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公开(公告)号：US20170145447A1
公开(公告)日：2017-05-25
申请号：US15370755
申请日：2016-12-06
发明人： Yajun Yan , Yuheng Lin
CPC分类号： C12P7/44 , C12N9/88 , C12N9/90 , C12N15/52 , C12P7/42 , C12Y113/11001 , C12Y114/13001 , C12Y402/99 , C12Y402/99021 , C12Y504/04002 , Y02P20/52
摘要： The invention provides a recombinant microorganism that has been genetically engineered to contain metabolic pathway for the production of muconic acid from a salicylic acid intermediate. The genetically engineered metabolic pathway comprises both biosynthetic and biodegradative elements.
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公开(公告)号：US09546387B2
公开(公告)日：2017-01-17
申请号：US14622155
申请日：2015-02-13
发明人： Yajun Yan , Yuheng Lin
CPC分类号： C12P7/44 , C12N9/88 , C12N9/90 , C12N15/52 , C12P7/42 , C12Y113/11001 , C12Y114/13001 , C12Y402/99 , C12Y402/99021 , C12Y504/04002 , Y02P20/52
摘要： The invention provides a recombinant microorganism that has been genetically engineered to contain metabolic pathway for the production of muconic acid from a salicylic acid intermediate. The genetically engineered metabolic pathway comprises both biosynthetic and biodegradative elements.
摘要翻译： 本发明提供了一种重组微生物，其经遗传工程化以含有从水杨酸中间体生产粘康酸的代谢途径。 遗传工程代谢途径包括生物合成和生物降解元件。
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公开(公告)号：US09719113B2
公开(公告)日：2017-08-01
申请号：US15370755
申请日：2016-12-06
发明人： Yajun Yan , Yuheng Lin
CPC分类号： C12P7/44 , C12N9/88 , C12N9/90 , C12N15/52 , C12P7/42 , C12Y113/11001 , C12Y114/13001 , C12Y402/99 , C12Y402/99021 , C12Y504/04002 , Y02P20/52
摘要： The invention provides a recombinant microorganism that has been genetically engineered to contain metabolic pathway for the production of muconic acid from a salicylic acid intermediate. The genetically engineered metabolic pathway comprises both biosynthetic and biodegradative elements.
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4.发明申请GENETICALLY ENGINEERED MICROORGANISMS FOR THE PRODUCTION OF CHORISMATE-DERIVED PRODUCTS 审中-公开用于生产合成产品的遗传工程微生物公开(公告)号：US20160348087A1
公开(公告)日：2016-12-01
申请号：US15166224
申请日：2016-05-26
CPC分类号： C12N9/88 , C12N1/20 , C12N15/52 , C12P1/04 , C12P7/42 , C12P13/005 , C12Y401/0304 , C12Y402/99021 , C12Y504/04002 , C12Y504/99005
摘要： The invention provides genetically engineered microorganisms and methods for producing chorismate-derived products, such as para-hydroxybenzoic acid, salicylate, 2-aminobenzoate, 2,3-dihydroxybenzoate, and 4-hydroxycyclohexane carboxylic acid. Typically, the microorganism comprises at least one of (a) an exogenous chorismate pyruvate lyase, (b) an exogenous isochorismate synthase, (c) an exogenous isochorismate pyruvate lyase, and (d) a prephenate synthase comprising a disruptive mutation.
