公开(公告)号：US07947465B2

公开(公告)日：2011-05-24

申请号：US12187661

申请日：2008-08-07

申请人： William F. Link ,  Renato B. del Rosario ,  Randy V. Sweet ,  David L. King

发明人： William F. Link ,  Renato B. del Rosario ,  Randy V. Sweet ,  David L. King

IPC分类号： G01N33/00

CPC分类号： G01N33/54326 ,  G01N33/94 ,  G01N2446/00 ,  Y10T436/101666 ,  Y10T436/108331 ,  Y10T436/25125

摘要： Bodily fluid is analyzed for the presence of drugs of a selected panel of drugs in a simultaneous assay in which sample of the fluid is incubated with additional amounts of all drugs of the panel, antibodies specific to each of the drugs of the panel, and microparticles, the microparticles being divided into subsets, one subset for each drug in the panel and each subset distinguishable from the others. The incubation is performed in a liquid medium in which competitive binding occurs, the drugs in the sample competing with those added to the assay medium for binding to the antibodies. In one procedure, the added drugs are pre-coupled to the microparticles while the antibodies are not, and the incubation is followed by further incubating the microparticles with labeled ligands that have affinity for the antibodies. In an alternative procedure, the added drugs are not coupled to the microparticles but are pre-labeled, while the antibodies are pre-coupled to the microparticles, and the assay proceeds without further incubation. In both alternatives, the microparticles are ultimately recovered from the assay medium and from any unbound species, and the recovered microparticles are analyzed by flow cytometry to obtain indications of the presence of the various drugs in the sample in an inverse manner by detection of the label, each drug differentiable from the others by the distinguishing features of the microparticles.

摘要翻译： 在同时测定中分析体液中所选择的药物组的药物的存在，其中将流体样品与附加量的所有药物，面板每种药物特异的抗体和微粒 ，将微粒分为子集，面板中每种药物的一个子集，以及与其他子集可区分的每个子集。 孵育在其中发生竞争性结合的液体培养基中进行，样品中的药物与添加到测定培养基中的药物与抗体结合。 在一个程序中，将所添加的药物预先偶联到微粒，而不是抗体，然后孵育后，用对抗体具有亲和性的标记配体进一步孵育微粒。 在替代方法中，所添加的药物不与微粒偶联，而是预先标记，而抗体预偶联于微粒，并且测定在不进一步孵育的情况下进行。 在两种替代方案中，微粒最终从测定培养基和任何未结合物质中回收，并且通过流式细胞术分析回收的微粒，以通过检测标签以相反的方式获得样品中各种药物的存在的迹象 ，每种药物通过微粒的区别特征与其他药物不同。

公开(公告)号：US07520917B2

公开(公告)日：2009-04-21

申请号：US11061237

申请日：2005-02-18

申请人： Ward E. TeGrotenhuis ,  Robert S. Wegeng ,  Greg A. Whyatt ,  David L. King ,  Kriston P. Brooks ,  Victoria S. Stenkamp

发明人： Ward E. TeGrotenhuis ,  Robert S. Wegeng ,  Greg A. Whyatt ,  David L. King ,  Kriston P. Brooks ,  Victoria S. Stenkamp

IPC分类号： B01D53/14

CPC分类号： B01J19/0093 ,  B01J2219/00822 ,  B01J2219/00835 ,  B01J2219/00844 ,  B01J2219/00858 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00905 ,  B01J2219/00918 ,  B01J2219/00921 ,  C01B3/384 ,  C01B3/48 ,  C01B2203/0233 ,  C01B2203/0283 ,  C01B2203/044 ,  C01B2203/047 ,  C01B2203/066 ,  C01B2203/0822 ,  C01B2203/0827 ,  C01B2203/1288 ,  C01B2203/148 ,  C01B2203/1614 ,  C01B2203/1647 ,  Y02P20/128

摘要： A microchannel device includes several mass transfer microchannels to receive a fluid media for processing at least one heat transfer microchannel in fluid communication with a heat transfer fluid defined by a thermally conductive wall, and at several thermally conductive fins each connected to the wall and extending therefrom to separate the mass transfer microchannels from one another. In one form, the device may optionally include another heat transfer microchannel and corresponding wall that is positioned opposite the first wall and has the fins and the mass transfer microchannels extending therebetween.

