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公开(公告)号：US09751828B2
公开(公告)日：2017-09-05
申请号：US14747038
申请日：2015-06-23
IPC分类号： C07C213/08 , C07C57/15 , C12P13/00 , C07C213/00 , C07C213/06 , C07C219/28 , C07C51/41 , C07C213/10 , C07C51/43
CPC分类号： C07C213/08 , C07C51/43 , C07C57/15 , C07C213/06 , C07C213/10 , C07C219/28 , C12P13/005
摘要： Substantially stable to degradation Fesoterodine fumarate, a process for its preparation and a process for the synthesis of specific degradation impurities of Fesoterodine fumarate are disclosed.
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公开(公告)号：US10752654B2
公开(公告)日：2020-08-25
申请号：US16090853
申请日：2017-04-03
发明人： Gabriele Razzetti , Anna Iuliano , Luca Giannotti , Grazia Iannucci , Emanuele Attolino , Vittorio Lucchini , Renzo Graziosi
摘要： The invention relates to a process for preparing a compound of formula (I) in particular obeticholic acid and intermediates suitable for its synthesis.
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公开(公告)号：US09687484B2
公开(公告)日：2017-06-27
申请号：US14791736
申请日：2015-07-06
发明人： Stefano Luca Giaffreda , Marco Curzi , Elena Dichiarante , Pietro Allegrini , Renzo Graziosi , Chiara Vladiskovic
IPC分类号： A61K31/495 , C07D295/096
CPC分类号： A61K31/495 , C07D295/096
摘要： The present invention relates to novel crystalline forms of vortioxetine hydrobromide, in particular three crystalline forms, a process for their preparation, a pharmaceutical composition containing said novel crystalline forms, and a process for the purification of vortioxetine or a salt thereof, comprising the formation of one or more of the novel crystalline forms of vortioxetine hydrobromide described herein.
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4.发明授权公开(公告)号：US09550743B2
公开(公告)日：2017-01-24
申请号：US14945654
申请日：2015-11-19
IPC分类号： C07D295/096 , C07C323/37 , C07C309/66 , C07D241/08
CPC分类号： C07D295/096 , C07C309/66 , C07C323/37 , C07D241/08
摘要： The present invention relates to a process for the preparation of 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine of formula (I), also known as vortioxetine, salts thereof, and intermediates useful for its synthesis.
摘要翻译： 本发明涉及一种制备式（I）的1- [2-（2,4-二甲基苯基硫烷基）苯基]哌嗪的方法，也称为伏妥托汀，其盐，以及用于其合成的中间体。
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