摘要翻译： 本发明提供了遗传工程化的微生物以及用于生产氯磺酸衍生产物的方法，例如对羟基苯甲酸，水杨酸酯，2-氨基苯甲酸酯，2,3-二羟基苯甲酸酯和4-羟基环己烷羧酸。 通常，微生物包括（a）外源性氯酸根丙酮酸裂解酶，（b）外源性等离子体合成酶，（c）外源性等酸性丙酮酸裂解酶和（d）包含破坏性突变的前苯甲酸合酶的至少一种。
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公开(公告)号：US20150225751A1
公开(公告)日：2015-08-13
申请号：US14622155
申请日：2015-02-13
发明人： YAJUN YAN , YUHENG LIN
CPC分类号： C12P7/44 , C12N9/88 , C12N9/90 , C12N15/52 , C12P7/42 , C12Y113/11001 , C12Y114/13001 , C12Y402/99 , C12Y402/99021 , C12Y504/04002 , Y02P20/52
摘要： The invention provides a recombinant microorganism that has been genetically engineered to contain metabolic pathway for the production of muconic acid from a salicylic acid intermediate. The genetically engineered metabolic pathway comprises both biosynthetic and biodegradative elements.
摘要翻译： 本发明提供了一种重组微生物，其经遗传工程化以含有从水杨酸中间体生产粘康酸的代谢途径。 遗传工程代谢途径包括生物合成和生物降解元件。
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公开(公告)号：US20230313210A1
公开(公告)日：2023-10-05
申请号：US18024647
申请日：2021-09-03
发明人： Eric H. Lyons , Scott Zentack , David A. Baltrus
CPC分类号： C12N15/78 , C12N9/1007 , C12N9/88 , C12Y402/99021 , C12N9/90 , C12Y504/04002 , C12N9/1029 , C12Y203/01084 , A61K8/99 , A61Q11/00 , A23K10/16 , A23K50/40
摘要： Described herein are engineered bacteria that can produce a volatile compound and formulations thereof. Also described herein are methods of improving the breath odor of a mammal by administering the engineered bacteria or formulation thereof to the oral cavity of the mammal.
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公开(公告)号：US11708590B2
公开(公告)日：2023-07-25
申请号：US16631232
申请日：2018-07-16
发明人： David Nielsen , Brian Thompson
CPC分类号： C12P7/46 , C12N9/0069 , C12N9/0073 , C12N9/88 , C12N9/90 , C12P7/22 , C12Y113/11001 , C12Y114/13002 , C12Y114/13007 , C12Y401/01061 , C12Y401/01063 , C12Y401/01091 , C12Y401/0304 , C12Y401/99002 , C12Y402/0101 , C12Y402/99021 , C12Y504/04002
摘要： Certain embodiments provide a method for preparing a biochemical product (e.g., phenol, catechol, or muconic acid, or a salt thereof). For example, such methods include contacting a recombinant host having two or more recombinant pathways with a fermentable carbon source and growing the recombinant cell for a time sufficient to synthesize the product. In certain embodiments, each recombinant pathway: 1) is capable of producing the same final biochemical product; 2) comprises at least one gene encoding a polypeptide; 3) is derived from a different endogenous metabolite as its immediate precursor; and 4) converges to the same final product or the same intermediate metabolite.
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公开(公告)号：US20180162906A1
公开(公告)日：2018-06-14
申请号：US15576494
申请日：2016-05-26
发明人： David H. Sherman , Fengan Yu , Chuanwu Xi , Jianfeng Wu , Pamela Schultz , Ashootosh Tripathi , Sung Ryeol Park
IPC分类号： C07K7/06 , C07K5/103 , A61K38/07 , A01N43/76 , A01N37/46 , A61K45/06 , C12N9/88 , C07K14/195
CPC分类号： C07K7/06 , A01N37/46 , A01N43/76 , A61K38/07 , A61K45/06 , C07D413/12 , C07K5/00 , C07K5/081 , C07K5/1013 , C07K14/195 , C12N9/88 , C12Y402/99021 , Y02A50/473
摘要： Provided herein are biofilm inhibitors obtained from marine microbial derived natural product extracts from Streptomyces gandocaensis, resulting in biofilm inhibitors, cahuitamycins. Also provided are mutant S. gandocaensis, methods of inhibiting biofilm formation, methods of producing, or increasing the production of, cahuitamycins, methods for synthesizing cahuitamycins, and methods of purifying cahuitamycins.
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