摘要翻译： 微通道装置包括几个传质微通道，用于接收流体介质，用于处理至少一个与由导热壁限定的传热流体流体连通的传热微通道，以及各自连接到壁并从其延伸的多个导热翅片 以将质量传递微通道彼此分开。 在一种形式中，该装置可以可选地包括另一个传热微通道和与第一壁相对定位的相应的壁，并且具有在其间延伸的翅片和传质微通道。

公开(公告)号：US5352585A

公开(公告)日：1994-10-04

申请号：US084845

申请日：1993-06-29

申请人： Steven R. Binder ,  David L. King

发明人： Steven R. Binder ,  David L. King

IPC分类号： G01N30/02 ,  G01N30/06 ,  G01N30/08 ,  G01N30/14 ,  G01N30/34 ,  G01N30/46 ,  G01N30/74 ,  G01N30/86 ,  G01N30/88

CPC分类号： G01N30/461 ,  G01N30/88 ,  G01N2030/027 ,  G01N2030/085 ,  G01N2030/8804 ,  G01N2030/8813 ,  G01N2030/8831 ,  G01N30/02 ,  G01N30/06 ,  G01N30/14 ,  G01N30/34 ,  G01N30/468 ,  G01N30/74 ,  G01N30/8606 ,  G01N30/8679 ,  Y10S436/901 ,  Y10T436/14 ,  Y10T436/145555 ,  Y10T436/17 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/255

摘要： Biological samples are analyzed for benzodiazepines in a single isocratic analysis using a chromatographic column system containing an immobilized enzyme reactor which cleaves glucuronic acid-conjugated benzodiazepines, an anion exchange column, a hydrophobic cation exchange column and a reverse-phase analytical column. Preferred methods of performing the analysis further involve the use of a hydrophobic cation exchange precolumn prior to the anion exchange column. The system readily lends itself to automation, automatic periodic sampling and benzodiazepine identification and quantification. The system is particularly well adapted to the determination and identification of benzodiazepines in urine samples.

摘要翻译： 在使用含有固定化酶反应器的色谱柱系统的单一等度分析中分析生物样品中的苯并二氮杂，所述固定化酶反应器切割葡糖醛酸 - 共轭苯并二氮杂，阴离子交换柱，疏水性阳离子交换柱和反相分析柱。 执行分析的优选方法还涉及在阴离子交换柱之前使用疏水性阳离子交换预柱。 该系统易于自动化，自动定期取样和苯二氮卓鉴定和定量。 该系统特别适用于尿液样品中苯二氮卓类的测定和鉴定。

公开(公告)号：US5008468A

公开(公告)日：1991-04-16

申请号：US384251

申请日：1989-08-21

申请人： David L. King ,  Michael D. Cooper ,  Michael A. Faber

发明人： David L. King ,  Michael D. Cooper ,  Michael A. Faber

IPC分类号： B01J31/10 ,  B01J31/16 ,  B01J31/18 ,  C07C2/66 ,  C07C45/45 ,  C07C45/46 ,  C07C45/53 ,  C07C45/74 ,  C07C201/08 ,  C07C205/06

CPC分类号： C07C45/455 ,  B01J31/10 ,  B01J31/1658 ,  B01J31/185 ,  C07C2/66 ,  C07C45/46 ,  C07C45/53 ,  C07C45/74 ,  C07C67/04 ,  B01J2231/12 ,  B01J2231/20 ,  B01J2231/323 ,  B01J2231/52 ,  B01J2531/48 ,  C07C2531/06

摘要： This invention provides an improved process for the conversion of reactant into a reaction product, in the presence of a solid acid catalyst comprising sulfonic acid groups covalently bonded to a polymeric chain, wherein the improvement comprises increasing the rate of conversion, on an equivalent sulfonic acid basis, by providing, as said polymeric chain a compound represented by the general formula:M(O.sub.3 ZO.sub.x R).sub.nwherein M is a tetravalent metal ion; Z is a pentavalent atom, selected from the group consisting of elements of Group V of the Periodic Table of the Elements having an atomic weight greater than 30; x varies from 0 to 1; R is select d from the group consisting or organo radicals and mixtures of hydrogen radicals and organo radicals; and n varies from 1 to 2; provided that n is 1 when R is terminated with a tri- or tetraoxy pentavalent atom.

摘要翻译： 本发明提供了在包含共价键合到聚合物链上的磺酸基团的固体酸催化剂存在下将反应物转化成反应产物的改进方法，其中改进包括增加转化速率等同于磺酸 通过提供作为所述聚合物链的由通式M（O 3 Z x R）n表示的化合物，其中M是四价金属离子; Z是选自原子量大于30的元素周期表第Ⅴ族的元素的五价原子; x从0变化到1; R是选自下组的组或有机基团和氢基团和有机基团的混合物; n从1变化到2; 条件是当R用三或四氧基五价原子封端时n为1。

公开(公告)号：US08956823B2

公开(公告)日：2015-02-17

申请号：US12184775

申请日：2008-08-01

申请人： William F. Link ,  Renato B. Del Rosario ,  Randy Sweet ,  David L. King

发明人： William F. Link ,  Renato B. Del Rosario ,  Randy Sweet ,  David L. King

IPC分类号： G01N33/00 ,  G01N33/53 ,  G01N33/566 ,  C12N11/00 ,  G01N33/532 ,  G01N33/543

CPC分类号： G01N33/54306 ,  G01N33/532

摘要： An anti-antibody reagent for use in a competitive or sandwich simplex or multiplex assay, said reagent comprising one or more labeled anti-antibodies for the primary antibodies to be determined in the assay, the reagent further comprising a corresponding unlabeled anti-antibody in an excess or near excess concentration with respect to their binding partners.

