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公开(公告)号：US20210261925A1
公开(公告)日：2021-08-26
申请号：US17228211
申请日：2021-04-12
IPC分类号： C12N9/02 , A61K31/4995 , C12P17/18
摘要： The disclosure provides biocatalysts that halogenate complex chemical compounds in specific and predictable ways. Also disclosed are halogenated complex organic compounds. The disclosure further provides methods for the halogenation of complex chemical compounds and methods of inhibiting the contraction of smooth muscle in mammals.
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2.发明申请BIOSYNTHETIC PATHWAY FOR HETEROLOGOUS EXPRESSION OF A NONRIBOSOMAL PEPTIDE SYNTHETASE DRUG AND ANALOGS 有权用于非特异性肽合成酶药物和模拟物的异位表达的生物路径公开(公告)号：US20150050704A1
公开(公告)日：2015-02-19
申请号：US14467851
申请日：2014-08-25
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , ALLEGHENY-SINGER RESEARCH INSTITUTE , COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
发明人： David H. Sherman , Garth D. Ehrlich , Benjamin Janto , Robert M. Williams , Christopher M. Rath
CPC分类号： C12P17/188 , C12N15/52 , C12N15/70 , C12P17/182
摘要： The present invention is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS) derived drug and analogs thereof. The invention also discloses polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS derived drug.
摘要翻译： 本发明涉及非核糖体肽合成酶（NRPS）衍生药物及其类似物的生物合成途径。 本发明还公开了用于合成NRPS衍生药物的方便微生物宿主中异源表达的多核苷酸序列。
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公开(公告)号：US11530204B2
公开(公告)日：2022-12-20
申请号：US17039001
申请日：2020-09-30
IPC分类号： C07D413/06 , C07D213/06 , A61K31/44
摘要： The disclosure provides cryptophycin intermediates, cryptophycin analogs, and cryptophycin chimeric molecules useful in treating cancer, as well as methods of producing these compounds and methods of treating cancer.
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公开(公告)号：US10239918B2
公开(公告)日：2019-03-26
申请号：US15576494
申请日：2016-05-26
发明人： David H. Sherman , Fengan Yu , Chuanwu Xi , Jianfeng Wu , Pamela J. Schultz , Ashootosh Tripathi , Sung Ryeol Park
IPC分类号： C07K4/00 , C07K7/06 , A01N37/46 , A01N43/76 , C07K5/00 , C07K5/083 , C07K5/103 , C07D413/12 , A61K38/07 , A61K45/06 , C07K14/195 , C12N9/88
摘要： Provided herein are biofilm inhibitors obtained from marine microbial derived natural product extracts from Streptomyces gandocaensis, resulting in biofilm inhibitors, cahuitamycins. Also provided are mutant S. gandocaensis, methods of inhibiting biofilm formation, methods of producing, or increasing the production of, cahuitamycins, methods for synthesizing cahuitamycins, and methods of purifying cahuitamycins.
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公开(公告)号：US20180162906A1
公开(公告)日：2018-06-14
申请号：US15576494
申请日：2016-05-26
发明人： David H. Sherman , Fengan Yu , Chuanwu Xi , Jianfeng Wu , Pamela Schultz , Ashootosh Tripathi , Sung Ryeol Park
IPC分类号： C07K7/06 , C07K5/103 , A61K38/07 , A01N43/76 , A01N37/46 , A61K45/06 , C12N9/88 , C07K14/195
CPC分类号： C07K7/06 , A01N37/46 , A01N43/76 , A61K38/07 , A61K45/06 , C07D413/12 , C07K5/00 , C07K5/081 , C07K5/1013 , C07K14/195 , C12N9/88 , C12Y402/99021 , Y02A50/473
摘要： Provided herein are biofilm inhibitors obtained from marine microbial derived natural product extracts from Streptomyces gandocaensis, resulting in biofilm inhibitors, cahuitamycins. Also provided are mutant S. gandocaensis, methods of inhibiting biofilm formation, methods of producing, or increasing the production of, cahuitamycins, methods for synthesizing cahuitamycins, and methods of purifying cahuitamycins.
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公开(公告)号：US09611491B2
公开(公告)日：2017-04-04
申请号：US14467851
申请日：2014-08-25
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , ALLEGHENY-SINGER RESEARCH INSTITUTE , COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
发明人： David H. Sherman , Garth D. Ehrlich , Benjamin Janto , Robert M. Williams , Christopher M. Rath
CPC分类号： C12P17/188 , C12N15/52 , C12N15/70 , C12P17/182
摘要： The present invention is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS) derived drug and analogs thereof. The invention also discloses polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS derived drug.
