公开(公告)号：US11071794B2

公开(公告)日：2021-07-27

申请号：US16824139

申请日：2020-03-19

Applicant: Five Eleven Pharma Inc.

Inventor： Zehui Wu ,  Zhihao Zha ,  Futao Liu ,  Karl Ploessl ,  Seok Rye Choi ,  Hank F. Kung

IPC: A61K51/00 ,  A61M36/14 ,  A61K51/04 ,  A61B6/03 ,  C07B59/00 ,  C07D221/06 ,  C07D213/64 ,  C07D405/04 ,  C07C217/80 ,  C07D471/04 ,  C07C323/37 ,  C07D277/66

Abstract: The present invention relates to deuterated compounds according to Formula I-A, Formula II-A, Formula II-D, and Formula III-A. These compounds can be used as PET imaging agents for evaluating Parkinson's Disease, Alzheimer Disease, and for determining specific serotonin reuptake inhibitor (SSRIi) activity for treatment of depression. The present invention also relates to pharmaceutical compositions comprising a pharmaceutical acceptable carrier and a compound of Formula I-A, Formulae II-A, Formula II-D, or Formula III-A, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US10912849B2

公开(公告)日：2021-02-09

申请号：US15994474

申请日：2018-05-31

Applicant: Five Eleven Pharma Inc.

Inventor： Zehui Wu ,  Zhihao Zha ,  Futao Liu ,  Karl Ploessl ,  Seok Rye Choi ,  Hank F. Kung

IPC: A61K51/00 ,  A61M36/14 ,  A61K51/04 ,  A61B6/03 ,  C07B59/00 ,  C07D221/06 ,  C07D213/64 ,  C07D405/04 ,  C07C217/80 ,  C07D471/04 ,  C07C323/37 ,  C07D277/66

Abstract: The present invention relates to deuterated compounds according to Formula I-A, Formula II-A, Formula II-D, and Formula III-A. These compounds can be used as PET imaging agents for evaluating Parkinson's Disease, Alzheimer Disease, and for determining specific serotonin reuptake inhibitor (SSRIi) activity for treatment of depression. The present invention also relates to pharmaceutical compositions comprising a pharmaceutical acceptable carrier and a compound of Formula I-A, Formulae II-A, Formula II-D, or Formula III-A, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US10688200B2

公开(公告)日：2020-06-23

申请号：US15385490

申请日：2016-12-20

Applicant: Five Eleven Pharma Inc.

Inventor： Hank F. Kung ,  Karl Ploessl ,  Seok Rye Choi ,  Zhihao Zha ,  Zehui Wu

IPC: A61K51/04 ,  C07K5/02

Abstract: The present invention relates to compounds according to Formula I and Formula IV. These compounds display very good binding affinities to the PSMA binding sites. They can be labeled with [68Ga]GaCl3 with high yields and excellent radiochemical purity. The present invention also relates to pharmaceutical compositions comprising a pharmaceutical acceptable carrier and a compound of Formula I or Formula IV, or a pharmaceutically acceptable salt thereof.