摘要翻译： 一种用于竞争性或夹心单形或多重测定中的抗抗体试剂，所述试剂包含一种或多种在测定中待测定的一级抗体的标记抗体，该试剂还包含相应的未标记抗体 相对于其结合配偶体过量或接近过量的浓度。

公开(公告)号：US08668211B2

公开(公告)日：2014-03-11

申请号：US13062337

申请日：2009-08-28

申请人： David L. King

发明人： David L. King

IPC分类号： B62B5/00

CPC分类号： B62B5/0083 ,  B62B2202/30 ,  B62B2205/006 ,  B62B2501/065

摘要： A high strength plastic furniture dolly employs a combination of structural features and high strength material to eliminate the need for metal or wood reinforcing elements. The dolly includes first and second longitudinal side members, first and second transverse end members, and caster wheel assemblies mounted longitudinally inward from the transverse end members. The longitudinal side members include a plurality of longitudinally extending parabolic ribs in a central portion and a plurality of non-parabolic ribs in end portions of each side member. The transverse end members include a plurality of transversely extending ribs which may be parabolic.

摘要翻译： 高强度塑料家具台车采用结构特征和高强度材料的组合，以消除对金属或木材增强元件的需要。 小车包括第一和第二纵向侧构件，第一和第二横向端构件以及从横向端构件纵向向内安装的脚轮组件。 纵向侧构件包括在中心部分中的多个纵向延伸的抛物线肋和在每个侧构件的端部中的多个非抛物线肋。 横向端构件包括可以是抛物线的多个横向延伸的肋。

公开(公告)号：US20110039686A1

公开(公告)日：2011-02-17

申请号：US12856239

申请日：2010-08-13

申请人： Liyu Li ,  Christopher J. Howard ,  David L. King ,  Mark A. Gerber ,  Robert A. Dagle ,  Don J. Stevens

发明人： Liyu Li ,  Christopher J. Howard ,  David L. King ,  Mark A. Gerber ,  Robert A. Dagle ,  Don J. Stevens

IPC分类号： B01J38/12

CPC分类号： B01J38/06 ,  B01J23/755 ,  B01J23/78 ,  B01J23/94 ,  B01J38/04 ,  B01J38/10 ,  B01J38/14 ,  C01B3/384 ,  C01B3/40 ,  C01B2203/0233 ,  C01B2203/0811 ,  C01B2203/1058 ,  C01B2203/1241 ,  Y02P20/52 ,  Y02P20/584

摘要： A new regeneration method has been developed which can effectively and efficiently remove sulfur from Ni-based steam reforming catalysts. In its simplest form the present invention comprises the steps of oxidizing a catalyst with a dilute O2 stream; decomposing the nickel sulfate under inert gas stream and removing sub-surface sulfur under steam reforming conditions. In some embodiments these steps can all be accomplished and the regenerated catalyst be reintroduced to a steam reforming operation in a matter of eight hours or less.

摘要翻译： 已经开发了一种可以有效和高效地从Ni基蒸汽重整催化剂中除去硫的新方法。 在其最简单的形式中，本发明包括用稀O 2流氧化催化剂的步骤; 在惰性气流下分解硫酸镍，并在蒸汽重整条件下除去表面硫。 在一些实施方案中，这些步骤都可以完成，并且再生催化剂在8小时以​​内重新引入蒸汽重整操作。

公开(公告)号：US07700517B2

公开(公告)日：2010-04-20

申请号：US11347459

申请日：2006-02-03

申请人： Liyu Li ,  David L. King

发明人： Liyu Li ,  David L. King

IPC分类号： B01J23/34 ,  B01J23/50 ,  B01J20/06

CPC分类号： B01D53/949 ,  B01D53/9422 ,  F01N3/021 ,  F01N3/0807 ,  F01N2570/04

摘要： Octahedral molecular sieve sorbents and catalysts are disclosed, including silver hollandite and cryptomelane. These materials can be used, for example, to catalyze the oxidation of COx (e.g., CO), NOx (e.g., NO), hydrocarbons (e.g., C3H6) and/or sulfur-containing compounds. The disclosed materials also may be used to catalyze other reactions, such as the reduction of NO2. In some cases, the disclosed materials are capable of sorbing certain products from the reactions they catalyze. Silver hollandite, in particular, can be used to remove a substantial portion of certain sulfur-containing compounds from a gas or liquid by catalysis and/or sorption. The gas or liquid can be, for example, natural gas or a liquid hydrocarbon.