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公开(公告)号：US09650656B2
公开(公告)日：2017-05-16
申请号：US14390360
申请日：2013-04-03
CPC分类号： C12P17/18 , C07G5/00 , C12N9/0006 , C12N9/0071 , C12N9/1085 , C12N9/93 , C12N15/52 , C12P5/007 , C12Y114/14001 , C12Y205/01 , C12Y603/02
摘要： The biosynthesis of fungal bicyclo[2.2.2]diazaoctane indole alkaloids with a wide spectrum of biological activities have attracted increasing interest. Their intriguing mode of assembly has long been proposed to feature a non-ribosomal peptide synthetase, a presumed intramolecular Diels-Alderase, a variant number of prenyltransferases, and a series of oxidases responsible for the diverse tailoring modifications of their cyclodipeptide-based structural core. Until recently, the details of these biosynthetic pathways have remained largely unknown due to lack of information on the fungal derived biosynthetic gene clusters. Herein, we report a comparative analysis of four natural product metabolic systems of a select group of bicyclo[2.2.2]diazaoctane indole alkaloids including (+)/(−)-notoamide, paraherquamide and malbrancheamide, in which we propose an enzyme for each step in the biosynthetic pathway based on deep annotation and on-going biochemical studies.
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公开(公告)号：US20150044735A1
公开(公告)日：2015-02-12
申请号：US14390360
申请日：2013-04-03
CPC分类号： C12P17/18 , C07G5/00 , C12N9/0006 , C12N9/0071 , C12N9/1085 , C12N9/93 , C12N15/52 , C12P5/007 , C12Y114/14001 , C12Y205/01 , C12Y603/02
摘要： The biosynthesis of fungal bicyclo[2.2.2]diazaoctane indole alkaloids with a wide spectrum of biological activities have attracted increasing interest. Their intriguing mode of assembly has long been proposed to feature a non-ribosomal peptide synthetase, a presumed intramolecular Diels-Alderase, a variant number of prenyltransferases, and a series of oxidases responsible for the diverse tailoring modifications of their cyclodipeptide-based structural core. Until recently, the details of these biosynthetic pathways have remained largely unknown due to lack of information on the fungal derived biosynthetic gene clusters. Herein, we report a comparative analysis of four natural product metabolic systems of a select group of bicyclo[2.2.2]diazaoctane indole alkaloids including (+)/(−)-notoamide, paraherquamide and malbrancheamide, in which we propose an enzyme for each step in the biosynthetic pathway based on deep annotation and on-going biochemical studies.
摘要翻译： 具有广泛生物活性的真菌双环[2.2.2]二氮杂辛烷吲哚生物碱的生物合成已引起越来越多的兴趣。 长期以来，它们的有趣的装配模式已经被提出以非核糖体肽合成酶，推定的分子内狄尔斯 - 阿尔德酶，异戊烯转移酶的变体数量和一系列负责其基于环二肽的结构核心的多样定制修饰的氧化酶的特征。 直到最近，由于缺乏关于真菌衍生的生物合成基因簇的信息，这些生物合成途径的细节仍然很大程度上是未知的。 在本文中，我们报告了一组选择性双环[2.2.2]二氮杂辛烷吲哚生物碱（包括（+）/（ - ） - 乙酰胺，对二甲苯胺和马来酰胺）的天然产物代谢系统的比较分析，其中我们为每个 基于深度注释和持续生物化学研究，生物合成途径的一步。
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公开(公告)号：US20240067634A1
公开(公告)日：2024-02-29
申请号：US18266688
申请日：2021-12-16
发明人： David H. Sherman , Morgan T. McCauley , Nolan Carney , Andrew W. Robertson , Mark M. Painter , Kathleen L. Collins , Ashootosh Tripathi , Alanna R. Condren
IPC分类号： C07D407/06 , A61P31/18 , C07D407/14 , C07H17/04
CPC分类号： C07D407/06 , A61P31/18 , C07D407/14 , C07H17/04
摘要： This disclosure relates generally to inhibitors of MHC-I downmodulation, and methods of treating or preventing an HIV infection by administering the inhibitors to a patient in need of treatment thereof.
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公开(公告)号：US11692176B2
公开(公告)日：2023-07-04
申请号：US17228211
申请日：2021-04-12
IPC分类号： C12N15/52 , C12N9/02 , A61K31/4995 , C12P17/18
CPC分类号： C12N9/0071 , A61K31/4995 , C12P17/182
摘要： The disclosure provides biocatalysts that halogenate complex chemical compounds in specific and predictable ways. Also disclosed are halogenated complex organic compounds. The disclosure further provides methods for the halogenation of complex chemical compounds and methods of inhibiting the contraction of smooth muscle in mammals.
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