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公开(公告)号：US11780951B2
公开(公告)日：2023-10-10
申请号：US17586144
申请日：2022-01-27
发明人： Xinrui Zhang , Xiaoyue Wang , Zenghui Yang , Yaoming Zhang , Qihua Wang , Tingmei Wang
IPC分类号： C07C319/22 , C08G18/38 , C07C323/37 , C08G18/10
CPC分类号： C08G18/3863 , C07C319/22 , C07C323/37 , C08G18/10
摘要： The present disclosure belongs to the technical field of polymer materials, and in particular relates to a chain extender and a preparation method and application thereof, a recyclable thermosetting polyurethane and a preparation method thereof. The present disclosure provides a chain extender whose chemical formula is shown in formula I. The chain extender provided by the present disclosure contains two types of dynamic covalent bonds, and the total number of dynamic covalent bonds is 4. The thermosetting polyurethane prepared by the provided chain extender has better hot-pressing repair efficiency. The results of the examples show that under the same hot-pressing conditions, the repair efficiency of the thermosetting polyurethane prepared by the 4,4′-dithiodianiline chain extender is 59%. The repair efficiency of thermosetting polyurethane is 97%, which is significantly improved.
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公开(公告)号：US11071794B2
公开(公告)日：2021-07-27
申请号：US16824139
申请日：2020-03-19
发明人： Zehui Wu , Zhihao Zha , Futao Liu , Karl Ploessl , Seok Rye Choi , Hank F. Kung
IPC分类号： A61K51/00 , A61M36/14 , A61K51/04 , A61B6/03 , C07B59/00 , C07D221/06 , C07D213/64 , C07D405/04 , C07C217/80 , C07D471/04 , C07C323/37 , C07D277/66
摘要： The present invention relates to deuterated compounds according to Formula I-A, Formula II-A, Formula II-D, and Formula III-A. These compounds can be used as PET imaging agents for evaluating Parkinson's Disease, Alzheimer Disease, and for determining specific serotonin reuptake inhibitor (SSRIi) activity for treatment of depression. The present invention also relates to pharmaceutical compositions comprising a pharmaceutical acceptable carrier and a compound of Formula I-A, Formulae II-A, Formula II-D, or Formula III-A, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20210163407A1
公开(公告)日：2021-06-03
申请号：US17251808
申请日：2019-06-19
发明人： THEOCHARIS V. KOFTIS , EFSTRATIOS NEOKOSMIDIS , THANOS ANDREOU , PETROS GKIZIS , ALEXANDRA LITHADIOTI
IPC分类号： C07C319/14 , C07C323/37
摘要： The present invention relates to a novel process for the preparation of Vortioxetine and a key intermediate thereof by employing a novel one-pot organo-pseudocatalytic C—H activation approach via hypervalent iodine chemistry.
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公开(公告)号：US20210024455A1
公开(公告)日：2021-01-28
申请号：US16982517
申请日：2019-03-14
申请人： HIROSHIMA UNIVERSITY
IPC分类号： C07C217/92 , C07C225/22 , C07C323/37
摘要： The compound according to the present invention is a compound represented by the following chemical formula: wherein, in the above-described chemical formula, R1 is oxygen or sulfur, and R2 to R6 are each independently selected from hydrogen, an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, an acyl group having 1 to 6 carbon atoms and a nitro group.
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5.发明申请公开(公告)号：US20200230263A1
公开(公告)日：2020-07-23
申请号：US16824139
申请日：2020-03-19
发明人： Zehui WU , Zhihao ZHA , Futao LIU , Karl PLOESSL , Seok Rye CHOI , Hank F. KUNG
IPC分类号： A61K51/04 , A61B6/03 , C07B59/00 , C07D221/06 , C07D213/64 , C07D405/04 , C07C217/80 , C07D471/04 , C07C323/37
摘要： The present invention relates to deuterated compounds according to Formula I-A, Formula II-A, Formula II-D, and Formula III-A. These compounds can be used as PET imaging agents for evaluating Parkinson's Disease, Alzheimer Disease, and for determining specific serotonin reuptake inhibitor (SSRIi) activity for treatment of depression. The present invention also relates to pharmaceutical compositions comprising a pharmaceutical acceptable carrier and a compound of Formula I-A, Formulae II-A, Formula II-D, or Formula III-A, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US10180626B2
公开(公告)日：2019-01-15
申请号：US15703037
申请日：2017-09-13
IPC分类号： G03F7/004 , G03F7/039 , H01L21/027 , C07C323/37 , C07D333/20 , C07D409/10 , C07C309/12 , C07C381/12 , C07J31/00 , G03F7/16 , G03F7/20 , G03F7/32 , G03F7/38 , G03F7/40
摘要： On use of a sulfonium salt of specific structure as PAG, acid diffusion is suppressed. A resist composition comprising the sulfonium salt forms a pattern with improved lithography properties including EL, MEF and LWR when processed by lithography.