摘要翻译： 公开了八面体分子筛吸附剂和催化剂，包括银胡萝卜素和cryptomelane。 这些材料可以用于例如催化COx（例如CO），NO x（例如NO），烃（例如C 3 H 6）和/或含硫化合物的氧化。 所公开的材料也可用于催化其它反应，例如还原NO 2。 在一些情况下，所公开的材料能够从它们催化的反应中吸收某些产物。 特别地，银矿砂可以用于通过催化和/或吸附从气体或液体中除去大部分某些含硫化合物。 气体或液体可以是例如天然气或液体烃。

公开(公告)号：US20090053832A1

公开(公告)日：2009-02-26

申请号：US11841649

申请日：2007-08-20

申请人： William F. Link ,  Renato B. Del Rosario ,  Randy V. Sweet ,  David L. King

发明人： William F. Link ,  Renato B. Del Rosario ,  Randy V. Sweet ,  David L. King

IPC分类号： G01N33/542

CPC分类号： G01N33/94 ,  G01N33/54333

摘要： A method and kits for assaying a sample of a human or mammalian bodily fluid to simultaneously determine whether one or more of a plurality of drugs and/or metabolites thereof are present in said sample and optionally to perform a semi-quantitative assay for said drug or drugs, comprising: (a) incubating the sample in a competitive assay with a plurality of drug conjugates and a plurality of primary antibodies that bind to the drugs whose presence and optionally whose amount is to be determined, wherein either the plurality of drugs or the plurality of primary antibodies is coupled to microparticles comprising magnetically responsive material, the particles being divided into subsets of particles, each distinguishable from the others by one or more differentiation parameters and by the drug to which they are coupled; (b) incubating the product of step (a) with a liquid medium comprising one or more labeled ligands for the primary antibodies or drug conjugates; (c) magnetically separating microparticles in all of said groups from said liquid medium; and defining said liquid medium as a first liquid medium; (d) resuspending said microparticles separated therefrom in a second liquid medium; and (e) analyzing said microparticles in said second liquid medium by flow cytometry and identifying drugs present in the sample, and optionally calculating a semi-quantitative result for drugs found to be present.

公开(公告)号：US5416023A

公开(公告)日：1995-05-16

申请号：US271390

申请日：1994-07-06

申请人： Steven R. Binder ,  David L. King

发明人： Steven R. Binder ,  David L. King

IPC分类号： G01N30/02 ,  G01N30/06 ,  G01N30/08 ,  G01N30/14 ,  G01N30/34 ,  G01N30/46 ,  G01N30/74 ,  G01N30/86 ,  G01N30/88

CPC分类号： G01N30/461 ,  G01N30/88 ,  G01N2030/027 ,  G01N2030/085 ,  G01N2030/8804 ,  G01N2030/8813 ,  G01N2030/8831 ,  G01N30/02 ,  G01N30/06 ,  G01N30/14 ,  G01N30/34 ,  G01N30/468 ,  G01N30/74 ,  G01N30/8606 ,  G01N30/8679 ,  Y10S436/901 ,  Y10T436/14 ,  Y10T436/145555 ,  Y10T436/17 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/255

摘要： Biological samples are analyzed for benzodiazepines in a single isocratic analysis using a chromatographic column system containing an immobilized enzyme reactor which cleaves glucuronic acid-conjugated benzodiazepines, an anion exchange column, a hydrophobic cation exchange column and a reverse-phase analytical column. Preferred methods of performing the analysis further involve the use of a hydrophobic cation exchange precolumn prior to the anion exchange column. The system readily lends itself to automation, automatic periodic sampling and benzodiazepine identification and quantification. The system is particularly well adapted to the determination and identification of benzodiazepines in urine samples.

摘要翻译： 在使用含有固定化酶反应器的色谱柱系统的单一等度分析中分析生物样品中的苯并二氮杂，所述固定化酶反应器切割葡糖醛酸 - 共轭苯并二氮杂，阴离子交换柱，疏水性阳离子交换柱和反相分析柱。 执行分析的优选方法还涉及在阴离子交换柱之前使用疏水性阳离子交换预柱。 该系统易于自动化，自动定期取样和苯二氮卓鉴定和定量。 该系统特别适用于尿液样品中苯二氮卓类的测定和鉴定。