- 专利标题: Synthetic metabolic funneling for biochemical production
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申请号: US16631232申请日: 2018-07-16
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公开(公告)号: US11708590B2公开(公告)日: 2023-07-25
- 发明人: David Nielsen , Brian Thompson
- 申请人: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
- 申请人地址: US AZ Scottsdale
- 专利权人: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
- 当前专利权人: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
- 当前专利权人地址: US AZ Scottsdale
- 代理机构: Viksnins Harris Padys Malen LLP
- 国际申请: PCT/US2018/042324 2018.07.16
- 国际公布: WO2019/018302A 2019.01.24
- 进入国家日期: 2020-01-15
- 主分类号: C12P7/18
- IPC分类号: C12P7/18 ; C12P7/46 ; C12N9/02 ; C12N9/88 ; C12N9/90 ; C12P7/22
摘要:
Certain embodiments provide a method for preparing a biochemical product (e.g., phenol, catechol, or muconic acid, or a salt thereof). For example, such methods include contacting a recombinant host having two or more recombinant pathways with a fermentable carbon source and growing the recombinant cell for a time sufficient to synthesize the product. In certain embodiments, each recombinant pathway: 1) is capable of producing the same final biochemical product; 2) comprises at least one gene encoding a polypeptide; 3) is derived from a different endogenous metabolite as its immediate precursor; and 4) converges to the same final product or the same intermediate metabolite.
公开/授权文献
- US20200216865A1 SYNTHETIC METABOLIC FUNNELING FOR BIOCHEMICAL PRODUCTION 公开/授权日:2020-07-09
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