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公开(公告)号：US20180258036A1
公开(公告)日：2018-09-13
申请号：US15976480
申请日：2018-05-10
申请人： BAYER CROPSCIENCE AG
IPC分类号： C07C319/06 , C07C323/35 , C07C323/37 , C07C319/22 , C07C319/24 , C07C323/09 , C07C323/34
CPC分类号： C07C319/06 , C07C319/22 , C07C319/24 , C07C323/09 , C07C323/34 , C07C323/35 , C07C323/37
摘要： The present invention relates to a novel method for preparing bis(3-aminophenyl) disulphides of the general formula (I) and 3-aminothiols of the general formula (II), where X,Y have the meanings stated in the description, which serve as intermediates for the preparation of phenyl sulphoxides having insecticidal, acaricidal and nematicidal activity.
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8.发明授权公开(公告)号：US09550743B2
公开(公告)日：2017-01-24
申请号：US14945654
申请日：2015-11-19
IPC分类号： C07D295/096 , C07C323/37 , C07C309/66 , C07D241/08
CPC分类号： C07D295/096 , C07C309/66 , C07C323/37 , C07D241/08
摘要： The present invention relates to a process for the preparation of 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine of formula (I), also known as vortioxetine, salts thereof, and intermediates useful for its synthesis.
摘要翻译： 本发明涉及一种制备式（I）的1- [2-（2,4-二甲基苯基硫烷基）苯基]哌嗪的方法，也称为伏妥托汀，其盐，以及用于其合成的中间体。
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公开(公告)号：US08906519B2
公开(公告)日：2014-12-09
申请号：US12441037
申请日：2007-09-05
申请人： Taku Kato , Takuji Yoshimoto
发明人： Taku Kato , Takuji Yoshimoto
IPC分类号： B32B9/04 , C07C211/54 , C07C213/00 , C07C217/92 , H05B33/22 , C07D493/18 , C07C211/55 , H01L51/00 , C07C323/37 , H01L51/50
CPC分类号： C07C323/37 , C07C211/55 , C07C217/92 , C07D493/18 , H01L51/0035 , H01L51/0059 , H01L51/5048 , H05B33/22
摘要： An oligoaniline compound represented by the formula (1) can provide a charge transporting thin film which shows a suppressed coloration in the visible range. Use of this thin film makes it possible to ensure a color reproducibility of a device without lowering the color purity of an electroluminescent light or a light having passed through a color filter. wherein R1 to R10 independently represent each a hydrogen atom, a halogen, etc.; m and n independently represent each an integer of 1 or more while satisfying the condition m+n≦20; and X is a structure represented by any of the following formulae (4) to (10), etc.; wherein R21 to R36 independently represent each a hydrogen atom, a hydroxyl group, etc.; p and q represent each an integer of 1 or more while satisfying the conditions p≦20 and q≦20; and W1s independently represent each —(CR1R2)p-, —O—, —S—, etc.
摘要翻译： 由式（1）表示的低聚苯胺化合物可以提供在可见光范围内显示抑制着色的电荷输送薄膜。 使用该薄膜可以确保器件的颜色再现性，而不会降低电致发光的颜色纯度或通过滤色器的光。 其中R1至R10独立地表示氢原子，卤素等; m和n分别独立地表示1或更大的整数，同时满足条件m + n＆nlE; 20; X为由下述式（4）〜（10）表示的结构等。 其中R 21至R 36各自独立地表示氢原子，羟基等; p和q分别表示1或更大的整数，同时满足条件p＆nlE; 20和q＆nlE; 20; 和W 1各自独立地表示 - （CR 1 R 2）p - ， - O - ， - S-等。
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公开(公告)号：US20130225687A1
公开(公告)日：2013-08-29
申请号：US13861646
申请日：2013-04-12
发明人： Janet Ajioka , Heidi S. Hummel , Rich B. Meyer , John Swindle
IPC分类号： C07C217/90 , C07C323/37
CPC分类号： C07C217/90 , A61K31/136 , A61K31/44 , C07C323/37
摘要： The present invention provides a method of selectively inhibiting PKCθ in the presence of PKCδ, by administering to a subject in need thereof, a therapeutically effective amount of a compound of Formula I. The present invention also provides a method of inhibiting cytokine synthesis in a T cell, a method of inhibiting T cell proliferation, and a method of inhibiting the replication of and cytokine production by T lymphocytes, while not stimulating or inhibiting the replication of B lymphocytes.
摘要翻译： 本发明提供了一种通过向有需要的受试者施用治疗有效量的式I化合物在PKCdelta的存在下选择性抑制PKCta的方法。本发明还提供了抑制T细胞因子合成的方法 细胞，抑制T细胞增殖的方法，以及抑制T淋巴细胞复制和细胞因子产生的方法，而不刺激或抑制B淋巴细胞的复制。
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