.

公开(公告)号：US20240270781A1

公开(公告)日：2024-08-15

申请号：US18290641

申请日：2021-10-19

Applicant: GUANGZHOU HANFANG PHARMACEUTICAL CO., LTD.

Inventor： Wendong XU ,  Cheng YUAN ,  Shunzhi TANG ,  Juyan LIU ,  Hongfei CAI ,  Bai BAI ,  Jing LI ,  Yuping FU ,  Songtao LI ,  Wancai PENG ,  Yonghua LI ,  Yao LI ,  Jirong LI ,  Shaoheng WEI ,  Jiali LI

IPC: C07H17/04

CPC classification number: C07H17/04

Abstract: Provided in the present disclosure is a preparation method of paeoniflorin-6′-O-benzene sulfonate. The method uses crude paeoniflorin instead of paeoniflorin as a raw material, which more complies with actual requirements of an industrial production process of paeoniflorin-6′-O-benzene sulfonate, and uses an organometallic catalyst, an acid-binding agent and chemically active benzenesulfonyl chloride to react with paeoniflorin. Compared with the prior art, the method significantly increases the yield of crude paeoniflorin-6′-O-benzene sulfonate which is separated and purified by means of column chromatography and then refined to obtain paeoniflorin-6′-O-benzenesulfonate with a content of at least 98%, thereby realizing industrial production of the paeoniflorin-6′-O-benzene sulfonate.

公开(公告)号：US20240067634A1

公开(公告)日：2024-02-29

申请号：US18266688

申请日：2021-12-16

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： David H. Sherman ,  Morgan T. McCauley ,  Nolan Carney ,  Andrew W. Robertson ,  Mark M. Painter ,  Kathleen L. Collins ,  Ashootosh Tripathi ,  Alanna R. Condren

IPC: C07D407/06 ,  A61P31/18 ,  C07D407/14 ,  C07H17/04

CPC classification number: C07D407/06 ,  A61P31/18 ,  C07D407/14 ,  C07H17/04

Abstract: This disclosure relates generally to inhibitors of MHC-I downmodulation, and methods of treating or preventing an HIV infection by administering the inhibitors to a patient in need of treatment thereof.

公开(公告)号：US11858955B2

公开(公告)日：2024-01-02

申请号：US17929298

申请日：2022-09-01

Applicant: MARS, INCORPORATED

Inventor： John Didzbalis ,  John P. Munafo

IPC: C07H17/04 ,  A23L27/20 ,  A23G4/06 ,  C07H15/04 ,  A23L27/00

CPC classification number: C07H17/04 ,  A23G4/06 ,  A23L27/2052 ,  A23L27/88 ,  C07H15/04

Abstract: A flavor composition containing at least one HMG glucoside compound that can be used to enhance the taste of edible compositions including sweet goods, such as confectionery goods, and savory goods, such as pet foods.

公开(公告)号：US20230138729A1

公开(公告)日：2023-05-04

申请号：US17943836

申请日：2022-09-13

Applicant: Rubedo Life Sciences, Inc.

Inventor： Paul Keitz ,  Gus Bergnes

IPC: C12Q1/40 ,  C07H15/207 ,  C07H17/075 ,  C07H15/26 ,  C07H17/04

Abstract: Provided herein are coumarin derivatives of sugar analogs which are used to measure the rate of hydrolysis of these sugar analogs when contacted with a glycosidase. The reactivity of the coumarin derivatives serves as a convenient method for estimating for the rate of hydrolysis of sugar analogs when used a promoiety with cytotoxic drugs to generate senolytic agents with improved selectivity for killing senescent cells.

公开(公告)号：US20230119068A1

公开(公告)日：2023-04-20

申请号：US17799393

申请日：2021-02-16

Applicant: Ohio State Innovation Foundation

Inventor： Xiaoyi ZHU ,  Nicole STRAATHOF ,  Gonzalo MIYAGUSUKU-CRUZADO ,  M. Monica GIUSTI ,  Israel Garcia CANO ,  Rafael JIMENEZ-FLORES

IPC: C07H17/04 ,  C07D493/06

Abstract: The present disclosure provides methods for the rapid synthesis of pyranoanthocyanins.

公开(公告)号：US20230092001A1

公开(公告)日：2023-03-23

申请号：US17786133

申请日：2020-12-18

Applicant: FUDAN UNIVERSITY

Inventor： Jun CHANG ,  Lin JIN ,  Heyanhao ZHANG ,  Tong NIU

IPC: C07H17/04

Abstract: Disclosed are a furaneol glycoside compound, a pharmaceutical composition thereof, a preparation method therefor, and an application thereof. Specifically disclosed are a compound as represented by formula A-1, a pharmaceutically acceptable salt thereof or a crystal form thereof. Also disclosed is a pharmaceutical composition, which comprises the compound as represented by formula A-1, the pharmaceutically acceptable salt thereof, and a pharmaceutical adjuvant. Also disclosed is an application of the compound as represented by formula A-1, the pharmaceutically acceptable salt thereof, the crystal form thereof, or the pharmaceutical composition in the preparation of drugs. The drugs are drugs for treating inflammatory bowel diseases. The furaneol glycoside compound has a good effect of treating inflammatory bowel diseases, particularly ulcerative colitis.

公开(公告)号：US20230086494A1

公开(公告)日：2023-03-23

申请号：US17929298

申请日：2022-09-01

Applicant: MARS, INCORPORATED

Inventor： John Didzbalis ,  John P. Munafo

IPC: C07H17/04 ,  C07H15/04 ,  A23L27/20 ,  A23L27/00

Abstract: A flavor composition containing at least one HMG glucoside compound that can be used to enhance the taste of edible compositions including sweet goods, such as confectionery goods, and savory goods, such as pet foods.

公开(公告)号：US11407742B2

公开(公告)日：2022-08-09

申请号：US16643347

申请日：2018-08-30

Applicant: THE KITASATO INSTITUTE ,  OP BIO FACTORY CO., LTD.

Inventor： Hiroshi Tomoda ,  Nobuhiro Koyama ,  Akihiko Kanamoto ,  Junko Hashimoto ,  Ikuko Kozone

IPC: C07D405/14 ,  A61P31/04 ,  C07H17/04

Abstract: The purpose of the present invention is to provide a novel compound which has antibacterial activity against Mycobacterium avium and Mycobacterium intracellulare that are causative bacteria of MAC infection and which is different in backbone structure from known drugs for treatment of MAC infection. One aspect of the present invention relates to a compound of Formula (I) [where R1 has the same meaning as described in the specification and claims] or a salt thereof, or a solvate thereof. Another aspect of the present invention relates to a method for producing the compound of Formula (I) or a salt thereof, or a solvate thereof, and a therapeutic agent for Mycobacterium avium complex infection (MAC infection), which comprises the compound or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof as an active ingredient.

公开(公告)号：US11337434B1

公开(公告)日：2022-05-24

申请号：US17015644

申请日：2020-09-09

Applicant: Paul Charles Wegner

Inventor： Paul Charles Wegner

IPC: C07H17/04 ,  A23B7/158 ,  A23B7/154

Abstract: An olive storage and processing method. In one embodiment of the invention, harvested olives are stored in a storage tank in a storage solution containing water wherein the storage solution contains olive juices and salts. The storage solution with olive juices and salts is passed to a first ion exchange vessel having a strong acid ion exchange resin in hydrogen form at ambient temperature and pressure. Potassium and nitrogen ions and other cations are converted by the strong acid ion exchange resin and organic acids are released in order to create an acidic solution. The acidic solution is then returned to the storage tank for reuse as a storage solution.